Nevirapine_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.0966082
TXNRD1 thioredoxin reductase 1 0.0622346
THSD4 thrombospondin, type I, domain containing 4 0.0565475
SMAD3 SMAD family member 3 0.0521779
NAMPT nicotinamide phosphoribosyltransferase 0.0511664
GRAMD1B GRAM domain containing 1B 0.0496789
SOD2 superoxide dismutase 2, mitochondrial 0.046125
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0451345
PTPRM protein tyrosine phosphatase, receptor type, M 0.0442789
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.042462
GCLC glutamate-cysteine ligase, catalytic subunit 0.0367755
RNF145 ring finger protein 145 0.0357985
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0315269
ARRDC3 arrestin domain containing 3 0.0313023
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0312492
FAM13A family with sequence similarity 13, member A 0.0307739
FNDC3B fibronectin type III domain containing 3B 0.0303103
RICTOR RPTOR independent companion of MTOR, complex 2 0.0293251
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0292363
LOC112694756 uncharaterized LOC112694756 0.0284089
USP3 ubiquitin specific peptidase 3 0.0277553
ATP13A3 ATPase type 13A3 0.0275038
PM20D1 peptidase M20 domain containing 1 0.0269758
KDM6A lysine (K)-specific demethylase 6A 0.0269548
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0269195
RAB27B RAB27B, member RAS oncogene family 0.0267613
MYOF myoferlin 0.0250874
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0250515
RPL3 ribosomal protein L3 0.0243709
LMO7 LIM domain 7 0.0242477
STRN3 striatin, calmodulin binding protein 3 0.0235431
CES1 carboxylesterase 1 0.0228459
HELZ helicase with zinc finger 0.0215289
HYOU1 hypoxia up-regulated 1 0.0214989
ANXA5 annexin A5 0.021158
NCKAP1 NCK-associated protein 1 0.0211562
ERRFI1 ERBB receptor feedback inhibitor 1 0.020815
PGK1 phosphoglycerate kinase 1 0.0201274
LDHA lactate dehydrogenase A 0.0199621
BZW1 basic leucine zipper and W2 domains 1 0.0194776
AHNAK AHNAK nucleoprotein 0.0190574
PDE4D phosphodiesterase 4D, cAMP-specific 0.0188225
NUP58 nucleoporin 58 0.0185833
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0185797
TOP1 topoisomerase (DNA) I 0.0180166
ADAM17 ADAM metallopeptidase domain 17 0.0180125
MYH9 myosin, heavy chain 9, non-muscle 0.0177545
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0175931
ADAM9 ADAM metallopeptidase domain 9 0.0174058
XPO1 exportin 1 0.0173324
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0172769
TFG TRK-fused gene 0.0172625
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0172283
TPD52 tumor protein D52 0.0170346
USP9X ubiquitin specific peptidase 9, X-linked 0.0169166
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0168494
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.016533
WAC WW domain containing adaptor with coiled-coil 0.0164964
SLMAP sarcolemma associated protein 0.0163867
PTK2 protein tyrosine kinase 2 0.0161866
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0158242
CAV1 caveolin 1, caveolae protein, 22kDa 0.0157956
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0156907
GSK3B glycogen synthase kinase 3 beta 0.0154298
ECT2 epithelial cell transforming 2 0.0151002
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0150866
RAD23B RAD23 homolog B (S. cerevisiae) 0.0150446
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0150275
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.014589
UVRAG UV radiation resistance associated 0.0144466
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0144336
NPTN neuroplastin 0.0142914
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0142335
DSPP dentin sialophosphoprotein 0.0140611
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0140528
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0139544
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0138854
ANKRD10 ankyrin repeat domain 10 0.0138097
RAD21 RAD21 homolog (S. pombe) 0.0137211
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0136171
ZC3H11A zinc finger CCCH-type containing 11A 0.0133413
FUBP1 far upstream element (FUSE) binding protein 1 0.01317
NPAS2 neuronal PAS domain protein 2 0.012394
AMOTL1 angiomotin like 1 0.0121913
SHB Src homology 2 domain containing adaptor protein B 0.0118128
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.011782
SREBF2 sterol regulatory element binding transcription factor 2 0.0116913
FNBP1L formin binding protein 1-like 0.0116798
IGF1R insulin-like growth factor 1 receptor 0.0116726
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0115942
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0115613
AHNAK2 AHNAK nucleoprotein 2 0.0115367
CSDE1 cold shock domain containing E1, RNA-binding 0.011517
GRB10 growth factor receptor-bound protein 10 0.0115002
TPM3 tropomyosin 3 0.0114375
ARL8B ADP-ribosylation factor-like 8B 0.0113936
