Nevirapine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GMDS GDP-mannose 4,6-dehydratase 0.122034
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0818757
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0636572
MACC1 metastasis associated in colon cancer 1 0.0604918
ARHGAP26 Rho GTPase activating protein 26 0.0562092
MSI2 musashi RNA-binding protein 2 0.055248
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0520428
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0504478
TRIO trio Rho guanine nucleotide exchange factor 0.0501443
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0496076
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0490891
FNDC3B fibronectin type III domain containing 3B 0.0481285
LYZ lysozyme 0.0473193
VCL vinculin 0.0451816
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0449569
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0411824
NPSR1 neuropeptide S receptor 1 0.0408048
ITGA6 integrin, alpha 6 0.0403759
PRKCA protein kinase C, alpha 0.0354263
SPATA13 spermatogenesis associated 13 0.035071
EXT1 exostosin glycosyltransferase 1 0.0345522
ERBIN erbb2 interacting protein 0.034481
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0343203
NKD1 naked cuticle homolog 1 (Drosophila) 0.0304771
ANKRD10 ankyrin repeat domain 10 0.0296001
IGF1R insulin-like growth factor 1 receptor 0.0295002
MLPH melanophilin 0.0294011
TSHZ2 teashirt zinc finger homeobox 2 0.0292621
NUP58 nucleoporin 58 0.0291882
FNIP1 folliculin interacting protein 1 0.0285644
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0285416
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0282047
STS steroid sulfatase (microsomal), isozyme S 0.0270793
SORBS1 sorbin and SH3 domain containing 1 0.0265351
TENT2 terminal nucleotidyltransferase 2 0.0263124
MAML2 mastermind-like 2 (Drosophila) 0.0258455
ZCCHC7 zinc finger, CCHC domain containing 7 0.0251699
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0251443
CTBP2 C-terminal binding protein 2 0.024931
MBNL2 muscleblind-like splicing regulator 2 0.024579
RSAD2 radical S-adenosyl methionine domain containing 2 0.0245424
KDM6A lysine (K)-specific demethylase 6A 0.0244582
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0244036
ATXN1 ataxin 1 0.02428
MYH9 myosin, heavy chain 9, non-muscle 0.02392
EPHB2 EPH receptor B2 0.0235516
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.023228
RNF149 ring finger protein 149 0.0231911
ITCH itchy E3 ubiquitin protein ligase 0.0227553
AKAP13 A kinase (PRKA) anchor protein 13 0.0227118
ZHX2 zinc fingers and homeoboxes 2 0.0222815
PDLIM5 PDZ and LIM domain 5 0.0221865
TNRC6A trinucleotide repeat containing 6A 0.0219148
BCL2L1 BCL2-like 1 0.0217283
BIRC6 baculoviral IAP repeat containing 6 0.0212589
LBR lamin B receptor 0.0210704
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0210513
RRM2 ribonucleotide reductase M2 0.0206118
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0203308
TM4SF19 transmembrane 4 L six family member 19 0.0202605
SAMD4A sterile alpha motif domain containing 4A 0.0202266
ATP11A ATPase, class VI, type 11A 0.0200621
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.019719
GPR107 G protein-coupled receptor 107 0.0195711
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0192789
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0190047
STYXL2 serine/threonine/tyrosine interacting like 2 0.0189315
MEF2A myocyte enhancer factor 2A 0.0189198
PTK2 protein tyrosine kinase 2 0.0189138
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0187621
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0186229
CATSPERB catsper channel auxiliary subunit beta 0.0184671
DDIT4 DNA-damage-inducible transcript 4 0.0182979
DENND1A DENN/MADD domain containing 1A 0.0179991
NEBL nebulette 0.017799
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0174577
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0170648
INTS6 integrator complex subunit 6 0.0167487
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0167383
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.0167166
EXOC4 exocyst complex component 4 0.0165759
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0164404
PDS5B PDS5 cohesin associated factor B 0.0163317
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0162594
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0162542
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0161016
CUX1 cut-like homeobox 1 0.0159458
SREBF2 sterol regulatory element binding transcription factor 2 0.0159201
WAC WW domain containing adaptor with coiled-coil 0.0159082
RAB6A RAB6A, member RAS oncogene family 0.0159009
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0158771
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0156339
RIGI RNA sensor RIG-I 0.0156326
ZSWIM6 zinc finger, SWIM-type containing 6 0.0155438
IARS1 isoleucyl-tRNA synthetase 1 0.0155118
CMIP c-Maf inducing protein 0.01519
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0151763
CARMIL1 capping protein regulator and myosin 1 linker 1 0.015165
