Neuroblastoma Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description A neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation.|A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)|A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome (MeSH). (Experimental Factor Ontology, EFO_0000621)
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Genes

101 genes associated with the trait Neuroblastoma in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
BARD1 BRCA1 associated RING domain 1 1.31348
CASC15 cancer susceptibility candidate 15 (non-protein coding) 1.28023
LMO1 LIM domain only 1 (rhombotin 1) 1.24893
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.701627
ZRANB3 zinc finger, RAN-binding domain containing 3 0.645136
DARS aspartyl-tRNA synthetase 0.595779
RALYL RALY RNA binding protein-like 0.590118
RSRC1 arginine/serine-rich coiled-coil 1 0.577162
NXPH2 neurexophilin 2 0.576793
FAM114A1 family with sequence similarity 114, member A1 0.561703
EHBP1 EH domain binding protein 1 0.552279
AIP aryl hydrocarbon receptor interacting protein 0.55085
CPZ carboxypeptidase Z 0.544291
XPO4 exportin 4 0.54144
NUP153 nucleoporin 153kDa 0.526873
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.50602
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.504327
EPHA3 EPH receptor A3 0.502754
GRB2 growth factor receptor-bound protein 2 0.493297
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.473425
LCT lactase 0.465645
MICB MHC class I polypeptide-related sequence B 0.460096
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.45403
C1ORF94 chromosome 1 open reading frame 94 0.403408
DUSP12 dual specificity phosphatase 12 0.399798
MICU3 mitochondrial calcium uptake family, member 3 0.398631
R3HDM1 R3H domain containing 1 0.396349
RP9P retinitis pigmentosa 9 pseudogene 0.38164
SACK1B scaffolding CK1 anchoring protein B 0.379369
IL9RP2 interleukin 9 receptor pseudogene 2 0.37838
CALCOCO2 calcium binding and coiled-coil domain 2 0.376199
TCF12 transcription factor 12 0.369329
PRDM5 PR domain containing 5 0.362069
DNAH7 dynein, axonemal, heavy chain 7 0.359953
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.356276
LRRC69 leucine rich repeat containing 69 0.353142
TIAM1 T-cell lymphoma invasion and metastasis 1 0.345624
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.34201
CABP4 calcium binding protein 4 0.341149
HKDC1 hexokinase domain containing 1 0.337794
MED12L mediator complex subunit 12-like 0.327622
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 0.327622
ANK2 ankyrin 2, neuronal 0.323808
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.323396
LINC00523 long intergenic non-protein coding RNA 523 0.320566
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.314195
TBX5 T-box 5 0.312379
MORC3 MORC family CW-type zinc finger 3 0.275137
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 0.241111
STIM2 stromal interaction molecule 2 0.235342
SLC39A10 solute carrier family 39 (zinc transporter), member 10 0.230863
LRP1B low density lipoprotein receptor-related protein 1B 0.21768
DRD1 dopamine receptor D1 0.208977
SPHKAP SPHK1 interactor, AKAP domain containing 0.199315
JARID2 jumonji, AT rich interactive domain 2 0.196615
STK4 serine/threonine kinase 4 0.195484
PEX14 peroxisomal biogenesis factor 14 0.186263
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.181688
NXPH1 neurexophilin 1 0.178486
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.163304
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.163304
PNLIP pancreatic lipase 0.162396
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.160312
SNF8 SNF8, ESCRT-II complex subunit 0.160312
CBLN4 cerebellin 4 precursor 0.155721
GLCCI1 glucocorticoid induced 1 0.152696
ATF6 activating transcription factor 6 0.142942
NRSN1 neurensin 1 0.137369
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.137112
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 0.13609
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 0.13609
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 0.13609
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.13609
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.13609
IRF4 interferon regulatory factor 4 0.132351
TOX thymocyte selection-associated high mobility group box 0.128287
SH3YL1 SH3 and SYLF domain containing 1 0.121259
ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene 0.114347
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense 0.113724
MAMDC2 MAM domain containing 2 0.113105
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.107718
SDK1 sidekick cell adhesion molecule 1 0.106945
KCTD10 potassium channel tetramerization domain containing 10 0.106753
MED13L mediator complex subunit 13-like 0.10542
KCNK10 potassium channel, two pore domain subfamily K, member 10 0.101897
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.099385
SLC38A9 solute carrier family 38, member 9 0.093268
LIN28B lin-28 homolog B (C. elegans) 0.093115
UBE3B ubiquitin protein ligase E3B 0.0919
ARHGAP26 Rho GTPase activating protein 26 0.09175
KIAA2013 KIAA2013 0.088503
TTLL6 tubulin tyrosine ligase-like family member 6 0.082098
FCRLA Fc receptor-like A 0.07959
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.0783
SFTA3 surfactant associated 3 0.077409
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.071902
PLSCR3 phospholipid scramblase 3 0.067269
MSRA methionine sulfoxide reductase A 0.064774
EXT1 exostosin glycosyltransferase 1 0.064338
MVK mevalonate kinase 0.062115
DGKI diacylglycerol kinase, iota 0.061031