Neuroactive ligand-receptor interaction Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description (Kyoto Encyclopedia of Genes and Genomes, hsa04080)
External Link https://www.kegg.jp/entry/hsa04080
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Genes

366 proteins participating in the Neuroactive ligand-receptor interaction pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADM adrenomedullin
ADM2 adrenomedullin 2
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA1D adrenoceptor alpha 1D
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AGXT alanine-glyoxylate aminotransferase
APELA apelin receptor early endogenous ligand
APLN apelin
APLNR apelin receptor
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
AVPR2 arginine vasopressin receptor 2
BDKRB1 bradykinin receptor B1
BDKRB2 bradykinin receptor B2
BRS3 bombesin-like receptor 3
C1QTNF1 C1q and tumor necrosis factor related protein 1
C3 complement component 3
C3AR1 complement component 3a receptor 1
C5 complement component 5
C5AR1 complement component 5a receptor 1
CALCA calcitonin-related polypeptide alpha
CALCB calcitonin-related polypeptide beta
CALCR calcitonin receptor
CALCRL calcitonin receptor-like
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CD200R1 CD200 receptor 1
CHGA chromogranin A
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CHRND cholinergic receptor, nicotinic, delta (muscle)
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CORT cortistatin
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
CSH2 chorionic somatomammotropin hormone 2
CSHL1 chorionic somatomammotropin hormone-like 1
CTSG cathepsin G
CYSLTR1 cysteinyl leukotriene receptor 1
CYSLTR2 cysteinyl leukotriene receptor 2
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
EDN1 endothelin 1
EDN2 endothelin 2
EDN3 endothelin 3
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F2RL2 coagulation factor II (thrombin) receptor-like 2
F2RL3 coagulation factor II (thrombin) receptor-like 3
FPR1 formyl peptide receptor 1
FPR2 formyl peptide receptor 2
FPR3 formyl peptide receptor 3
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene)
GALP galanin-like peptide
GALR1 galanin receptor 1
GALR2 galanin receptor 2
GALR3 galanin receptor 3
GCG glucagon
GCGR glucagon receptor
GH1 growth hormone 1
GH2 growth hormone 2
GHR growth hormone receptor
GHRH growth hormone releasing hormone
GHRHR growth hormone releasing hormone receptor
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GIPR gastric inhibitory polypeptide receptor
GLP1R glucagon-like peptide 1 receptor
GLP2R glucagon-like peptide 2 receptor
GLRA1 glycine receptor, alpha 1
GLRA2 glycine receptor, alpha 2
GLRA3 glycine receptor, alpha 3
GLRB glycine receptor, beta
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRH2 gonadotropin-releasing hormone 2
GNRHR gonadotropin-releasing hormone receptor
GPHA2 glycoprotein hormone alpha 2
GPHB5 glycoprotein hormone beta 5
GPNMB glycoprotein (transmembrane) nmb
GPR156 G protein-coupled receptor 156
GPR35 G protein-coupled receptor 35
GPR50 G protein-coupled receptor 50
GPR83 G protein-coupled receptor 83
GPRIN1 G protein regulated inducer of neurite outgrowth 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRID1 glutamate receptor, ionotropic, delta 1
GRID2 glutamate receptor, ionotropic, delta 2
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIK3 glutamate receptor, ionotropic, kainate 3
GRIK4 glutamate receptor, ionotropic, kainate 4
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRM1 glutamate receptor, metabotropic 1
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
GRM4 glutamate receptor, metabotropic 4
GRM5 glutamate receptor, metabotropic 5
GRM6 glutamate receptor, metabotropic 6
GRM7 glutamate receptor, metabotropic 7
GRM8 glutamate receptor, metabotropic 8
GRPR gastrin-releasing peptide receptor
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HCRT hypocretin (orexin) neuropeptide precursor
HCRTR1 hypocretin (orexin) receptor 1
HRH2 histamine receptor H2
HRH3 histamine receptor H3
HRH4 histamine receptor H4
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IAPP islet amyloid polypeptide
INSL3 insulin-like 3 (Leydig cell)
INSL5 insulin-like 5
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
KNG1 kininogen 1
LEP leptin
LEPROT leptin receptor overlapping transcript
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
LPAR1 lysophosphatidic acid receptor 1
LPAR2 lysophosphatidic acid receptor 2
LPAR3 lysophosphatidic acid receptor 3
LPAR4 lysophosphatidic acid receptor 4
LPAR6 lysophosphatidic acid receptor 6
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
LYNX1 Ly6/neurotoxin 1
LYPD6 LY6/PLAUR domain containing 6
