Nevirapine_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.204605
NLGN1 neuroligin 1 0.131769
DST dystonin 0.0922871
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0802473
PDE4D phosphodiesterase 4D, cAMP-specific 0.0712846
PCBP2 poly(rC) binding protein 2 0.0664037
EEF2 eukaryotic translation elongation factor 2 0.0620356
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0601267
RPL3 ribosomal protein L3 0.054265
TENM3 teneurin transmembrane protein 3 0.0518415
CCNL1 cyclin L1 0.0481813
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0466611
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0437614
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0434113
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0427918
XPO1 exportin 1 0.0417497
TPI1 triosephosphate isomerase 1 0.0412739
ANXA1 annexin A1 0.0406435
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0402015
YAP1 Yes-associated protein 1 0.0388178
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0387263
ECT2 epithelial cell transforming 2 0.0387222
MMP12 matrix metallopeptidase 12 0.0378605
YBX1 Y box binding protein 1 0.0377188
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0376706
PLK2 polo-like kinase 2 0.0375789
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0373983
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0373969
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0371598
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0365889
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0363135
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0361846
TMSB10 thymosin beta 10 0.0347683
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.034266
WDR43 WD repeat domain 43 0.0334227
CENPF centromere protein F, 350/400kDa 0.0334168
PNN pinin, desmosome associated protein 0.0329642
LMO7 LIM domain 7 0.03227
FXR1 fragile X mental retardation, autosomal homolog 1 0.0317577
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0317259
LDHA lactate dehydrogenase A 0.0309085
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0305535
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.030542
RPS19 ribosomal protein S19 0.0304139
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0300667
TXNRD1 thioredoxin reductase 1 0.0299882
PDGFC platelet derived growth factor C 0.0298167
EIF4B eukaryotic translation initiation factor 4B 0.0295524
MATR3 matrin 3 0.0294629
CPOX coproporphyrinogen oxidase 0.0289267
DPYD dihydropyrimidine dehydrogenase 0.0287766
EEF1G eukaryotic translation elongation factor 1 gamma 0.02815
PICALM phosphatidylinositol binding clathrin assembly protein 0.0280633
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0280253
SFPQ splicing factor proline/glutamine-rich 0.0279996
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.0278909
NCKAP1 NCK-associated protein 1 0.0278683
GJA1 gap junction protein, alpha 1, 43kDa 0.0277587
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.027522
ERRFI1 ERBB receptor feedback inhibitor 1 0.0269274
CELF2 CUGBP, Elav-like family member 2 0.0268922
CNRIP1 cannabinoid receptor interacting protein 1 0.026781
RSRC1 arginine/serine-rich coiled-coil 1 0.0267322
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0266713
CHD1 chromodomain helicase DNA binding protein 1 0.0264537
BIRC2 baculoviral IAP repeat containing 2 0.0262475
CCN2 cellular communication network factor 2 0.0260551
IL6ST interleukin 6 signal transducer 0.0258654
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0255075
ENO1 enolase 1, (alpha) 0.0253202
GASK1B golgi associated kinase 1B 0.0253172
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0252322
AXIN2 axin 2 0.0249847
HDAC9 histone deacetylase 9 0.0247994
MED13L mediator complex subunit 13-like 0.0247904
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0246819
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0246685
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0245626
PRR16 proline rich 16 0.0243945
CDK17 cyclin-dependent kinase 17 0.0242742
MARCHF6 membrane associated ring-CH-type finger 6 0.0241265
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0241143
RPS4X ribosomal protein S4, X-linked 0.0240555
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0239541
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0238904
PDIA6 protein disulfide isomerase family A, member 6 0.0236902
PUM2 pumilio RNA-binding family member 2 0.0234437
RPL18 ribosomal protein L18 0.0234258
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0232985
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0230335
TPM3 tropomyosin 3 0.0230202
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0229965
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0228519
RACK1 receptor for activated C kinase 1 0.0228041
MYH9 myosin, heavy chain 9, non-muscle 0.0227318
NEK7 NIMA-related kinase 7 0.0227067
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0225959
