Niclosamide (olamine)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH13 cadherin 13 0.152472
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.112871
COL5A1 collagen, type V, alpha 1 0.104037
AHNAK AHNAK nucleoprotein 0.0888198
PODXL podocalyxin-like 0.0866835
SQSTM1 sequestosome 1 0.0841561
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.082812
MAP1B microtubule-associated protein 1B 0.0803898
IGFBP3 insulin-like growth factor binding protein 3 0.0793723
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0733472
FN1 fibronectin 1 0.0676182
TPM4 tropomyosin 4 0.0674078
EGFR epidermal growth factor receptor 0.0661895
SLC39A11 solute carrier family 39, member 11 0.0659057
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0633258
MACF1 microtubule-actin crosslinking factor 1 0.0607173
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0548364
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.05455
FLNA filamin A, alpha 0.0525397
VIM vimentin 0.0512218
EEF2 eukaryotic translation elongation factor 2 0.051091
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0502559
HSPH1 heat shock 105kDa/110kDa protein 1 0.0459537
FSTL1 follistatin-like 1 0.0451478
ASPH aspartate beta-hydroxylase 0.0446305
CALR calreticulin 0.044103
AHNAK2 AHNAK nucleoprotein 2 0.0430953
ABI3BP ABI family, member 3 (NESH) binding protein 0.0428007
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0422312
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0412604
RND3 Rho family GTPase 3 0.0407181
PBX3 pre-B-cell leukemia homeobox 3 0.0393383
MSN moesin 0.0380323
TPM3 tropomyosin 3 0.0365103
CENPF centromere protein F, 350/400kDa 0.0361462
DST dystonin 0.0360829
NIBAN1 niban apoptosis regulator 1 0.0359225
CYTH3 cytohesin 3 0.0359151
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0347184
SUCNR1 succinate receptor 1 0.0345702
EFNA5 ephrin-A5 0.0335909
POTEF POTE ankyrin domain family, member F 0.0332482
ALCAM activated leukocyte cell adhesion molecule 0.0328545
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.032745
ANKRD11 ankyrin repeat domain 11 0.0327102
LRRC17 leucine rich repeat containing 17 0.0326038
GOLGA4 golgin A4 0.0316897
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0309809
SORBS2 sorbin and SH3 domain containing 2 0.0308783
LMNA lamin A/C 0.0308456
CANX calnexin 0.0303212
BHLHE40 basic helix-loop-helix family, member e40 0.0298136
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0295266
ERBIN erbb2 interacting protein 0.0294857
GOLGB1 golgin B1 0.0287269
TUSC3 tumor suppressor candidate 3 0.0286632
MYH9 myosin, heavy chain 9, non-muscle 0.0284264
PKM pyruvate kinase, muscle 0.0282296
APP amyloid beta (A4) precursor protein 0.0278429
CLTC clathrin, heavy chain (Hc) 0.0273655
E2F7 E2F transcription factor 7 0.027201
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0265969
COPA coatomer protein complex, subunit alpha 0.0265386
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.026448
SPIRE1 spire-type actin nucleation factor 1 0.0264432
ZSWIM6 zinc finger, SWIM-type containing 6 0.0261127
RHOBTB3 Rho-related BTB domain containing 3 0.0257094
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.025636
FLT1 fms-related tyrosine kinase 1 0.0255083
TXNRD1 thioredoxin reductase 1 0.0245925
PLEC plectin 0.0244603
MPRIP myosin phosphatase Rho interacting protein 0.0243507
DDR2 discoidin domain receptor tyrosine kinase 2 0.0241199
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0240561
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0234947
DGKG diacylglycerol kinase, gamma 90kDa 0.0233303
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.023276
SET SET nuclear proto-oncogene 0.0230271
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.022682
HDAC9 histone deacetylase 9 0.0225699
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0223032
S100A6 S100 calcium binding protein A6 0.0222636
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0221848
HSPB1 heat shock 27kDa protein 1 0.0220431
NCOR2 nuclear receptor corepressor 2 0.0219094
CALU calumenin 0.0217032
IARS1 isoleucyl-tRNA synthetase 1 0.0215957
RHOA ras homolog family member A 0.0215405
MBNL1 muscleblind-like splicing regulator 1 0.0213431
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0211884
GDI2 GDP dissociation inhibitor 2 0.0211441
LIMS1 LIM and senescent cell antigen-like domains 1 0.0210327
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0209872
ANXA1 annexin A1 0.0209794
PLXNA2 plexin A2 0.0208689
L1CAM L1 cell adhesion molecule 0.0207941
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0206516
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.020616
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0202743
ELOVL5 ELOVL fatty acid elongase 5 0.0202472

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121388
MT2A metallothionein 2A -0.102938
