Neratinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.157669
TXNRD1 thioredoxin reductase 1 0.114196
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.106846
GRAMD1B GRAM domain containing 1B 0.0689887
TFPI2 tissue factor pathway inhibitor 2 0.0486019
KTN1 kinectin 1 (kinesin receptor) 0.0452053
TRIO trio Rho guanine nucleotide exchange factor 0.044126
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0439655
TPM3 tropomyosin 3 0.0425192
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0417731
ERRFI1 ERBB receptor feedback inhibitor 1 0.0417476
CSDE1 cold shock domain containing E1, RNA-binding 0.0386355
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0382212
SMAD3 SMAD family member 3 0.0377555
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0375434
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0352246
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0328618
ANO6 anoctamin 6 0.0324704
XPO1 exportin 1 0.0306924
EML4 echinoderm microtubule associated protein like 4 0.0305677
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0302441
RTN4 reticulon 4 0.0301436
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0300697
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0294307
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0288134
MARCHF4 membrane associated ring-CH-type finger 4 0.0286323
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0283749
SENP6 SUMO1/sentrin specific peptidase 6 0.0282985
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.027178
BIRC2 baculoviral IAP repeat containing 2 0.0271358
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0262768
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0261002
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0258965
CD2AP CD2-associated protein 0.0256924
RAD51B RAD51 paralog B 0.0247989
LATS2 large tumor suppressor kinase 2 0.0247338
PHF20 PHD finger protein 20 0.0247159
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0246437
PGK1 phosphoglycerate kinase 1 0.024307
NCKAP1 NCK-associated protein 1 0.0242534
BZW1 basic leucine zipper and W2 domains 1 0.0239959
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0239361
DOCK5 dedicator of cytokinesis 5 0.0233233
IGF1R insulin-like growth factor 1 receptor 0.0230481
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0229734
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0228904
ANKRD17 ankyrin repeat domain 17 0.0224281
VMP1 vacuole membrane protein 1 0.0224147
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0223511
MMP12 matrix metallopeptidase 12 0.0223302
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0222826
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.022172
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0220278
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0217249
DSPP dentin sialophosphoprotein 0.021682
STC1 stanniocalcin 1 0.0216464
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0216159
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0216158
CHD4 chromodomain helicase DNA binding protein 4 0.0215188
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0214322
AHNAK AHNAK nucleoprotein 0.0214054
TRIP12 thyroid hormone receptor interactor 12 0.0211474
ARHGAP5 Rho GTPase activating protein 5 0.0208576
SPRED2 sprouty-related, EVH1 domain containing 2 0.0207804
DST dystonin 0.0206324
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0205637
USP9X ubiquitin specific peptidase 9, X-linked 0.0205224
CCND1 cyclin D1 0.0204584
ADGRG6 adhesion G protein-coupled receptor G6 0.0204473
RRM2 ribonucleotide reductase M2 0.0202413
ATP11A ATPase, class VI, type 11A 0.0199241
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0198643
THRAP3 thyroid hormone receptor associated protein 3 0.0198291
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0196057
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0195869
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0195622
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0194307
VCL vinculin 0.0194157
RNF145 ring finger protein 145 0.0193884
RAB10 RAB10, member RAS oncogene family 0.0192987
ZFR zinc finger RNA binding protein 0.0192954
BICD1 bicaudal D homolog 1 (Drosophila) 0.0192655
IPO7 importin 7 0.0190977
NUP153 nucleoporin 153kDa 0.0190694
EHBP1 EH domain binding protein 1 0.0190466
WASF2 WAS protein family, member 2 0.0190194
ATP13A3 ATPase type 13A3 0.0189522
TAGLN2 transgelin 2 0.0187727
ANXA5 annexin A5 0.0187575
KDM3A lysine (K)-specific demethylase 3A 0.0187404
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0186384
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0185715
ETNK1 ethanolamine kinase 1 0.0184805
NF1 neurofibromin 1 0.0184775
ARB2A ARB2 cotranscriptional regulator A 0.0184526
CSNK1A1 casein kinase 1, alpha 1 0.018439
