Nevirapine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.0811827
MYH9 myosin, heavy chain 9, non-muscle 0.0403275
ERRFI1 ERBB receptor feedback inhibitor 1 0.0384109
FN1 fibronectin 1 0.0375151
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.02787
AKAP12 A kinase (PRKA) anchor protein 12 0.0273826
FRMD6 FERM domain containing 6 0.0255725
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0244479
MYOF myoferlin 0.0230071
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0227334
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0225118
MAML2 mastermind-like 2 (Drosophila) 0.0217779
NKD1 naked cuticle homolog 1 (Drosophila) 0.0217732
CDH13 cadherin 13 0.0210976
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0205323
ANO6 anoctamin 6 0.0204982
SOD2 superoxide dismutase 2, mitochondrial 0.0198618
FMNL2 formin-like 2 0.0196837
KDM6A lysine (K)-specific demethylase 6A 0.0196304
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0196288
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0194077
TVP23C-CDRT4 TVP23C-CDRT4 readthrough 0.0188577
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0184195
SH3GL1 SH3-domain GRB2-like 1 0.0182333
SON SON DNA binding protein 0.018099
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0177553
ESYT2 extended synaptotagmin-like protein 2 0.0174685
DST dystonin 0.0172754
PLEC plectin 0.0172671
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0170889
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0169726
LOXL2 lysyl oxidase-like 2 0.0164982
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0162523
ANKRD11 ankyrin repeat domain 11 0.0161562
RASAL2 RAS protein activator like 2 0.0161404
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0161043
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0159927
YTHDC1 YTH domain containing 1 0.0156038
MEF2A myocyte enhancer factor 2A 0.0153096
SMYD3 SET and MYND domain containing 3 0.0151585
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0147982
INTS10 integrator complex subunit 10 0.0146623
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0144608
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0144519
RASA3 RAS p21 protein activator 3 0.0143859
ATP13A3 ATPase type 13A3 0.0140017
TENT5A terminal nucleotidyltransferase 5A 0.0139881
CKAP5 cytoskeleton associated protein 5 0.0139368
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0137569
MSH3 mutS homolog 3 0.0137173
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0136353
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0135792
ABI2 abl-interactor 2 0.0135654
SERINC3 serine incorporator 3 0.0133366
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0132545
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0132393
SEPTIN2 septin 2 0.0131925
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.013151
EPS8 epidermal growth factor receptor pathway substrate 8 0.0130914
MARF1 meiosis regulator and mRNA stability factor 1 0.0130223
SEPTIN9 septin 9 0.0128486
ITCH itchy E3 ubiquitin protein ligase 0.0127772
HJURP Holliday junction recognition protein 0.0127009
NUDCD3 NudC domain containing 3 0.0126207
NOTCH2 notch 2 0.0125883
PREPL prolyl endopeptidase-like 0.0125844
WASHC4 WASH complex subunit 4 0.0125197
ANLN anillin, actin binding protein 0.0125001
TBC1D22A TBC1 domain family, member 22A 0.0124169
TCERG1 transcription elongation regulator 1 0.0123834
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0123234
PATJ PATJ crumbs cell polarity complex component 0.0123195
VGF VGF nerve growth factor inducible 0.0122942
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0122639
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 0.0122526
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0121807
ZFR zinc finger RNA binding protein 0.0121542
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 0.0119222
SLC35F5 solute carrier family 35, member F5 0.0119068
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.0119052
ARRDC3 arrestin domain containing 3 0.0118548
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0117471
ATXN1 ataxin 1 0.0117449
CBFB core-binding factor, beta subunit 0.0117332
PDE4D phosphodiesterase 4D, cAMP-specific 0.0116463
CDC42 cell division cycle 42 0.0116322
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0115791
LRP12 low density lipoprotein receptor-related protein 12 0.0115483
BICD1 bicaudal D homolog 1 (Drosophila) 0.0115226
FAM219A family with sequence similarity 219, member A 0.0115073
PDE8A phosphodiesterase 8A 0.0115009
TP53BP1 tumor protein p53 binding protein 1 0.0114809
NCOR1 nuclear receptor corepressor 1 0.0114779
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0114361
ACTN1 actinin, alpha 1 0.0114194
WWC2 WW and C2 domain containing 2 0.0113939
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.011391