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0843428
FBN1 fibrillin 1 -0.0790371
TMSB10 thymosin beta 10 -0.0738745
DLG1 discs, large homolog 1 (Drosophila) -0.0625487
FNDC3B fibronectin type III domain containing 3B -0.0589838
NDRG1 N-myc downstream regulated 1 -0.0564218
UBC ubiquitin C -0.0497591
OGA O-GlcNAcase -0.0486124
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0485945
ELL2 elongation factor, RNA polymerase II, 2 -0.0467398
SBF2 SET binding factor 2 -0.0450884
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0414682
LOXL2 lysyl oxidase-like 2 -0.041149
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0410422
SOD2 superoxide dismutase 2, mitochondrial -0.0397375
STC1 stanniocalcin 1 -0.0396208
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0379414
LOX lysyl oxidase -0.0371216
FLNB filamin B, beta -0.0362662
ADM adrenomedullin -0.0349783
MT1X metallothionein 1X -0.034888
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0346282
MXI1 MAX interactor 1, dimerization protein -0.0340195
CD44 CD44 molecule (Indian blood group) -0.0339283
KDM3A lysine (K)-specific demethylase 3A -0.0338393
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0326509
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0326508
HLA-B major histocompatibility complex, class I, B -0.0323704
NT5C2 5'-nucleotidase, cytosolic II -0.0314652
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0311858
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0309128
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0308716
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.030776
ZNF292 zinc finger protein 292 -0.0305867
MEIS2 Meis homeobox 2 -0.030316
TXNIP thioredoxin interacting protein -0.0302761
KLF7 Kruppel-like factor 7 (ubiquitous) -0.029855
UBE2O ubiquitin-conjugating enzyme E2O -0.0294644
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0286066
AUTS2 autism susceptibility candidate 2 -0.0280488
IFIH1 interferon induced with helicase C domain 1 -0.0276009
PSD3 pleckstrin and Sec7 domain containing 3 -0.0273933
AKAP12 A kinase (PRKA) anchor protein 12 -0.0269839
WTAP Wilms tumor 1 associated protein -0.0264679
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0263677
ZBTB20 zinc finger and BTB domain containing 20 -0.0262498
ARRDC3 arrestin domain containing 3 -0.0261483
RNF24 ring finger protein 24 -0.0260549
HELZ helicase with zinc finger -0.0257093
WSB1 WD repeat and SOCS box containing 1 -0.0251667
GPC6 glypican 6 -0.0250389
FAM162A family with sequence similarity 162, member A -0.0250291
IFITM3 interferon induced transmembrane protein 3 -0.0248794
COL8A1 collagen, type VIII, alpha 1 -0.0248135
NAMPT nicotinamide phosphoribosyltransferase -0.024571
TMOD1 tropomodulin 1 -0.0244517
INSIG2 insulin induced gene 2 -0.0244126
B2M beta-2-microglobulin -0.024301
IFITM1 interferon induced transmembrane protein 1 -0.0238198
HILPDA hypoxia inducible lipid droplet-associated -0.0237781
FNBP1 formin binding protein 1 -0.0234467
THBS2 thrombospondin 2 -0.0233517
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0233203
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0228021
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.022636
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0223892
PLAUR plasminogen activator, urokinase receptor -0.0222122
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0217098
COL1A2 collagen, type I, alpha 2 -0.0217088
RLF rearranged L-myc fusion -0.0210929
ESYT2 extended synaptotagmin-like protein 2 -0.0209908
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0207451
NGLY1 N-glycanase 1 -0.0207086
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0204838
FAM13A family with sequence similarity 13, member A -0.0203769
DTNA dystrobrevin, alpha -0.0201024
OPTN optineurin -0.0197722
CCL5 chemokine (C-C motif) ligand 5 -0.0197355
USP3 ubiquitin specific peptidase 3 -0.019692
ANKRD12 ankyrin repeat domain 12 -0.0194497
FRMD5 FERM domain containing 5 -0.0192729
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0192523
C1ORF21 chromosome 1 open reading frame 21 -0.0191843
HIP1 huntingtin interacting protein 1 -0.0191125
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0190985
SSBP2 single-stranded DNA binding protein 2 -0.0190657
GLIS3 GLIS family zinc finger 3 -0.0190084
SLC22A23 solute carrier family 22, member 23 -0.0186571
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0184893
DENND5A DENN/MADD domain containing 5A -0.0182585
WDR45B WD repeat domain 45B -0.018253
TRIM56 tripartite motif containing 56 -0.018156
MB21D2 Mab-21 domain containing 2 -0.0181536
FBXL2 F-box and leucine-rich repeat protein 2 -0.0177377
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0177101
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0175736
MTSS1 metastasis suppressor 1 -0.0174714
CD47 CD47 molecule -0.017398