| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| JMJD1C | jumonji domain containing 1C | 0.0642102 |
| PDE10A | phosphodiesterase 10A | 0.0593212 |
| RTN4 | reticulon 4 | 0.0569743 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0569675 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0569501 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0535235 |
| PCM1 | pericentriolar material 1 | 0.0533922 |
| ZNF292 | zinc finger protein 292 | 0.0518915 |
| XPO1 | exportin 1 | 0.0498897 |
| SETD2 | SET domain containing 2 | 0.0497531 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0496546 |
| HELZ | helicase with zinc finger | 0.0490875 |
| IGF1R | insulin-like growth factor 1 receptor | 0.048218 |
| AFDN | afadin, adherens junction formation factor | 0.0481186 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.045884 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0443518 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0426862 |
| APP | amyloid beta (A4) precursor protein | 0.0426426 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0420828 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0412221 |
| MATR3 | matrin 3 | 0.0408124 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0404101 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0402292 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0401705 |
| KIAA1958 | KIAA1958 | 0.0392788 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0389483 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0379196 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0374218 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0368192 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0367963 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0366732 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0364898 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0363148 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0360645 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0360071 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0351925 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0351183 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0343857 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0342612 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0341145 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0340189 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0337623 |
| SETD5 | SET domain containing 5 | 0.033691 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0334015 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0333586 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0330758 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0329396 |
| FNIP1 | folliculin interacting protein 1 | 0.0324734 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0319611 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0314882 |
| RAD51B | RAD51 paralog B | 0.031372 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0310396 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0308946 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0301513 |
| SBF2 | SET binding factor 2 | 0.0297229 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0294597 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0294218 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0292879 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0285875 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0279556 |
| MYOF | myoferlin | 0.0277416 |
| GNAS | GNAS complex locus | 0.0273221 |
| PHF3 | PHD finger protein 3 | 0.027138 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0267672 |
| RBM39 | RNA binding motif protein 39 | 0.0267198 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0266069 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0262357 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0261592 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0254959 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0254702 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.025292 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0252428 |
| ERBIN | erbb2 interacting protein | 0.0242878 |
| TJP1 | tight junction protein 1 | 0.0242344 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0242069 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0239459 |
| PTK2 | protein tyrosine kinase 2 | 0.0236644 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0235104 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0229748 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0227647 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0225262 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0223638 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.022212 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0221618 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0219747 |
| STK24 | serine/threonine kinase 24 | 0.0217998 |
| LAMC2 | laminin, gamma 2 | 0.0217733 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0213564 |
| TMSB4X | thymosin beta 4, X-linked | 0.0212208 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0209054 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0207568 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0207375 |
| RBM25 | RNA binding motif protein 25 | 0.0202739 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0202511 |
| QKI | QKI, KH domain containing, RNA binding | 0.0197779 |
| CLASP1 | cytoplasmic linker associated protein 1 | 0.019769 |
| RPL5 | ribosomal protein L5 | 0.0191337 |
| POTEF | POTE ankyrin domain family, member F | 0.0189237 |
| RASA2 | RAS p21 protein activator 2 | 0.0189223 |
| NIPSNAP2 | nipsnap homolog 2 | 0.0180268 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.176975 |
| PTMA | prothymosin, alpha | -0.145435 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.100359 |
| LMO7 | LIM domain 7 | -0.0944464 |
| HLA-B | major histocompatibility complex, class I, B | -0.0870732 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0801975 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0700425 |
| EGFR | epidermal growth factor receptor | -0.068908 |
| FTL | ferritin, light polypeptide | -0.0661791 |
| RPL19 | ribosomal protein L19 | -0.0609456 |
| RPS8 | ribosomal protein S8 | -0.0600284 |
| TMSB10 | thymosin beta 10 | -0.0586257 |
| B2M | beta-2-microglobulin | -0.0564646 |
| ASPH | aspartate beta-hydroxylase | -0.0551034 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0529902 |
| IER3 | immediate early response 3 | -0.050561 |
| FN1 | fibronectin 1 | -0.0464066 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0449928 |
| IGF2 | insulin-like growth factor 2 | -0.0443635 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0433762 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0427696 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0427217 |
| RPL7A | ribosomal protein L7a | -0.0415139 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0386307 |
| SQSTM1 | sequestosome 1 | -0.037616 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0369794 |
| SLTM | SAFB-like, transcription modulator | -0.0360724 |
| RPLP1 | ribosomal protein, large, P1 | -0.0356019 |
| GPHN | gephyrin | -0.03503 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0346119 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0345009 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0338871 |
| RPS3 | ribosomal protein S3 | -0.0337567 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0337492 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0332954 |
| FAT1 | FAT atypical cadherin 1 | -0.0326531 |
| MSI2 | musashi RNA-binding protein 2 | -0.0325756 |
| RPS21 | ribosomal protein S21 | -0.0323173 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.031162 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.031094 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.030905 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.030584 |
| PRELID2 | PRELI domain containing 2 | -0.0303064 |
| UBC | ubiquitin C | -0.0297778 |
| WASF2 | WAS protein family, member 2 | -0.0297684 |
| RPL11 | ribosomal protein L11 | -0.0296622 |
| CALR | calreticulin | -0.0291931 |
| ACTG1 | actin gamma 1 | -0.0280415 |
| MEIS2 | Meis homeobox 2 | -0.0272838 |
| RPL35A | ribosomal protein L35a | -0.0263601 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0261239 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0258562 |
| CCNI | cyclin I | -0.0256158 |
| BPTF | bromodomain PHD finger transcription factor | -0.0255522 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0251775 |
| NUP98 | nucleoporin 98kDa | -0.0250185 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0246039 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0240097 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0239755 |
| MAP7 | microtubule-associated protein 7 | -0.0235548 |
| PKM | pyruvate kinase, muscle | -0.0233703 |
| MED13L | mediator complex subunit 13-like | -0.0232448 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0231154 |
| MYO1E | myosin IE | -0.0222129 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.022192 |
| PLEC | plectin | -0.0219443 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0212333 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0204472 |
| LDHA | lactate dehydrogenase A | -0.0199506 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0199154 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0197642 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0196032 |
| ANKRD10 | ankyrin repeat domain 10 | -0.018943 |
| RPL9 | ribosomal protein L9 | -0.018715 |
| CDK6 | cyclin-dependent kinase 6 | -0.0186724 |
| KRT17 | keratin 17, type I | -0.0186567 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0183392 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0176664 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0175914 |
| PGK1 | phosphoglycerate kinase 1 | -0.0172686 |
| RPL26 | ribosomal protein L26 | -0.0171949 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0170576 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0169809 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0167847 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0166343 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0154274 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0152683 |
| FAM107B | family with sequence similarity 107, member B | -0.0150436 |
| ANXA2 | annexin A2 | -0.0148653 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0146393 |
| H3-3B | H3.3 histone B | -0.0144124 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0127762 |
| RPL37A | ribosomal protein L37a | -0.0127675 |
| HLA-A | major histocompatibility complex, class I, A | -0.0123462 |
| CDH13 | cadherin 13 | -0.0122647 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0119208 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0118836 |
| SEPTIN9 | septin 9 | -0.0114352 |
| MT2A | metallothionein 2A | -0.0112506 |
| RPS25 | ribosomal protein S25 | -0.0112066 |
