Nevirapine_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.106432
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0488068
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0442431
TPM3 tropomyosin 3 0.0426023
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0416381
LDHA lactate dehydrogenase A 0.0366836
RPL3 ribosomal protein L3 0.0312202
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0286118
HSPA8 heat shock 70kDa protein 8 0.0266441
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0260386
EEF2 eukaryotic translation elongation factor 2 0.0248573
PLEC plectin 0.0243322
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0237487
ERRFI1 ERBB receptor feedback inhibitor 1 0.0235245
RPL23 ribosomal protein L23 0.0214916
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0202107
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0200262
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0197684
SAMD4A sterile alpha motif domain containing 4A 0.0189512
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0185531
TRIO trio Rho guanine nucleotide exchange factor 0.0176076
CCDC200 coiled-coil domain containing 200 0.0175347
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0173178
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0166107
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0165441
MYOF myoferlin 0.0164239
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0163168
LPP LIM domain containing preferred translocation partner in lipoma 0.0161614
MYH9 myosin, heavy chain 9, non-muscle 0.0158021
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0155231
KDM3A lysine (K)-specific demethylase 3A 0.0155194
FMNL2 formin-like 2 0.0154692
FLNA filamin A, alpha 0.014552
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0142418
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0140126
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0137462
ERBIN erbb2 interacting protein 0.0135643
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.013471
SAFB2 scaffold attachment factor B2 0.0132279
DDIT4 DNA-damage-inducible transcript 4 0.0131728
RPL13A ribosomal protein L13a 0.0129992
ADGRG6 adhesion G protein-coupled receptor G6 0.0128924
RPS3 ribosomal protein S3 0.0125882
APP amyloid beta (A4) precursor protein 0.0125274
RBM8A RNA binding motif protein 8A 0.0125268
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0123912
HYOU1 hypoxia up-regulated 1 0.0123705
GJA1 gap junction protein, alpha 1, 43kDa 0.0120831
EIF3I eukaryotic translation initiation factor 3, subunit I 0.0120241
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0119737
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0115976
AHNAK AHNAK nucleoprotein 0.0115467
RPS7 ribosomal protein S7 0.0114904
CCNY cyclin Y 0.0114888
NARS1 asparaginyl-tRNA synthetase 1 0.0113087
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0112339
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0112134
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.0110127
CAVIN1 caveolae associated protein 1 0.0108588
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.010755
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0105755
OAZ1 ornithine decarboxylase antizyme 1 0.0104693
RPL4 ribosomal protein L4 0.0104076
BZW1 basic leucine zipper and W2 domains 1 0.0103927
HMGB2 high mobility group box 2 0.0103074
EEF1G eukaryotic translation elongation factor 1 gamma 0.0102003
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0101427
PRR16 proline rich 16 0.0100826
STAG2 stromal antigen 2 0.0100312
ARHGAP29 Rho GTPase activating protein 29 0.0100085
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.00959748
RYK receptor-like tyrosine kinase 0.00959058
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.00957223
ILF3 interleukin enhancer binding factor 3, 90kDa 0.00948172
MOK MOK protein kinase 0.00937416
BRWD1 bromodomain and WD repeat domain containing 1 0.00934536
SLTM SAFB-like, transcription modulator 0.00928477
YBX1 Y box binding protein 1 0.00923024
TMSB4X thymosin beta 4, X-linked 0.00914768
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00909528
RPL10A ribosomal protein L10a 0.0090734
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0089922
CCL2 chemokine (C-C motif) ligand 2 0.00893547
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.00892649
AHR aryl hydrocarbon receptor 0.00886136
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00877474
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.00872848
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.00870476
SUN1 Sad1 and UNC84 domain containing 1 0.00868757
NAP1L1 nucleosome assembly protein 1-like 1 0.00862525
RPL41 ribosomal protein L41 0.00861856
ASPH aspartate beta-hydroxylase 0.00854263
SOD2 superoxide dismutase 2, mitochondrial 0.00846371
SSRP1 structure specific recognition protein 1 0.00837902
ACADVL acyl-CoA dehydrogenase, very long chain 0.00835418
PRRC2A proline-rich coiled-coil 2A 0.00834352
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.00824784
