Neratinib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.141143
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0864297
CXCL8 chemokine (C-X-C motif) ligand 8 0.0849317
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0817956
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0727827
RNF145 ring finger protein 145 0.0608863
APLP2 amyloid beta (A4) precursor-like protein 2 0.0593382
PCBP2 poly(rC) binding protein 2 0.0572561
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0555305
ASPH aspartate beta-hydroxylase 0.0541031
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.053904
KMT2E lysine (K)-specific methyltransferase 2E 0.0509741
PSD3 pleckstrin and Sec7 domain containing 3 0.049549
NUP58 nucleoporin 58 0.0490879
MSN moesin 0.0490841
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0476223
VMP1 vacuole membrane protein 1 0.0469776
LDHA lactate dehydrogenase A 0.0469007
CTSC cathepsin C 0.0467418
NAMPT nicotinamide phosphoribosyltransferase 0.0448401
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0444487
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0440599
CD109 CD109 molecule 0.0415247
PDLIM5 PDZ and LIM domain 5 0.0409812
KTN1 kinectin 1 (kinesin receptor) 0.0407738
IGFBP3 insulin-like growth factor binding protein 3 0.0406849
B2M beta-2-microglobulin 0.0405052
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0398483
ENO1 enolase 1, (alpha) 0.0389662
UBA6 ubiquitin-like modifier activating enzyme 6 0.0384527
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.037907
ITPRID2 ITPR interacting domain containing 2 0.0377923
MCL1 myeloid cell leukemia 1 0.0375083
HILPDA hypoxia inducible lipid droplet-associated 0.0371226
PDIA3 protein disulfide isomerase family A, member 3 0.0370034
STC1 stanniocalcin 1 0.0368232
PDIA6 protein disulfide isomerase family A, member 6 0.0367144
FAM13A family with sequence similarity 13, member A 0.0359108
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0358843
MFF mitochondrial fission factor 0.0352508
CENPF centromere protein F, 350/400kDa 0.0350611
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0349916
TXNIP thioredoxin interacting protein 0.0348629
FNDC3B fibronectin type III domain containing 3B 0.0348402
FTH1 ferritin, heavy polypeptide 1 0.0339139
TXNRD1 thioredoxin reductase 1 0.0327684
SET SET nuclear proto-oncogene 0.0313665
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0309499
LAMB1 laminin, beta 1 0.0304108
TPM3 tropomyosin 3 0.0301088
NRG1 neuregulin 1 0.0295631
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0287707
SPTBN1 spectrin, beta, non-erythrocytic 1 0.028334
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0280264
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0278426
ADAM9 ADAM metallopeptidase domain 9 0.0276888
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0271768
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0266176
KDM6A lysine (K)-specific demethylase 6A 0.0264819
COL4A6 collagen, type IV, alpha 6 0.0260128
MYOF myoferlin 0.0259619
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0251514
ANXA5 annexin A5 0.0250788
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0248181
SP3 Sp3 transcription factor 0.0245007
CUL3 cullin 3 0.0244943
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0244455
CHD1L chromodomain helicase DNA binding protein 1-like 0.0242467
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0242167
FXR1 fragile X mental retardation, autosomal homolog 1 0.0237015
DPY19L1 dpy-19-like 1 (C. elegans) 0.0236331
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0236098
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0234476
SH3KBP1 SH3-domain kinase binding protein 1 0.023278
WAC WW domain containing adaptor with coiled-coil 0.0231742
PTGR1 prostaglandin reductase 1 0.0230337
ITGA6 integrin, alpha 6 0.0227512
CD46 CD46 molecule, complement regulatory protein 0.0226857
CTSL cathepsin L 0.0225788
ATP5F1B ATP synthase F1 subunit beta 0.0220429
USP9X ubiquitin specific peptidase 9, X-linked 0.0217127
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0215375
AHR aryl hydrocarbon receptor 0.0213894
FAM120A family with sequence similarity 120A 0.0213794
HDGF hepatoma-derived growth factor 0.021371
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0213676
DSTN destrin (actin depolymerizing factor) 0.0213557
PKM pyruvate kinase, muscle 0.021236
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0208848
XPO1 exportin 1 0.0208765
ZNF292 zinc finger protein 292 0.0206482
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.020126
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.0200645
STC2 stanniocalcin 2 0.0200069
FOSL1 FOS-like antigen 1 0.019967
PGM2L1 phosphoglucomutase 2-like 1 0.0197973
DUSP4 dual specificity phosphatase 4 0.0196343
