Nevirapine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.186238
TXNRD1 thioredoxin reductase 1 0.142386
GDA guanine deaminase 0.138289
ASPH aspartate beta-hydroxylase 0.126944
NAMPT nicotinamide phosphoribosyltransferase 0.123921
NEK7 NIMA-related kinase 7 0.095671
GRAMD1B GRAM domain containing 1B 0.0708051
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0694467
TRIO trio Rho guanine nucleotide exchange factor 0.0677668
COL8A1 collagen, type VIII, alpha 1 0.0642732
EFNA5 ephrin-A5 0.0605225
NRCAM neuronal cell adhesion molecule 0.0604111
RTN4 reticulon 4 0.0563379
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0530472
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0526925
CTSC cathepsin C 0.0491424
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.048837
CD109 CD109 molecule 0.0481917
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0471458
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.047128
FNDC3B fibronectin type III domain containing 3B 0.0464296
TNPO1 transportin 1 0.0460663
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0452954
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0441867
CXCL8 chemokine (C-X-C motif) ligand 8 0.0418992
PSD3 pleckstrin and Sec7 domain containing 3 0.041881
SAMD4A sterile alpha motif domain containing 4A 0.041021
MYOF myoferlin 0.0399293
CENPF centromere protein F, 350/400kDa 0.0396002
AGFG1 ArfGAP with FG repeats 1 0.0392974
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0376367
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.036997
ENAH enabled homolog (Drosophila) 0.036805
CARD16 caspase recruitment domain family, member 16 0.0358623
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0356425
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0356151
TGFBR1 transforming growth factor, beta receptor 1 0.0356023
ARHGAP29 Rho GTPase activating protein 29 0.0344293
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0343077
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0337868
ZEB2 zinc finger E-box binding homeobox 2 0.0335552
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0329067
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0328684
BCAR3 breast cancer anti-estrogen resistance 3 0.0326999
RPL3 ribosomal protein L3 0.0319078
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0317424
PTEN phosphatase and tensin homolog 0.0313599
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0303581
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0297612
ELL2 elongation factor, RNA polymerase II, 2 0.0296441
ANKRD28 ankyrin repeat domain 28 0.0295738
ATP13A3 ATPase type 13A3 0.0295213
MFF mitochondrial fission factor 0.0294495
COL5A2 collagen, type V, alpha 2 0.0288568
PCBP2 poly(rC) binding protein 2 0.0286848
MKI67 marker of proliferation Ki-67 0.0284864
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0284008
TMX4 thioredoxin-related transmembrane protein 4 0.027872
RAB3B RAB3B, member RAS oncogene family 0.0276395
ADAM9 ADAM metallopeptidase domain 9 0.0268676
ANKRD11 ankyrin repeat domain 11 0.0267768
USP9X ubiquitin specific peptidase 9, X-linked 0.0267674
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.026491
FLNB filamin B, beta 0.0259123
MCL1 myeloid cell leukemia 1 0.025347
WDFY2 WD repeat and FYVE domain containing 2 0.025326
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0253011
KDM6A lysine (K)-specific demethylase 6A 0.0249189
WDR43 WD repeat domain 43 0.0249158
PTGR1 prostaglandin reductase 1 0.0245677
DOCK4 dedicator of cytokinesis 4 0.0245006
NCKAP1 NCK-associated protein 1 0.0244514
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0241322
LAMA1 laminin, alpha 1 0.0239029
DST dystonin 0.0237678
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0237155
MSN moesin 0.0236154
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0234105
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0232317
CDK6 cyclin-dependent kinase 6 0.023231
SFPQ splicing factor proline/glutamine-rich 0.0231321
PALLD palladin, cytoskeletal associated protein 0.0230092
TFPI2 tissue factor pathway inhibitor 2 0.0229931
ECT2 epithelial cell transforming 2 0.0229763
ANLN anillin, actin binding protein 0.0228991
XPO1 exportin 1 0.0227893
GPRIN3 GPRIN family member 3 0.0227067
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0225377
RBM39 RNA binding motif protein 39 0.0223244
ADAM17 ADAM metallopeptidase domain 17 0.022207
EZR ezrin 0.0220907
PTK2 protein tyrosine kinase 2 0.021938
TBXT T-box transcription factor T 0.0218261
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0216347
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0215666
COL4A6 collagen, type IV, alpha 6 0.0214512
CDK17 cyclin-dependent kinase 17 0.021307
BDNF brain-derived neurotrophic factor 0.0211938
