Nevirapine_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0432415
MEF2A myocyte enhancer factor 2A 0.0416914
FAM13A family with sequence similarity 13, member A 0.038512
IGFBP3 insulin-like growth factor binding protein 3 0.0380494
GRB10 growth factor receptor-bound protein 10 0.0357571
USP3 ubiquitin specific peptidase 3 0.0301829
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0281005
DDIT3 DNA-damage-inducible transcript 3 0.0275822
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.023412
WAC WW domain containing adaptor with coiled-coil 0.0225348
HILPDA hypoxia inducible lipid droplet-associated 0.0225258
FN1 fibronectin 1 0.0220868
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.021566
ATP13A3 ATPase type 13A3 0.0201999
RUNX2 runt-related transcription factor 2 0.019516
RPL3 ribosomal protein L3 0.0191877
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0188724
NDRG1 N-myc downstream regulated 1 0.0172994
RPL35A ribosomal protein L35a 0.0165667
KDM3A lysine (K)-specific demethylase 3A 0.0164469
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0163944
ESYT2 extended synaptotagmin-like protein 2 0.0163651
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0160451
NUP58 nucleoporin 58 0.0158767
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0158677
ANKRD11 ankyrin repeat domain 11 0.0156226
SSBP2 single-stranded DNA binding protein 2 0.0155434
PIAS2 protein inhibitor of activated STAT, 2 0.0155194
UBA6 ubiquitin-like modifier activating enzyme 6 0.0149579
ZFAND3 zinc finger, AN1-type domain 3 0.0147951
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0146245
PSD3 pleckstrin and Sec7 domain containing 3 0.0142875
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0142353
HELZ helicase with zinc finger 0.0141758
TRA2A transformer 2 alpha homolog (Drosophila) 0.0138292
NPEPPS aminopeptidase puromycin sensitive 0.0137742
QKI QKI, KH domain containing, RNA binding 0.0135981
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0134139
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0133223
RIOK3 RIO kinase 3 0.0129764
KMT2C lysine (K)-specific methyltransferase 2C 0.0128027
KDM6A lysine (K)-specific demethylase 6A 0.0125726
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.012546
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0125136
CCNL1 cyclin L1 0.0123626
RAI1 retinoic acid induced 1 0.0123384
GARS1 glycyl-tRNA synthetase 1 0.0120004
DDIT4 DNA-damage-inducible transcript 4 0.0119956
JARID2 jumonji, AT rich interactive domain 2 0.0119686
CDC73 cell division cycle 73 0.0119355
HMGA2 high mobility group AT-hook 2 0.0117613
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.011761
EPS8 epidermal growth factor receptor pathway substrate 8 0.0117029
FXR1 fragile X mental retardation, autosomal homolog 1 0.0114124
MYO1B myosin IB 0.0113333
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0110967
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0109523
CCDC200 coiled-coil domain containing 200 0.0109251
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0108838
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0107834
PLEC plectin 0.0107405
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0106953
RAB8B RAB8B, member RAS oncogene family 0.0105886
RNF145 ring finger protein 145 0.0105763
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0105037
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0105021
LRRC8C leucine rich repeat containing 8 family, member C 0.010462
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0101455
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.0098299
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.00980088
SUN1 Sad1 and UNC84 domain containing 1 0.00977419
ERRFI1 ERBB receptor feedback inhibitor 1 0.00971794
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.00969563
TPD52 tumor protein D52 0.00967787
PTK2 protein tyrosine kinase 2 0.00961626
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.00956314
PDPK1 3-phosphoinositide dependent protein kinase 1 0.00953738
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.00949813
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.00943375
CD109 CD109 molecule 0.00942325
UBQLN1 ubiquilin 1 0.00928785
MAT2A methionine adenosyltransferase II, alpha 0.00927885
PPARG peroxisome proliferator-activated receptor gamma 0.00921558
NUMA1 nuclear mitotic apparatus protein 1 0.00919462
CHD1 chromodomain helicase DNA binding protein 1 0.00917024
RNASE3 ribonuclease, RNase A family, 3 0.00906224
PLIN2 perilipin 2 0.00903432
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00892502
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.00884133
PDGFC platelet derived growth factor C 0.00883793
SLMAP sarcolemma associated protein 0.00878946
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.00876766
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.00869011
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.00867878
BCLAF1 BCL2-associated transcription factor 1 0.00864486
ADAM17 ADAM metallopeptidase domain 17 0.00854933
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.00840522
