Nevirapine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.176492
FNDC3B fibronectin type III domain containing 3B 0.10307
DOCK4 dedicator of cytokinesis 4 0.0855355
SAMD4A sterile alpha motif domain containing 4A 0.0715517
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0647957
PEG3 paternally expressed 3 0.0581263
FBF1 Fas (TNFRSF6) binding factor 1 0.0575574
LRMDA leucine rich melanocyte differentiation associated 0.0560169
NKD1 naked cuticle homolog 1 (Drosophila) 0.0559889
DST dystonin 0.0504619
EXT1 exostosin glycosyltransferase 1 0.0501725
FAT1 FAT atypical cadherin 1 0.0488003
MAML2 mastermind-like 2 (Drosophila) 0.0487732
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0476873
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.04633
FMNL2 formin-like 2 0.045917
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.045346
PTPRM protein tyrosine phosphatase, receptor type, M 0.043884
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0433337
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0421198
PLIN2 perilipin 2 0.0391755
PARD3 par-3 family cell polarity regulator 0.0390336
DLC1 DLC1 Rho GTPase activating protein 0.0386017
SLC38A2 solute carrier family 38, member 2 0.0385671
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0377647
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0377444
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0377437
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0374236
GMDS GDP-mannose 4,6-dehydratase 0.0371364
ATXN1 ataxin 1 0.0356096
ITGAV integrin, alpha V 0.0353397
OSBPL10 oxysterol binding protein-like 10 0.0347903
LMCD1 LIM and cysteine-rich domains 1 0.0347429
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0336435
GPC6 glypican 6 0.033306
SESTD1 SEC14 and spectrin domains 1 0.0324743
MBNL2 muscleblind-like splicing regulator 2 0.032313
ATP10A ATPase, class V, type 10A 0.0320035
NPAS2 neuronal PAS domain protein 2 0.0319158
ADGRG6 adhesion G protein-coupled receptor G6 0.0316529
EHBP1 EH domain binding protein 1 0.0315731
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0311313
TMEM123 transmembrane protein 123 0.0308898
ZBTB20 zinc finger and BTB domain containing 20 0.0307636
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0306856
RNF213 ring finger protein 213 0.0302135
CMIP c-Maf inducing protein 0.0300435
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.029867
ARHGAP12 Rho GTPase activating protein 12 0.0292291
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0290088
PICALM phosphatidylinositol binding clathrin assembly protein 0.0281248
ADAM9 ADAM metallopeptidase domain 9 0.0280635
HDAC4 histone deacetylase 4 0.0279206
FRMD5 FERM domain containing 5 0.0276359
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0262059
ATP11A ATPase, class VI, type 11A 0.0261015
PHF21A PHD finger protein 21A 0.0252466
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0252152
SEPTIN9 septin 9 0.0248556
LOC112694756 uncharaterized LOC112694756 0.0247847
RUNX1 runt-related transcription factor 1 0.0247194
JUN jun proto-oncogene 0.0246223
SBF2 SET binding factor 2 0.0246215
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0244521
TOP2A topoisomerase (DNA) II alpha 170kDa 0.024451
PTK2 protein tyrosine kinase 2 0.0241862
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0240705
PLEC plectin 0.0240403
PTPRK protein tyrosine phosphatase, receptor type, K 0.0238579
IGF1R insulin-like growth factor 1 receptor 0.023836
CEMIP2 cell migration inducing hyaluronidase 2 0.0236882
STK39 serine threonine kinase 39 0.0233807
STK17A serine/threonine kinase 17a 0.0228366
SOD2 superoxide dismutase 2, mitochondrial 0.0228361
TNS3 tensin 3 0.0225587
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.022347
PTCHD4 patched domain containing 4 0.0222312
KDM4C lysine (K)-specific demethylase 4C 0.0220409
AGO2 argonaute RISC catalytic component 2 0.0220307
AHR aryl hydrocarbon receptor 0.0217537
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.02166
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.021586
USP9X ubiquitin specific peptidase 9, X-linked 0.021249
MTUS1 microtubule associated tumor suppressor 1 0.0212072
TPM4 tropomyosin 4 0.0211666
TXNRD1 thioredoxin reductase 1 0.0210534
OSBPL3 oxysterol binding protein-like 3 0.021007
PHF3 PHD finger protein 3 0.0207623
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.020733
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0206421
DISC1 disrupted in schizophrenia 1 0.020214
EML4 echinoderm microtubule associated protein like 4 0.0201368
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.019893
KIF1B kinesin family member 1B 0.0197704
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0196191
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0195599
