Nevirapine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.122071
MKI67 marker of proliferation Ki-67 0.104442
PCBP2 poly(rC) binding protein 2 0.101968
PTK2 protein tyrosine kinase 2 0.099501
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0922155
KMT2C lysine (K)-specific methyltransferase 2C 0.0908073
SNX9 sorting nexin 9 0.0888804
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0879963
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0847926
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0844757
PCM1 pericentriolar material 1 0.083043
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0820093
MEF2A myocyte enhancer factor 2A 0.0775201
NGLY1 N-glycanase 1 0.0774451
SUN1 Sad1 and UNC84 domain containing 1 0.0729736
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0725945
WAC WW domain containing adaptor with coiled-coil 0.0723291
RERE arginine-glutamic acid dipeptide (RE) repeats 0.072196
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0718992
MATR3 matrin 3 0.0715134
FNIP1 folliculin interacting protein 1 0.0710744
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0707917
DTNA dystrobrevin, alpha 0.0707543
RTN4 reticulon 4 0.0671293
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0664001
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.064929
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0646653
ZNF292 zinc finger protein 292 0.0646313
FNDC3A fibronectin type III domain containing 3A 0.0605272
HELZ helicase with zinc finger 0.060329
SPAG9 sperm associated antigen 9 0.0562011
RICTOR RPTOR independent companion of MTOR, complex 2 0.0547388
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0531935
USP9X ubiquitin specific peptidase 9, X-linked 0.0530124
EFNA5 ephrin-A5 0.0529694
TNRC6B trinucleotide repeat containing 6B 0.052228
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0512714
ANKRD12 ankyrin repeat domain 12 0.0511202
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0499697
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0495124
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0483828
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0471569
MBD5 methyl-CpG binding domain protein 5 0.0460524
NCOA3 nuclear receptor coactivator 3 0.044881
PARD3 par-3 family cell polarity regulator 0.0448756
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0443835
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0429041
ERRFI1 ERBB receptor feedback inhibitor 1 0.0425057
CAMTA1 calmodulin binding transcription activator 1 0.0403903
EXT1 exostosin glycosyltransferase 1 0.0402983
CANX calnexin 0.0395099
KDM2A lysine (K)-specific demethylase 2A 0.0389349
NCOR1 nuclear receptor corepressor 1 0.0388322
ZBTB20 zinc finger and BTB domain containing 20 0.0384151
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0379134
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0377106
JAK1 Janus kinase 1 0.0375529
RBM39 RNA binding motif protein 39 0.0364727
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0350862
NKTR natural killer cell triggering receptor 0.0333409
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0327191
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0324712
FNDC3B fibronectin type III domain containing 3B 0.0320559
PRRC2C proline-rich coiled-coil 2C 0.0307544
LOC112694756 uncharaterized LOC112694756 0.0306457
BIRC6 baculoviral IAP repeat containing 6 0.0291738
GOLGA4 golgin A4 0.0284825
MYH9 myosin, heavy chain 9, non-muscle 0.0272206
TPI1 triosephosphate isomerase 1 0.0270373
EZR ezrin 0.025942
UBA6 ubiquitin-like modifier activating enzyme 6 0.0253638
ZFAND3 zinc finger, AN1-type domain 3 0.0248203
OGA O-GlcNAcase 0.0246315
ESYT2 extended synaptotagmin-like protein 2 0.0243518
TBC1D22A TBC1 domain family, member 22A 0.0242248
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0232523
MON2 MON2 homolog (S. cerevisiae) 0.0229303
AKAP9 A kinase (PRKA) anchor protein 9 0.0222674
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0204427
PDE10A phosphodiesterase 10A 0.0196449
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0190394
DSCAM Down syndrome cell adhesion molecule 0.0189947
ARID4B AT rich interactive domain 4B (RBP1-like) 0.017689
ANKRD11 ankyrin repeat domain 11 0.0174424
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0172698
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0171822
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0163831
TRIO trio Rho guanine nucleotide exchange factor 0.0162459
NKD1 naked cuticle homolog 1 (Drosophila) 0.0158966
PSD3 pleckstrin and Sec7 domain containing 3 0.0153816
RPLP1 ribosomal protein, large, P1 0.0153727
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0146984
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0136873
CD44 CD44 molecule (Indian blood group) 0.0136179
RPL7A ribosomal protein L7a 0.0134946
