| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Neratinib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Neratinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.125323 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.120013 |
| TMEM156 | transmembrane protein 156 | 0.0840876 |
| TXNIP | thioredoxin interacting protein | 0.0803821 |
| ITGA1 | integrin, alpha 1 | 0.0793409 |
| NRP1 | neuropilin 1 | 0.0788559 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0697272 |
| OSMR | oncostatin M receptor | 0.069427 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0683964 |
| GLIS3 | GLIS family zinc finger 3 | 0.0653337 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0646077 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0595037 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0514285 |
| PELO | pelota homolog (Drosophila) | 0.0505833 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.050243 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0483096 |
| TXNRD1 | thioredoxin reductase 1 | 0.0475403 |
| MKI67 | marker of proliferation Ki-67 | 0.0460332 |
| EREG | epiregulin | 0.0458168 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.042895 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0423488 |
| CDCP1 | CUB domain containing protein 1 | 0.0422793 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0385061 |
| SYT1 | synaptotagmin I | 0.03844 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.038342 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0370274 |
| CD44 | CD44 molecule (Indian blood group) | 0.0369493 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0368003 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0348598 |
| CAB39 | calcium binding protein 39 | 0.0345202 |
| SSH1 | slingshot protein phosphatase 1 | 0.0344653 |
| FOXP1 | forkhead box P1 | 0.0337183 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0332394 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0331324 |
| CENPF | centromere protein F, 350/400kDa | 0.0323219 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0322997 |
| SMOX | spermine oxidase | 0.0320494 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0316163 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0314181 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0313751 |
| KLHL5 | kelch-like family member 5 | 0.0306093 |
| ADD3 | adducin 3 (gamma) | 0.0303431 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0303429 |
| SMYD3 | SET and MYND domain containing 3 | 0.0302986 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0302057 |
| PLPP6 | phospholipid phosphatase 6 | 0.0301967 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.030133 |
| SYNJ2 | synaptojanin 2 | 0.0299012 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0298706 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0296582 |
| TMEM165 | transmembrane protein 165 | 0.0295927 |
| IL6ST | interleukin 6 signal transducer | 0.0295809 |
| FAF2 | Fas associated factor family member 2 | 0.0285015 |
| ETV6 | ets variant 6 | 0.0281137 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0280623 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.027727 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0275664 |
| AHR | aryl hydrocarbon receptor | 0.0274188 |
| ITGB5 | integrin, beta 5 | 0.0273721 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0269379 |
| RUNX2 | runt-related transcription factor 2 | 0.0264741 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0263926 |
| ETV1 | ets variant 1 | 0.0259959 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0257225 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0256783 |
| FNBP1 | formin binding protein 1 | 0.0256185 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.025529 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0252917 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0251908 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0251826 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.025075 |
| CEP350 | centrosomal protein 350kDa | 0.0248775 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0248381 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0247683 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0246311 |
| FRYL | FRY-like | 0.0244938 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0240288 |
| DST | dystonin | 0.0240016 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0233664 |
| RAB31 | RAB31, member RAS oncogene family | 0.0230043 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0227907 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0226526 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.022492 |
| ETNK1 | ethanolamine kinase 1 | 0.0224023 |
| CLOCK | clock circadian regulator | 0.0222431 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0222409 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0221169 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0221002 |
| CCNJL | cyclin J-like | 0.0219827 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0212677 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0212195 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0210399 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0209408 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0207605 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.020756 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.020722 |
| ANO6 | anoctamin 6 | 0.020611 |
| SP3 | Sp3 transcription factor | 0.0204359 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0203245 |
