Neratinib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDLIM5 PDZ and LIM domain 5 0.0527586
SLTM SAFB-like, transcription modulator 0.0511796
PTPRM protein tyrosine phosphatase, receptor type, M 0.0482487
PDE4D phosphodiesterase 4D, cAMP-specific 0.0477225
INTS6 integrator complex subunit 6 0.0426266
ASPH aspartate beta-hydroxylase 0.0406031
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0389637
EFNA5 ephrin-A5 0.0369425
ZSWIM6 zinc finger, SWIM-type containing 6 0.034062
HOMER1 homer scaffolding protein 1 0.0339374
PM20D1 peptidase M20 domain containing 1 0.0326838
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0312389
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0309147
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0301565
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0297455
NABP1 nucleic acid binding protein 1 0.0297401
VCL vinculin 0.0287607
THSD4 thrombospondin, type I, domain containing 4 0.0286344
DSCAM Down syndrome cell adhesion molecule 0.0286267
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0278995
RNF213 ring finger protein 213 0.0275123
MAP7 microtubule-associated protein 7 0.0260532
SP100 SP100 nuclear antigen 0.0259421
HSPA8 heat shock 70kDa protein 8 0.023718
MCTP1 multiple C2 domains, transmembrane 1 0.0212262
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0209727
CEMIP cell migration inducing protein, hyaluronan binding 0.0209253
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0206327
ANKRD10 ankyrin repeat domain 10 0.0200172
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0196621
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0194675
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0191899
SMOC1 SPARC related modular calcium binding 1 0.0189012
TUFT1 tuftelin 1 0.0187501
ELL2 elongation factor, RNA polymerase II, 2 0.0183746
LRP1B low density lipoprotein receptor-related protein 1B 0.0178657
GPHN gephyrin 0.0176391
IGF1R insulin-like growth factor 1 receptor 0.0175615
MYO1E myosin IE 0.0171602
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0170998
KYNU kynureninase 0.0168131
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0168115
NSUN6 NOP2/Sun domain family, member 6 0.0167343
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0163308
CATSPERB catsper channel auxiliary subunit beta 0.0162189
LPP LIM domain containing preferred translocation partner in lipoma 0.0161219
MYOF myoferlin 0.0155186
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0151353
ARHGAP26 Rho GTPase activating protein 26 0.0148415
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0145322
FNDC3A fibronectin type III domain containing 3A 0.0142236
CCSER1 coiled-coil serine-rich protein 1 0.0139655
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0138623
NTN4 netrin 4 0.0137558
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0135806
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0134527
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0134177
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0131618
MYH9 myosin, heavy chain 9, non-muscle 0.0129414
MIPOL1 mirror-image polydactyly 1 0.0127346
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0127219
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0126911
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.01256
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0125134
VMP1 vacuole membrane protein 1 0.0124978
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0121537
PLSCR1 phospholipid scramblase 1 0.0118663
BMP6 bone morphogenetic protein 6 0.0117961
AEBP2 AE binding protein 2 0.0117183
MBNL1 muscleblind-like splicing regulator 1 0.0116309
DST dystonin 0.0116205
RIMS2 regulating synaptic membrane exocytosis 2 0.0115273
KIAA1217 KIAA1217 0.0114634
DOCK5 dedicator of cytokinesis 5 0.0114146
BZW1 basic leucine zipper and W2 domains 1 0.011356
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0112762
KRT86 keratin 86, type II 0.0112636
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0112197
MRPS35 mitochondrial ribosomal protein S35 0.0112025
SIK3 SIK family kinase 3 0.0109698
GPATCH2L G patch domain containing 2-like 0.0109274
MX1 MX dynamin-like GTPase 1 0.0109239
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0108407
RAD51B RAD51 paralog B 0.0108203
ADAM32 ADAM metallopeptidase domain 32 0.0107948
SMAD3 SMAD family member 3 0.0107275
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0106769
FAF1 Fas (TNFRSF6) associated factor 1 0.0104499
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0103661
TRAPPC9 trafficking protein particle complex 9 0.0103039
ARMH4 armadillo like helical domain containing 4 0.0102254
NFE2L2 nuclear factor, erythroid 2-like 2 0.0101674
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.010155
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0100087
PARP14 poly (ADP-ribose) polymerase family, member 14 0.00992586
RPS2 ribosomal protein S2 0.00985196
MKI67 marker of proliferation Ki-67 0.00982458