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0181783
EIF4B eukaryotic translation initiation factor 4B 0.018095
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0179849
KMT2A lysine (K)-specific methyltransferase 2A 0.0178572

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147975
TMSB10 thymosin beta 10 -0.075219
VIM vimentin -0.0729401
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0495211
EGR1 early growth response 1 -0.0422159
RPLP1 ribosomal protein, large, P1 -0.0409545
RPL35A ribosomal protein L35a -0.0383796
RPL23 ribosomal protein L23 -0.0365525
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0344815
RPS8 ribosomal protein S8 -0.0344472
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0344277
RPL37A ribosomal protein L37a -0.0333785
RPS27 ribosomal protein S27 -0.0331416
RPS19 ribosomal protein S19 -0.0314468
RPL26 ribosomal protein L26 -0.0300898
RPS3 ribosomal protein S3 -0.0293778
TPT1 tumor protein, translationally-controlled 1 -0.0273138
RPL31 ribosomal protein L31 -0.0272551
RPL34 ribosomal protein L34 -0.0253397
HLA-B major histocompatibility complex, class I, B -0.0248391
RPS15 ribosomal protein S15 -0.0242898
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0241265
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0235347
RPL8 ribosomal protein L8 -0.0219839
RPS29 ribosomal protein S29 -0.0219617
RPL12 ribosomal protein L12 -0.0218838
RPL28 ribosomal protein L28 -0.0212065
FTL ferritin, light polypeptide -0.0210481
RPL5 ribosomal protein L5 -0.0207199
PFN1 profilin 1 -0.0206709
RPL36 ribosomal protein L36 -0.0206559
RPL19 ribosomal protein L19 -0.0202361
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0198036
RPS17 ribosomal protein S17 -0.0188554
RPLP2 ribosomal protein, large, P2 -0.0184553
PRKCE protein kinase C, epsilon -0.0181197
RPL11 ribosomal protein L11 -0.017935
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0177063
RPS12 ribosomal protein S12 -0.0176601
RPS4X ribosomal protein S4, X-linked -0.0174909
NACA nascent polypeptide-associated complex alpha subunit -0.0172906
RPL9 ribosomal protein L9 -0.0172815
RPS6 ribosomal protein S6 -0.016972
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.01692
RPS10 ribosomal protein S10 -0.0164989
RPL27 ribosomal protein L27 -0.0161253
AEBP2 AE binding protein 2 -0.0158936
RPS23 ribosomal protein S23 -0.0155579
RPL38 ribosomal protein L38 -0.0155324
RPL37 ribosomal protein L37 -0.0153073
RPS24 ribosomal protein S24 -0.0152173
RPL35 ribosomal protein L35 -0.0152055
PRELID2 PRELI domain containing 2 -0.0151087
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0148399
DDIT3 DNA-damage-inducible transcript 3 -0.0145339
YBX1 Y box binding protein 1 -0.0143419
EIF1 eukaryotic translation initiation factor 1 -0.0142504
RPS13 ribosomal protein S13 -0.0140984
ACTG1 actin gamma 1 -0.0138642
SDK1 sidekick cell adhesion molecule 1 -0.0137909
PTMA prothymosin, alpha -0.0137821
RAB7A RAB7A, member RAS oncogene family -0.0137583
WSB1 WD repeat and SOCS box containing 1 -0.01363
SESN2 sestrin 2 -0.0134753
RPS21 ribosomal protein S21 -0.0134555
MT2A metallothionein 2A -0.01319
EEF2 eukaryotic translation elongation factor 2 -0.0131714
RPL32 ribosomal protein L32 -0.0131489
RPL7A ribosomal protein L7a -0.0128411
ATF6 activating transcription factor 6 -0.0127791
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0126466
PDIA3 protein disulfide isomerase family A, member 3 -0.0125845
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0124576
NDRG1 N-myc downstream regulated 1 -0.0123086
TPM2 tropomyosin 2 (beta) -0.0122722
RPL18 ribosomal protein L18 -0.0122113
INTS6 integrator complex subunit 6 -0.0120075
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0119342
WDR45B WD repeat domain 45B -0.0119327
KDM4B lysine (K)-specific demethylase 4B -0.0119263
MRTFA myocardin related transcription factor A -0.0119217
PDE8A phosphodiesterase 8A -0.0119147
FLNA filamin A, alpha -0.0118901
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0118442
HYOU1 hypoxia up-regulated 1 -0.0117536
MEF2D myocyte enhancer factor 2D -0.0115802
RPL30 ribosomal protein L30 -0.0115619
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0113744
WWOX WW domain containing oxidoreductase -0.0112279
RPS14 ribosomal protein S14 -0.0111432
NEK10 NIMA-related kinase 10 -0.0110063
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0109882
COPA coatomer protein complex, subunit alpha -0.0109329
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0108171
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0108127
ATP5F1E ATP synthase F1 subunit epsilon -0.0107798
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0107109
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0107094
FHIT fragile histidine triad -0.0106676
FUS FUS RNA binding protein -0.0106366