Nevirapine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.0917969
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0695608
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0537376
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0456758
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0427601
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0422737
FMNL2 formin-like 2 0.0368649
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.035729
ADGRG6 adhesion G protein-coupled receptor G6 0.0342459
XPO1 exportin 1 0.033986
EEF2 eukaryotic translation elongation factor 2 0.0338349
CENPF centromere protein F, 350/400kDa 0.032989
APP amyloid beta (A4) precursor protein 0.0312561
RTN4 reticulon 4 0.0305493
SPAG9 sperm associated antigen 9 0.0299021
ZFAND3 zinc finger, AN1-type domain 3 0.0292245
TRIP12 thyroid hormone receptor interactor 12 0.0289538
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0285642
TXNRD1 thioredoxin reductase 1 0.0279296
KMT2C lysine (K)-specific methyltransferase 2C 0.0277564
PUM1 pumilio RNA-binding family member 1 0.0270508
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0268881
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0268519
MYH9 myosin, heavy chain 9, non-muscle 0.0267318
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0264875
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.026467
KDM3A lysine (K)-specific demethylase 3A 0.0262993
ANKRD11 ankyrin repeat domain 11 0.026043
AHNAK AHNAK nucleoprotein 0.0260198
JMJD1C jumonji domain containing 1C 0.0257879
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0252503
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0250942
ADAM17 ADAM metallopeptidase domain 17 0.0249461
WDR43 WD repeat domain 43 0.0248227
EZR ezrin 0.0248025
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0248005
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0247708
MATR3 matrin 3 0.0247167
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0247085
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0246992
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0244313
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0244
CKAP5 cytoskeleton associated protein 5 0.0242948
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0240439
RPL3 ribosomal protein L3 0.0236825
BCAR3 breast cancer anti-estrogen resistance 3 0.0236433
ETNK1 ethanolamine kinase 1 0.023133
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0230451
SFPQ splicing factor proline/glutamine-rich 0.0230234
PTK2 protein tyrosine kinase 2 0.0229904
ANLN anillin, actin binding protein 0.0228882
SRPK2 SRSF protein kinase 2 0.0226313
ECT2 epithelial cell transforming 2 0.0224387
RBM39 RNA binding motif protein 39 0.0224136
PUM2 pumilio RNA-binding family member 2 0.0223644
NUP58 nucleoporin 58 0.0221474
MACF1 microtubule-actin crosslinking factor 1 0.0218631
TOP1 topoisomerase (DNA) I 0.0214838
PLEC plectin 0.0211554
MARCHF6 membrane associated ring-CH-type finger 6 0.0211553
WAC WW domain containing adaptor with coiled-coil 0.0209789
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0207484
OGA O-GlcNAcase 0.020422
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0202926
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0199287
USP9X ubiquitin specific peptidase 9, X-linked 0.0199168
CHD1 chromodomain helicase DNA binding protein 1 0.0197192
NUP153 nucleoporin 153kDa 0.0197005
FXR1 fragile X mental retardation, autosomal homolog 1 0.0196504
GARS1 glycyl-tRNA synthetase 1 0.0195711
MOK MOK protein kinase 0.0195576
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0192738
QKI QKI, KH domain containing, RNA binding 0.0192613
ZNF292 zinc finger protein 292 0.0190867
BIRC6 baculoviral IAP repeat containing 6 0.0190781
PTBP2 polypyrimidine tract binding protein 2 0.0188348
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0187283
MKI67 marker of proliferation Ki-67 0.0186436
BRWD1 bromodomain and WD repeat domain containing 1 0.0186046
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0185505
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0185439
NEK7 NIMA-related kinase 7 0.0184338
ADAM9 ADAM metallopeptidase domain 9 0.0184335
STRN3 striatin, calmodulin binding protein 3 0.0184272
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0183058
NAMPT nicotinamide phosphoribosyltransferase 0.0180725
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0180508
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0180021
IPO7 importin 7 0.0179607
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0179339
FUBP1 far upstream element (FUSE) binding protein 1 0.0175348
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0175292