ZFR zinc finger RNA binding protein 0.0113327
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0112058
ZFC3H1 zinc finger, C3H1-type containing 0.0111735
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0110899

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.517631
TMSB10 thymosin beta 10 -0.140331
TPT1 tumor protein, translationally-controlled 1 -0.104697
NDRG1 N-myc downstream regulated 1 -0.0940623
MT2A metallothionein 2A -0.0929817
EGFR epidermal growth factor receptor -0.0910233
FTL ferritin, light polypeptide -0.0848166
RPS3 ribosomal protein S3 -0.0844298
PTMA prothymosin, alpha -0.0819523
EGR1 early growth response 1 -0.0694766
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0654613
RPS8 ribosomal protein S8 -0.0637179
RPL35A ribosomal protein L35a -0.0632312
INTS6 integrator complex subunit 6 -0.0629125
RPL37A ribosomal protein L37a -0.0603545
RPLP1 ribosomal protein, large, P1 -0.0603217
RPL31 ribosomal protein L31 -0.05837
ANKRD12 ankyrin repeat domain 12 -0.0568824
RPS25 ribosomal protein S25 -0.0561767
RPS6 ribosomal protein S6 -0.0556496
S100A10 S100 calcium binding protein A10 -0.0542029
FTH1 ferritin, heavy polypeptide 1 -0.0535062
EIF1 eukaryotic translation initiation factor 1 -0.0524414
ACTG1 actin gamma 1 -0.0500794
RPS12 ribosomal protein S12 -0.0468624
CST3 cystatin C -0.0466057
RPS23 ribosomal protein S23 -0.0465152
MCL1 myeloid cell leukemia 1 -0.0438569
RPL34 ribosomal protein L34 -0.0437701
RPS27A ribosomal protein S27a -0.0435241
NABP1 nucleic acid binding protein 1 -0.0434132
RPS29 ribosomal protein S29 -0.0431589
SEC61G Sec61 gamma subunit -0.0420252
GOLGB1 golgin B1 -0.0415297
JMJD1C jumonji domain containing 1C -0.0409286
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0403219
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0401448
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0396403
RPS24 ribosomal protein S24 -0.0384363
DSCAM Down syndrome cell adhesion molecule -0.0375329
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0370126
S100P S100 calcium binding protein P -0.0363372
STAT1 signal transducer and activator of transcription 1, 91kDa -0.035656
B2M beta-2-microglobulin -0.0349037
RPS17 ribosomal protein S17 -0.0348281
NSUN6 NOP2/Sun domain family, member 6 -0.0345095
AKAP9 A kinase (PRKA) anchor protein 9 -0.0341867
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0339849
RPL11 ribosomal protein L11 -0.0338531
LAMC2 laminin, gamma 2 -0.0337704
RPS27 ribosomal protein S27 -0.0336284
PKM pyruvate kinase, muscle -0.0334844
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0325222
MYO1E myosin IE -0.0322124
RPL37 ribosomal protein L37 -0.0321755
RPL5 ribosomal protein L5 -0.0319873
WASF2 WAS protein family, member 2 -0.0319806
HLA-B major histocompatibility complex, class I, B -0.0318701
RPLP2 ribosomal protein, large, P2 -0.0317975
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0316732
FBXO11 F-box protein 11 -0.0315321
RPS13 ribosomal protein S13 -0.0314915
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0311987
BLZF1 basic leucine zipper nuclear factor 1 -0.0311644
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0306581
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0299864
SP100 SP100 nuclear antigen -0.029896
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0296556
RPL9 ribosomal protein L9 -0.0296034
SLC38A1 solute carrier family 38, member 1 -0.0291315
PATJ PATJ crumbs cell polarity complex component -0.0286396
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0284927
USP34 ubiquitin specific peptidase 34 -0.0281572
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0280411
RPS2 ribosomal protein S2 -0.0280269
RPL19 ribosomal protein L19 -0.027919
SEC31A SEC31 homolog A (S. cerevisiae) -0.0276126
ATF4 activating transcription factor 4 -0.0274685
RPL7 ribosomal protein L7 -0.0274124
AREG amphiregulin -0.0264113
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0259781
MCTP1 multiple C2 domains, transmembrane 1 -0.0254928
RPS19 ribosomal protein S19 -0.0254713
IER3 immediate early response 3 -0.0252502
RPL38 ribosomal protein L38 -0.0252407
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0250789
RPL30 ribosomal protein L30 -0.0250016
BTG1 B-cell translocation gene 1, anti-proliferative -0.0249504
PDLIM5 PDZ and LIM domain 5 -0.024855
FNIP1 folliculin interacting protein 1 -0.0246493
DOCK5 dedicator of cytokinesis 5 -0.0245661
GPHN gephyrin -0.024483
RAB7A RAB7A, member RAS oncogene family -0.0243446
RPL8 ribosomal protein L8 -0.0238319
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0237436
CCNI cyclin I -0.0236352
WSB1 WD repeat and SOCS box containing 1 -0.0233029
ZBTB20 zinc finger and BTB domain containing 20 -0.0232802
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0232484
GOLGA4 golgin A4 -0.0231962