Nevirapine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.131328
MEF2A myocyte enhancer factor 2A 0.0765067
FLNB filamin B, beta 0.0732098
BCL2L1 BCL2-like 1 0.070149
ITGA6 integrin, alpha 6 0.0661721
FOXO1 forkhead box O1 0.0631086
ESYT2 extended synaptotagmin-like protein 2 0.0594085
EZR ezrin 0.05767
NAMPT nicotinamide phosphoribosyltransferase 0.0427837
PODXL podocalyxin-like 0.042487
CLU clusterin 0.0420097
NCOR2 nuclear receptor corepressor 2 0.0416726
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0411204
NEK7 NIMA-related kinase 7 0.0398069
ITCH itchy E3 ubiquitin protein ligase 0.0395174
TGM2 transglutaminase 2 0.0389784
KDM6A lysine (K)-specific demethylase 6A 0.0382325
ANXA11 annexin A11 0.0380187
EMP1 epithelial membrane protein 1 0.037328
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0363724
MYO10 myosin X 0.0363101
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.03562
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0343516
MSN moesin 0.0338448
MYH9 myosin, heavy chain 9, non-muscle 0.0337092
CEMIP cell migration inducing protein, hyaluronan binding 0.0333463
RBM39 RNA binding motif protein 39 0.033247
GOLGA4 golgin A4 0.032641
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0322929
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0312188
RICTOR RPTOR independent companion of MTOR, complex 2 0.0311888
CMIP c-Maf inducing protein 0.0311872
OSBPL3 oxysterol binding protein-like 3 0.0309028
CALU calumenin 0.0306429
PLAT plasminogen activator, tissue 0.0298468
IGF2 insulin-like growth factor 2 0.0298066
METTL15 methyltransferase like 15 0.029586
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0295813
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0294368
SLK STE20-like kinase 0.0293324
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0293302
TPM4 tropomyosin 4 0.0288958
ARHGAP23 Rho GTPase activating protein 23 0.0287154
UBE2H ubiquitin-conjugating enzyme E2H 0.0286211
APLP2 amyloid beta (A4) precursor-like protein 2 0.0285789
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0282563
ADAM9 ADAM metallopeptidase domain 9 0.0280822
PTK2 protein tyrosine kinase 2 0.0279874
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0279348
ZFAND3 zinc finger, AN1-type domain 3 0.0277077
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0268424
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0266285
COG5 component of oligomeric golgi complex 5 0.0266049
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0263252
TSC22D1 TSC22 domain family, member 1 0.0261083
CD44 CD44 molecule (Indian blood group) 0.0259641
UBA6 ubiquitin-like modifier activating enzyme 6 0.0257125
COG6 component of oligomeric golgi complex 6 0.025488
KDM2A lysine (K)-specific demethylase 2A 0.0250286
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0248431
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0247617
CD99 CD99 molecule 0.0247321
DGKD diacylglycerol kinase, delta 130kDa 0.0244205
RTN4 reticulon 4 0.024344
LNPEP leucyl/cystinyl aminopeptidase 0.0235663
CEP170 centrosomal protein 170kDa 0.023563
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0233747
KIF16B kinesin family member 16B 0.0232311
APP amyloid beta (A4) precursor protein 0.0230973
SEPTIN9 septin 9 0.0230503
DOCK9 dedicator of cytokinesis 9 0.0230018
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0227368
NIBAN2 niban apoptosis regulator 2 0.0226778
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.022235
DOCK5 dedicator of cytokinesis 5 0.0222287
FOSL1 FOS-like antigen 1 0.0221977
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0221701
FAT1 FAT atypical cadherin 1 0.0219956
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0218703
ATP13A3 ATPase type 13A3 0.0215812
FOXP1 forkhead box P1 0.0215359
SUCO SUN domain containing ossification factor 0.0214006
EIF4A2 eukaryotic translation initiation factor 4A2 0.0213197
NAV2 neuron navigator 2 0.0212794
BIRC6 baculoviral IAP repeat containing 6 0.0211932
NRG1 neuregulin 1 0.0211679
AFAP1 actin filament associated protein 1 0.0210634
ZEB1 zinc finger E-box binding homeobox 1 0.0209246
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.020895
COPA coatomer protein complex, subunit alpha 0.0208425
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0207881
SLC45A4 solute carrier family 45, member 4 0.0207789
SRP54 signal recognition particle 54kDa 0.020626
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0204878
TM9SF3 transmembrane 9 superfamily member 3 0.0204178
NBAS neuroblastoma amplified sequence 0.0203444
ARF4 ADP-ribosylation factor 4 0.0202908
CUL4B cullin 4B 0.0202584
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0202065
