Neratinib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Neratinib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Neratinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.107125
FTH1 ferritin, heavy polypeptide 1 0.0420834
MATR3 matrin 3 0.0408985
FAM13A family with sequence similarity 13, member A 0.0368861
TRA2A transformer 2 alpha homolog (Drosophila) 0.0351471
ARRDC3 arrestin domain containing 3 0.0295993
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0286149
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0267553
CBX3 chromobox homolog 3 0.0261401
ZNF148 zinc finger protein 148 0.0259136
CCDC14 coiled-coil domain containing 14 0.025092
ELL2 elongation factor, RNA polymerase II, 2 0.0248845
MAP1B microtubule-associated protein 1B 0.0245912
NUP58 nucleoporin 58 0.0245269
SPAG9 sperm associated antigen 9 0.0242469
IL6ST interleukin 6 signal transducer 0.0237685
RTN4 reticulon 4 0.0231121
ZBTB20 zinc finger and BTB domain containing 20 0.0225932
WDR43 WD repeat domain 43 0.0225029
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0217847
USP9X ubiquitin specific peptidase 9, X-linked 0.0209814
RAB8B RAB8B, member RAS oncogene family 0.0203935
ANXA5 annexin A5 0.0203695
MT1X metallothionein 1X 0.0202431
DPY19L1 dpy-19-like 1 (C. elegans) 0.0199711
SEM1 SEM1 26S proteasome subunit 0.0194682
PCBP2 poly(rC) binding protein 2 0.0193375
DCP2 decapping mRNA 2 0.0193158
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0192454
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0192097
TRIO trio Rho guanine nucleotide exchange factor 0.0185899
ATP13A3 ATPase type 13A3 0.018267
ZNF451 zinc finger protein 451 0.0181429
RIOK3 RIO kinase 3 0.0179298
CADM1 cell adhesion molecule 1 0.0177901
SFXN1 sideroflexin 1 0.0177066
MED13L mediator complex subunit 13-like 0.0175991
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0175599
MEF2A myocyte enhancer factor 2A 0.0174254
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0172907
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0172287
STK4 serine/threonine kinase 4 0.0171429
FXR1 fragile X mental retardation, autosomal homolog 1 0.0169264
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0166384
NKD1 naked cuticle homolog 1 (Drosophila) 0.0164918
SFPQ splicing factor proline/glutamine-rich 0.0164201
RBM25 RNA binding motif protein 25 0.0163907
PDE4D phosphodiesterase 4D, cAMP-specific 0.0163025
ERRFI1 ERBB receptor feedback inhibitor 1 0.0162669
RNF24 ring finger protein 24 0.0161869
AKAP9 A kinase (PRKA) anchor protein 9 0.0161669
EIF4B eukaryotic translation initiation factor 4B 0.0161433
NCKAP1 NCK-associated protein 1 0.0160015
AVL9 AVL9 homolog (S. cerevisiase) 0.0160007
RPN2 ribophorin II 0.0159515
H2AZ2 H2A.Z variant histone 2 0.015892
ARHGAP26 Rho GTPase activating protein 26 0.0158162
SCAF8 SR-related CTD-associated factor 8 0.0154614
OLA1 Obg-like ATPase 1 0.0154474
IL6 interleukin 6 0.015435
ZCCHC7 zinc finger, CCHC domain containing 7 0.0152902
FOSL1 FOS-like antigen 1 0.0152558
TXNL1 thioredoxin-like 1 0.0152194
DSCAM Down syndrome cell adhesion molecule 0.0152018
SYT1 synaptotagmin I 0.0151846
FEM1C fem-1 homolog c (C. elegans) 0.0150439
WTAP Wilms tumor 1 associated protein 0.0149965
PUM1 pumilio RNA-binding family member 1 0.0148926
GARS1 glycyl-tRNA synthetase 1 0.0146513
NUDCD3 NudC domain containing 3 0.0144157
UGCG UDP-glucose ceramide glucosyltransferase 0.0143316
SRSF1 serine/arginine-rich splicing factor 1 0.0142251
RPL21 ribosomal protein L21 0.0141421
USP12 ubiquitin specific peptidase 12 0.014017
SRRM2 serine/arginine repetitive matrix 2 0.0140057
COL5A2 collagen, type V, alpha 2 0.0140028
NIPBL Nipped-B homolog (Drosophila) 0.0139411
MT2A metallothionein 2A 0.01394
CHIC2 cysteine-rich hydrophobic domain 2 0.0139065
GMDS GDP-mannose 4,6-dehydratase 0.0138718
LOXL2 lysyl oxidase-like 2 0.0138618
SOD2 superoxide dismutase 2, mitochondrial 0.0137332
MARCHF7 membrane associated ring-CH-type finger 7 0.0136839
OSBPL9 oxysterol binding protein-like 9 0.013661
SCAF11 SR-related CTD-associated factor 11 0.0134312
SAMD4A sterile alpha motif domain containing 4A 0.0134242
MED14 mediator complex subunit 14 0.013394
EWSR1 EWS RNA-binding protein 1 0.0132869
TXNIP thioredoxin interacting protein 0.0132054
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0131318
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0130912
KDM6A lysine (K)-specific demethylase 6A 0.0130674
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0130263
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0129689
RYBP RING1 and YY1 binding protein 0.0129196
EFCAB11 EF-hand calcium binding domain 11 0.012878
KDM1A lysine (K)-specific demethylase 1A 0.0128715
PTMS parathymosin 0.0128553
MED12 mediator complex subunit 12 0.0128084
INVS inversin 0.012742

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196813
