Neratinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

104 genes differentially expressed following the Neratinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.311744
PRRC2C proline-rich coiled-coil 2C 0.184436
USP34 ubiquitin specific peptidase 34 0.166282
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.155088
RBM39 RNA binding motif protein 39 0.149312
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.142114
YBX3 Y box binding protein 3 0.136424
RTN4 reticulon 4 0.132998
KMT2C lysine (K)-specific methyltransferase 2C 0.129371
PABPC1 poly(A) binding protein, cytoplasmic 1 0.124051
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.121407
EIF1 eukaryotic translation initiation factor 1 0.120868
PTK2 protein tyrosine kinase 2 0.114886
WAC WW domain containing adaptor with coiled-coil 0.113329
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0993799
PDLIM5 PDZ and LIM domain 5 0.0990494
ZFAND3 zinc finger, AN1-type domain 3 0.096779
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0924334
TRIO trio Rho guanine nucleotide exchange factor 0.092045
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0841536
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.080866
PDE4D phosphodiesterase 4D, cAMP-specific 0.069242
PTMA prothymosin, alpha 0.0635779
KMT2E lysine (K)-specific methyltransferase 2E 0.063149
BIRC6 baculoviral IAP repeat containing 6 0.0569609
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0521525
SBF2 SET binding factor 2 0.0499045
TPT1 tumor protein, translationally-controlled 1 0.0442238
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0354373
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0316561
JMJD1C jumonji domain containing 1C 0.0300387
SRRM2 serine/arginine repetitive matrix 2 0.0272972
EZR ezrin 0.0264807
IGF2 insulin-like growth factor 2 0.0254928
VMP1 vacuole membrane protein 1 0.0194623
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.016135
TMSB10 thymosin beta 10 0.0160204
AKAP12 A kinase (PRKA) anchor protein 12 0.0108299
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0105378
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0065941
MYO1E myosin IE 0.00571796
NKD1 naked cuticle homolog 1 (Drosophila) 0.00343439
FNDC3B fibronectin type III domain containing 3B 0.00332362
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.00305288
PARD3 par-3 family cell polarity regulator 0.00138114

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.174332
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.134428
FN1 fibronectin 1 -0.11974
GMDS GDP-mannose 4,6-dehydratase -0.112954
IGFBP5 insulin-like growth factor binding protein 5 -0.0987861
MACF1 microtubule-actin crosslinking factor 1 -0.0950293
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0926825
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0920524
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.086203
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0839179
GPC6 glypican 6 -0.0830408
CARD16 caspase recruitment domain family, member 16 -0.0791755
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0790573
RPS16 ribosomal protein S16 -0.0771474
SNX9 sorting nexin 9 -0.0741936
LAMB3 laminin, beta 3 -0.0733119
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0726053
STAG2 stromal antigen 2 -0.0659622
EGFR epidermal growth factor receptor -0.0644193
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0628505
SPATA13 spermatogenesis associated 13 -0.0610005
MAML2 mastermind-like 2 (Drosophila) -0.0609449
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0601847
MAML3 mastermind-like 3 (Drosophila) -0.0595434
LMO7 LIM domain 7 -0.0593672
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0592005
RBM25 RNA binding motif protein 25 -0.058282
RPLP2 ribosomal protein, large, P2 -0.0517541
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0511489
MYOF myoferlin -0.048355
NAV2 neuron navigator 2 -0.0477745
PGK1 phosphoglycerate kinase 1 -0.0477573
CEMIP cell migration inducing protein, hyaluronan binding -0.046888
MYO5B myosin VB -0.0463913
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0455063
NPAS2 neuronal PAS domain protein 2 -0.0451602
WASF2 WAS protein family, member 2 -0.0445567
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0406851
ASPH aspartate beta-hydroxylase -0.0400274
ITGA6 integrin, alpha 6 -0.0395318
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0380411
VIM vimentin -0.0365055
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0322762
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0318624
SPAG9 sperm associated antigen 9 -0.0272402
MON2 MON2 homolog (S. cerevisiae) -0.0248277
EXT1 exostosin glycosyltransferase 1 -0.0247883
ZBTB20 zinc finger and BTB domain containing 20 -0.0235486
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0233104
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0182578
MYH9 myosin, heavy chain 9, non-muscle -0.013485
RPL26 ribosomal protein L26 -0.0118773
RPS8 ribosomal protein S8 -0.00766413
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.00718294
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.00584858
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.00522767
OGA O-GlcNAcase -0.00436068
LDHA lactate dehydrogenase A -0.00212482
RPLP1 ribosomal protein, large, P1 -0.00187052