Nevirapine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
THSD4 thrombospondin, type I, domain containing 4 0.123067
RAD51B RAD51 paralog B 0.10413
AKAP12 A kinase (PRKA) anchor protein 12 0.0944955
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0895052
IGF1R insulin-like growth factor 1 receptor 0.077677
CSDE1 cold shock domain containing E1, RNA-binding 0.0714342
GRAMD1B GRAM domain containing 1B 0.0709601
VCL vinculin 0.0692823
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0650399
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0649805
CCDC200 coiled-coil domain containing 200 0.0582694
RPL3 ribosomal protein L3 0.05792
MCL1 myeloid cell leukemia 1 0.0565243
CCNL1 cyclin L1 0.0562522
PLEC plectin 0.0560259
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0557229
CDK17 cyclin-dependent kinase 17 0.0516189
EML4 echinoderm microtubule associated protein like 4 0.0511545
PDE4D phosphodiesterase 4D, cAMP-specific 0.0506717
TAS2R14 taste receptor, type 2, member 14 0.0504611
SMAD3 SMAD family member 3 0.0494219
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0489783
EEF2 eukaryotic translation elongation factor 2 0.0484943
FNDC3B fibronectin type III domain containing 3B 0.0477208
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0463795
PDE10A phosphodiesterase 10A 0.0462606
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0454958
ZFAND3 zinc finger, AN1-type domain 3 0.0453278
RBM39 RNA binding motif protein 39 0.0439625
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0429758
TPM4 tropomyosin 4 0.0416599
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0415886
HMGA2 high mobility group AT-hook 2 0.0411041
SFPQ splicing factor proline/glutamine-rich 0.040345
DOCK5 dedicator of cytokinesis 5 0.0398027
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0392513
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0391364
EXOC4 exocyst complex component 4 0.038804
MED13L mediator complex subunit 13-like 0.0386035
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0385876
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0385153
RRM2 ribonucleotide reductase M2 0.0383156
AHNAK AHNAK nucleoprotein 0.0370376
TRIP12 thyroid hormone receptor interactor 12 0.03668
LPP LIM domain containing preferred translocation partner in lipoma 0.0361744
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0359485
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0359038
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0357921
RERE arginine-glutamic acid dipeptide (RE) repeats 0.035706
NCOA7 nuclear receptor coactivator 7 0.0356089
ERRFI1 ERBB receptor feedback inhibitor 1 0.0347826
AFF3 AF4/FMR2 family, member 3 0.0346932
FMNL2 formin-like 2 0.0338761
NCOR2 nuclear receptor corepressor 2 0.0334616
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0330523
ITSN1 intersectin 1 (SH3 domain protein) 0.03302
DIAPH2 diaphanous-related formin 2 0.0330014
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0326089
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0322368
BTBD9 BTB (POZ) domain containing 9 0.0310739
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0309071
FAM168A family with sequence similarity 168, member A 0.0307873
DENND1A DENN/MADD domain containing 1A 0.0305013
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0300687
NUMA1 nuclear mitotic apparatus protein 1 0.0296558
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0294985
SSH2 slingshot protein phosphatase 2 0.0289574
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0288849
RPTOR regulatory associated protein of MTOR, complex 1 0.028395
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0283354
VMP1 vacuole membrane protein 1 0.0283039
PCBP2 poly(rC) binding protein 2 0.0279858
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0279404
ATXN1 ataxin 1 0.0272641
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0270663
MYH9 myosin, heavy chain 9, non-muscle 0.026957
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0267727
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0267108
FLNA filamin A, alpha 0.0265772
ANKRD11 ankyrin repeat domain 11 0.0265317
PRRC2B proline-rich coiled-coil 2B 0.0264514
TNRC18 trinucleotide repeat containing 18 0.0263562
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0262752
OSMR oncostatin M receptor 0.0259017
AKAP13 A kinase (PRKA) anchor protein 13 0.0257997
NFE2L1 nuclear factor, erythroid 2-like 1 0.0257733
RSRC1 arginine/serine-rich coiled-coil 1 0.0254793
NF1 neurofibromin 1 0.0254329
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0253142
BIRC6 baculoviral IAP repeat containing 6 0.024857
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0245058
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0243537
MACF1 microtubule-actin crosslinking factor 1 0.0243318
ZNFX1 zinc finger, NFX1-type containing 1 0.0242362
USP22 ubiquitin specific peptidase 22 0.0242143
