| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Neratinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.0930723 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0872041 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0637273 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0626228 |
| POTEF | POTE ankyrin domain family, member F | 0.0541265 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0516939 |
| PCBP2 | poly(rC) binding protein 2 | 0.0512444 |
| CANX | calnexin | 0.046117 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0460125 |
| B2M | beta-2-microglobulin | 0.0444379 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0425103 |
| TPM3 | tropomyosin 3 | 0.0371709 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0349081 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0319301 |
| CBX3 | chromobox homolog 3 | 0.031095 |
| SFRP4 | secreted frizzled-related protein 4 | 0.0308098 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0306512 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0305609 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.030428 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0290091 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0274728 |
| NTM | neurotrimin | 0.0263219 |
| SET | SET nuclear proto-oncogene | 0.0262174 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0260463 |
| PFN1 | profilin 1 | 0.0257782 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0256342 |
| RPS12 | ribosomal protein S12 | 0.0255478 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0255421 |
| FBL | fibrillarin | 0.0248851 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0245859 |
| TMEM87A | transmembrane protein 87A | 0.0233851 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0230464 |
| EZR | ezrin | 0.0229136 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0227384 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0226275 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0222127 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0221344 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0215937 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0215393 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0209094 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0207379 |
| MLEC | malectin | 0.0205414 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0203637 |
| PRKCI | protein kinase C, iota | 0.0202899 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.0202845 |
| JUN | jun proto-oncogene | 0.0197324 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0191681 |
| UBXN4 | UBX domain protein 4 | 0.0191468 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0190011 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0188748 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0187886 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0186929 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0185045 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0183404 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0181576 |
| NOP58 | NOP58 ribonucleoprotein | 0.0181483 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0180482 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0177896 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0177774 |
| ZFP36 | ZFP36 ring finger protein | 0.0176831 |
| GSPT1 | G1 to S phase transition 1 | 0.017682 |
| DICER1 | dicer 1, ribonuclease type III | 0.0176711 |
| SFTPA2 | surfactant protein A2 | 0.0175979 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0173588 |
| RPL37A | ribosomal protein L37a | 0.0173292 |
| RPN2 | ribophorin II | 0.017145 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0171191 |
| GART | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | 0.0171164 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0171028 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0170351 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0169986 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.016896 |
| SNX3 | sorting nexin 3 | 0.0168358 |
| GAP43 | growth associated protein 43 | 0.016756 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0167383 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0167253 |
| RPS6 | ribosomal protein S6 | 0.0167091 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0165087 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0164549 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.0164381 |
| RPL21 | ribosomal protein L21 | 0.016433 |
| RPL11 | ribosomal protein L11 | 0.01643 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0163505 |
| RPS27 | ribosomal protein S27 | 0.0162816 |
| TRIM37 | tripartite motif containing 37 | 0.0160956 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.0160482 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0159628 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | 0.0158403 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0156412 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0155767 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0155413 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0155374 |
| UBP1 | upstream binding protein 1 (LBP-1a) | 0.0153929 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0152922 |
| CCDC88A | coiled-coil domain containing 88A | 0.0151737 |
| RPL3 | ribosomal protein L3 | 0.0151578 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0150867 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0150352 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0149827 |
| MSI2 | musashi RNA-binding protein 2 | 0.0149795 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.201405 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.163083 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.136713 |
| COL5A2 | collagen, type V, alpha 2 | -0.134386 |
| TENM3 | teneurin transmembrane protein 3 | -0.121334 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.117607 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.114401 |
| FOXP2 | forkhead box P2 | -0.111313 |
| CADM2 | cell adhesion molecule 2 | -0.10124 |
| VIM | vimentin | -0.0904937 |
| DST | dystonin | -0.0872558 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0834765 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0752201 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0738671 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.072653 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0674525 |
| MEIS2 | Meis homeobox 2 | -0.0668891 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.064007 |
| COL3A1 | collagen, type III, alpha 1 | -0.06246 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0555462 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0551112 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0536577 |
| PDGFC | platelet derived growth factor C | -0.0518277 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0513494 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0492265 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0467449 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0462126 |
| NFIA | nuclear factor I/A | -0.045115 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0437993 |
| PRKD1 | protein kinase D1 | -0.0433131 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0429719 |
| GPC3 | glypican 3 | -0.0425009 |
| ACTG1 | actin gamma 1 | -0.0420901 |
| ZNF608 | zinc finger protein 608 | -0.0420221 |
| H1-0 | H1.0 linker histone | -0.0418521 |
| HMGA2 | high mobility group AT-hook 2 | -0.0400471 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0397949 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0393572 |
| AHNAK | AHNAK nucleoprotein | -0.0389831 |
| SMYD3 | SET and MYND domain containing 3 | -0.0389124 |
| LIN28B | lin-28 homolog B (C. elegans) | -0.0381572 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0380913 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.037974 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0373235 |
| SHROOM3 | shroom family member 3 | -0.0359553 |
| ANK2 | ankyrin 2, neuronal | -0.0356429 |
| DMD | dystrophin | -0.0351902 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0349403 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0337659 |
| CENPE | centromere protein E, 312kDa | -0.0336274 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0335606 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.033365 |
| VCL | vinculin | -0.0333086 |
| EMP1 | epithelial membrane protein 1 | -0.0329598 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0329112 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0314478 |
| MKI67 | marker of proliferation Ki-67 | -0.0313912 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.03113 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0310985 |
| PCDH9 | protocadherin 9 | -0.030871 |
| FIGN | fidgetin | -0.0307129 |
| ZNF385D | zinc finger protein 385D | -0.0305112 |
| METAP2 | methionyl aminopeptidase 2 | -0.030441 |
| JMJD1C | jumonji domain containing 1C | -0.0304344 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0304075 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0304019 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0302423 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0300941 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0300869 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0295601 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0294795 |
| MEF2C | myocyte enhancer factor 2C | -0.0293801 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0293426 |
| BPTF | bromodomain PHD finger transcription factor | -0.0292859 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0283604 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0280383 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0273486 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0269557 |
| SYT1 | synaptotagmin I | -0.0269159 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0269053 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 | -0.026855 |
| HMGB2 | high mobility group box 2 | -0.0265841 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0265406 |
| RBM20 | RNA binding motif protein 20 | -0.0264681 |
| SIK2 | salt-inducible kinase 2 | -0.0264294 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.026138 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0260182 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | -0.0258134 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0257086 |
| COL1A2 | collagen, type I, alpha 2 | -0.0255348 |
| RAB31 | RAB31, member RAS oncogene family | -0.0255106 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0254484 |
| LRRC4C | leucine rich repeat containing 4C | -0.0252485 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0252042 |
| WDR70 | WD repeat domain 70 | -0.0251849 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.025182 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0251306 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0251267 |
| ECT2 | epithelial cell transforming 2 | -0.0249148 |
| AK1 | adenylate kinase 1 | -0.024867 |
