Nevirapine_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.106272
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0948032
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0786581
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0739361
LOC112694756 uncharaterized LOC112694756 0.0623747
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0621976
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0586054
NUP58 nucleoporin 58 0.0541159
RPL23 ribosomal protein L23 0.047058
EEF2 eukaryotic translation elongation factor 2 0.0431239
TXNRD1 thioredoxin reductase 1 0.0424242
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0404657
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0401358
WAC WW domain containing adaptor with coiled-coil 0.038566
RPS12 ribosomal protein S12 0.0385145
CALU calumenin 0.0374224
EIF1 eukaryotic translation initiation factor 1 0.0366516
SET SET nuclear proto-oncogene 0.0366106
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.03656
ZNF292 zinc finger protein 292 0.0348689
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0334466
TNPO1 transportin 1 0.0333869
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0332782
ANKRD37 ankyrin repeat domain 37 0.0314896
RPS3 ribosomal protein S3 0.030396
PCBP2 poly(rC) binding protein 2 0.0300547
COPA coatomer protein complex, subunit alpha 0.0298838
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0296896
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0295954
BIRC3 baculoviral IAP repeat containing 3 0.0292207
RPLP0 ribosomal protein, large, P0 0.0286972
FTL ferritin, light polypeptide 0.0286591
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.028531
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0285079
HILPDA hypoxia inducible lipid droplet-associated 0.0283011
RACK1 receptor for activated C kinase 1 0.0280476
RPLP1 ribosomal protein, large, P1 0.0278223
CENPF centromere protein F, 350/400kDa 0.0276081
RPL9 ribosomal protein L9 0.0275503
RPL3 ribosomal protein L3 0.0275211
RPL26 ribosomal protein L26 0.0274411
IARS1 isoleucyl-tRNA synthetase 1 0.0274044
PDIA3 protein disulfide isomerase family A, member 3 0.0273097
ENO1 enolase 1, (alpha) 0.0269835
SEC23A Sec23 homolog A (S. cerevisiae) 0.0267891
TFG TRK-fused gene 0.0267871
RPS17 ribosomal protein S17 0.0264935
RPS8 ribosomal protein S8 0.0260273
COPB1 coatomer protein complex, subunit beta 1 0.025631
CLTC clathrin, heavy chain (Hc) 0.0254831
MT2A metallothionein 2A 0.0254338
PUM2 pumilio RNA-binding family member 2 0.0253405
UBC ubiquitin C 0.0252439
UBA6 ubiquitin-like modifier activating enzyme 6 0.0250207
RPL11 ribosomal protein L11 0.0247621
CHD1 chromodomain helicase DNA binding protein 1 0.0244649
RPL5 ribosomal protein L5 0.0243116
RPL12 ribosomal protein L12 0.0239704
RAB5A RAB5A, member RAS oncogene family 0.0239605
LOC102724023 ES1 protein homolog, mitochondrial 0.0234629
NAMPT nicotinamide phosphoribosyltransferase 0.023415
HMGB2 high mobility group box 2 0.0232347
SGO2 shugoshin 2 0.0231516
RRBP1 ribosome binding protein 1 0.0227535
RARS1 arginyl-tRNA synthetase 1 0.022536
ECT2 epithelial cell transforming 2 0.0225219
NAP1L1 nucleosome assembly protein 1-like 1 0.022316
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0222738
COG6 component of oligomeric golgi complex 6 0.0219612
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0218891
CKAP2L cytoskeleton associated protein 2-like 0.0218202
HSPA8 heat shock 70kDa protein 8 0.0218201
GOLGA2 golgin A2 0.021777
HSPH1 heat shock 105kDa/110kDa protein 1 0.0217687
DIAPH3 diaphanous-related formin 3 0.0217255
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0216909
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0216333
RPS25 ribosomal protein S25 0.0215225
DDB1 damage-specific DNA binding protein 1, 127kDa 0.0215211
HJURP Holliday junction recognition protein 0.0214731
RPS6 ribosomal protein S6 0.0214698
TPX2 TPX2, microtubule-associated 0.0214583
COG5 component of oligomeric golgi complex 5 0.0211233
TXN2 thioredoxin 2 0.0211084
CLIP2 CAP-GLY domain containing linker protein 2 0.0207947
PRRC1 proline-rich coiled-coil 1 0.0207749
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 0.0206797
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0205597
HP1BP3 heterochromatin protein 1, binding protein 3 0.0205161
KIAA1958 KIAA1958 0.0204203
GOLT1B golgi transport 1B 0.0203078
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0202286
RPL35A ribosomal protein L35a 0.0202277
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0201702
LDHA lactate dehydrogenase A 0.0201257
TTK TTK protein kinase 0.0200812
SNX1 sorting nexin 1 0.019933
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.019919
MTDH metadherin 0.019779
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0195953

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.149627
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.119108