WWOX WW domain containing oxidoreductase 0.0239065
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0238729
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0238419
CLDN1 claudin 1 0.0238255
THADA thyroid adenoma associated 0.0237359

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.312601
TFPI2 tissue factor pathway inhibitor 2 -0.167341
KTN1 kinectin 1 (kinesin receptor) -0.0961762
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0866001
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0755536
NIPBL Nipped-B homolog (Drosophila) -0.0716798
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0659332
PTMA prothymosin, alpha -0.0640867
PRRC2C proline-rich coiled-coil 2C -0.0597718
ZNF638 zinc finger protein 638 -0.0571252
ANKRD12 ankyrin repeat domain 12 -0.0562978
TM4SF1 transmembrane 4 L six family member 1 -0.0553036
WSB1 WD repeat and SOCS box containing 1 -0.053707
SMC4 structural maintenance of chromosomes 4 -0.0476685
PHIP pleckstrin homology domain interacting protein -0.0456207
EGR1 early growth response 1 -0.0449728
RPS15 ribosomal protein S15 -0.0438264
RPL26 ribosomal protein L26 -0.0437044
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0419645
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0410488
RPS21 ribosomal protein S21 -0.0406019
GOLGA4 golgin A4 -0.0404997
ACTG1 actin gamma 1 -0.0399948
AKAP9 A kinase (PRKA) anchor protein 9 -0.0399258
MYL12B myosin, light chain 12B, regulatory -0.0397771
RPS8 ribosomal protein S8 -0.0389016
RPL5 ribosomal protein L5 -0.0382361
CBX3 chromobox homolog 3 -0.0379145
RPLP1 ribosomal protein, large, P1 -0.0376526
RPS29 ribosomal protein S29 -0.0367244
GOLGB1 golgin B1 -0.0364192
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0361228
RPL11 ribosomal protein L11 -0.035921
RBM25 RNA binding motif protein 25 -0.0356894
GCC2 GRIP and coiled-coil domain containing 2 -0.0349314
STC1 stanniocalcin 1 -0.0344334
LMAN1 lectin, mannose-binding, 1 -0.033966
PLCB4 phospholipase C, beta 4 -0.0332722
RPL8 ribosomal protein L8 -0.0330911
KDM7A lysine (K)-specific demethylase 7A -0.0330747
KIF5B kinesin family member 5B -0.0329516
WNK1 WNK lysine deficient protein kinase 1 -0.0326644
RB1CC1 RB1-inducible coiled-coil 1 -0.0324442
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.032342
RPL36 ribosomal protein L36 -0.0316191
SEPTIN7 septin 7 -0.0312162
MKI67 marker of proliferation Ki-67 -0.0309449
SSB Sjogren syndrome antigen B (autoantigen La) -0.0307328
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0305901
FER fer (fps/fes related) tyrosine kinase -0.0300456
RPL37A ribosomal protein L37a -0.0300152
RPS2 ribosomal protein S2 -0.0289464
DCAF7 DDB1 and CUL4 associated factor 7 -0.0289051
ZC3H13 zinc finger CCCH-type containing 13 -0.0287005
ZBTB20 zinc finger and BTB domain containing 20 -0.028311
ZNF654 zinc finger protein 654 -0.0281774
SERBP1 SERPINE1 mRNA binding protein 1 -0.0280033
TUBA1B tubulin, alpha 1b -0.027525
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.027475
BBX bobby sox homolog (Drosophila) -0.0273721
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0273308
RTN4 reticulon 4 -0.0272185
AFF4 AF4/FMR2 family, member 4 -0.0270815
PPME1 protein phosphatase methylesterase 1 -0.0268916
IGF2 insulin-like growth factor 2 -0.026761
RPL28 ribosomal protein L28 -0.026758
RPL37 ribosomal protein L37 -0.0262131
SRSF11 serine/arginine-rich splicing factor 11 -0.0261639
RPL38 ribosomal protein L38 -0.025947
GOLT1B golgi transport 1B -0.0256537
MYPN myopalladin -0.0255429
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0254579
AHCYL1 adenosylhomocysteinase-like 1 -0.0249732
TPR translocated promoter region, nuclear basket protein -0.0245245
SCAF11 SR-related CTD-associated factor 11 -0.0245214
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.0244698
RPS6 ribosomal protein S6 -0.0241879
ATP5F1B ATP synthase F1 subunit beta -0.0240747
MT2A metallothionein 2A -0.0240154
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0239849
EXOC6B exocyst complex component 6B -0.0237892
RPL19 ribosomal protein L19 -0.0237633
RPL9 ribosomal protein L9 -0.02359
OGA O-GlcNAcase -0.0232073
PCLO piccolo presynaptic cytomatrix protein -0.0231395
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0231182
KDM2A lysine (K)-specific demethylase 2A -0.0230647
GPHN gephyrin -0.02302
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0230177
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0229241
CHIC2 cysteine-rich hydrophobic domain 2 -0.0229184
PREPL prolyl endopeptidase-like -0.0228832
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0228172
RECQL RecQ helicase-like -0.022775
RPL32 ribosomal protein L32 -0.0227115
AVL9 AVL9 homolog (S. cerevisiase) -0.0227051
SET SET nuclear proto-oncogene -0.0226481
WAC WW domain containing adaptor with coiled-coil -0.0225718
HMGA1 high mobility group AT-hook 1 -0.0225484
WDR45B WD repeat domain 45B -0.0224465