Niclosamide (olamine)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.111729
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0836905
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0793302
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0553185
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0542145
H1-0 H1.0 linker histone 0.0521693
XPO1 exportin 1 0.0508654
FXR1 fragile X mental retardation, autosomal homolog 1 0.050318
PTMA prothymosin, alpha 0.050156
ERRFI1 ERBB receptor feedback inhibitor 1 0.0421688
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0410689
NAP1L1 nucleosome assembly protein 1-like 1 0.0409625
EEF2 eukaryotic translation elongation factor 2 0.0405595
GPBP1 GC-rich promoter binding protein 1 0.0387041
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0385042
EIF4A2 eukaryotic translation initiation factor 4A2 0.0370719
SPAG9 sperm associated antigen 9 0.0367473
SLC38A1 solute carrier family 38, member 1 0.0366187
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0360424
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0360268
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0351636
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0350794
TXNRD1 thioredoxin reductase 1 0.0347359
ANXA1 annexin A1 0.033218
KDM3A lysine (K)-specific demethylase 3A 0.0321753
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.031969
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0311629
PUM2 pumilio RNA-binding family member 2 0.0311223
CANX calnexin 0.0306454
RBM39 RNA binding motif protein 39 0.0305245
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.030405
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0304038
CALR calreticulin 0.0303498
MED13L mediator complex subunit 13-like 0.0286505
MARCHF6 membrane associated ring-CH-type finger 6 0.0281689
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0281258
BIRC6 baculoviral IAP repeat containing 6 0.0277562
TOP2A topoisomerase (DNA) II alpha 170kDa 0.027101
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0270531
PDIA6 protein disulfide isomerase family A, member 6 0.0268743
SQSTM1 sequestosome 1 0.0268344
HSPH1 heat shock 105kDa/110kDa protein 1 0.026617
KMT2E lysine (K)-specific methyltransferase 2E 0.0262811
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0261548
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0259941
WAC WW domain containing adaptor with coiled-coil 0.025415
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0252713
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0250424
KPNB1 karyopherin (importin) beta 1 0.0250111
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0250032
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0246779
ECT2 epithelial cell transforming 2 0.0245812
RAB1A RAB1A, member RAS oncogene family 0.0244326
SETD5 SET domain containing 5 0.0237694
KLF6 Kruppel-like factor 6 0.0237531
CLDN1 claudin 1 0.0236828
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0236487
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0236028
NAMPT nicotinamide phosphoribosyltransferase 0.0235638
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0235093
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0232686
THOC1 THO complex 1 0.022971
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0229674
BIRC3 baculoviral IAP repeat containing 3 0.0220689
CPOX coproporphyrinogen oxidase 0.0219637
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0219191
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0219147
MATR3 matrin 3 0.0217438
NIPBL Nipped-B homolog (Drosophila) 0.0211568
PRRC2C proline-rich coiled-coil 2C 0.0211554
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0208137
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0206755
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0205067
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0202461
LDHB lactate dehydrogenase B 0.0201324
KTN1 kinectin 1 (kinesin receptor) 0.020039
PAPOLA poly(A) polymerase alpha 0.0199942
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0196571
ZNF292 zinc finger protein 292 0.0193938
NPEPPS aminopeptidase puromycin sensitive 0.0193236
TFG TRK-fused gene 0.0192971
HSPB1 heat shock 27kDa protein 1 0.0191368
APP amyloid beta (A4) precursor protein 0.0190132
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0189715
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0188963
U2SURP U2 snRNP-associated SURP domain containing 0.0188668
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0187643
CAMTA1 calmodulin binding transcription activator 1 0.018744
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0185995
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.01858
KIF5B kinesin family member 5B 0.0185772
TRIO trio Rho guanine nucleotide exchange factor 0.0185314
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0185298
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0184181
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0184032
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0179646
