Neuroblastoma Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation.|A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)|A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome (MeSH). (Experimental Factor Ontology, EFO_0000621)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D009447
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Genes

183 genes/proteins associated with the disease Neuroblastoma from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.88009
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 2.88009
IFNB1 interferon, beta 1, fibroblast 2.88009
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 2.88009
CHEK2 checkpoint kinase 2 2.88009
MET MET proto-oncogene, receptor tyrosine kinase 2.88009
CDKN2A cyclin-dependent kinase inhibitor 2A 2.88009
AURKA aurora kinase A 2.88009
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.88009
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 2.88009
ALK anaplastic lymphoma receptor tyrosine kinase 2.88009
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.88009
ATRX alpha thalassemia/mental retardation syndrome X-linked 2.88009
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.88009
NBLST6 Neuroblastoma, susceptibility to, 6 2.88009
PINK1 PTEN induced putative kinase 1 2.88009
NBLST4 Neuroblastoma, susceptibility to, 4 2.88009
NME1 NME/NM23 nucleoside diphosphate kinase 1 2.88009
CHD6 chromodomain helicase DNA binding protein 6 2.88009
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.88009
PHOX2B paired-like homeobox 2b 2.88009
PTPN11 protein tyrosine phosphatase, non-receptor type 11 2.88009
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 2.88009
ARID1A AT rich interactive domain 1A (SWI-like) 2.88009
ARID1B AT rich interactive domain 1B (SWI1-like) 2.88009
GNAS GNAS complex locus 2.88009
BCHE butyrylcholinesterase 2.88009
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.88009
NNAT neuronatin 2.88009
BARD1 BRCA1 associated RING domain 1 2.88009
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 2.88009
LIN28B lin-28 homolog B (C. elegans) 2.88009
HRAS Harvey rat sarcoma viral oncogene homolog 2.88009
NBLST5 Neuroblastoma, susceptibility to, 5 2.88009
KIF1B kinesin family member 1B 2.88009
TP53 tumor protein p53 2.88009
COX2 2.88009
BCL2L1 BCL2-like 1 1.87975
GSTP1 glutathione S-transferase pi 1 1.87059
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.78816
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.78701
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.72529
BCL2 B-cell CLL/lymphoma 2 1.70119
BAX BCL2-associated X protein 1.69232
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.68761
PARP1 poly (ADP-ribose) polymerase 1 1.62268
H2AFX H2A histone family, member X 1.62176
CHEK1 checkpoint kinase 1 1.60547
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.54912
GDF15 growth differentiation factor 15 1.52439
BAK1 BCL2-antagonist/killer 1 1.52413
FAS Fas cell surface death receptor 1.51835
MGMT O-6-methylguanine-DNA methyltransferase 1.50223
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.49356
BIRC5 baculoviral IAP repeat containing 5 1.48864
CFLAR CASP8 and FADD-like apoptosis regulator 1.43076
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.42374
TOP2A topoisomerase (DNA) II alpha 170kDa 1.42047
VEGFA vascular endothelial growth factor A 1.39535
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.3903
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.38946
GADD45A growth arrest and DNA-damage-inducible, alpha 1.38071
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.36706
BID BH3 interacting domain death agonist 1.36447
IL6 interleukin 6 1.34576
GSTM1 glutathione S-transferase mu 1 1.34576
FASLG Fas ligand (TNF superfamily, member 6) 1.34053
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.33405
TGFA transforming growth factor, alpha 1.32162
KAT2B K(lysine) acetyltransferase 2B 1.31656
BIRC2 baculoviral IAP repeat containing 2 1.31566
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.31178
GPX3 glutathione peroxidase 3 1.29812
DDIT3 DNA-damage-inducible transcript 3 1.29595
BCL2L2 BCL2-like 2 1.29502
SOD2 superoxide dismutase 2, mitochondrial 1.29317
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.28703
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.28641
ERBB2 erb-b2 receptor tyrosine kinase 2 1.27751
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.27409
ATM ATM serine/threonine kinase 1.26669
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.25245
RB1 retinoblastoma 1 1.24905
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.24781
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.2393