CD44 CD44 molecule (Indian blood group) -0.107565
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0837669
HMGA2 high mobility group AT-hook 2 -0.0813206
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0804013
RIGI RNA sensor RIG-I -0.0712347
DST dystonin -0.0706074
AHNAK AHNAK nucleoprotein -0.069584
ZBTB20 zinc finger and BTB domain containing 20 -0.0614109
TAS2R14 taste receptor, type 2, member 14 -0.0607234
SMYD3 SET and MYND domain containing 3 -0.0601995
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0548029
SLC38A2 solute carrier family 38, member 2 -0.0547424
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0528297
SVIL supervillin -0.0525025
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0519751
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0517606
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.051541
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0512917
PRKCA protein kinase C, alpha -0.0509246
NT5E 5'-nucleotidase, ecto (CD73) -0.0509045
SH3KBP1 SH3-domain kinase binding protein 1 -0.0504589
ATM ATM serine/threonine kinase -0.0500314
DPYD dihydropyrimidine dehydrogenase -0.0498129
NAV2 neuron navigator 2 -0.0491639
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0488621
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.048669
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0482443
FMN1 formin 1 -0.0480147
ANO6 anoctamin 6 -0.0479273
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0475013
RNF213 ring finger protein 213 -0.0462978
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0447429
SAMD4A sterile alpha motif domain containing 4A -0.0442946
HDAC9 histone deacetylase 9 -0.0437573
FLNB filamin B, beta -0.0435749
IGF2 insulin-like growth factor 2 -0.0434577
VCL vinculin -0.0433755
COL5A1 collagen, type V, alpha 1 -0.0414621
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0407861
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0405593
ANGPTL4 angiopoietin-like 4 -0.040498
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.040253
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0401429
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0398264
GPC6 glypican 6 -0.0396171
OSMR oncostatin M receptor -0.0395114
RAI14 retinoic acid induced 14 -0.0391829
TRIO trio Rho guanine nucleotide exchange factor -0.038226
ATXN1 ataxin 1 -0.0380573
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0380451
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0374635
EFNA5 ephrin-A5 -0.0373776
IGF1R insulin-like growth factor 1 receptor -0.0372543
FMNL2 formin-like 2 -0.035878
ANXA2 annexin A2 -0.0355613
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0355549
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0354198
BASP1 brain abundant, membrane attached signal protein 1 -0.0352149
TNRC6B trinucleotide repeat containing 6B -0.0351392
MACF1 microtubule-actin crosslinking factor 1 -0.0351378
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0349005
MBD5 methyl-CpG binding domain protein 5 -0.0346808
CAPRIN2 caprin family member 2 -0.0346636
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0345723
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.034564
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0345052
FER fer (fps/fes related) tyrosine kinase -0.0340953
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0340687
IL1RAP interleukin 1 receptor accessory protein -0.0339046
EGR1 early growth response 1 -0.0336765
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0335306
AEBP2 AE binding protein 2 -0.0330986
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.032495
PTK2 protein tyrosine kinase 2 -0.0322956
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0320757
PARD3 par-3 family cell polarity regulator -0.0318849
TPT1 tumor protein, translationally-controlled 1 -0.0316294
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0311115
PCED1B PC-esterase domain containing 1B -0.0308562
LPP LIM domain containing preferred translocation partner in lipoma -0.0304815
SMAD3 SMAD family member 3 -0.0302677
BCAR3 breast cancer anti-estrogen resistance 3 -0.030123
MYO9B myosin IXB -0.0300615
IGFBP3 insulin-like growth factor binding protein 3 -0.0297186
SEPTIN9 septin 9 -0.0296483
FNDC3A fibronectin type III domain containing 3A -0.0295762
EXT1 exostosin glycosyltransferase 1 -0.0294505
TCF12 transcription factor 12 -0.0294451
BHLHE40 basic helix-loop-helix family, member e40 -0.0292903
CCNH cyclin H -0.029097
CYTH1 cytohesin 1 -0.0290656
CEP112 centrosomal protein 112kDa -0.0289431
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0289258
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0287155
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0285045
ZNF609 zinc finger protein 609 -0.028419
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0281352
CUX1 cut-like homeobox 1 -0.0276528