Neratinib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.070278
RPL35A ribosomal protein L35a 0.050583
FTH1 ferritin, heavy polypeptide 1 0.048657
IGFBP3 insulin-like growth factor binding protein 3 0.0484658
MT2A metallothionein 2A 0.0462011
TMSB10 thymosin beta 10 0.0458684
TPT1 tumor protein, translationally-controlled 1 0.0443833
HLA-B major histocompatibility complex, class I, B 0.036434
EIF1 eukaryotic translation initiation factor 1 0.03429
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0291774
HLA-A major histocompatibility complex, class I, A 0.0291155
RPLP1 ribosomal protein, large, P1 0.0283105
PLIN2 perilipin 2 0.0280507
BTG1 B-cell translocation gene 1, anti-proliferative 0.0264097
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0262229
IER3 immediate early response 3 0.0256079
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0256022
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0246887
IFITM3 interferon induced transmembrane protein 3 0.0239603
RPLP0 ribosomal protein, large, P0 0.0237812
RPS19 ribosomal protein S19 0.0222046
RPL7A ribosomal protein L7a 0.0219988
B2M beta-2-microglobulin 0.02102
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0208906
RPLP2 ribosomal protein, large, P2 0.0203182
RPL37 ribosomal protein L37 0.0200568
VDAC1 voltage-dependent anion channel 1 0.0195875
RPS21 ribosomal protein S21 0.0186732
RPL37A ribosomal protein L37a 0.0184532
RPL36 ribosomal protein L36 0.0183369
RPL13A ribosomal protein L13a 0.0180368
RPS4X ribosomal protein S4, X-linked 0.0177947
UGCG UDP-glucose ceramide glucosyltransferase 0.0174482
RPL36A ribosomal protein L36a 0.0171239
RPS6 ribosomal protein S6 0.0164459
RPS23 ribosomal protein S23 0.0163193
RPL19 ribosomal protein L19 0.0161305
NPEPPS aminopeptidase puromycin sensitive 0.0161224
PNRC1 proline-rich nuclear receptor coactivator 1 0.0160181
S100A9 S100 calcium binding protein A9 0.0160085
HILPDA hypoxia inducible lipid droplet-associated 0.0158868
ADM adrenomedullin 0.0157616
PGK1 phosphoglycerate kinase 1 0.0155679
RACK1 receptor for activated C kinase 1 0.0155234
RPS20 ribosomal protein S20 0.0153678
FAM162A family with sequence similarity 162, member A 0.0153655
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0152334
IFITM1 interferon induced transmembrane protein 1 0.0149483
RPS3 ribosomal protein S3 0.0149456
RPS13 ribosomal protein S13 0.0147864
GNAS GNAS complex locus 0.0147436
RPS8 ribosomal protein S8 0.0146968
RPL27A ribosomal protein L27a 0.0144315
RPS16 ribosomal protein S16 0.014293
RPL11 ribosomal protein L11 0.0142721
RPL32 ribosomal protein L32 0.0142573
RPS14 ribosomal protein S14 0.0140228
RPL31 ribosomal protein L31 0.0137556
EGR1 early growth response 1 0.0135637
RPL12 ribosomal protein L12 0.0135021
MT1X metallothionein 1X 0.0132586
HMGA1 high mobility group AT-hook 1 0.013213
RPL35 ribosomal protein L35 0.0127765
WSB1 WD repeat and SOCS box containing 1 0.0127494
LMAN1 lectin, mannose-binding, 1 0.0125492
S100A6 S100 calcium binding protein A6 0.012522
RPS29 ribosomal protein S29 0.0121202
PTMA prothymosin, alpha 0.0119436
RPL10A ribosomal protein L10a 0.0119306
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0119175
RPS15 ribosomal protein S15 0.0118605
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0118375
RPL28 ribosomal protein L28 0.0116576
INSIG1 insulin induced gene 1 0.0116178
RPS25 ribosomal protein S25 0.0115619
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0114994
RPL27 ribosomal protein L27 0.0112767
RPL34 ribosomal protein L34 0.0112121
RPS11 ribosomal protein S11 0.0111765
UBE2O ubiquitin-conjugating enzyme E2O 0.011168
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0110621
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.010882
CAVIN1 caveolae associated protein 1 0.0105831
LOC112694756 uncharaterized LOC112694756 0.0104474
RPS10 ribosomal protein S10 0.010329
TUBB tubulin, beta class I 0.010326
ENO2 enolase 2 (gamma, neuronal) 0.010294
PAIP2 poly(A) binding protein interacting protein 2 0.0101862
ZFP36L1 ZFP36 ring finger protein-like 1 0.0101721
STC2 stanniocalcin 2 0.0100898
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 0.00990056
TMSB4X thymosin beta 4, X-linked 0.00989795
VKORC1 vitamin K epoxide reductase complex, subunit 1 0.00987518
UQCRB ubiquinol-cytochrome c reductase binding protein 0.00973413
RPL30 ribosomal protein L30 0.00965456
CTSD cathepsin D 0.00954732
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.00952705
ACTG1 actin gamma 1 0.00950029
RAB7A RAB7A, member RAS oncogene family 0.00942459
TBCA tubulin folding cofactor A 0.00931102

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.130151
MYH9 myosin, heavy chain 9, non-muscle -0.126101