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.23837
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.23712
BIK BCL2-interacting killer (apoptosis-inducing) 1.23552
CDK2 cyclin-dependent kinase 2 1.23456
PCNA proliferating cell nuclear antigen 1.23328
VCAN versican 1.22884
BIRC3 baculoviral IAP repeat containing 3 1.2208
HBEGF heparin-binding EGF-like growth factor 1.21855
JUN jun proto-oncogene 1.21043
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.20784
RAD51 RAD51 recombinase 1.2059
CCND1 cyclin D1 1.20493
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.20361
APAF1 apoptotic peptidase activating factor 1 1.20163
EPO erythropoietin 1.20163
MPO myeloperoxidase 1.2013
TNF tumor necrosis factor 1.19933
MAPK3 mitogen-activated protein kinase 3 1.1977
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.19014
MAPK1 mitogen-activated protein kinase 1 1.1862
FANCG Fanconi anemia, complementation group G 1.18424
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 1.18424
STAT1 signal transducer and activator of transcription 1, 91kDa 1.18359
VIM vimentin 1.18093
TXNIP thioredoxin interacting protein 1.17993
EGFR epidermal growth factor receptor 1.17497
MCL1 myeloid cell leukemia 1 1.17366
MKNK2 MAP kinase interacting serine/threonine kinase 2 1.17067
INSIG1 insulin induced gene 1 1.17034
BRCA1 breast cancer 1, early onset 1.16833
DUSP2 dual specificity phosphatase 2 1.16633
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.16434
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.16236
SGK1 serum/glucocorticoid regulated kinase 1 1.15763
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.15055
CAT catalase 1.14816
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.14781
CCNB1 cyclin B1 1.14781
RBM17 RNA binding motif protein 17 1.14747
TPD52L1 tumor protein D52-like 1 1.14098
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.13862
FOS FBJ murine osteosarcoma viral oncogene homolog 1.13758
IFITM1 interferon induced transmembrane protein 1 1.13724
BECN1 beclin 1, autophagy related 1.13518
CD44 CD44 molecule (Indian blood group) 1.13484
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.13415
SQSTM1 sequestosome 1 1.12634
PHLDA1 pleckstrin homology-like domain, family A, member 1 1.11396
EGR1 early growth response 1 1.11396
HMGA2 high mobility group AT-hook 2 1.11081
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.10734
TYMS thymidylate synthetase 1.10699
DUSP10 dual specificity phosphatase 10 1.10388
IL23A interleukin 23, alpha subunit p19 1.10388
RGL1 ral guanine nucleotide dissociation stimulator-like 1 1.09927
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.09576
GPX1 glutathione peroxidase 1 1.09119
ATP7A ATPase, Cu++ transporting, alpha polypeptide 1.09047
RARB retinoic acid receptor, beta 1.0894
CDK1 cyclin-dependent kinase 1 1.08904
PHLDA2 pleckstrin homology-like domain, family A, member 2 1.0869
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.08126
MKI67 marker of proliferation Ki-67 1.0766
CDC25C cell division cycle 25C 1.07093
S100A8 S100 calcium binding protein A8 1.06881
SLC31A1 solute carrier family 31 (copper transporter), member 1 1.06771
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.06771
SPP1 secreted phosphoprotein 1 1.06588
THBS1 thrombospondin 1 1.06297
BBC3 BCL2 binding component 3 1.06297
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.06225
SFN stratifin 1.05828
SESN1 sestrin 1 1.05535
FANCC Fanconi anemia, complementation group C 1.05386
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.05089
EPCAM epithelial cell adhesion molecule 1.04941
IER3 immediate early response 3 1.04721
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.04684
WEE1 WEE1 G2 checkpoint kinase 1.04647
TGFB1 transforming growth factor, beta 1 1.04538
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.04538
XAF1 XIAP associated factor 1 1.04352
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.03567
EP300 E1A binding protein p300 1.02933
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 1.02933
FASN fatty acid synthase 1.02708
BCL2A1 BCL2-related protein A1 1.02671
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.02559
HSPA1A heat shock 70kDa protein 1A 1.02559
CXCL8 chemokine (C-X-C motif) ligand 8 1.02522
HSPB1 heat shock 27kDa protein 1 1.02447
DKK3 dickkopf WNT signaling pathway inhibitor 3 1.0241
SESN2 sestrin 2 1.02114
SAT1 spermidine/spermine N1-acetyltransferase 1 1.02114
MCM4 minichromosome maintenance complex component 4 1.01587
LCN2 lipocalin 2 1.01062
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.01025
RUNX3 runt-related transcription factor 3 1.01025