Nevirapine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.0595929
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0509656
GRB10 growth factor receptor-bound protein 10 0.0463658
MYH9 myosin, heavy chain 9, non-muscle 0.0423832
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0383614
IGFBP3 insulin-like growth factor binding protein 3 0.0304704
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0295923
EXT1 exostosin glycosyltransferase 1 0.0288183
MSN moesin 0.0287315
SAMD4A sterile alpha motif domain containing 4A 0.0277395
VEGFA vascular endothelial growth factor A 0.0236201
FNDC3B fibronectin type III domain containing 3B 0.0222936
RCOR1 REST corepressor 1 0.0210986
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0208456
LIMCH1 LIM and calponin homology domains 1 0.020515
PPARD peroxisome proliferator-activated receptor delta 0.0202181
ERBIN erbb2 interacting protein 0.0201502
RPL3 ribosomal protein L3 0.0194
DTNA dystrobrevin, alpha 0.0190961
NDRG1 N-myc downstream regulated 1 0.0190532
APLP2 amyloid beta (A4) precursor-like protein 2 0.0189986
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0186218
KDM6A lysine (K)-specific demethylase 6A 0.0184599
DSPP dentin sialophosphoprotein 0.0172836
UBE2H ubiquitin-conjugating enzyme E2H 0.0166394
EFNA5 ephrin-A5 0.0162898
CD109 CD109 molecule 0.0162697
SEC23A Sec23 homolog A (S. cerevisiae) 0.0162607
AKAP13 A kinase (PRKA) anchor protein 13 0.0161524
OCLN occludin 0.0161471
NAV2 neuron navigator 2 0.0156529
DUSP10 dual specificity phosphatase 10 0.0155935
FNIP1 folliculin interacting protein 1 0.015179
MYO1E myosin IE 0.0148971
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0148953
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0147218
MACF1 microtubule-actin crosslinking factor 1 0.0144425
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0144423
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0143943
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0142099
PICALM phosphatidylinositol binding clathrin assembly protein 0.0139988
NRIP1 nuclear receptor interacting protein 1 0.0139736
EIF5 eukaryotic translation initiation factor 5 0.0136417
LPP LIM domain containing preferred translocation partner in lipoma 0.0134776
MCL1 myeloid cell leukemia 1 0.0134596
USP9X ubiquitin specific peptidase 9, X-linked 0.01331
PDLIM5 PDZ and LIM domain 5 0.0132189
UBA6 ubiquitin-like modifier activating enzyme 6 0.0131579
TPM3 tropomyosin 3 0.0131028
PCBP2 poly(rC) binding protein 2 0.0129958
ERRFI1 ERBB receptor feedback inhibitor 1 0.0129006
ELL2 elongation factor, RNA polymerase II, 2 0.0127517
PTK2 protein tyrosine kinase 2 0.0126468
MSI2 musashi RNA-binding protein 2 0.0124035
CCNY cyclin Y 0.0123991
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0123902
BLTP1 bridge-like lipid transfer protein family member 1 0.0118396
GLS2 glutaminase 2 (liver, mitochondrial) 0.0117627
FBXO34 F-box protein 34 0.0117153
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0114116
CSNK1A1 casein kinase 1, alpha 1 0.0113989
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0113592
MYO6 myosin VI 0.0112445
TMF1 TATA element modulatory factor 1 0.0112118
SRPK2 SRSF protein kinase 2 0.0111654
XPO1 exportin 1 0.0110726
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0109615
PTEN phosphatase and tensin homolog 0.0109179
LNPEP leucyl/cystinyl aminopeptidase 0.0109094
DOCK5 dedicator of cytokinesis 5 0.0108639
AFDN afadin, adherens junction formation factor 0.0107874
VCL vinculin 0.0105597
HPCAL1 hippocalcin-like 1 0.0104265
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0103885
TUFT1 tuftelin 1 0.0103684
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0103542
RAI14 retinoic acid induced 14 0.0102815
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0101117
WNK1 WNK lysine deficient protein kinase 1 0.0100287
NUP58 nucleoporin 58 0.0100058
VMP1 vacuole membrane protein 1 0.00989715
PTBP2 polypyrimidine tract binding protein 2 0.00977396
TBC1D23 TBC1 domain family, member 23 0.00976948
AKAP9 A kinase (PRKA) anchor protein 9 0.00960735
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.00953734
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00953248
RAD51B RAD51 paralog B 0.00950059
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.00941784
JARID2 jumonji, AT rich interactive domain 2 0.0094057
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.00937762
SUCO SUN domain containing ossification factor 0.00937101
ATOSA atos homolog A 0.00936345
ZFC3H1 zinc finger, C3H1-type containing 0.00936241
YEATS2 YEATS domain containing 2 0.00935654
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00934695
RSF1 remodeling and spacing factor 1 0.00934158