TMEM245 transmembrane protein 245 0.0113241
PTGES2 prostaglandin E synthase 2 0.0113097
DYNC2I1 dynein 2 intermediate chain 1 0.0113022

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.158931
TMSB10 thymosin beta 10 -0.14783
MT2A metallothionein 2A -0.132751
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123899
VIM vimentin -0.122119
HLA-B major histocompatibility complex, class I, B -0.0979325
TGFBI transforming growth factor, beta-induced, 68kDa -0.0883837
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0579953
FTL ferritin, light polypeptide -0.0573781
B2M beta-2-microglobulin -0.0554639
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0550818
CALD1 caldesmon 1 -0.050377
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0501324
IGFBP7 insulin-like growth factor binding protein 7 -0.0484203
CALR calreticulin -0.0423321
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0415465
MT1X metallothionein 1X -0.0412891
POTEF POTE ankyrin domain family, member F -0.0393665
FTH1 ferritin, heavy polypeptide 1 -0.0385113
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0366971
HIP1 huntingtin interacting protein 1 -0.0352479
RPS8 ribosomal protein S8 -0.0308536
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0307938
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0306565
NAMPT nicotinamide phosphoribosyltransferase -0.0296074
PTMA prothymosin, alpha -0.0289135
RPL23 ribosomal protein L23 -0.028567
RPL34 ribosomal protein L34 -0.0284963
TPT1 tumor protein, translationally-controlled 1 -0.0277116
GARS1 glycyl-tRNA synthetase 1 -0.0272885
RPL35A ribosomal protein L35a -0.0265156
ANXA2 annexin A2 -0.0257783
RPLP1 ribosomal protein, large, P1 -0.0241042
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0240372
CAVIN1 caveolae associated protein 1 -0.0237955
ADM adrenomedullin -0.0236756
RNF145 ring finger protein 145 -0.0233427
RPLP2 ribosomal protein, large, P2 -0.0232552
PGK1 phosphoglycerate kinase 1 -0.0231842
WAC WW domain containing adaptor with coiled-coil -0.0230845
S100A6 S100 calcium binding protein A6 -0.0226169
STC1 stanniocalcin 1 -0.0222986
SLC38A2 solute carrier family 38, member 2 -0.0220269
TNS3 tensin 3 -0.0217095
NDRG1 N-myc downstream regulated 1 -0.0215409
RND3 Rho family GTPase 3 -0.0212998
RPL37 ribosomal protein L37 -0.0210991
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0208545
HLA-A major histocompatibility complex, class I, A -0.0205664
S100A9 S100 calcium binding protein A9 -0.020549
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0205448
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0205375
RBM39 RNA binding motif protein 39 -0.0204798
OSMR oncostatin M receptor -0.0203775
ACTG1 actin gamma 1 -0.020122
RPL11 ribosomal protein L11 -0.0201094
ZFAND3 zinc finger, AN1-type domain 3 -0.0200113
PDIA6 protein disulfide isomerase family A, member 6 -0.0199483
SERF2 small EDRK-rich factor 2 -0.0197325
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0193055
PTN pleiotrophin -0.0191611
TPM4 tropomyosin 4 -0.0191381
RPL37A ribosomal protein L37a -0.0189962
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0189696
GNAS GNAS complex locus -0.0187246
RPL28 ribosomal protein L28 -0.0185007
ZNF395 zinc finger protein 395 -0.0182016
S100A10 S100 calcium binding protein A10 -0.0176596
RAB7A RAB7A, member RAS oncogene family -0.0176022
RPS27A ribosomal protein S27a -0.017492
HLA-C major histocompatibility complex, class I, C -0.01725
SRP72 signal recognition particle 72kDa -0.0170764
MAP1B microtubule-associated protein 1B -0.0168935
CBX3 chromobox homolog 3 -0.0167842
RACK1 receptor for activated C kinase 1 -0.0167434
KYNU kynureninase -0.0167066
RPS6 ribosomal protein S6 -0.0162956
CNOT8 CCR4-NOT transcription complex, subunit 8 -0.0162273
BHLHE40 basic helix-loop-helix family, member e40 -0.0161399
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0161299
SETD5 SET domain containing 5 -0.0157316
RPL26 ribosomal protein L26 -0.0157114
UBC ubiquitin C -0.0156117
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0153903
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0153143
MAP4 microtubule-associated protein 4 -0.0153055
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0152465
SEPTIN7 septin 7 -0.0150536
TPI1 triosephosphate isomerase 1 -0.0150078
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0147079
DSTN destrin (actin depolymerizing factor) -0.0146857
CCNI cyclin I -0.0145752
PRSS23 protease, serine, 23 -0.0145085
ENO1 enolase 1, (alpha) -0.0145028
TBCA tubulin folding cofactor A -0.0144403
FAF2 Fas associated factor family member 2 -0.0144279
CKAP4 cytoskeleton-associated protein 4 -0.0143994
PDLIM5 PDZ and LIM domain 5 -0.01436
RAB1A RAB1A, member RAS oncogene family -0.0143385
UBXN4 UBX domain protein 4 -0.01432