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0151578
HELZ helicase with zinc finger 0.0151077

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.224786
TPT1 tumor protein, translationally-controlled 1 -0.166582
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.1656
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128833
LCN2 lipocalin 2 -0.110963
ZMYND8 zinc finger, MYND-type containing 8 -0.109184
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0951137
RPS6 ribosomal protein S6 -0.0864398
IFNGR1 interferon gamma receptor 1 -0.0808608
HLA-B major histocompatibility complex, class I, B -0.0794945
EPSTI1 epithelial stromal interaction 1 (breast) -0.0757343
PDIA3 protein disulfide isomerase family A, member 3 -0.0715671
DSCAM Down syndrome cell adhesion molecule -0.0703402
RNF43 ring finger protein 43 -0.0688566
TXNIP thioredoxin interacting protein -0.0674077
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0670689
PTBP3 polypyrimidine tract binding protein 3 -0.064177
NCKAP5 NCK-associated protein 5 -0.0640159
LMO7 LIM domain 7 -0.0636076
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0618078
PERP PERP, TP53 apoptosis effector -0.0608033
PRRC2C proline-rich coiled-coil 2C -0.0605763
GOLGB1 golgin B1 -0.0603161
RPL35A ribosomal protein L35a -0.0599722
FTL ferritin, light polypeptide -0.059497
UBC ubiquitin C -0.0594409
EPCAM epithelial cell adhesion molecule -0.0590636
PTMA prothymosin, alpha -0.0585181
MT2A metallothionein 2A -0.0579162
IFI27 interferon, alpha-inducible protein 27 -0.0574927
TMC5 transmembrane channel-like 5 -0.056876
IFI6 interferon, alpha-inducible protein 6 -0.0564834
C6ORF132 chromosome 6 open reading frame 132 -0.0557883
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0557563
EIF1 eukaryotic translation initiation factor 1 -0.0556134
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0531953
BPTF bromodomain PHD finger transcription factor -0.0529455
RPLP1 ribosomal protein, large, P1 -0.0524827
DSTN destrin (actin depolymerizing factor) -0.0524482
RHOBTB3 Rho-related BTB domain containing 3 -0.0513647
AHI1 Abelson helper integration site 1 -0.0512121
RPS8 ribosomal protein S8 -0.04983
PKM pyruvate kinase, muscle -0.0490573
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0480466
AKAP9 A kinase (PRKA) anchor protein 9 -0.0479192
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0473352
CALR calreticulin -0.0471015
TMSB10 thymosin beta 10 -0.046455
NRIP1 nuclear receptor interacting protein 1 -0.0446523
RPS19 ribosomal protein S19 -0.0442364
RRBP1 ribosome binding protein 1 -0.0440477
WSB1 WD repeat and SOCS box containing 1 -0.0438988
RPL26 ribosomal protein L26 -0.0438584
RPL12 ribosomal protein L12 -0.043632
ANKRD12 ankyrin repeat domain 12 -0.0422726
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.042049
IRF1 interferon regulatory factor 1 -0.0414025
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0411448
IRS2 insulin receptor substrate 2 -0.0410155
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0396789
RPL11 ribosomal protein L11 -0.0393104
RPL23 ribosomal protein L23 -0.0391812
RPS27 ribosomal protein S27 -0.0390391
RPL34 ribosomal protein L34 -0.0389146
SRRM2 serine/arginine repetitive matrix 2 -0.038736
TC2N tandem C2 domains, nuclear -0.0380325
MPHOSPH8 M-phase phosphoprotein 8 -0.037539
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0373334
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0372542
GCLC glutamate-cysteine ligase, catalytic subunit -0.0370574
IL20RA interleukin 20 receptor, alpha -0.0368558
DSPP dentin sialophosphoprotein -0.036726
RPL19 ribosomal protein L19 -0.0361892
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.036048
RPS3 ribosomal protein S3 -0.0359028
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.035229
ENO1 enolase 1, (alpha) -0.0351632
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0351245
KRT19 keratin 19, type I -0.0350932
RPS12 ribosomal protein S12 -0.0347889
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0347071
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0344361
MYO1E myosin IE -0.0342547
ASPH aspartate beta-hydroxylase -0.0338209
OARD1 O-acyl-ADP-ribose deacylase 1 -0.0334803
GCC2 GRIP and coiled-coil domain containing 2 -0.0332448
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0331011
RPS13 ribosomal protein S13 -0.0328737
PHF3 PHD finger protein 3 -0.0328231
BICRAL BICRA like chromatin remodeling complex associated protein -0.0326976
RBM25 RNA binding motif protein 25 -0.0320846
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0314662
SFTPA2 surfactant protein A2 -0.0314446
TPR translocated promoter region, nuclear basket protein -0.0309537
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0308446
TSC22D1 TSC22 domain family, member 1 -0.0307598
SEC62 SEC62 homolog (S. cerevisiae) -0.0306423
PDIA4 protein disulfide isomerase family A, member 4 -0.0305967
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0305616
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0304199