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.00822063
LARS1 leucyl-tRNA synthetase 1 0.00821242
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.00818176

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.376723
MT2A metallothionein 2A -0.28311
GRAMD1B GRAM domain containing 1B -0.13925
VIM vimentin -0.121384
FTH1 ferritin, heavy polypeptide 1 -0.11092
IGF2 insulin-like growth factor 2 -0.10727
TMSB10 thymosin beta 10 -0.102152
TM4SF1 transmembrane 4 L six family member 1 -0.0915332
ACTG1 actin gamma 1 -0.0871866
PDE4D phosphodiesterase 4D, cAMP-specific -0.0793133
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0698328
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0601701
PM20D1 peptidase M20 domain containing 1 -0.0555091
FTL ferritin, light polypeptide -0.0553273
POTEF POTE ankyrin domain family, member F -0.052497
EIF1 eukaryotic translation initiation factor 1 -0.0490447
RPLP1 ribosomal protein, large, P1 -0.0435079
TXNRD1 thioredoxin reductase 1 -0.0380165
RPS29 ribosomal protein S29 -0.0371818
PFN1 profilin 1 -0.0371242
HLA-B major histocompatibility complex, class I, B -0.0366495
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0360804
LOC102724023 ES1 protein homolog, mitochondrial -0.0342662
RPS21 ribosomal protein S21 -0.0338997
S100A6 S100 calcium binding protein A6 -0.0335467
S100A10 S100 calcium binding protein A10 -0.0329211
AKAP12 A kinase (PRKA) anchor protein 12 -0.0326555
BASP1 brain abundant, membrane attached signal protein 1 -0.0325032
RPS15 ribosomal protein S15 -0.0316011
OSMR oncostatin M receptor -0.0314948
STC1 stanniocalcin 1 -0.031074
EGR1 early growth response 1 -0.0307796
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0291783
RPS8 ribosomal protein S8 -0.0291734
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0288918
SVIL supervillin -0.0282679
PYGL phosphorylase, glycogen, liver -0.0281093
RTN4 reticulon 4 -0.0275126
RPL28 ribosomal protein L28 -0.0267518
RPS11 ribosomal protein S11 -0.0265241
IL6 interleukin 6 -0.0262162
RPL8 ribosomal protein L8 -0.0255686
IGFBP3 insulin-like growth factor binding protein 3 -0.0249738
RPS23 ribosomal protein S23 -0.0245524
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0244584
MAP1B microtubule-associated protein 1B -0.0236895
RPS6 ribosomal protein S6 -0.0220967
RPS19 ribosomal protein S19 -0.0218928
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0217598
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0216276
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0216081
GLG1 golgi glycoprotein 1 -0.0215276
ASTN2 astrotactin 2 -0.021513
ATP5F1B ATP synthase F1 subunit beta -0.0214225
RPL31 ribosomal protein L31 -0.0214115
DEK DEK proto-oncogene -0.0211551
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0202839
NNMT nicotinamide N-methyltransferase -0.0197514
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0197418
FNDC3B fibronectin type III domain containing 3B -0.0197236
TFPI2 tissue factor pathway inhibitor 2 -0.0196522
SLC38A2 solute carrier family 38, member 2 -0.0195906
UBC ubiquitin C -0.0195317
RPS5 ribosomal protein S5 -0.0195111
SRGN serglycin -0.0189523
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0185726
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.018554
RPS10 ribosomal protein S10 -0.0181469
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0180644
BIRC3 baculoviral IAP repeat containing 3 -0.0179386
HSPB1 heat shock 27kDa protein 1 -0.0177003
DOCK4 dedicator of cytokinesis 4 -0.0176012
C15ORF48 chromosome 15 open reading frame 48 -0.0175483
IGFBP4 insulin-like growth factor binding protein 4 -0.0175423
NRG1 neuregulin 1 -0.0174605
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0171125
NPC1 Niemann-Pick disease, type C1 -0.0168584
FGB fibrinogen beta chain -0.0168502
S100A11 S100 calcium binding protein A11 -0.0167743
SOX4 SRY (sex determining region Y)-box 4 -0.0167739
ATP5F1E ATP synthase F1 subunit epsilon -0.0167724
VMP1 vacuole membrane protein 1 -0.0163995
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0163905
KLF6 Kruppel-like factor 6 -0.016176
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.016159
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0161391
KPNB1 karyopherin (importin) beta 1 -0.0160407
RPL32 ribosomal protein L32 -0.0157654
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -0.0156571
ANKRD12 ankyrin repeat domain 12 -0.0156275
CD44 CD44 molecule (Indian blood group) -0.0155263
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0154974
LRP10 low density lipoprotein receptor-related protein 10 -0.0154009
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -0.0153938
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.015364
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0153299
CCL5 chemokine (C-C motif) ligand 5 -0.0150243
HMGA1 high mobility group AT-hook 1 -0.0149667
TMOD3 tropomodulin 3 (ubiquitous) -0.0147675
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0147303