| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.139053 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0834381 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0646401 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0548761 |
| ENO1 | enolase 1, (alpha) | 0.0529468 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0494397 |
| ASPH | aspartate beta-hydroxylase | 0.0433427 |
| NRG1 | neuregulin 1 | 0.0415126 |
| STC1 | stanniocalcin 1 | 0.0388349 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0376505 |
| FMNL2 | formin-like 2 | 0.0343204 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0334382 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0323187 |
| ERBIN | erbb2 interacting protein | 0.0288903 |
| PKM | pyruvate kinase, muscle | 0.0288584 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0287949 |
| CALU | calumenin | 0.0272266 |
| MAP1B | microtubule-associated protein 1B | 0.0270113 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0266396 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0246245 |
| PDS5A | PDS5 cohesin associated factor A | 0.0239704 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0236968 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0235027 |
| ITSN2 | intersectin 2 | 0.0234587 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0229122 |
| FLNB | filamin B, beta | 0.0229027 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0228767 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0226815 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0224387 |
| PYGL | phosphorylase, glycogen, liver | 0.0216858 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0213395 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0212573 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0211147 |
| TPM3 | tropomyosin 3 | 0.021049 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0206721 |
| ITGA6 | integrin, alpha 6 | 0.019913 |
| KIAA0319 | KIAA0319 | 0.0197152 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0195919 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0194773 |
| FN1 | fibronectin 1 | 0.0194473 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0194251 |
| RPL31 | ribosomal protein L31 | 0.0193295 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0192587 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0192569 |
| XPO1 | exportin 1 | 0.0189934 |
| ATXN1 | ataxin 1 | 0.0189358 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0189296 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.0187441 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0187279 |
| B2M | beta-2-microglobulin | 0.0185837 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0185542 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0184604 |
| S100A10 | S100 calcium binding protein A10 | 0.0184042 |
| HMGA1 | high mobility group AT-hook 1 | 0.0183708 |
| RAI1 | retinoic acid induced 1 | 0.0183544 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0181784 |
| RHBDD1 | rhomboid domain containing 1 | 0.0180987 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.01809 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0176564 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0176048 |
| STAG2 | stromal antigen 2 | 0.0174317 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.0172708 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.0171892 |
| CEP350 | centrosomal protein 350kDa | 0.0169884 |
| ERH | enhancer of rudimentary homolog (Drosophila) | 0.0166107 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.0165259 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0164589 |
| NBEAL1 | neurobeachin-like 1 | 0.016414 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0163857 |
| CANX | calnexin | 0.0163826 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0163602 |
| CUX1 | cut-like homeobox 1 | 0.0163588 |
| R3HDM1 | R3H domain containing 1 | 0.0163157 |
| FDPS | farnesyl diphosphate synthase | 0.0162888 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0162879 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0160531 |
| RNF213 | ring finger protein 213 | 0.0160118 |
| SMAD3 | SMAD family member 3 | 0.0159076 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0158866 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0158476 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0158362 |
| HEATR5A | HEAT repeat containing 5A | 0.0157471 |
| PURA | purine-rich element binding protein A | 0.0156694 |
| CD9 | CD9 molecule | 0.015627 |
| HMGA2 | high mobility group AT-hook 2 | 0.0155383 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0154869 |
| ZNF451 | zinc finger protein 451 | 0.0154666 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0153543 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.015345 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0151783 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0151576 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0150662 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0149709 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0149338 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0148073 |
| PFDN1 | prefoldin subunit 1 | 0.0148051 |
| CDCP1 | CUB domain containing protein 1 | 0.0147974 |
| ANXA4 | annexin A4 | 0.014795 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0147211 |
| ZC3H6 | zinc finger CCCH-type containing 6 | 0.0146663 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | -0.191889 |
| GRAMD1B | GRAM domain containing 1B | -0.176141 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.107992 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.107576 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0855417 |
| RBM39 | RNA binding motif protein 39 | -0.0840315 |
| VIM | vimentin | -0.0825989 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0770952 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0769708 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0765328 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0744165 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.06461 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0593028 |
| EGR1 | early growth response 1 | -0.0544533 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.054106 |
| MCL1 | myeloid cell leukemia 1 | -0.0537312 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0530104 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0520056 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0498749 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0493163 |
| RPL23 | ribosomal protein L23 | -0.0492914 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.048105 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0465334 |
| DENND4A | DENN/MADD domain containing 4A | -0.0460666 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0458716 |
| IGF2 | insulin-like growth factor 2 | -0.0447187 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.044454 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0422165 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0420105 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0412114 |
| PTK2 | protein tyrosine kinase 2 | -0.0407903 |
| TPD52 | tumor protein D52 | -0.040654 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0402797 |
| RLF | rearranged L-myc fusion | -0.0394829 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0393799 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0392915 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0389629 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0385467 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0375599 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0369721 |
| SVIL | supervillin | -0.0368502 |
| RBM25 | RNA binding motif protein 25 | -0.036828 |
| RPS19 | ribosomal protein S19 | -0.0368207 |
| RPS2 | ribosomal protein S2 | -0.0366646 |
| MT2A | metallothionein 2A | -0.0350893 |
| OSMR | oncostatin M receptor | -0.0348668 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0345681 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0345301 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0342166 |
| KYNU | kynureninase | -0.03406 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0336471 |
| EWSR1 | EWS RNA-binding protein 1 | -0.0334126 |
| CCNL1 | cyclin L1 | -0.0332799 |
| RPLP2 | ribosomal protein, large, P2 | -0.0331403 |
| YBX3 | Y box binding protein 3 | -0.0329657 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0325616 |
| FAM107B | family with sequence similarity 107, member B | -0.0323285 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0323139 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0318484 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0316661 |
| RPL36A | ribosomal protein L36a | -0.0315947 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0310811 |
| PNN | pinin, desmosome associated protein | -0.0309505 |
| WDR43 | WD repeat domain 43 | -0.0308352 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0307499 |
| FBXO11 | F-box protein 11 | -0.0305692 |
| RPS12 | ribosomal protein S12 | -0.0305436 |
| SIK3 | SIK family kinase 3 | -0.0302766 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0301643 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.029615 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0293353 |
| NOP58 | NOP58 ribonucleoprotein | -0.0291252 |
| TOP1 | topoisomerase (DNA) I | -0.0290626 |
| ZNF804A | zinc finger protein 804A | -0.0290105 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0288433 |
| GOLGA4 | golgin A4 | -0.0283343 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0281195 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0280544 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0279909 |
| TMSB10 | thymosin beta 10 | -0.02761 |
| RPLP1 | ribosomal protein, large, P1 | -0.0274105 |
| KCMF1 | potassium channel modulatory factor 1 | -0.027082 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0270461 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0268808 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | -0.0268714 |
| WWOX | WW domain containing oxidoreductase | -0.0267739 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0267534 |
| IER2 | immediate early response 2 | -0.0267428 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0262697 |
| TMEM87A | transmembrane protein 87A | -0.0262115 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0262041 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | -0.0261664 |
| RPL36 | ribosomal protein L36 | -0.0260052 |
| CRY1 | cryptochrome circadian clock 1 | -0.0258597 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.025822 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0257748 |
| MED13 | mediator complex subunit 13 | -0.0256132 |
| RIOK3 | RIO kinase 3 | -0.0254973 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.025304 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0251667 |