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0211731
MED13L mediator complex subunit 13-like 0.0211091

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.301693
PDE4D phosphodiesterase 4D, cAMP-specific -0.165554
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.11381
VIM vimentin -0.109615
TPT1 tumor protein, translationally-controlled 1 -0.093678
TMSB10 thymosin beta 10 -0.0769792
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0743298
RPS6 ribosomal protein S6 -0.0717169
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0612898
RPL37A ribosomal protein L37a -0.0578739
RPLP1 ribosomal protein, large, P1 -0.0577367
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0570685
LSAMP limbic system-associated membrane protein -0.0519322
RPS8 ribosomal protein S8 -0.0518487
NALF1 NALCN channel auxiliary factor 1 -0.0508195
RPL31 ribosomal protein L31 -0.049776
RPL26 ribosomal protein L26 -0.0491277
RPL35A ribosomal protein L35a -0.0474268
RPS12 ribosomal protein S12 -0.0468602
PRKN parkin RBR E3 ubiquitin protein ligase -0.045487
FN1 fibronectin 1 -0.0453845
PDE10A phosphodiesterase 10A -0.0443845
RPS19 ribosomal protein S19 -0.0441596
FTL ferritin, light polypeptide -0.0427684
WARS1 tryptophanyl-tRNA synthetase 1 -0.042475
RPL9 ribosomal protein L9 -0.0412766
P3H2 prolyl 3-hydroxylase 2 -0.040723
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0406283
FNDC3A fibronectin type III domain containing 3A -0.0402439
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0394498
PRELID2 PRELI domain containing 2 -0.0394294
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0387337
RPS24 ribosomal protein S24 -0.0384296
CDH13 cadherin 13 -0.0378789
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0376986
PTMA prothymosin, alpha -0.0371276
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0367181
MAP7 microtubule-associated protein 7 -0.0353951
RPS3 ribosomal protein S3 -0.0343581
RPL12 ribosomal protein L12 -0.034243
RPS27A ribosomal protein S27a -0.0340107
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0337196
RPL7A ribosomal protein L7a -0.0331481
AUTS2 autism susceptibility candidate 2 -0.0322059
NBEAL1 neurobeachin-like 1 -0.0319543
RPL37 ribosomal protein L37 -0.0316992
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0314413
DENND1A DENN/MADD domain containing 1A -0.0305583
MT2A metallothionein 2A -0.0303227
RPL34 ribosomal protein L34 -0.0300263
PTPRM protein tyrosine phosphatase, receptor type, M -0.0300175
RPS27 ribosomal protein S27 -0.0299944
RPS23 ribosomal protein S23 -0.0297551
RAD51B RAD51 paralog B -0.029294
RPL36A ribosomal protein L36a -0.029203
HLA-B major histocompatibility complex, class I, B -0.0288971
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0285818
RPS29 ribosomal protein S29 -0.0285426
RPL38 ribosomal protein L38 -0.0283135
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0280559
RPL36 ribosomal protein L36 -0.0279176
PCDH15 protocadherin-related 15 -0.0277322
S100A6 S100 calcium binding protein A6 -0.0274676
CUX1 cut-like homeobox 1 -0.0274635
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0273928
RPL19 ribosomal protein L19 -0.0268605
SOX4 SRY (sex determining region Y)-box 4 -0.0266783
RPLP2 ribosomal protein, large, P2 -0.0263541
RPS21 ribosomal protein S21 -0.0258264
WSB1 WD repeat and SOCS box containing 1 -0.0257372
ADGRD1 adhesion G protein-coupled receptor D1 -0.0249902
SMAD2 SMAD family member 2 -0.0247123
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0246699
OASL 2'-5'-oligoadenylate synthetase-like -0.0246079
TENM2 teneurin transmembrane protein 2 -0.0245759
NAP1L1 nucleosome assembly protein 1-like 1 -0.0244139
AGTPBP1 ATP/GTP binding protein 1 -0.0236659
NCKAP5 NCK-associated protein 5 -0.0235696
IFIH1 interferon induced with helicase C domain 1 -0.0233223
XYLT1 xylosyltransferase I -0.0230963
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0230532
FNIP1 folliculin interacting protein 1 -0.023006
SQSTM1 sequestosome 1 -0.0228421
RPS25 ribosomal protein S25 -0.0226798
RPS16 ribosomal protein S16 -0.022607
AEBP2 AE binding protein 2 -0.0225188
RPLP0 ribosomal protein, large, P0 -0.022078
RPL35 ribosomal protein L35 -0.0220217
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.021758
RPS14 ribosomal protein S14 -0.0217563
BTG1 B-cell translocation gene 1, anti-proliferative -0.0214723
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0214551
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0214056
RACK1 receptor for activated C kinase 1 -0.0213821
RPS17 ribosomal protein S17 -0.021212
RIGI RNA sensor RIG-I -0.0202898
RPL11 ribosomal protein L11 -0.0202629
GLRX glutaredoxin (thioltransferase) -0.0197343
IL6 interleukin 6 -0.0194642
CADM2 cell adhesion molecule 2 -0.0192655