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0117442
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0116774
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0106881
NSD2 nuclear receptor binding SET domain protein 2 0.0106555
ANO6 anoctamin 6 0.0105182

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.419521
TMSB10 thymosin beta 10 -0.156926
RPS6 ribosomal protein S6 -0.147249
VIM vimentin -0.14263
RPS8 ribosomal protein S8 -0.123521
FN1 fibronectin 1 -0.11922
NAP1L1 nucleosome assembly protein 1-like 1 -0.116835
PKM pyruvate kinase, muscle -0.110838
AKAP12 A kinase (PRKA) anchor protein 12 -0.0951584
FTL ferritin, light polypeptide -0.0935693
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0918144
TPT1 tumor protein, translationally-controlled 1 -0.0863866
RPL35A ribosomal protein L35a -0.0810515
RPS12 ribosomal protein S12 -0.0689039
RPL26 ribosomal protein L26 -0.068416
STC1 stanniocalcin 1 -0.0649464
PDE4D phosphodiesterase 4D, cAMP-specific -0.0616156
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0604218
PTMA prothymosin, alpha -0.0596656
ASPH aspartate beta-hydroxylase -0.058956
FMNL2 formin-like 2 -0.0580267
INTS6 integrator complex subunit 6 -0.0577314
RPL37A ribosomal protein L37a -0.0523732
LDHA lactate dehydrogenase A -0.0517252
AHNAK AHNAK nucleoprotein -0.0509869
CCNI cyclin I -0.0508956
MCL1 myeloid cell leukemia 1 -0.0508202
HLA-B major histocompatibility complex, class I, B -0.0483414
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0460722
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0454382
AKAP13 A kinase (PRKA) anchor protein 13 -0.0426087
SLC38A2 solute carrier family 38, member 2 -0.0425025
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0422935
NF1 neurofibromin 1 -0.0419569
KMT2E lysine (K)-specific methyltransferase 2E -0.0416222
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0412058
UBC ubiquitin C -0.0402503
JMJD1C jumonji domain containing 1C -0.0401432
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0396415
OSMR oncostatin M receptor -0.039239
S100A9 S100 calcium binding protein A9 -0.0383204
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.036259
NAV1 neuron navigator 1 -0.036019
B2M beta-2-microglobulin -0.0352848
VCL vinculin -0.0350946
POTEF POTE ankyrin domain family, member F -0.0339478
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0337177
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0319057
FLNB filamin B, beta -0.0317467
RPL12 ribosomal protein L12 -0.030943
RAB1A RAB1A, member RAS oncogene family -0.0308591
MAP1B microtubule-associated protein 1B -0.0299289
DST dystonin -0.0298991
SP100 SP100 nuclear antigen -0.0291511
MAP4 microtubule-associated protein 4 -0.0282651
FTH1 ferritin, heavy polypeptide 1 -0.0276038
SEC31A SEC31 homolog A (S. cerevisiae) -0.027493
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0274866
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0264816
SLMAP sarcolemma associated protein -0.025628
RPL13A ribosomal protein L13a -0.0254955
RPL19 ribosomal protein L19 -0.025437
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0253533
SETD5 SET domain containing 5 -0.0251019
PRELID2 PRELI domain containing 2 -0.0241905
RPLP2 ribosomal protein, large, P2 -0.0239059
LPP LIM domain containing preferred translocation partner in lipoma -0.0232845
RPL37 ribosomal protein L37 -0.0228335
RPLP0 ribosomal protein, large, P0 -0.02219
MYO1E myosin IE -0.021371
BBX bobby sox homolog (Drosophila) -0.0208862
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0208839
EIF1 eukaryotic translation initiation factor 1 -0.0198607
WSB1 WD repeat and SOCS box containing 1 -0.0197067
CNKSR3 CNKSR family member 3 -0.019607
LMNA lamin A/C -0.0190213
CDCP1 CUB domain containing protein 1 -0.0182644
SMAD3 SMAD family member 3 -0.016987
RPL11 ribosomal protein L11 -0.0167
ADAM10 ADAM metallopeptidase domain 10 -0.0164279
LAMB3 laminin, beta 3 -0.0154739
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0153197
ACTG1 actin gamma 1 -0.0142184
RNF213 ring finger protein 213 -0.0138982
PRKCA protein kinase C, alpha -0.0137326
MT2A metallothionein 2A -0.0133935
PGK1 phosphoglycerate kinase 1 -0.0133518
TRIP12 thyroid hormone receptor interactor 12 -0.0129347
FOXP1 forkhead box P1 -0.0129002
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0128366
MED13L mediator complex subunit 13-like -0.0126612
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0126093
TAS2R14 taste receptor, type 2, member 14 -0.0123851
RACK1 receptor for activated C kinase 1 -0.0123522
S100A6 S100 calcium binding protein A6 -0.0121793
CSNK1A1 casein kinase 1, alpha 1 -0.011873
RPL15 ribosomal protein L15 -0.011692
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0116266
MACF1 microtubule-actin crosslinking factor 1 -0.0112979
TAOK3 TAO kinase 3 -0.0111795