| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.182363 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.172493 |
| HMGA2 | high mobility group AT-hook 2 | 0.107146 |
| LOX | lysyl oxidase | 0.10339 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0827476 |
| PCBP2 | poly(rC) binding protein 2 | 0.0780611 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0761462 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0680747 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0679126 |
| MEF2A | myocyte enhancer factor 2A | 0.0627378 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0586124 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0556894 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0554429 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0538818 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0507297 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.05054 |
| FAM20C | family with sequence similarity 20, member C | 0.0505351 |
| GLCCI1 | glucocorticoid induced 1 | 0.0504469 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0496729 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0483179 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0462729 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.045942 |
| VMP1 | vacuole membrane protein 1 | 0.0459073 |
| FBN1 | fibrillin 1 | 0.0443812 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0438079 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0409211 |
| DPYD | dihydropyrimidine dehydrogenase | 0.040777 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0405359 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0402819 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.039802 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0380765 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0370878 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0355119 |
| FTL | ferritin, light polypeptide | 0.0353353 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0352896 |
| TMSB10 | thymosin beta 10 | 0.03487 |
| AADAC | arylacetamide deacetylase | 0.0341941 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0337405 |
| PTMA | prothymosin, alpha | 0.0336646 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0334119 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0333766 |
| PLIN2 | perilipin 2 | 0.0329626 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0322556 |
| ENO1 | enolase 1, (alpha) | 0.0319767 |
| PGK1 | phosphoglycerate kinase 1 | 0.0314146 |
| MEMO1 | mediator of cell motility 1 | 0.0312251 |
| CANX | calnexin | 0.0311838 |
| S100A6 | S100 calcium binding protein A6 | 0.0308474 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0307135 |
| COL12A1 | collagen, type XII, alpha 1 | 0.0300332 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0298915 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0298875 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0286446 |
| NRG1 | neuregulin 1 | 0.0285877 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0278876 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0278594 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0278476 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0278352 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0271233 |
| LDHA | lactate dehydrogenase A | 0.0264609 |
| PDE7B | phosphodiesterase 7B | 0.0262009 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0261024 |
| DNER | delta/notch-like EGF repeat containing | 0.0258145 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0256977 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0254723 |
| WLS | wntless Wnt ligand secretion mediator | 0.0254524 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0250425 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0249262 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0246478 |
| CLIC4 | chloride intracellular channel 4 | 0.0246351 |
| GPC6 | glypican 6 | 0.0244981 |
| NTN4 | netrin 4 | 0.0242743 |
| TMEM41B | transmembrane protein 41B | 0.0242234 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0239501 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0237676 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0235659 |
| EGR1 | early growth response 1 | 0.0234542 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0233591 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0231561 |
| RUNX2 | runt-related transcription factor 2 | 0.0231435 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0230451 |
| JUN | jun proto-oncogene | 0.0230212 |
| TGFB1 | transforming growth factor, beta 1 | 0.0229732 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.022928 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.0229078 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0228905 |
| RAI14 | retinoic acid induced 14 | 0.0228566 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.022553 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0215392 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0208819 |
| OXR1 | oxidation resistance 1 | 0.0208349 |
| GLIS3 | GLIS family zinc finger 3 | 0.0204404 |
| SQSTM1 | sequestosome 1 | 0.0203608 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0203555 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.02032 |
| HTRA3 | HtrA serine peptidase 3 | 0.0202421 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0201555 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0201234 |
| CA12 | carbonic anhydrase XII | 0.0201153 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.0200779 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.129591 |
| VIM | vimentin | -0.110771 |
| MT2A | metallothionein 2A | -0.0929561 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0881776 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.086892 |
| SMAD3 | SMAD family member 3 | -0.0861717 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0796273 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0706486 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0652252 |
| NDRG1 | N-myc downstream regulated 1 | -0.0614854 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0606051 |
| CD44 | CD44 molecule (Indian blood group) | -0.0604645 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0593778 |
| NAV2 | neuron navigator 2 | -0.0578849 |
| RUNX1 | runt-related transcription factor 1 | -0.0576039 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0549749 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.051056 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0494556 |
| GOLGA4 | golgin A4 | -0.0473433 |
| CDCP1 | CUB domain containing protein 1 | -0.0461659 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0454541 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.044828 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0448245 |
| LRRC49 | leucine rich repeat containing 49 | -0.0446789 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0445965 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0419685 |
| USP34 | ubiquitin specific peptidase 34 | -0.0409032 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0408846 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0399026 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0398114 |
| KLF6 | Kruppel-like factor 6 | -0.0396667 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0388688 |
| MYO6 | myosin VI | -0.037192 |
| ATXN1 | ataxin 1 | -0.0363488 |
| PDE8A | phosphodiesterase 8A | -0.0363137 |
| AHNAK | AHNAK nucleoprotein | -0.0360918 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0360473 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0349923 |
| OSMR | oncostatin M receptor | -0.0349093 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0344385 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0335585 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0334693 |
| MSN | moesin | -0.0334179 |
| EFNA5 | ephrin-A5 | -0.0332932 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0325678 |
| NRP1 | neuropilin 1 | -0.0323803 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.032286 |
| SLFN5 | schlafen family member 5 | -0.0322216 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0318932 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0318775 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0317595 |
| SBF2 | SET binding factor 2 | -0.0316363 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0309071 |
| FLNB | filamin B, beta | -0.0300177 |
| NPC1 | Niemann-Pick disease, type C1 | -0.029958 |
| RPS2 | ribosomal protein S2 | -0.0297364 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0289984 |
| SPAG9 | sperm associated antigen 9 | -0.0289222 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0288964 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0287496 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | -0.0285176 |
| DUSP5 | dual specificity phosphatase 5 | -0.028456 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0282969 |
| NBAS | neuroblastoma amplified sequence | -0.0282524 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0276852 |
| EXOC6B | exocyst complex component 6B | -0.0276504 |
| PRELID2 | PRELI domain containing 2 | -0.0268635 |
| ANK2 | ankyrin 2, neuronal | -0.026774 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0266449 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0265251 |
| KIAA1217 | KIAA1217 | -0.0264887 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0264869 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0264451 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0261121 |
| ANKRD36 | ankyrin repeat domain 36 | -0.0259869 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0253149 |
| EGFR | epidermal growth factor receptor | -0.0250354 |
| JMJD1C | jumonji domain containing 1C | -0.0249689 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0247731 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.024515 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0244461 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.024437 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0243158 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | -0.0241638 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0239773 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0238906 |
| MPZL1 | myelin protein zero-like 1 | -0.0237554 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0235503 |
| GRAMD1B | GRAM domain containing 1B | -0.0232218 |
| RNF149 | ring finger protein 149 | -0.0231275 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0230457 |
| MAP1B | microtubule-associated protein 1B | -0.0230046 |
| RPL9 | ribosomal protein L9 | -0.0228171 |
| FAM3C | family with sequence similarity 3, member C | -0.0227768 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0223741 |
| ECE1 | endothelin converting enzyme 1 | -0.022293 |
| RPS6 | ribosomal protein S6 | -0.022232 |
| ANXA1 | annexin A1 | -0.0221688 |
| PARD3 | par-3 family cell polarity regulator | -0.0221545 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0219222 |
