Nevirapine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Nevirapine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Nevirapine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0873972
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0858537
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0660502
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0652982
OGA O-GlcNAcase 0.0603869
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0561887
WAC WW domain containing adaptor with coiled-coil 0.0492507
CENPF centromere protein F, 350/400kDa 0.0457735
NEK7 NIMA-related kinase 7 0.0429101
ETNK1 ethanolamine kinase 1 0.0378761
EPS8 epidermal growth factor receptor pathway substrate 8 0.0359479
TM9SF3 transmembrane 9 superfamily member 3 0.0357499
MIS18BP1 MIS18 binding protein 1 0.0356855
NAP1L1 nucleosome assembly protein 1-like 1 0.0353922
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0353584
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0353184
PABPC1 poly(A) binding protein, cytoplasmic 1 0.035192
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0345073
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0338756
PNISR PNN-interacting serine/arginine-rich protein 0.0338481
LCORL ligand dependent nuclear receptor corepressor-like 0.0333637
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0326805
ZNF292 zinc finger protein 292 0.0326515
SMOX spermine oxidase 0.0325835
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0311808
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0308175
COG5 component of oligomeric golgi complex 5 0.0305931
AHR aryl hydrocarbon receptor 0.029814
NIPBL Nipped-B homolog (Drosophila) 0.0297618
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0296789
RNF145 ring finger protein 145 0.0296023
MARCHF6 membrane associated ring-CH-type finger 6 0.0294653
RAB8B RAB8B, member RAS oncogene family 0.0294423
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0293279
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0290571
XPO1 exportin 1 0.029023
RAD21 RAD21 homolog (S. pombe) 0.0286886
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0282582
ANLN anillin, actin binding protein 0.0282255
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0281989
NRIP1 nuclear receptor interacting protein 1 0.0281192
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0277101
ARRDC3 arrestin domain containing 3 0.0271037
SINHCAF SIN3-HDAC complex associated factor 0.026997
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0267234
CDC73 cell division cycle 73 0.0265347
TXNIP thioredoxin interacting protein 0.0264888
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0263987
RBM33 RNA binding motif protein 33 0.0259003
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0253599
RIOK3 RIO kinase 3 0.0249667
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0249459
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0249207
WDR26 WD repeat domain 26 0.0247371
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0246629
PCM1 pericentriolar material 1 0.0244243
SUCO SUN domain containing ossification factor 0.024395
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0242409
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0241586
RAB18 RAB18, member RAS oncogene family 0.024034
OLA1 Obg-like ATPase 1 0.0240231
JMJD1C jumonji domain containing 1C 0.0240073
RICTOR RPTOR independent companion of MTOR, complex 2 0.0239319
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0238756
GOLGA4 golgin A4 0.0237647
ZFR zinc finger RNA binding protein 0.0236911
ZC3H15 zinc finger CCCH-type containing 15 0.0234741
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0232804
SPRED2 sprouty-related, EVH1 domain containing 2 0.0232232
NCKAP1 NCK-associated protein 1 0.0231341
FGFR1OP2 FGFR1 oncogene partner 2 0.0231061
FBXL5 F-box and leucine-rich repeat protein 5 0.0229032
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0227986
TFG TRK-fused gene 0.0227759
SGO2 shugoshin 2 0.0224103
ZC3H11A zinc finger CCCH-type containing 11A 0.0222972
IPMK inositol polyphosphate multikinase 0.0222963
PTK2 protein tyrosine kinase 2 0.0222955
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0222921
EEF2 eukaryotic translation elongation factor 2 0.022291
SLTM SAFB-like, transcription modulator 0.022134
CLINT1 clathrin interactor 1 0.0221191
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.022061
PRRC2C proline-rich coiled-coil 2C 0.0219386
SEPTIN7 septin 7 0.021897
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0218477
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0218152
SMAD3 SMAD family member 3 0.0218092
TENT2 terminal nucleotidyltransferase 2 0.0216
KTN1 kinectin 1 (kinesin receptor) 0.021477
PUM2 pumilio RNA-binding family member 2 0.0213915
GRB2 growth factor receptor-bound protein 2 0.021181
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0211649
FAM168B family with sequence similarity 168, member B 0.0210891
ECT2 epithelial cell transforming 2 0.0209861
GCC2 GRIP and coiled-coil domain containing 2 0.0208162
