Nevirapine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.2177
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0913378
NAMPT nicotinamide phosphoribosyltransferase 0.067562
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0653209
COL6A3 collagen, type VI, alpha 3 0.064193
DST dystonin 0.0594589
FNDC3B fibronectin type III domain containing 3B 0.0547237
CADM1 cell adhesion molecule 1 0.0510818
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0491212
FRMD4A FERM domain containing 4A 0.0482989
ZNF292 zinc finger protein 292 0.0467543
FN1 fibronectin 1 0.0467089
VCAN versican 0.0451732
MYH9 myosin, heavy chain 9, non-muscle 0.0446612
NAV2 neuron navigator 2 0.0434862
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0379136
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0379034
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0352305
FAM20C family with sequence similarity 20, member C 0.0349374
CDH13 cadherin 13 0.0346948
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0345449
ARF4 ADP-ribosylation factor 4 0.034135
SDK1 sidekick cell adhesion molecule 1 0.0337612
TENT5A terminal nucleotidyltransferase 5A 0.0319212
TNS3 tensin 3 0.0319113
RNF213 ring finger protein 213 0.0311354
FLNA filamin A, alpha 0.0300504
XRN1 5'-3' exoribonuclease 1 0.0291889
PRELID2 PRELI domain containing 2 0.0283162
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0281044
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0273452
MX1 MX dynamin-like GTPase 1 0.0270517
MMP12 matrix metallopeptidase 12 0.0266166
AFDN afadin, adherens junction formation factor 0.0265609
PDE10A phosphodiesterase 10A 0.0264156
EXT1 exostosin glycosyltransferase 1 0.0261176
MYOF myoferlin 0.0250612
USP9X ubiquitin specific peptidase 9, X-linked 0.0247773
CEP250 centrosomal protein 250kDa 0.0241551
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0237432
PLEC plectin 0.0235254
HELZ helicase with zinc finger 0.0233735
SMYD3 SET and MYND domain containing 3 0.0231307
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0228089
COL5A1 collagen, type V, alpha 1 0.0221254
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0220198
MACF1 microtubule-actin crosslinking factor 1 0.021717
UTRN utrophin 0.0212601
TM9SF3 transmembrane 9 superfamily member 3 0.0209204
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.019677
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0193225
CCBE1 collagen and calcium binding EGF domains 1 0.0190842
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0189874
NEK6 NIMA-related kinase 6 0.0189558
BBX bobby sox homolog (Drosophila) 0.0188174
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0182167
XPO1 exportin 1 0.018196
ICAM1 intercellular adhesion molecule 1 0.0181534
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0179977
TGFBR1 transforming growth factor, beta receptor 1 0.017809
UBE2O ubiquitin-conjugating enzyme E2O 0.0176245
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.017541
IGF2R insulin-like growth factor 2 receptor 0.0174958
BNC2 basonuclin 2 0.0173731
DIAPH2 diaphanous-related formin 2 0.0172871
COL7A1 collagen, type VII, alpha 1 0.0172641
PHF21A PHD finger protein 21A 0.0172166
HBP1 HMG-box transcription factor 1 0.0171784
MLPH melanophilin 0.0171344
NBAS neuroblastoma amplified sequence 0.0171326
ZMYND8 zinc finger, MYND-type containing 8 0.0169409
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0167255
ZNF654 zinc finger protein 654 0.0167099
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0166203
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0165899
TXNIP thioredoxin interacting protein 0.0165831
DIAPH3 diaphanous-related formin 3 0.0165686
CLIC4 chloride intracellular channel 4 0.0164499
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0163324
MARCHF6 membrane associated ring-CH-type finger 6 0.0162803
CANX calnexin 0.0162659
MXI1 MAX interactor 1, dimerization protein 0.0161191
RAD51B RAD51 paralog B 0.016088
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0158318
AHNAK AHNAK nucleoprotein 0.0158115
AUTS2 autism susceptibility candidate 2 0.0157381
KCNIP4 Kv channel interacting protein 4 0.0154443
AFAP1 actin filament associated protein 1 0.0154383
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0154379
CALU calumenin 0.0154126
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0152518
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0152506
MYO1B myosin IB 0.0151167
RUNX1 runt-related transcription factor 1 0.0150391
ATP13A3 ATPase type 13A3 0.0149738
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.01477
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0147288
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0147203