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0175104
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0175
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0173964
PGK1 phosphoglycerate kinase 1 0.0173933
AFF4 AF4/FMR2 family, member 4 0.0172545
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0172386
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0172148
NCKAP1 NCK-associated protein 1 0.0170888

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.184417
VIM vimentin -0.177351
MT2A metallothionein 2A -0.111843
TMSB10 thymosin beta 10 -0.105588
PTMA prothymosin, alpha -0.079553
RPL35A ribosomal protein L35a -0.0770906
FTL ferritin, light polypeptide -0.0738126
RPS8 ribosomal protein S8 -0.0715499
TP63 tumor protein p63 -0.0702072
HLA-B major histocompatibility complex, class I, B -0.0652697
RPL37A ribosomal protein L37a -0.0560718
RPL31 ribosomal protein L31 -0.0559785
RPS6 ribosomal protein S6 -0.0537714
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.053218
RPS19 ribosomal protein S19 -0.0511563
TPT1 tumor protein, translationally-controlled 1 -0.0481944
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0473067
RPL36 ribosomal protein L36 -0.0443481
RPL26 ribosomal protein L26 -0.0425545
RPL12 ribosomal protein L12 -0.041663
RPS12 ribosomal protein S12 -0.0409118
RPLP2 ribosomal protein, large, P2 -0.0384017
RPLP1 ribosomal protein, large, P1 -0.0376014
RPS29 ribosomal protein S29 -0.037474
RPS3 ribosomal protein S3 -0.0350713
HMGA1 high mobility group AT-hook 1 -0.0343862
RPL28 ribosomal protein L28 -0.033807
RPS23 ribosomal protein S23 -0.0335712
CSMD3 CUB and Sushi multiple domains 3 -0.0325216
RPS27 ribosomal protein S27 -0.0309961
RPL19 ribosomal protein L19 -0.0307234
RPS27A ribosomal protein S27a -0.030538
RPS25 ribosomal protein S25 -0.0295885
RPS13 ribosomal protein S13 -0.0295747
RPL37 ribosomal protein L37 -0.02929
RPS10 ribosomal protein S10 -0.0292705
RPL36A ribosomal protein L36a -0.0279464
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0276013
RPL9 ribosomal protein L9 -0.0273192
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0272909
RPL7A ribosomal protein L7a -0.0269805
RPS17 ribosomal protein S17 -0.0265745
MT1E metallothionein 1E -0.0264435
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0261974
EGR1 early growth response 1 -0.0259949
RPL38 ribosomal protein L38 -0.0253808
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0251808
RPS24 ribosomal protein S24 -0.0244137
RPS14 ribosomal protein S14 -0.024259
ENO2 enolase 2 (gamma, neuronal) -0.0242502
RPL23 ribosomal protein L23 -0.024229
TNS3 tensin 3 -0.0239646
ACTG1 actin gamma 1 -0.0239389
RPS21 ribosomal protein S21 -0.0234725
RPL27 ribosomal protein L27 -0.023455
RPL35 ribosomal protein L35 -0.0230603
RPL11 ribosomal protein L11 -0.022716
CADM2 cell adhesion molecule 2 -0.0226733
HLA-A major histocompatibility complex, class I, A -0.0223202
RPL34 ribosomal protein L34 -0.022284
CD44 CD44 molecule (Indian blood group) -0.0220137
SDK1 sidekick cell adhesion molecule 1 -0.0220111
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0217646
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0207943
TM4SF1 transmembrane 4 L six family member 1 -0.0204522
RPL5 ribosomal protein L5 -0.020266
EHBP1 EH domain binding protein 1 -0.0198906
INTS6 integrator complex subunit 6 -0.0197129
EFNA5 ephrin-A5 -0.0195752
IFITM1 interferon induced transmembrane protein 1 -0.0194928
HDAC9 histone deacetylase 9 -0.0193456
RACK1 receptor for activated C kinase 1 -0.0191708
RPS15 ribosomal protein S15 -0.018968
PDE10A phosphodiesterase 10A -0.0187552
RPL8 ribosomal protein L8 -0.0186767
RPS16 ribosomal protein S16 -0.018257
TTC3 tetratricopeptide repeat domain 3 -0.0182399
RPS5 ribosomal protein S5 -0.0179958
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0176478
B2M beta-2-microglobulin -0.0175139
ECE1 endothelin converting enzyme 1 -0.0171768
RPS28 ribosomal protein S28 -0.0171499
FTH1 ferritin, heavy polypeptide 1 -0.0167321
RPL32 ribosomal protein L32 -0.0166768
EGFR epidermal growth factor receptor -0.0165532
MYOF myoferlin -0.0160688
RPS11 ribosomal protein S11 -0.0158614
LOXL2 lysyl oxidase-like 2 -0.0157868
PFN1 profilin 1 -0.0154152
EPHA4 EPH receptor A4 -0.0153496
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0153329
RPL18 ribosomal protein L18 -0.0151587
S100A6 S100 calcium binding protein A6 -0.0151382
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0148746
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0147863
RPL27A ribosomal protein L27a -0.0146265
ANGPTL4 angiopoietin-like 4 -0.0145573
SP100 SP100 nuclear antigen -0.0144718
ISG15 ISG15 ubiquitin-like modifier -0.0142867
RPS20 ribosomal protein S20 -0.0141722