VIM vimentin -0.187269
TGFBI transforming growth factor, beta-induced, 68kDa -0.180743
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.156254
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.150537
HLA-B major histocompatibility complex, class I, B -0.0881181
FN1 fibronectin 1 -0.0845477
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0764204
TMSB10 thymosin beta 10 -0.0709343
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0684612
COL1A1 collagen, type I, alpha 1 -0.0638248
PTMA prothymosin, alpha -0.0563721
TPT1 tumor protein, translationally-controlled 1 -0.0536232
ENO1 enolase 1, (alpha) -0.0504253
HLA-C major histocompatibility complex, class I, C -0.0498328
EGFR epidermal growth factor receptor -0.0495291
CALR calreticulin -0.0459126
CDH13 cadherin 13 -0.0454533
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0453061
S100A10 S100 calcium binding protein A10 -0.0397942
COL5A1 collagen, type V, alpha 1 -0.0394916
RPL34 ribosomal protein L34 -0.0391586
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0382993
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0359282
CAVIN1 caveolae associated protein 1 -0.0353049
F3 coagulation factor III (thromboplastin, tissue factor) -0.0349601
CANX calnexin -0.034839
WSB1 WD repeat and SOCS box containing 1 -0.0344276
POTEF POTE ankyrin domain family, member F -0.0339382
SEC24D SEC24 family member D -0.033654
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0332907
CALU calumenin -0.0331901
PGK1 phosphoglycerate kinase 1 -0.0329492
RRBP1 ribosome binding protein 1 -0.0313523
PKM pyruvate kinase, muscle -0.0312105
NRXN3 neurexin 3 -0.0310784
PSD3 pleckstrin and Sec7 domain containing 3 -0.0307151
FTL ferritin, light polypeptide -0.0304334
RPL37 ribosomal protein L37 -0.0298754
IGFBP3 insulin-like growth factor binding protein 3 -0.0294668
PDIA4 protein disulfide isomerase family A, member 4 -0.0294618
ADM adrenomedullin -0.0293585
EXT1 exostosin glycosyltransferase 1 -0.0293021
RPLP1 ribosomal protein, large, P1 -0.0290539
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0279562
TPM4 tropomyosin 4 -0.0272405
NDRG1 N-myc downstream regulated 1 -0.0269217
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0267747
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.026756
CD44 CD44 molecule (Indian blood group) -0.0266736
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0266191
RPS23 ribosomal protein S23 -0.026486
LMNA lamin A/C -0.0264286
GCC2 GRIP and coiled-coil domain containing 2 -0.026111
DPYD dihydropyrimidine dehydrogenase -0.0253495
VDAC1 voltage-dependent anion channel 1 -0.0253317
HM13 histocompatibility (minor) 13 -0.0253254
COPB1 coatomer protein complex, subunit beta 1 -0.0251183
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0249472
YIPF5 Yip1 domain family, member 5 -0.0245364
B2M beta-2-microglobulin -0.0244952
RPL37A ribosomal protein L37a -0.023904
SPDYA speedy/RINGO cell cycle regulator family member A -0.023838
CDK6 cyclin-dependent kinase 6 -0.0230862
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0226963
DNAH11 dynein, axonemal, heavy chain 11 -0.0225093
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0222886
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0222004
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0218061
FKBP10 FK506 binding protein 10, 65 kDa -0.0217651
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0216936
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0216086
MACF1 microtubule-actin crosslinking factor 1 -0.0213429
ZMYND8 zinc finger, MYND-type containing 8 -0.0213133
HMGA2 high mobility group AT-hook 2 -0.0211098
VCP valosin containing protein -0.0210863
STAU1 staufen double-stranded RNA binding protein 1 -0.0209137
RPS8 ribosomal protein S8 -0.020708
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0205963
NAV1 neuron navigator 1 -0.0204202
FRMD4A FERM domain containing 4A -0.020199
COL6A1 collagen, type VI, alpha 1 -0.0201935
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0201821
GNAS GNAS complex locus -0.0199795
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0199748
COPA coatomer protein complex, subunit alpha -0.0198663
FBXO11 F-box protein 11 -0.0198363
ENO2 enolase 2 (gamma, neuronal) -0.019775
SNX14 sorting nexin 14 -0.0196738
RPL35A ribosomal protein L35a -0.0196431
QKI QKI, KH domain containing, RNA binding -0.0196307
FNDC3B fibronectin type III domain containing 3B -0.0188386
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0183758
CMIP c-Maf inducing protein -0.0180818
RPL31 ribosomal protein L31 -0.0178796
CHD9 chromodomain helicase DNA binding protein 9 -0.0178792
TM4SF1 transmembrane 4 L six family member 1 -0.0178566
LDHA lactate dehydrogenase A -0.0178141
RPL23 ribosomal protein L23 -0.0177601
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0176008