LYPD6B LY6/PLAUR domain containing 6B
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MC5R melanocortin 5 receptor
MCHR1 melanin-concentrating hormone receptor 1
MCHR2 melanin-concentrating hormone receptor 2
MLNR motilin receptor
MRLN myoregulin
MTNR1A melatonin receptor 1A
MTNR1B melatonin receptor 1B
NLRP3 NLR family, pyrin domain containing 3
NMBR neuromedin B receptor
NMS neuromedin S
NMU neuromedin U
NMUR1 neuromedin U receptor 1
NMUR2 neuromedin U receptor 2
NPB neuropeptide B
NPBWR1 neuropeptides B/W receptor 1
NPBWR2 neuropeptides B/W receptor 2
NPFF neuropeptide FF-amide peptide precursor
NPFFR1 neuropeptide FF receptor 1
NPFFR2 neuropeptide FF receptor 2
NPS neuropeptide S
NPSR1 neuropeptide S receptor 1
NPVF neuropeptide VF precursor
NPW neuropeptide W
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NPY4R2 neuropeptide Y receptor Y4-2
NPY5R neuropeptide Y receptor Y5
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTS neurotensin
NTSR1 neurotensin receptor 1 (high affinity)
NTSR2 neurotensin receptor 2
OGFR opioid growth factor receptor
OGFRL1 opioid growth factor receptor-like 1
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
OXT oxytocin/neurophysin I prepropeptide
OXTR oxytocin receptor
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY10 purinergic receptor P2Y, G-protein coupled, 10
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
P2RY8 purinergic receptor P2Y, G-protein coupled, 8
PAQR6 progestin and adipoQ receptor family member VI
PAQR9 progestin and adipoQ receptor family member IX
PATE1 prostate and testis expressed 1
PATE2 prostate and testis expressed 2
PATE3 prostate and testis expressed 3
PATE4 prostate and testis expressed 4
PCDHA4 protocadherin alpha 4
PCDHA6 protocadherin alpha 6
PDYN prodynorphin
PENK proenkephalin
PGRMC1 progesterone receptor membrane component 1
PGRMC2 progesterone receptor membrane component 2
PLG plasminogen
PMCH pro-melanin-concentrating hormone
PMPCB peptidase (mitochondrial processing) beta
PNOC prepronociceptin
POMC proopiomelanocortin
PPAN-P2RY11 PPAN-P2RY11 readthrough
PPY pancreatic polypeptide
PRL prolactin
PRLH prolactin releasing hormone
PRLHR prolactin releasing hormone receptor
PRLR prolactin receptor
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PRSS58 protease, serine, 58
PTAFR platelet-activating factor receptor
PTGDR prostaglandin D2 receptor (DP)
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGFR prostaglandin F receptor (FP)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTH1R parathyroid hormone 1 receptor
PTH2 parathyroid hormone 2
PTH2R parathyroid hormone 2 receptor
PTRH2 peptidyl-tRNA hydrolase 2
PYY peptide YY
QRFP pyroglutamylated RFamide peptide
QRFPR pyroglutamylated RFamide peptide receptor
RIPK2 receptor-interacting serine-threonine kinase 2
RLN1 relaxin 1
RLN2 relaxin 2
RLN3 relaxin 3
RXFP1 relaxin/insulin-like family peptide receptor 1
RXFP2 relaxin/insulin-like family peptide receptor 2
RXFP3 relaxin/insulin-like family peptide receptor 3
RXFP4 relaxin/insulin-like family peptide receptor 4
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
S1PR3 sphingosine-1-phosphate receptor 3
S1PR4 sphingosine-1-phosphate receptor 4
S1PR5 sphingosine-1-phosphate receptor 5
SCT secretin
SCTR secretin receptor
SLURP1 secreted LY6/PLAUR domain containing 1
SLURP2 secreted LY6/PLAUR domain containing 2
SPX spexin hormone
SST somatostatin
SSTR1 somatostatin receptor 1
SSTR2 somatostatin receptor 2
SSTR3 somatostatin receptor 3
SSTR4 somatostatin receptor 4
SSTR5 somatostatin receptor 5
TAAR1 trace amine associated receptor 1
TAAR2 trace amine associated receptor 2
TAAR5 trace amine associated receptor 5
TAAR6 trace amine associated receptor 6
TAAR8 trace amine associated receptor 8
TAAR9 trace amine associated receptor 9 (gene/pseudogene)
TAC1 tachykinin, precursor 1
TAC3 tachykinin 3
TAC4 tachykinin 4 (hemokinin)
TACR1 tachykinin receptor 1
TACR2 tachykinin receptor 2
TACR3 tachykinin receptor 3
TBXA2R thromboxane A2 receptor
THRA thyroid hormone receptor, alpha
THRB thyroid hormone receptor, beta
TMEM97 transmembrane protein 97
TRH thyrotropin-releasing hormone
TRHR thyrotropin-releasing hormone receptor
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSHB thyroid stimulating hormone, beta
TSHR thyroid stimulating hormone receptor
TSPO translocator protein (18kDa)
TTF2 transcription termination factor, RNA polymerase II
UCMA upper zone of growth plate and cartilage matrix associated
UCN urocortin
UCN2 urocortin 2
UCN3 urocortin 3
UTS2 urotensin 2
UTS2B urotensin 2B
UTS2R urotensin 2 receptor
VGF VGF nerve growth factor inducible
VIPR1 vasoactive intestinal peptide receptor 1
VIPR2 vasoactive intestinal peptide receptor 2