CHD6 chromodomain helicase DNA binding protein 6 0.0146899
KDM6A lysine (K)-specific demethylase 6A 0.0145068

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.233065
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147456
TMSB10 thymosin beta 10 -0.118692
FTL ferritin, light polypeptide -0.116772
RPS6 ribosomal protein S6 -0.113261
MT2A metallothionein 2A -0.101053
HLA-B major histocompatibility complex, class I, B -0.0995372
RPS12 ribosomal protein S12 -0.091132
CD44 CD44 molecule (Indian blood group) -0.079481
TPT1 tumor protein, translationally-controlled 1 -0.0766985
RPS3 ribosomal protein S3 -0.0752095
RPLP2 ribosomal protein, large, P2 -0.075048
RPS8 ribosomal protein S8 -0.0730138
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0712692
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0700183
RPL37A ribosomal protein L37a -0.0660783
SLC38A2 solute carrier family 38, member 2 -0.0658801
RPL35A ribosomal protein L35a -0.0643872
RPL23 ribosomal protein L23 -0.0614469
AKAP12 A kinase (PRKA) anchor protein 12 -0.0593526
B2M beta-2-microglobulin -0.0577842
EIF1 eukaryotic translation initiation factor 1 -0.0573739
RPS24 ribosomal protein S24 -0.0569858
HDAC9 histone deacetylase 9 -0.0557894
RPL19 ribosomal protein L19 -0.0554448
PTMA prothymosin, alpha -0.0546345
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0543302
RPS13 ribosomal protein S13 -0.0532448
RPL9 ribosomal protein L9 -0.0529465
RPL36A ribosomal protein L36a -0.0498002
VCL vinculin -0.0484781
RPL31 ribosomal protein L31 -0.0465323
RPLP1 ribosomal protein, large, P1 -0.0461449
RPL26 ribosomal protein L26 -0.0454926
RPL12 ribosomal protein L12 -0.0439512
RPS19 ribosomal protein S19 -0.0437195
PALLD palladin, cytoskeletal associated protein -0.0427562
RPS14 ribosomal protein S14 -0.0427457
NAP1L1 nucleosome assembly protein 1-like 1 -0.0418222
RPL5 ribosomal protein L5 -0.0410261
IER3 immediate early response 3 -0.0407446
RPS27A ribosomal protein S27a -0.0403854
VMP1 vacuole membrane protein 1 -0.0402077
RPS23 ribosomal protein S23 -0.039644
RPS16 ribosomal protein S16 -0.0387097
EGR1 early growth response 1 -0.038343
RPL35 ribosomal protein L35 -0.0382649
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0381892
RPL36 ribosomal protein L36 -0.0376244
RPL32 ribosomal protein L32 -0.0375439
KYNU kynureninase -0.0374242
HMGA2 high mobility group AT-hook 2 -0.0372874
IFITM3 interferon induced transmembrane protein 3 -0.0370908
S100A9 S100 calcium binding protein A9 -0.035923
RPL7A ribosomal protein L7a -0.0354817
RPS25 ribosomal protein S25 -0.0350017
RACK1 receptor for activated C kinase 1 -0.0347976
BTG1 B-cell translocation gene 1, anti-proliferative -0.0338491
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0331802
RPS21 ribosomal protein S21 -0.0331789
FLNB filamin B, beta -0.0331678
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0331224
RPLP0 ribosomal protein, large, P0 -0.0330138
STC1 stanniocalcin 1 -0.0329119
RPS2 ribosomal protein S2 -0.0328429
RPS10 ribosomal protein S10 -0.0325344
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0322584
RPS17 ribosomal protein S17 -0.0317548
NABP1 nucleic acid binding protein 1 -0.0315376
RPL11 ribosomal protein L11 -0.0311587
HLA-A major histocompatibility complex, class I, A -0.0308593
RPL28 ribosomal protein L28 -0.0307314
RPL7 ribosomal protein L7 -0.0301154
IGFBP7 insulin-like growth factor binding protein 7 -0.0298784
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0295352
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0294747
RPS5 ribosomal protein S5 -0.0293301
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0289246
RAB7A RAB7A, member RAS oncogene family -0.0288226
RND3 Rho family GTPase 3 -0.0286014
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0276983
IGFBP3 insulin-like growth factor binding protein 3 -0.0276479
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0274466
LOX lysyl oxidase -0.026909
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.026743
WSB1 WD repeat and SOCS box containing 1 -0.0261852
RPL27A ribosomal protein L27a -0.0259465
SLC38A1 solute carrier family 38, member 1 -0.0256958
SRSF11 serine/arginine-rich splicing factor 11 -0.0256217
RPL21 ribosomal protein L21 -0.0251018
RPL15 ribosomal protein L15 -0.0250522
TBCA tubulin folding cofactor A -0.0249151
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0246535
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.024494
MBNL1 muscleblind-like splicing regulator 1 -0.0244546
MAP1B microtubule-associated protein 1B -0.0242408
ASTN2 astrotactin 2 -0.0241752
RPL18 ribosomal protein L18 -0.0241691
KTN1 kinectin 1 (kinesin receptor) -0.0240109
UQCRB ubiquinol-cytochrome c reductase binding protein -0.023788