Nevirapine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0160575
VGF VGF nerve growth factor inducible 0.014923
SEPTIN9 septin 9 0.0143764
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.0138512
CCDC200 coiled-coil domain containing 200 0.0129561
COL18A1 collagen, type XVIII, alpha 1 0.0128407
MEF2A myocyte enhancer factor 2A 0.0126273
FAM13A family with sequence similarity 13, member A 0.0117731
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0115128
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0114541
RPL3 ribosomal protein L3 0.0110979
RPTOR regulatory associated protein of MTOR, complex 1 0.010945
PSD3 pleckstrin and Sec7 domain containing 3 0.0109348
PLEC plectin 0.0108993
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0108617
ESYT2 extended synaptotagmin-like protein 2 0.0108428
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0107827
ELL2 elongation factor, RNA polymerase II, 2 0.0103767
IGSF9B immunoglobulin superfamily, member 9B 0.0103631
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0102805
IGF1R insulin-like growth factor 1 receptor 0.0101677
ERRFI1 ERBB receptor feedback inhibitor 1 0.0101206
RNF150 ring finger protein 150 0.00991896
TTC17 tetratricopeptide repeat domain 17 0.00982563
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.00953242
KIRREL1 kirre like nephrin family adhesion molecule 1 0.00933111
CDPF1 cysteine-rich, DPF motif domain containing 1 0.00930681
MON2 MON2 homolog (S. cerevisiae) 0.00917774
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.00907716
NSD3 nuclear receptor binding SET domain protein 3 0.00905773
GRIK5 glutamate receptor, ionotropic, kainate 5 0.00902894
NUP58 nucleoporin 58 0.0090136
CABIN1 calcineurin binding protein 1 0.00899787
MARCHF6 membrane associated ring-CH-type finger 6 0.00888823
ZNF395 zinc finger protein 395 0.00882324
SSBP3 single stranded DNA binding protein 3 0.0087682
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.00873797
CCP110 centriolar coiled coil protein 110kDa 0.00870978
H2AC6 H2A clustered histone 6 0.00868544
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 0.00868344
LMO7 LIM domain 7 0.0086477
FRMD6 FERM domain containing 6 0.00858826
SAMD5 sterile alpha motif domain containing 5 0.00856967
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00856396
SOX5 SRY (sex determining region Y)-box 5 0.0085438
ADAM12 ADAM metallopeptidase domain 12 0.00849674
SLC35F3 solute carrier family 35, member F3 0.00843208
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.00840986
PTBP3 polypyrimidine tract binding protein 3 0.00834618
SEC24D SEC24 family member D 0.00831803
OXR1 oxidation resistance 1 0.0082046
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.00819783
HDAC5 histone deacetylase 5 0.0081493
KDM2A lysine (K)-specific demethylase 2A 0.00813166
CD46 CD46 molecule, complement regulatory protein 0.00804029
TBC1D4 TBC1 domain family, member 4 0.00800344
HPS3 Hermansky-Pudlak syndrome 3 0.00796629
ANGPT1 angiopoietin 1 0.00795398
ADARB1 adenosine deaminase, RNA-specific, B1 0.00782562
ATP13A3 ATPase type 13A3 0.00782399
SAV1 salvador family WW domain containing protein 1 0.00775805
TIMP3 TIMP metallopeptidase inhibitor 3 0.00771154
BLTP1 bridge-like lipid transfer protein family member 1 0.00762426
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.00761762
ZNF721 zinc finger protein 721 0.00760246
PATJ PATJ crumbs cell polarity complex component 0.00759896
PAQR5 progestin and adipoQ receptor family member V 0.00748501
NBPF15 neuroblastoma breakpoint family, member 15 0.00746437
RLIM ring finger protein, LIM domain interacting 0.00746014
PPARG peroxisome proliferator-activated receptor gamma 0.00743647
HEATR1 HEAT repeat containing 1 0.00743455
FRAS1 Fraser extracellular matrix complex subunit 1 0.00742249
PXK PX domain containing serine/threonine kinase 0.00741714
LAPTM4B lysosomal protein transmembrane 4 beta 0.00741696
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.00737745
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.00737314
ANXA1 annexin A1 0.00733201
MCMBP minichromosome maintenance complex binding protein 0.00731241
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.00729848
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.00724358
CPE carboxypeptidase E 0.00723912
CD164 CD164 molecule, sialomucin 0.00723637
EWSR1 EWS RNA-binding protein 1 0.00723504
SSBP4 single stranded DNA binding protein 4 0.00720174
IPMK inositol polyphosphate multikinase 0.00719949
CEP44 centrosomal protein 44kDa 0.00719765
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 0.0071948
PTPRM protein tyrosine phosphatase, receptor type, M 0.00718486
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00716379
CASC3 cancer susceptibility candidate 3 0.00714597
PDS5B PDS5 cohesin associated factor B 0.00711048
FBXO33 F-box protein 33 0.00710087
BMPR1B bone morphogenetic protein receptor, type IB 0.00708466
ZMIZ1 zinc finger, MIZ-type containing 1 0.00706322
FAM168A family with sequence similarity 168, member A 0.00705243