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0179638
PDIA3 protein disulfide isomerase family A, member 3 0.0179587
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.017953
CXADR coxsackie virus and adenovirus receptor 0.0178164

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.229845
NLGN1 neuroligin 1 -0.152944
PDE4D phosphodiesterase 4D, cAMP-specific -0.146996
AREG amphiregulin -0.0842397
PCDH7 protocadherin 7 -0.0805243
TMSB10 thymosin beta 10 -0.0746591
DPYD dihydropyrimidine dehydrogenase -0.0679609
ZBTB20 zinc finger and BTB domain containing 20 -0.0589834
TENM3 teneurin transmembrane protein 3 -0.0519024
CELF2 CUGBP, Elav-like family member 2 -0.0509707
SLC38A2 solute carrier family 38, member 2 -0.0489142
PDGFC platelet derived growth factor C -0.0476013
MTAP methylthioadenosine phosphorylase -0.0451517
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0440397
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0426871
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0409036
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0405937
EHBP1 EH domain binding protein 1 -0.0395302
EDARADD EDAR-associated death domain -0.039091
NEBL nebulette -0.0363682
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0357143
HMGA2 high mobility group AT-hook 2 -0.03442
CCSER1 coiled-coil serine-rich protein 1 -0.033394
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0333178
ANKRD12 ankyrin repeat domain 12 -0.0331258
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0329353
ZNF804A zinc finger protein 804A -0.0326665
CMIP c-Maf inducing protein -0.0322206
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0319879
RPS12 ribosomal protein S12 -0.0316292
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0313393
MARCHF4 membrane associated ring-CH-type finger 4 -0.0312204
RIMS2 regulating synaptic membrane exocytosis 2 -0.0305838
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0301164
RABGAP1L RAB GTPase activating protein 1-like -0.0298613
DTNA dystrobrevin, alpha -0.02869
RASAL2 RAS protein activator like 2 -0.0285429
NRXN3 neurexin 3 -0.0276058
VIM vimentin -0.0275436
DST dystonin -0.0263756
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0256522
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0249606
RTN4 reticulon 4 -0.0248816
CCN2 cellular communication network factor 2 -0.0240053
EGR1 early growth response 1 -0.0238222
NABP1 nucleic acid binding protein 1 -0.0237462
DLC1 DLC1 Rho GTPase activating protein -0.0233904
RPLP2 ribosomal protein, large, P2 -0.0233613
TAS2R14 taste receptor, type 2, member 14 -0.0228452
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.021609
MSRB3 methionine sulfoxide reductase B3 -0.0215881
EXOC6B exocyst complex component 6B -0.0215748
VCL vinculin -0.021154
PRR16 proline rich 16 -0.0211314
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0206541
RANBP17 RAN binding protein 17 -0.020402
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0203606
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0201933
NHSL1 NHS-like 1 -0.0201209
SMYD3 SET and MYND domain containing 3 -0.0200774
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0200141
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0198722
MYPN myopalladin -0.0196255
EXOC4 exocyst complex component 4 -0.0192475
RPL12 ribosomal protein L12 -0.0191181
TEAD4 TEA domain family member 4 -0.0189084
NCEH1 neutral cholesterol ester hydrolase 1 -0.0185729
RPL26 ribosomal protein L26 -0.0180277
TRAPPC9 trafficking protein particle complex 9 -0.0177832
PHF14 PHD finger protein 14 -0.0177167
RPS6 ribosomal protein S6 -0.0174806
NEGR1 neuronal growth regulator 1 -0.0173192
TMCC1 transmembrane and coiled-coil domain family 1 -0.0173188
CEP112 centrosomal protein 112kDa -0.0171367
RPL37 ribosomal protein L37 -0.0169909
ANKRD28 ankyrin repeat domain 28 -0.016875
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0168065
RPS19 ribosomal protein S19 -0.0167012
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0164882
RAD51B RAD51 paralog B -0.016316
RPL9 ribosomal protein L9 -0.0163159
ANKRD17 ankyrin repeat domain 17 -0.0160204
MYL12B myosin, light chain 12B, regulatory -0.0159758
RSU1 Ras suppressor protein 1 -0.0159645
RPL11 ribosomal protein L11 -0.0156914
CNRIP1 cannabinoid receptor interacting protein 1 -0.0156508
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0155093
CARD16 caspase recruitment domain family, member 16 -0.015307
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0151654
RPS13 ribosomal protein S13 -0.0149548
RPS29 ribosomal protein S29 -0.014323
SPIDR scaffolding protein involved in DNA repair -0.014224
RPS2 ribosomal protein S2 -0.0142102
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0141799
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0140987
BCAS3 breast carcinoma amplified sequence 3 -0.0137382
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0137352
DOCK1 dedicator of cytokinesis 1 -0.013709
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0136977
EGFR epidermal growth factor receptor -0.0136956