| AOPEP | aminopeptidase O (putative) | 0.020183 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.146371 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.133514 |
| FN1 | fibronectin 1 | -0.0998326 |
| PTMA | prothymosin, alpha | -0.0651009 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0635663 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0619516 |
| SQSTM1 | sequestosome 1 | -0.0613443 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0605706 |
| INTS6 | integrator complex subunit 6 | -0.0549154 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0527141 |
| HLA-B | major histocompatibility complex, class I, B | -0.0510486 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0510476 |
| CADM1 | cell adhesion molecule 1 | -0.0509424 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0500144 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0491923 |
| SPAG9 | sperm associated antigen 9 | -0.0490211 |
| LMNA | lamin A/C | -0.048902 |
| RPL26 | ribosomal protein L26 | -0.0488352 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0483302 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0455397 |
| RPL37A | ribosomal protein L37a | -0.0446187 |
| TMSB10 | thymosin beta 10 | -0.0412013 |
| GNAS | GNAS complex locus | -0.0407044 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0371278 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0362348 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0360648 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0341079 |
| RPL35A | ribosomal protein L35a | -0.0336862 |
| AEBP2 | AE binding protein 2 | -0.0325193 |
| EMP1 | epithelial membrane protein 1 | -0.0321004 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0320004 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0317419 |
| S100A6 | S100 calcium binding protein A6 | -0.031555 |
| NDRG1 | N-myc downstream regulated 1 | -0.0308228 |
| RPS12 | ribosomal protein S12 | -0.029939 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0298161 |
| JUN | jun proto-oncogene | -0.0292089 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0290166 |
| RPS24 | ribosomal protein S24 | -0.0288734 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0287672 |
| LRRC23 | leucine rich repeat containing 23 | -0.0285461 |
| RPL31 | ribosomal protein L31 | -0.0285072 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0284122 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0278296 |
| TENM4 | teneurin transmembrane protein 4 | -0.0275926 |
| FMNL2 | formin-like 2 | -0.0267941 |
| RPL12 | ribosomal protein L12 | -0.026489 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0264092 |
| ACTG1 | actin gamma 1 | -0.0263843 |
| RACK1 | receptor for activated C kinase 1 | -0.0262767 |
| CANX | calnexin | -0.0258811 |
| S100A10 | S100 calcium binding protein A10 | -0.025609 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0255325 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0254777 |
| RPL19 | ribosomal protein L19 | -0.0245701 |
| NOP58 | NOP58 ribonucleoprotein | -0.0244081 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0236441 |
| TUFT1 | tuftelin 1 | -0.0234243 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0233023 |
| IER3 | immediate early response 3 | -0.0232309 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.023101 |
| RND3 | Rho family GTPase 3 | -0.0229336 |
| H1-0 | H1.0 linker histone | -0.0227922 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0226768 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0226244 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.022581 |
| RPLP1 | ribosomal protein, large, P1 | -0.022533 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.022405 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0223464 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.022215 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0219385 |
| PALLD | palladin, cytoskeletal associated protein | -0.0219195 |
| STC2 | stanniocalcin 2 | -0.021794 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0215515 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0213537 |
| AHNAK | AHNAK nucleoprotein | -0.02134 |
| CTBP2 | C-terminal binding protein 2 | -0.0213135 |
| TMSB4X | thymosin beta 4, X-linked | -0.0210079 |
| RPL34 | ribosomal protein L34 | -0.0208751 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.020834 |
| TMEM263 | transmembrane protein 263 | -0.0206815 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0204102 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0202803 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0201986 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0201082 |
| MMP13 | matrix metallopeptidase 13 | -0.0200149 |
| RPL11 | ribosomal protein L11 | -0.0199511 |
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | -0.019883 |
| VCL | vinculin | -0.0197688 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0197638 |
| CCDC138 | coiled-coil domain containing 138 | -0.0197175 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0196427 |
| SFTPA2 | surfactant protein A2 | -0.0193565 |
| RPS8 | ribosomal protein S8 | -0.019249 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0189313 |
| RHEB | Ras homolog enriched in brain | -0.0188689 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0188621 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0187742 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0186841 |
| RPS6 | ribosomal protein S6 | -0.0186159 |