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.00976959
IFI44L interferon-induced protein 44-like 0.00960973
GPC5 glypican 5 0.0094761

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.213508
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.180801
NDRG1 N-myc downstream regulated 1 -0.144772
TMSB10 thymosin beta 10 -0.0913109
TXNRD1 thioredoxin reductase 1 -0.0903553
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0682496
FTH1 ferritin, heavy polypeptide 1 -0.0546494
MT2A metallothionein 2A -0.0503589
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0499808
FAM13A family with sequence similarity 13, member A -0.0490314
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0460246
S100A10 S100 calcium binding protein A10 -0.0411103
HDLBP high density lipoprotein binding protein -0.0398096
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0396252
BRWD1 bromodomain and WD repeat domain containing 1 -0.0378097
PKM pyruvate kinase, muscle -0.0375359
ZMYND8 zinc finger, MYND-type containing 8 -0.0373656
PDIA3 protein disulfide isomerase family A, member 3 -0.0370839
ACTG1 actin gamma 1 -0.0369571
CAV1 caveolin 1, caveolae protein, 22kDa -0.0368772
LMO7 LIM domain 7 -0.0346068
H1-0 H1.0 linker histone -0.0339739
LAMC2 laminin, gamma 2 -0.0331409
TMEM165 transmembrane protein 165 -0.0331233
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0321282
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0305948
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0303788
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0299698
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0298185
PRRC2C proline-rich coiled-coil 2C -0.0287806
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0274327
CAMTA1 calmodulin binding transcription activator 1 -0.0267987
OSMR oncostatin M receptor -0.0267619
FTL ferritin, light polypeptide -0.0267605
TPT1 tumor protein, translationally-controlled 1 -0.0263946
SEC61G Sec61 gamma subunit -0.0261913
SEC31A SEC31 homolog A (S. cerevisiae) -0.0260968
GOLGB1 golgin B1 -0.0259944
LAMA4 laminin, alpha 4 -0.0255195
WASF2 WAS protein family, member 2 -0.0250436
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0248059
LDHA lactate dehydrogenase A -0.024509
RAB1A RAB1A, member RAS oncogene family -0.0241902
GOLGA4 golgin A4 -0.0240874
CD163L1 CD163 molecule-like 1 -0.0240455
PATJ PATJ crumbs cell polarity complex component -0.0239424
PDE8A phosphodiesterase 8A -0.023586
NAMPT nicotinamide phosphoribosyltransferase -0.0232294
STC1 stanniocalcin 1 -0.0226821
NGLY1 N-glycanase 1 -0.0224989
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0222467
PTMA prothymosin, alpha -0.0221616
KMT2E lysine (K)-specific methyltransferase 2E -0.0217324
HM13 histocompatibility (minor) 13 -0.0216896
CST3 cystatin C -0.0213525
RIN2 Ras and Rab interactor 2 -0.0212559
GCLC glutamate-cysteine ligase, catalytic subunit -0.0210391
BIRC6 baculoviral IAP repeat containing 6 -0.021009
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0209799
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0206043
EMP1 epithelial membrane protein 1 -0.0205256
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0204971
SRP54 signal recognition particle 54kDa -0.0203798
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0203486
HYOU1 hypoxia up-regulated 1 -0.0201858
CCNI cyclin I -0.0201682
IGFBP3 insulin-like growth factor binding protein 3 -0.0199612
SEC24D SEC24 family member D -0.0199386
SLC38A1 solute carrier family 38, member 1 -0.0198982
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0197801
CD99 CD99 molecule -0.0196467
CDCP1 CUB domain containing protein 1 -0.0195219
RICTOR RPTOR independent companion of MTOR, complex 2 -0.019511
KDM5B lysine (K)-specific demethylase 5B -0.019413
HMGA1 high mobility group AT-hook 1 -0.0192751
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0192119
SEC24A SEC24 family member A -0.0191486
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0191018
ZFAND3 zinc finger, AN1-type domain 3 -0.0190882
EGR1 early growth response 1 -0.0189307
KMT2A lysine (K)-specific methyltransferase 2A -0.0182184
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0180917
RNF149 ring finger protein 149 -0.0180519
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0180342
WDR45B WD repeat domain 45B -0.0179999
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0179564
PFN1 profilin 1 -0.0175977
POTEF POTE ankyrin domain family, member F -0.0175734
SEPTIN2 septin 2 -0.0175539
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0174583
RAB27B RAB27B, member RAS oncogene family -0.0174444
PERP PERP, TP53 apoptosis effector -0.01728
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0172369
MT1X metallothionein 1X -0.017129
ESRP1 epithelial splicing regulatory protein 1 -0.0166977
CES1 carboxylesterase 1 -0.0165566
CSTB cystatin B (stefin B) -0.0164543
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0161211
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0161117
LMAN1 lectin, mannose-binding, 1 -0.0160998