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.00699403
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 0.0069858
OTULINL OTU deubiquitinase with linear linkage specificity like 0.0069796
ZNF266 zinc finger protein 266 0.00697024
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.00695881

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.367863
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201163
VIM vimentin -0.154304
PTMA prothymosin, alpha -0.112483
RPL23 ribosomal protein L23 -0.0990106
IGF2 insulin-like growth factor 2 -0.0868028
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0675153
RPS27A ribosomal protein S27a -0.0668145
RPL19 ribosomal protein L19 -0.0608996
TMSB10 thymosin beta 10 -0.060428
SYT1 synaptotagmin I -0.0598822
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0580239
EEF2 eukaryotic translation elongation factor 2 -0.0545873
AHNAK AHNAK nucleoprotein -0.0538845
COL1A1 collagen, type I, alpha 1 -0.0535765
RPS6 ribosomal protein S6 -0.0509596
TLE4 transducin-like enhancer of split 4 -0.0495356
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0493795
UBC ubiquitin C -0.0478116
PCBP2 poly(rC) binding protein 2 -0.0466108
DSCAM Down syndrome cell adhesion molecule -0.0463025
LPIN1 lipin 1 -0.046181
RPS12 ribosomal protein S12 -0.0445869
RPL37A ribosomal protein L37a -0.0433656
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0432763
PRRC2C proline-rich coiled-coil 2C -0.0423723
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0422742
RPL34 ribosomal protein L34 -0.042009
RPS3 ribosomal protein S3 -0.0419779
PLAT plasminogen activator, tissue -0.041298
ACTG1 actin gamma 1 -0.0411271
EIF1 eukaryotic translation initiation factor 1 -0.0409049
COL3A1 collagen, type III, alpha 1 -0.0399371
PKM pyruvate kinase, muscle -0.0389782
VMP1 vacuole membrane protein 1 -0.0387423
DST dystonin -0.03823
TPT1 tumor protein, translationally-controlled 1 -0.0377092
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0374354
RPLP1 ribosomal protein, large, P1 -0.035984
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -0.0359511
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0354824
ENO1 enolase 1, (alpha) -0.0350186
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0347095
B2M beta-2-microglobulin -0.034008
HMGB2 high mobility group box 2 -0.0338142
ZNF292 zinc finger protein 292 -0.0337913
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0334645
SET SET nuclear proto-oncogene -0.0333635
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0325504
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0324029
NAP1L1 nucleosome assembly protein 1-like 1 -0.0319038
POTEF POTE ankyrin domain family, member F -0.0318134
PRKCA protein kinase C, alpha -0.0318095
RPL26 ribosomal protein L26 -0.0317158
FTL ferritin, light polypeptide -0.0311316
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0304623
RPS27 ribosomal protein S27 -0.0299103
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0297583
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0294067
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0291503
RPS24 ribosomal protein S24 -0.0289036
PGK1 phosphoglycerate kinase 1 -0.0288583
NRP1 neuropilin 1 -0.0284126
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0282336
EEF1G eukaryotic translation elongation factor 1 gamma -0.0282187
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0281593
RPS29 ribosomal protein S29 -0.0277992
RPL12 ribosomal protein L12 -0.0276758
MED13 mediator complex subunit 13 -0.0276476
BPTF bromodomain PHD finger transcription factor -0.0274914
RPL32 ribosomal protein L32 -0.0273959
IFI16 interferon, gamma-inducible protein 16 -0.0269892
OGA O-GlcNAcase -0.0269606
RPL31 ribosomal protein L31 -0.0267594
CANX calnexin -0.0266922
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0266223
MAP1B microtubule-associated protein 1B -0.0263444
PNISR PNN-interacting serine/arginine-rich protein -0.0261032
SRRM2 serine/arginine repetitive matrix 2 -0.0259451
RPS8 ribosomal protein S8 -0.0256589
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0255582
GNAS GNAS complex locus -0.0254679
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0252556
NAMPT nicotinamide phosphoribosyltransferase -0.0251793
TRIO trio Rho guanine nucleotide exchange factor -0.0251587
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0247002
AOPEP aminopeptidase O (putative) -0.0246984
ZFC3H1 zinc finger, C3H1-type containing -0.0246839
RPS17 ribosomal protein S17 -0.0244455
RPL35A ribosomal protein L35a -0.0243613
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0242589
MED13L mediator complex subunit 13-like -0.0241204
RPL7A ribosomal protein L7a -0.0237195
CSNK1A1 casein kinase 1, alpha 1 -0.0236207
TRIB2 tribbles pseudokinase 2 -0.0233674
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0233536
RSF1 remodeling and spacing factor 1 -0.0232695
SETD5 SET domain containing 5 -0.0232638
S100A9 S100 calcium binding protein A9 -0.0232074
ANXA2 annexin A2 -0.0231946