Neratinib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.135516
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.117865
POTEF POTE ankyrin domain family, member F 0.113063
TSC22D2 TSC22 domain family, member 2 0.108403
PCBP2 poly(rC) binding protein 2 0.0719787
APLP2 amyloid beta (A4) precursor-like protein 2 0.0672383
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0654279
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.064804
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0645011
FXR1 fragile X mental retardation, autosomal homolog 1 0.0579914
NAMPT nicotinamide phosphoribosyltransferase 0.0579225
GRB10 growth factor receptor-bound protein 10 0.0535094
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0505493
LDHA lactate dehydrogenase A 0.050179
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0480322
VEGFA vascular endothelial growth factor A 0.0456655
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0444765
RHOA ras homolog family member A 0.044061
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0426271
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0416129
TPM3 tropomyosin 3 0.0415253
UBA6 ubiquitin-like modifier activating enzyme 6 0.0410688
MYH9 myosin, heavy chain 9, non-muscle 0.040086
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0387074
MSN moesin 0.0386036
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0378777
FAM13A family with sequence similarity 13, member A 0.0373537
PTK2 protein tyrosine kinase 2 0.0366152
EZR ezrin 0.0349705
SET SET nuclear proto-oncogene 0.0336479
DSTN destrin (actin depolymerizing factor) 0.0334869
ZNF292 zinc finger protein 292 0.0333261
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0329983
BHLHE40 basic helix-loop-helix family, member e40 0.0320895
RNF145 ring finger protein 145 0.0317726
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0312771
IGFBP3 insulin-like growth factor binding protein 3 0.031238
ZFP36L1 ZFP36 ring finger protein-like 1 0.0311984
NUP58 nucleoporin 58 0.0311796
RPS2 ribosomal protein S2 0.0311434
HILPDA hypoxia inducible lipid droplet-associated 0.0310558
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0305953
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0305158
CCNL1 cyclin L1 0.0304703
FNDC3B fibronectin type III domain containing 3B 0.0291603
KMT2E lysine (K)-specific methyltransferase 2E 0.0291341
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0284208
MXD1 MAX dimerization protein 1 0.0278359
CANX calnexin 0.0277331
RLF rearranged L-myc fusion 0.0268777
ASPH aspartate beta-hydroxylase 0.026869
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0268594
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0264904
PDLIM5 PDZ and LIM domain 5 0.0264315
SSBP2 single-stranded DNA binding protein 2 0.0257533
YBX1 Y box binding protein 1 0.0254487
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0254192
ADAM9 ADAM metallopeptidase domain 9 0.0252032
ANXA5 annexin A5 0.0248408
TOP1 topoisomerase (DNA) I 0.0247535
RYBP RING1 and YY1 binding protein 0.0247249
RCOR1 REST corepressor 1 0.0246526
SFPQ splicing factor proline/glutamine-rich 0.0244072
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.024142
CD46 CD46 molecule, complement regulatory protein 0.0231836
PEG10 paternally expressed 10 0.023168
COPA coatomer protein complex, subunit alpha 0.0231581
ARRDC3 arrestin domain containing 3 0.0226801
LIMCH1 LIM and calponin homology domains 1 0.0224247
RBM39 RNA binding motif protein 39 0.0217654
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0215398
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0215111
PUM1 pumilio RNA-binding family member 1 0.0214337
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0212937
MBNL1 muscleblind-like splicing regulator 1 0.0210371
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0210263
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0208665
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0207752
IRF6 interferon regulatory factor 6 0.0203237
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0203222
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0201347
HELZ helicase with zinc finger 0.0197844
PAPOLA poly(A) polymerase alpha 0.0197371
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0196051
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0195647
TMEM39A transmembrane protein 39A 0.0195457
WDR43 WD repeat domain 43 0.0194572
AREG amphiregulin 0.0194378
BRD2 bromodomain containing 2 0.0194222
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.019233
USP3 ubiquitin specific peptidase 3 0.0191317
USP9X ubiquitin specific peptidase 9, X-linked 0.0190929
KDM6A lysine (K)-specific demethylase 6A 0.0190691
KDM5B lysine (K)-specific demethylase 5B 0.0189627