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0222045
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0221314
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.021972

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.363037
VIM vimentin -0.268443
AREG amphiregulin -0.246215
ACTG1 actin gamma 1 -0.0885552
PTMA prothymosin, alpha -0.0736576
ANKRD12 ankyrin repeat domain 12 -0.0610264
EHBP1 EH domain binding protein 1 -0.0586914
TPT1 tumor protein, translationally-controlled 1 -0.056374
VMP1 vacuole membrane protein 1 -0.0520011
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0456169
RPS23 ribosomal protein S23 -0.0410569
RPS8 ribosomal protein S8 -0.0408023
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0394722
RPS24 ribosomal protein S24 -0.038887
TM4SF1 transmembrane 4 L six family member 1 -0.0355638
MYL12B myosin, light chain 12B, regulatory -0.0349485
ASPH aspartate beta-hydroxylase -0.0344081
JMJD1C jumonji domain containing 1C -0.0341584
ZBTB20 zinc finger and BTB domain containing 20 -0.0334868
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.033448
TAS2R14 taste receptor, type 2, member 14 -0.0329556
EGR1 early growth response 1 -0.0327219
INTS6 integrator complex subunit 6 -0.0322601
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0315746
RPS15 ribosomal protein S15 -0.0315727
S100A10 S100 calcium binding protein A10 -0.0309953
IFIH1 interferon induced with helicase C domain 1 -0.0302569
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0289211
NEBL nebulette -0.0287836
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0285886
BPTF bromodomain PHD finger transcription factor -0.0279497
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0272654
HMGA2 high mobility group AT-hook 2 -0.0259015
RAB10 RAB10, member RAS oncogene family -0.025762
CSNK1A1 casein kinase 1, alpha 1 -0.0253633
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0244902
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0244547
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0241935
KDM2A lysine (K)-specific demethylase 2A -0.0239856
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0235833
RPL34 ribosomal protein L34 -0.0235344
VDAC1 voltage-dependent anion channel 1 -0.0234109
EIF1 eukaryotic translation initiation factor 1 -0.0233023
RTN4 reticulon 4 -0.0229736
GLG1 golgi glycoprotein 1 -0.0226697
PHF20 PHD finger protein 20 -0.0223792
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0221931
RPS29 ribosomal protein S29 -0.0220477
SBF2 SET binding factor 2 -0.0220019
GCG glucagon -0.0217898
TBC1D32 TBC1 domain family, member 32 -0.0216421
CAMTA1 calmodulin binding transcription activator 1 -0.0214412
FER fer (fps/fes related) tyrosine kinase -0.021054
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0209848
SNX14 sorting nexin 14 -0.0208437
CCNI cyclin I -0.0207784
CCND1 cyclin D1 -0.0206525
RBMX RNA binding motif protein, X-linked -0.0204251
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0198332
MYO1D myosin ID -0.0198261
WSB1 WD repeat and SOCS box containing 1 -0.0198119
TBCA tubulin folding cofactor A -0.0197611
LRRC23 leucine rich repeat containing 23 -0.0195834
RPS11 ribosomal protein S11 -0.0192444
CEP350 centrosomal protein 350kDa -0.0191296
HSPB1 heat shock 27kDa protein 1 -0.0191246
RASAL2 RAS protein activator like 2 -0.0190229
BRCA1 breast cancer 1, early onset -0.0190114
KDM4C lysine (K)-specific demethylase 4C -0.019001
RPL8 ribosomal protein L8 -0.0189443
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0188768
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0186811
SEPTIN7 septin 7 -0.0186807
GOLGB1 golgin B1 -0.0186699
CBX3 chromobox homolog 3 -0.0186648
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0186538
KPNB1 karyopherin (importin) beta 1 -0.0186428
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0185157
AKAP12 A kinase (PRKA) anchor protein 12 -0.0182996
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0180058
LOC102724023 ES1 protein homolog, mitochondrial -0.0176317
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0176133
PCDH9 protocadherin 9 -0.0175791
PCLO piccolo presynaptic cytomatrix protein -0.0171197
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0171069
ATP11A ATPase, class VI, type 11A -0.0169833
HLA-B major histocompatibility complex, class I, B -0.0168552
H1-0 H1.0 linker histone -0.0164119
KIF13A kinesin family member 13A -0.016358
WASF2 WAS protein family, member 2 -0.0163489
RPS13 ribosomal protein S13 -0.0162438
TULP3 tubby like protein 3 -0.0162314
PDCD6 programmed cell death 6 -0.0160155
RPL38 ribosomal protein L38 -0.015949
RPL28 ribosomal protein L28 -0.0159342
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0159196
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0158795
BRI3BP BRI3 binding protein -0.0157808
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0157254
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0156996