RAP1GAP2 RAP1 GTPase activating protein 2 0.0195458
CRY1 cryptochrome circadian clock 1 0.0194933
PAWR PRKC, apoptosis, WT1, regulator 0.0193167
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0192776

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.286635
APOB apolipoprotein B -0.142447
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.133819
MT2A metallothionein 2A -0.133505
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.126927
RPS6 ribosomal protein S6 -0.119292
RPL37A ribosomal protein L37a -0.114007
IGFBP1 insulin-like growth factor binding protein 1 -0.113342
RPS12 ribosomal protein S12 -0.106513
RPL11 ribosomal protein L11 -0.102655
TPT1 tumor protein, translationally-controlled 1 -0.100833
RPS8 ribosomal protein S8 -0.0946866
RPL26 ribosomal protein L26 -0.0746908
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0737434
RPL9 ribosomal protein L9 -0.0735474
C3 complement component 3 -0.0704527
RPS19 ribosomal protein S19 -0.0691827
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0653318
RPLP1 ribosomal protein, large, P1 -0.0652854
RPL5 ribosomal protein L5 -0.0645356
RPS24 ribosomal protein S24 -0.0626764
RPS27A ribosomal protein S27a -0.0595549
RPS29 ribosomal protein S29 -0.0580812
RPL7 ribosomal protein L7 -0.0558389
RPL31 ribosomal protein L31 -0.0548974
RPS3 ribosomal protein S3 -0.0524344
RPL19 ribosomal protein L19 -0.0518292
FTL ferritin, light polypeptide -0.050511
RPS2 ribosomal protein S2 -0.0498724
RPS17 ribosomal protein S17 -0.0485013
CCL20 chemokine (C-C motif) ligand 20 -0.0463106
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0461076
RPS13 ribosomal protein S13 -0.0459456
RPL38 ribosomal protein L38 -0.0458748
NAP1L1 nucleosome assembly protein 1-like 1 -0.0436035
SVIL supervillin -0.0434843
RPL12 ribosomal protein L12 -0.0421219
RPLP2 ribosomal protein, large, P2 -0.0421116
RPS16 ribosomal protein S16 -0.0406518
RPS21 ribosomal protein S21 -0.0401932
RPL36 ribosomal protein L36 -0.0396209
RPL30 ribosomal protein L30 -0.0393882
GPC3 glypican 3 -0.0386456
RPL10A ribosomal protein L10a -0.0386272
RPL23 ribosomal protein L23 -0.0383076
RPS10 ribosomal protein S10 -0.0382129
SET SET nuclear proto-oncogene -0.037742
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0366639
RPL37 ribosomal protein L37 -0.034809
NACA nascent polypeptide-associated complex alpha subunit -0.0343204
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0339233
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0333749
RPL34 ribosomal protein L34 -0.0328868
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0324591
TMSB10 thymosin beta 10 -0.0322499
RPL7A ribosomal protein L7a -0.0320837
B2M beta-2-microglobulin -0.0317734
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0313325
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0306798
UBXN4 UBX domain protein 4 -0.0303805
RPL13A ribosomal protein L13a -0.0302028
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.029686
TRIM26 tripartite motif containing 26 -0.0295609
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0294565
PRPF4B pre-mRNA processing factor 4B -0.0291931
LCN2 lipocalin 2 -0.0287796
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0287192
GOLGA4 golgin A4 -0.0285743
APOE apolipoprotein E -0.0285689
APOA2 apolipoprotein A-II -0.0284105
RPS25 ribosomal protein S25 -0.0282325
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0282212
PAPOLA poly(A) polymerase alpha -0.0279248
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0277423
RRBP1 ribosome binding protein 1 -0.027145
SRSF11 serine/arginine-rich splicing factor 11 -0.0269785
JAK1 Janus kinase 1 -0.0268799
EIF5B eukaryotic translation initiation factor 5B -0.0267855
NCKAP1 NCK-associated protein 1 -0.0267588
AKAP12 A kinase (PRKA) anchor protein 12 -0.0266602
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0266204
EIF1 eukaryotic translation initiation factor 1 -0.0260236
SERINC1 serine incorporator 1 -0.0259541
RPL21 ribosomal protein L21 -0.0257746
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0257238
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0253592
RSRC2 arginine/serine-rich coiled-coil 2 -0.0252537
MATR3 matrin 3 -0.0251835
RPS14 ribosomal protein S14 -0.0249479
RPS15 ribosomal protein S15 -0.0248443
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0247968
ATF4 activating transcription factor 4 -0.0247515
RPL35A ribosomal protein L35a -0.0246223
ACSL5 acyl-CoA synthetase long-chain family member 5 -0.0240897
RPL4 ribosomal protein L4 -0.0240281
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0239096
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0235059
PTMA prothymosin, alpha -0.0234885
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0234761
AMBP alpha-1-microglobulin/bikunin precursor -0.0233062