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0195169
RBM25 RNA binding motif protein 25 0.0195006
UBXN4 UBX domain protein 4 0.0193325

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.24628
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.205222
TPT1 tumor protein, translationally-controlled 1 -0.138841
PDE10A phosphodiesterase 10A -0.138443
EFNA5 ephrin-A5 -0.132256
PDE4D phosphodiesterase 4D, cAMP-specific -0.130655
VIM vimentin -0.123796
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.115251
TMSB10 thymosin beta 10 -0.0903289
RPLP1 ribosomal protein, large, P1 -0.0883592
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0809416
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0786379
TM4SF1 transmembrane 4 L six family member 1 -0.0750329
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0719524
RPS24 ribosomal protein S24 -0.0705078
TBXT T-box transcription factor T -0.0599975
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0587484
CDH13 cadherin 13 -0.0549111
FNDC3A fibronectin type III domain containing 3A -0.0518337
TFPI2 tissue factor pathway inhibitor 2 -0.0513841
TRIO trio Rho guanine nucleotide exchange factor -0.0507008
RPL34 ribosomal protein L34 -0.05003
RPL26 ribosomal protein L26 -0.0497897
RPL12 ribosomal protein L12 -0.0496006
RPL23 ribosomal protein L23 -0.0493554
RPL19 ribosomal protein L19 -0.0485091
PRKN parkin RBR E3 ubiquitin protein ligase -0.0476044
CTIF CBP80/20-dependent translation initiation factor -0.0473875
SMAD2 SMAD family member 2 -0.0469552
PTMA prothymosin, alpha -0.0466245
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0465567
RPS8 ribosomal protein S8 -0.0455988
RPL38 ribosomal protein L38 -0.0452813
KYNU kynureninase -0.0448692
ACTG1 actin gamma 1 -0.0448532
ADGRD1 adhesion G protein-coupled receptor D1 -0.0437253
RPS6 ribosomal protein S6 -0.0436186
S100A10 S100 calcium binding protein A10 -0.043598
RPS27A ribosomal protein S27a -0.0432459
RPL37A ribosomal protein L37a -0.0416533
NT5C2 5'-nucleotidase, cytosolic II -0.0405056
RPL31 ribosomal protein L31 -0.0403734
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0397423
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0397088
SMYD3 SET and MYND domain containing 3 -0.0390917
RPL35A ribosomal protein L35a -0.0385306
RPS29 ribosomal protein S29 -0.0383107
RPS19 ribosomal protein S19 -0.0376891
RPL9 ribosomal protein L9 -0.0374278
RPL36 ribosomal protein L36 -0.0358659
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0358178
CREB5 cAMP responsive element binding protein 5 -0.0354315
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0342498
RPS21 ribosomal protein S21 -0.0341115
SAMD4A sterile alpha motif domain containing 4A -0.0335928
YBX3 Y box binding protein 3 -0.0333975
AGTPBP1 ATP/GTP binding protein 1 -0.0329637
MBD5 methyl-CpG binding domain protein 5 -0.0328691
WARS1 tryptophanyl-tRNA synthetase 1 -0.032779
RPS16 ribosomal protein S16 -0.0320343
RPL37 ribosomal protein L37 -0.0315802
RPL4 ribosomal protein L4 -0.0315712
BASP1 brain abundant, membrane attached signal protein 1 -0.0310514
INTS6 integrator complex subunit 6 -0.0298688
FNIP1 folliculin interacting protein 1 -0.0290722
GDA guanine deaminase -0.02886
NCOA7 nuclear receptor coactivator 7 -0.0288316
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0287983
PLCB4 phospholipase C, beta 4 -0.0286987
RPL35 ribosomal protein L35 -0.0281918
HDAC4 histone deacetylase 4 -0.0279461
RPS25 ribosomal protein S25 -0.0278231
PALLD palladin, cytoskeletal associated protein -0.0276303
MORF4L2 mortality factor 4 like 2 -0.0275906
RPH3AL rabphilin 3A-like (without C2 domains) -0.0275523
RPL36A ribosomal protein L36a -0.0272723
RPS12 ribosomal protein S12 -0.0271613
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0270215
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0269809
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0266627
RPS23 ribosomal protein S23 -0.0266388
RPL32 ribosomal protein L32 -0.026378
GPC6 glypican 6 -0.0260313
RPS28 ribosomal protein S28 -0.025752
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0254386
RPL11 ribosomal protein L11 -0.0254198
ANKRD11 ankyrin repeat domain 11 -0.0253325
OSMR oncostatin M receptor -0.0252726
GNAS GNAS complex locus -0.0252269
RIGI RNA sensor RIG-I -0.0251198
RPL30 ribosomal protein L30 -0.0249602
SMOC1 SPARC related modular calcium binding 1 -0.0249292
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0249046
SLC38A2 solute carrier family 38, member 2 -0.0247924
IARS1 isoleucyl-tRNA synthetase 1 -0.024752
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0246931
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0244755
LAMA1 laminin, alpha 1 -0.024375
ANTXR1 anthrax toxin receptor 1 -0.0237862
EXT1 exostosin glycosyltransferase 1 -0.0237767