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0201202

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.279972
TPT1 tumor protein, translationally-controlled 1 -0.121328
TMSB10 thymosin beta 10 -0.112886
RPS21 ribosomal protein S21 -0.0971619
RPLP2 ribosomal protein, large, P2 -0.093809
RPL11 ribosomal protein L11 -0.0854388
MT2A metallothionein 2A -0.0853936
B2M beta-2-microglobulin -0.0813757
INTS6 integrator complex subunit 6 -0.0811853
PDE4D phosphodiesterase 4D, cAMP-specific -0.079155
RPS8 ribosomal protein S8 -0.0760654
RPS6 ribosomal protein S6 -0.0754198
RPS3 ribosomal protein S3 -0.0734009
RPS19 ribosomal protein S19 -0.0726022
TMSB4X thymosin beta 4, X-linked -0.0718484
PDLIM5 PDZ and LIM domain 5 -0.0711132
KLF5 Kruppel-like factor 5 (intestinal) -0.0653528
RPLP1 ribosomal protein, large, P1 -0.064679
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0630363
HMGA2 high mobility group AT-hook 2 -0.0594549
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0579323
RPS13 ribosomal protein S13 -0.0549575
RPL12 ribosomal protein L12 -0.0531841
RPL19 ribosomal protein L19 -0.0529873
LMNA lamin A/C -0.051959
RPL37 ribosomal protein L37 -0.0516536
IFITM3 interferon induced transmembrane protein 3 -0.051556
PTMA prothymosin, alpha -0.0509822
RPS12 ribosomal protein S12 -0.0507068
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0505642
RPS24 ribosomal protein S24 -0.050317
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0502816
RIGI RNA sensor RIG-I -0.050123
S100A2 S100 calcium binding protein A2 -0.0498674
CAV1 caveolin 1, caveolae protein, 22kDa -0.0491063
RPL23 ribosomal protein L23 -0.0485564
DPYD dihydropyrimidine dehydrogenase -0.0484874
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0484363
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0458654
RPL35A ribosomal protein L35a -0.0451662
RPS25 ribosomal protein S25 -0.0447322
RPS27A ribosomal protein S27a -0.0438247
IFITM1 interferon induced transmembrane protein 1 -0.0437305
RPL37A ribosomal protein L37a -0.0429559
RPL34 ribosomal protein L34 -0.0428643
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0424665
RPL7A ribosomal protein L7a -0.0424056
RACK1 receptor for activated C kinase 1 -0.0423329
RAD51B RAD51 paralog B -0.0415841
RPL26 ribosomal protein L26 -0.0413349
RPL9 ribosomal protein L9 -0.0411553
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0405605
GNAS GNAS complex locus -0.0399399
RPL5 ribosomal protein L5 -0.0388524
RPL7 ribosomal protein L7 -0.0380294
RPL35 ribosomal protein L35 -0.0380146
RPL13A ribosomal protein L13a -0.0372322
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0362819
HLA-B major histocompatibility complex, class I, B -0.0361264
PRSS23 protease, serine, 23 -0.0358526
RPL21 ribosomal protein L21 -0.0357608
LDHA lactate dehydrogenase A -0.0352787
RPS27 ribosomal protein S27 -0.0346552
RPL31 ribosomal protein L31 -0.0345645
STC1 stanniocalcin 1 -0.0344987
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0341919
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0339044
S100A9 S100 calcium binding protein A9 -0.033599
LMO7 LIM domain 7 -0.033254
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.032984
S100A11 S100 calcium binding protein A11 -0.0329358
RABGAP1L RAB GTPase activating protein 1-like -0.0328544
ACTG1 actin gamma 1 -0.0326652
LAMC2 laminin, gamma 2 -0.0325267
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0325125
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0324234
RPS16 ribosomal protein S16 -0.0322639
ALCAM activated leukocyte cell adhesion molecule -0.0320272
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0320106
RPS20 ribosomal protein S20 -0.0312089
ABI3BP ABI family, member 3 (NESH) binding protein -0.0309325
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0308844
NAP1L1 nucleosome assembly protein 1-like 1 -0.0308578
HDAC9 histone deacetylase 9 -0.0306988
RPS29 ribosomal protein S29 -0.030421
SULF1 sulfatase 1 -0.0303949
RPS14 ribosomal protein S14 -0.0299735
ISG15 ISG15 ubiquitin-like modifier -0.0298904
MTAP methylthioadenosine phosphorylase -0.02984
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0298169
PRELID2 PRELI domain containing 2 -0.0297482
SLC38A2 solute carrier family 38, member 2 -0.0294585
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0294411
RPL36 ribosomal protein L36 -0.0291847
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0290937
IFI27 interferon, alpha-inducible protein 27 -0.0288207
RPL32 ribosomal protein L32 -0.0286938
PSD3 pleckstrin and Sec7 domain containing 3 -0.0286775
RPL30 ribosomal protein L30 -0.0281085
PRRC2C proline-rich coiled-coil 2C -0.0280257