RAB6A RAB6A, member RAS oncogene family 0.00837471
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.00826596
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0082387

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.254186
VIM vimentin -0.171187
CD44 CD44 molecule (Indian blood group) -0.145364
UBC ubiquitin C -0.0953112
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0875489
EFNA5 ephrin-A5 -0.0720322
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0684879
PCBP2 poly(rC) binding protein 2 -0.0653435
TMSB10 thymosin beta 10 -0.0584427
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0577674
PDE4D phosphodiesterase 4D, cAMP-specific -0.0575081
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0564215
MT2A metallothionein 2A -0.0545333
FNDC3B fibronectin type III domain containing 3B -0.0542729
USP34 ubiquitin specific peptidase 34 -0.0539281
P4HB prolyl 4-hydroxylase, beta polypeptide -0.048972
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0487179
AHNAK AHNAK nucleoprotein -0.0485149
TM4SF1 transmembrane 4 L six family member 1 -0.047146
LOX lysyl oxidase -0.0452897
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0444824
DSCAM Down syndrome cell adhesion molecule -0.0439945
KDM2A lysine (K)-specific demethylase 2A -0.0437437
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0429725
OSMR oncostatin M receptor -0.0423139
DOCK5 dedicator of cytokinesis 5 -0.0418858
EEF2 eukaryotic translation elongation factor 2 -0.0418603
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0416945
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0409393
ARHGAP5 Rho GTPase activating protein 5 -0.0396404
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0388922
BASP1 brain abundant, membrane attached signal protein 1 -0.0383595
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0366773
AKAP12 A kinase (PRKA) anchor protein 12 -0.036504
PDIA4 protein disulfide isomerase family A, member 4 -0.0361131
PTMA prothymosin, alpha -0.035798
NCOA7 nuclear receptor coactivator 7 -0.0356603
TGM2 transglutaminase 2 -0.0354038
ENO1 enolase 1, (alpha) -0.0349585
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0349528
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0345594
SMAD3 SMAD family member 3 -0.0345472
CALR calreticulin -0.0345383
NAV2 neuron navigator 2 -0.0343174
ZBTB20 zinc finger and BTB domain containing 20 -0.0339919
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin -0.0330924
EGFR epidermal growth factor receptor -0.0329641
GLCCI1 glucocorticoid induced 1 -0.0327818
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0321926
CANX calnexin -0.0319923
NRP1 neuropilin 1 -0.0305491
STC1 stanniocalcin 1 -0.0297117
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0295948
ECE1 endothelin converting enzyme 1 -0.0294933
FAM107B family with sequence similarity 107, member B -0.0291239
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0290124
KYNU kynureninase -0.0287954
ASPH aspartate beta-hydroxylase -0.0286753
VMP1 vacuole membrane protein 1 -0.0283274
IFI16 interferon, gamma-inducible protein 16 -0.0278586
RPS27A ribosomal protein S27a -0.0278439
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0274653
ATF7 activating transcription factor 7 -0.0268781
ANTXR2 anthrax toxin receptor 2 -0.026696
SAMD4A sterile alpha motif domain containing 4A -0.0266611
BPTF bromodomain PHD finger transcription factor -0.0265973
LMAN1 lectin, mannose-binding, 1 -0.0264097
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0262303
AKAP9 A kinase (PRKA) anchor protein 9 -0.0257864
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.025637
AKAP13 A kinase (PRKA) anchor protein 13 -0.0254628
RPLP1 ribosomal protein, large, P1 -0.0252752
KIAA1217 KIAA1217 -0.0246752
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0244206
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0243255
HDLBP high density lipoprotein binding protein -0.0238967
ZC3H12C zinc finger CCCH-type containing 12C -0.0236916
ATXN1 ataxin 1 -0.0234957
RPS8 ribosomal protein S8 -0.0232926
WWTR1 WW domain containing transcription regulator 1 -0.0232032
APP amyloid beta (A4) precursor protein -0.0231461
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.023024
FLNB filamin B, beta -0.0228797
FNBP1 formin binding protein 1 -0.0225079
EHBP1 EH domain binding protein 1 -0.0224746
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0222685
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0222123
RPL23 ribosomal protein L23 -0.0221743
BMAL2 basic helix-loop-helix ARNT like 2 -0.0220377
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0217635
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0217547
TUT7 terminal uridylyl transferase 7 -0.0215631
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.020882
NPC1 Niemann-Pick disease, type C1 -0.0208618
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.020841
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0208155
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0207578
BCAS3 breast carcinoma amplified sequence 3 -0.0207047
MEIS1 Meis homeobox 1 -0.0203018
ANGPTL4 angiopoietin-like 4 -0.0202361