SOD2 superoxide dismutase 2, mitochondrial -0.119723
NAV2 neuron navigator 2 -0.100785
NAMPT nicotinamide phosphoribosyltransferase -0.0965577
CD44 CD44 molecule (Indian blood group) -0.091531
FNDC3B fibronectin type III domain containing 3B -0.0900178
TRIO trio Rho guanine nucleotide exchange factor -0.0808142
COL6A3 collagen, type VI, alpha 3 -0.0611696
DST dystonin -0.0574839
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0574269
AKAP12 A kinase (PRKA) anchor protein 12 -0.055082
MSN moesin -0.0546706
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 -0.0544297
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0533428
PDE10A phosphodiesterase 10A -0.0530568
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0524397
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0518002
UBC ubiquitin C -0.0504219
ELL2 elongation factor, RNA polymerase II, 2 -0.0499976
SPAG9 sperm associated antigen 9 -0.0499526
EEF2 eukaryotic translation elongation factor 2 -0.0464223
SMAD3 SMAD family member 3 -0.0463046
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0446177
KYNU kynureninase -0.0443008
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0437203
VIM vimentin -0.0427211
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0408546
AHNAK AHNAK nucleoprotein -0.0402984
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0395795
TNIP1 TNFAIP3 interacting protein 1 -0.0395446
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0382876
MKI67 marker of proliferation Ki-67 -0.0372393
FNIP1 folliculin interacting protein 1 -0.0366789
HDAC9 histone deacetylase 9 -0.0362366
FRMD4A FERM domain containing 4A -0.0349584
CENPF centromere protein F, 350/400kDa -0.0344422
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0343377
TNS3 tensin 3 -0.034217
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.033336
SNX9 sorting nexin 9 -0.0320179
RTN4 reticulon 4 -0.0306506
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0306227
CDCP1 CUB domain containing protein 1 -0.0304186
MLPH melanophilin -0.0292117
AFDN afadin, adherens junction formation factor -0.0291392
SMYD3 SET and MYND domain containing 3 -0.0287855
MYOF myoferlin -0.0287443
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0286967
ZFAND3 zinc finger, AN1-type domain 3 -0.0283698
ASPH aspartate beta-hydroxylase -0.028152
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0279456
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0275072
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0270666
OGA O-GlcNAcase -0.0269704
RUNX1 runt-related transcription factor 1 -0.0267645
ZNF292 zinc finger protein 292 -0.0266601
CLTC clathrin, heavy chain (Hc) -0.0264451
FMNL2 formin-like 2 -0.0264354
LAMP2 lysosomal-associated membrane protein 2 -0.0263604
ZBTB38 zinc finger and BTB domain containing 38 -0.0260369
ARRDC3 arrestin domain containing 3 -0.0260122
CKAP5 cytoskeleton associated protein 5 -0.0258708
ATXN1 ataxin 1 -0.0255377
ICAM1 intercellular adhesion molecule 1 -0.0254058
JMJD1C jumonji domain containing 1C -0.0253683
PPARD peroxisome proliferator-activated receptor delta -0.025291
SBF2 SET binding factor 2 -0.0252863
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0249933
FLNA filamin A, alpha -0.0248003
RPS2 ribosomal protein S2 -0.0239452
APP amyloid beta (A4) precursor protein -0.0238788
GPC6 glypican 6 -0.0237347
BIRC2 baculoviral IAP repeat containing 2 -0.0235624
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0235249
ARFGEF3 ARFGEF family member 3 -0.0232791
USP9X ubiquitin specific peptidase 9, X-linked -0.0232694
ANLN anillin, actin binding protein -0.0231545
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0229826
DUSP5 dual specificity phosphatase 5 -0.0228175
PKM pyruvate kinase, muscle -0.0226244
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.022537
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0224378
BCAR3 breast cancer anti-estrogen resistance 3 -0.0222617
PTPRK protein tyrosine phosphatase, receptor type, K -0.021982
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0217182
VMP1 vacuole membrane protein 1 -0.0216514
NAV1 neuron navigator 1 -0.0214792
FLNB filamin B, beta -0.0213482
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0205895
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0204961
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0204796
NDRG1 N-myc downstream regulated 1 -0.0204
STAG2 stromal antigen 2 -0.0203332
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0200078
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0199557
ANXA2 annexin A2 -0.0199043
TPM3 tropomyosin 3 -0.0196728
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0195093
FRMD5 FERM domain containing 5 -0.0193431