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00927081
BIRC6 baculoviral IAP repeat containing 6 0.00923131
MIDEAS mitotic deacetylase associated SANT domain protein 0.00922013
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.00917718

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.298619
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.262164
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.211584
TMSB10 thymosin beta 10 -0.200241
PTMA prothymosin, alpha -0.197473
TPT1 tumor protein, translationally-controlled 1 -0.136234
S100A6 S100 calcium binding protein A6 -0.134633
ACTG1 actin gamma 1 -0.126881
RPL35A ribosomal protein L35a -0.102401
RPLP1 ribosomal protein, large, P1 -0.0966193
BHLHE40 basic helix-loop-helix family, member e40 -0.0920121
ANXA2 annexin A2 -0.0867051
RPL34 ribosomal protein L34 -0.0856593
TM4SF1 transmembrane 4 L six family member 1 -0.0838083
SLC38A1 solute carrier family 38, member 1 -0.0808308
RPS3 ribosomal protein S3 -0.0802051
S100A10 S100 calcium binding protein A10 -0.0790746
ASPH aspartate beta-hydroxylase -0.07844
MT2A metallothionein 2A -0.0781951
POTEF POTE ankyrin domain family, member F -0.077136
RPS8 ribosomal protein S8 -0.0753576
RPS19 ribosomal protein S19 -0.0751342
HMGA1 high mobility group AT-hook 1 -0.0716695
RPLP2 ribosomal protein, large, P2 -0.0693269
RPL8 ribosomal protein L8 -0.0685265
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0680374
RACK1 receptor for activated C kinase 1 -0.0680335
KRT7 keratin 7, type II -0.0674
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0671906
RPL19 ribosomal protein L19 -0.0665439
LAMB3 laminin, beta 3 -0.0652359
RPL23 ribosomal protein L23 -0.0643318
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0630242
TMSB4X thymosin beta 4, X-linked -0.0616684
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0605415
RPL12 ribosomal protein L12 -0.0603877
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0603113
RPS29 ribosomal protein S29 -0.0595375
EIF1 eukaryotic translation initiation factor 1 -0.0584604
ISG15 ISG15 ubiquitin-like modifier -0.0555477
RPL32 ribosomal protein L32 -0.0555271
ALCAM activated leukocyte cell adhesion molecule -0.0540716
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0538405
RPLP0 ribosomal protein, large, P0 -0.0517715
GNAS GNAS complex locus -0.0504042
HMGB2 high mobility group box 2 -0.0502294
RPL37A ribosomal protein L37a -0.0490125
RPS6 ribosomal protein S6 -0.0489565
RPL37 ribosomal protein L37 -0.0479951
CSTB cystatin B (stefin B) -0.0474494
RPS13 ribosomal protein S13 -0.0470947
CCND1 cyclin D1 -0.0463083
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0461255
RPS24 ribosomal protein S24 -0.0460182
RPL11 ribosomal protein L11 -0.0459441
IFITM3 interferon induced transmembrane protein 3 -0.0458853
RPS14 ribosomal protein S14 -0.0446582
RPS27A ribosomal protein S27a -0.0445543
NAMPT nicotinamide phosphoribosyltransferase -0.0444633
SQSTM1 sequestosome 1 -0.043693
PGK1 phosphoglycerate kinase 1 -0.0436267
RPS27 ribosomal protein S27 -0.0436228
RAD21 RAD21 homolog (S. pombe) -0.0429884
RPS23 ribosomal protein S23 -0.0428098
ENO1 enolase 1, (alpha) -0.0427637
LMO7 LIM domain 7 -0.0421211
RPS25 ribosomal protein S25 -0.0419076
VIM vimentin -0.0416475
RPL36 ribosomal protein L36 -0.0413006
RPL28 ribosomal protein L28 -0.0409616
RPL30 ribosomal protein L30 -0.0408062
LMNA lamin A/C -0.0406529
LAMC2 laminin, gamma 2 -0.0401225
IFI27 interferon, alpha-inducible protein 27 -0.0399878
S100A9 S100 calcium binding protein A9 -0.0397941
IFITM1 interferon induced transmembrane protein 1 -0.0396584
RPS5 ribosomal protein S5 -0.0393649
EPCAM epithelial cell adhesion molecule -0.0393639
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0392466
PLAU plasminogen activator, urokinase -0.0389377
RPL9 ribosomal protein L9 -0.0383415
TPI1 triosephosphate isomerase 1 -0.0372234
RPS21 ribosomal protein S21 -0.0369972
RPL27A ribosomal protein L27a -0.0368884
NPC2 Niemann-Pick disease, type C2 -0.0368131
RPL36A ribosomal protein L36a -0.0364504
MARCHF6 membrane associated ring-CH-type finger 6 -0.0363151
RPL5 ribosomal protein L5 -0.0363109
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0360579
RPL15 ribosomal protein L15 -0.0360371
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0359478
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0357452
RPL31 ribosomal protein L31 -0.0357037
RPS16 ribosomal protein S16 -0.0354122
NAP1L1 nucleosome assembly protein 1-like 1 -0.0347504
FN1 fibronectin 1 -0.0347269
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0343395
YBX3 Y box binding protein 3 -0.0342887
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0342796
GPX4 glutathione peroxidase 4 -0.033572