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0207825
SCAF11 SR-related CTD-associated factor 11 0.0207635
NUP58 nucleoporin 58 0.0206561
PELO pelota homolog (Drosophila) 0.0206409

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.305669
NRG1 neuregulin 1 -0.288343
HMGA2 high mobility group AT-hook 2 -0.146085
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.121585
MRPS6 mitochondrial ribosomal protein S6 -0.11623
NDRG1 N-myc downstream regulated 1 -0.0964122
TMSB10 thymosin beta 10 -0.0955042
SQSTM1 sequestosome 1 -0.0932368
STC2 stanniocalcin 2 -0.0917652
FTL ferritin, light polypeptide -0.0902532
ITGA1 integrin, alpha 1 -0.0885381
GRB10 growth factor receptor-bound protein 10 -0.086123
PTMA prothymosin, alpha -0.0835323
RAI14 retinoic acid induced 14 -0.0797552
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0792029
TRIO trio Rho guanine nucleotide exchange factor -0.077112
ASPH aspartate beta-hydroxylase -0.0766251
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0750636
IFI27 interferon, alpha-inducible protein 27 -0.0739711
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0722098
LIMCH1 LIM and calponin homology domains 1 -0.070839
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0706502
PLIN2 perilipin 2 -0.0700565
SYT1 synaptotagmin I -0.0682307
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0656037
AKAP12 A kinase (PRKA) anchor protein 12 -0.0651975
ENO2 enolase 2 (gamma, neuronal) -0.0612911
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0595313
POTEF POTE ankyrin domain family, member F -0.0594408
HLA-B major histocompatibility complex, class I, B -0.0553835
LOC102724023 ES1 protein homolog, mitochondrial -0.0539159
EFNA5 ephrin-A5 -0.0521153
ACTG1 actin gamma 1 -0.0511014
CADM1 cell adhesion molecule 1 -0.0499537
SOX4 SRY (sex determining region Y)-box 4 -0.0484242
HIPK2 homeodomain interacting protein kinase 2 -0.0480853
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0433556
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0422981
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0414798
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0412547
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0401748
IGFBP3 insulin-like growth factor binding protein 3 -0.0400609
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0397961
LMNA lamin A/C -0.0377473
FBN1 fibrillin 1 -0.0366776
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.036609
S100A6 S100 calcium binding protein A6 -0.0364533
SLC35F3 solute carrier family 35, member F3 -0.0360572
TMSB4X thymosin beta 4, X-linked -0.0359112
ENO1 enolase 1, (alpha) -0.0358436
DNAH5 dynein, axonemal, heavy chain 5 -0.0356921
EGR1 early growth response 1 -0.0352599
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0349265
TPT1 tumor protein, translationally-controlled 1 -0.0343384
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.034221
AHRR aryl-hydrocarbon receptor repressor -0.0340297
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0331569
ZBTB20 zinc finger and BTB domain containing 20 -0.0323644
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0323149
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0322262
CTBP2 C-terminal binding protein 2 -0.0314059
PDE4D phosphodiesterase 4D, cAMP-specific -0.0312169
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0311608
FTH1 ferritin, heavy polypeptide 1 -0.0310286
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0304493
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.030305
SOX5 SRY (sex determining region Y)-box 5 -0.0301835
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0298244
IFI6 interferon, alpha-inducible protein 6 -0.029451
GLUL glutamate-ammonia ligase -0.0292996
CUX1 cut-like homeobox 1 -0.0290849
TNS3 tensin 3 -0.0288431
MYO1E myosin IE -0.0285726
RNF213 ring finger protein 213 -0.0282759
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0280221
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0279819
TENM4 teneurin transmembrane protein 4 -0.0276859
IL6 interleukin 6 -0.0273324
DUSP6 dual specificity phosphatase 6 -0.0272937
TGFA transforming growth factor, alpha -0.0270183
RAD51B RAD51 paralog B -0.0268764
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0268639
RASAL2 RAS protein activator like 2 -0.026768
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0267313
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0265753
PKM pyruvate kinase, muscle -0.0265392
MCL1 myeloid cell leukemia 1 -0.026271
ZMYND8 zinc finger, MYND-type containing 8 -0.0260287
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0258883
IER3 immediate early response 3 -0.0258203
MYOF myoferlin -0.0253378
SLC38A2 solute carrier family 38, member 2 -0.0252294
MAP1B microtubule-associated protein 1B -0.0251123
LRMDA leucine rich melanocyte differentiation associated -0.0248714
SFRP1 secreted frizzled-related protein 1 -0.02482
PRKCA protein kinase C, alpha -0.0247803
HMGA1 high mobility group AT-hook 1 -0.0246034
LOXL2 lysyl oxidase-like 2 -0.0245327
KRT81 keratin 81, type II -0.024509
ARHGAP35 Rho GTPase activating protein 35 -0.0242413