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0189166
RIOK3 RIO kinase 3 0.0188932
CCND1 cyclin D1 0.0188315
QKI QKI, KH domain containing, RNA binding 0.0186726
HDGF hepatoma-derived growth factor 0.0184375
SEC24A SEC24 family member A 0.0184206

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.328766
FTL ferritin, light polypeptide -0.169191
ACTG1 actin gamma 1 -0.164539
TMSB10 thymosin beta 10 -0.158861
TPT1 tumor protein, translationally-controlled 1 -0.120198
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.118079
NDRG1 N-myc downstream regulated 1 -0.117017
RPLP1 ribosomal protein, large, P1 -0.0950644
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0909932
RPL34 ribosomal protein L34 -0.0870853
S100A10 S100 calcium binding protein A10 -0.0826118
RPS23 ribosomal protein S23 -0.0743958
RPL35A ribosomal protein L35a -0.0644925
FN1 fibronectin 1 -0.062255
RPLP2 ribosomal protein, large, P2 -0.0616594
MT2A metallothionein 2A -0.0589423
RPL8 ribosomal protein L8 -0.0584402
IFI6 interferon, alpha-inducible protein 6 -0.0565739
LAMB3 laminin, beta 3 -0.0550593
RPL23 ribosomal protein L23 -0.0514282
S100A6 S100 calcium binding protein A6 -0.0512981
FBXO32 F-box protein 32 -0.0504077
RPS29 ribosomal protein S29 -0.0502264
IFI27 interferon, alpha-inducible protein 27 -0.0498301
HLA-B major histocompatibility complex, class I, B -0.0497151
RPS8 ribosomal protein S8 -0.0494553
VIM vimentin -0.0485177
RPL32 ribosomal protein L32 -0.0478119
ISG15 ISG15 ubiquitin-like modifier -0.0456078
LMO7 LIM domain 7 -0.0448128
EIF1 eukaryotic translation initiation factor 1 -0.0445827
UBC ubiquitin C -0.0441267
RPS19 ribosomal protein S19 -0.0441088
UPP1 uridine phosphorylase 1 -0.0438052
RPL9 ribosomal protein L9 -0.0419854
RPS13 ribosomal protein S13 -0.0416029
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0399747
RPS6 ribosomal protein S6 -0.0397589
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.039564
PTMA prothymosin, alpha -0.0381943
TM4SF1 transmembrane 4 L six family member 1 -0.0377936
MDK midkine (neurite growth-promoting factor 2) -0.0372478
AHNAK AHNAK nucleoprotein -0.0367128
RPS21 ribosomal protein S21 -0.0364533
RPS15 ribosomal protein S15 -0.0357759
RPL31 ribosomal protein L31 -0.0354573
RPL12 ribosomal protein L12 -0.0340392
RPS14 ribosomal protein S14 -0.0338439
EXT1 exostosin glycosyltransferase 1 -0.0338186
CDCP1 CUB domain containing protein 1 -0.0335352
CSTB cystatin B (stefin B) -0.0333618
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0332353
RPS27A ribosomal protein S27a -0.0330138
C15ORF48 chromosome 15 open reading frame 48 -0.0328696
HLA-A major histocompatibility complex, class I, A -0.0322237
S100A9 S100 calcium binding protein A9 -0.0321905
LAMC2 laminin, gamma 2 -0.0321687
IFITM3 interferon induced transmembrane protein 3 -0.0317153
RPL38 ribosomal protein L38 -0.0313353
RPL30 ribosomal protein L30 -0.0313007
IFI16 interferon, gamma-inducible protein 16 -0.0311212
TUBB4B tubulin, beta 4B class IVb -0.0310868
RPS24 ribosomal protein S24 -0.0308873
RPL19 ribosomal protein L19 -0.0305479
CCNI cyclin I -0.0302068
TMSB4X thymosin beta 4, X-linked -0.0293639
RPL28 ribosomal protein L28 -0.0290499
HMGA1 high mobility group AT-hook 1 -0.0289534
RPS11 ribosomal protein S11 -0.0285186
IFITM1 interferon induced transmembrane protein 1 -0.0282994
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0279465
RPS27 ribosomal protein S27 -0.0272766
DSG2 desmoglein 2 -0.0270047
BASP1 brain abundant, membrane attached signal protein 1 -0.0268985
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.026859
NPC2 Niemann-Pick disease, type C2 -0.0267743
KRT8 keratin 8, type II -0.0265366
RACK1 receptor for activated C kinase 1 -0.0262614
RPS16 ribosomal protein S16 -0.0262034
RPS10 ribosomal protein S10 -0.0252781
RPS5 ribosomal protein S5 -0.024899
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0247806
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0247502
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0245948
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0241839
RPL5 ribosomal protein L5 -0.0240282
ARHGAP5 Rho GTPase activating protein 5 -0.0240104
PLAUR plasminogen activator, urokinase receptor -0.0239866
VGLL3 vestigial-like family member 3 -0.0239605
WSB1 WD repeat and SOCS box containing 1 -0.023841
MYO1E myosin IE -0.0238407
RPL36AL ribosomal protein L36a-like -0.0236459
NIPBL Nipped-B homolog (Drosophila) -0.0235978
CTSB cathepsin B -0.0235553
RPL37 ribosomal protein L37 -0.0235006
SH3KBP1 SH3-domain kinase binding protein 1 -0.0233891
RPL36 ribosomal protein L36 -0.0233665
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0232661
NDFIP1 Nedd4 family interacting protein 1 -0.0231511
SDC4 syndecan 4 -0.0228702