Niclosamide (olamine)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPTBN1 spectrin, beta, non-erythrocytic 1 0.124935
SPAG9 sperm associated antigen 9 0.087179
USP3 ubiquitin specific peptidase 3 0.0760715
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0722333
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0708237
NDRG1 N-myc downstream regulated 1 0.0703862
HELZ helicase with zinc finger 0.0703714
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.070205
ANXA2 annexin A2 0.0592617
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0579685
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0541202
NAV2 neuron navigator 2 0.0535758
KCTD9 potassium channel tetramerization domain containing 9 0.0524299
EEF2 eukaryotic translation elongation factor 2 0.0520631
ANKRD11 ankyrin repeat domain 11 0.0520295
FMNL2 formin-like 2 0.0483338
STC1 stanniocalcin 1 0.0483031
FLNB filamin B, beta 0.0479282
KDM3A lysine (K)-specific demethylase 3A 0.0479266
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0476563
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0464158
NUP58 nucleoporin 58 0.0448292
GOLGA4 golgin A4 0.0445494
RB1CC1 RB1-inducible coiled-coil 1 0.0420562
UBA6 ubiquitin-like modifier activating enzyme 6 0.0412257
PGK1 phosphoglycerate kinase 1 0.0401623
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0388555
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0387918
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.038437
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0383109
FAM107B family with sequence similarity 107, member B 0.0380941
OGA O-GlcNAcase 0.0373525
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0364332
FNDC3B fibronectin type III domain containing 3B 0.0362941
WDR45B WD repeat domain 45B 0.0353129
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0337876
MYH9 myosin, heavy chain 9, non-muscle 0.0333235
GRB10 growth factor receptor-bound protein 10 0.0330133
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.032879
UBC ubiquitin C 0.0327884
RAB1A RAB1A, member RAS oncogene family 0.032666
ELL2 elongation factor, RNA polymerase II, 2 0.0326416
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0309246
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0308938
HILPDA hypoxia inducible lipid droplet-associated 0.0306338
LDHA lactate dehydrogenase A 0.030325
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0296589
SUCO SUN domain containing ossification factor 0.0293
RND3 Rho family GTPase 3 0.0292241
DGKD diacylglycerol kinase, delta 130kDa 0.029187
UBE2O ubiquitin-conjugating enzyme E2O 0.0290697
IQGAP1 IQ motif containing GTPase activating protein 1 0.0288334
CDCA2 cell division cycle associated 2 0.0287763
ADM adrenomedullin 0.0285177
MYOF myoferlin 0.0280021
MORF4L2 mortality factor 4 like 2 0.0279554
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0275109
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0274387
ZNF292 zinc finger protein 292 0.0273548
BIRC6 baculoviral IAP repeat containing 6 0.0270249
NGLY1 N-glycanase 1 0.0268221
KMT2C lysine (K)-specific methyltransferase 2C 0.0267491
C1D C1D nuclear receptor corepressor 0.0265904
TNIP1 TNFAIP3 interacting protein 1 0.0260876
ADAM17 ADAM metallopeptidase domain 17 0.0257121
KMT2E lysine (K)-specific methyltransferase 2E 0.0256407
TPD52 tumor protein D52 0.0254003
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0253538
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0252974
NBAS neuroblastoma amplified sequence 0.0252944
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0249963
RYBP RING1 and YY1 binding protein 0.0247479
ACBD3 acyl-CoA binding domain containing 3 0.024241
TENT4A terminal nucleotidyltransferase 4A 0.0240644
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0236064
RTN4 reticulon 4 0.0234864
ERRFI1 ERBB receptor feedback inhibitor 1 0.0234246
INSIG2 insulin induced gene 2 0.0231845
PLEC plectin 0.0231613
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0230989
RAB7A RAB7A, member RAS oncogene family 0.023097
SEC24A SEC24 family member A 0.0230683
TRA2A transformer 2 alpha homolog (Drosophila) 0.0230619
MCTP1 multiple C2 domains, transmembrane 1 0.0228081
CA12 carbonic anhydrase XII 0.0227055
MAP2K1 mitogen-activated protein kinase kinase 1 0.0225623
MXI1 MAX interactor 1, dimerization protein 0.0224724
ANLN anillin, actin binding protein 0.0221207
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0220797
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0220632
WAC WW domain containing adaptor with coiled-coil 0.021997
CTBP2 C-terminal binding protein 2 0.0219429
PKM pyruvate kinase, muscle 0.0216681
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0214355
CALU calumenin 0.0213328
USP47 ubiquitin specific peptidase 47 0.0212531
TFG TRK-fused gene 0.0211431
ARL5B ADP-ribosylation factor-like 5B 0.0211092
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.020763
FA2H fatty acid 2-hydroxylase 0.0205113

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.222941
TMSB10 thymosin beta 10 -0.111025
MT2A metallothionein 2A -0.0885388
KYNU kynureninase -0.0879691
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0830206
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0797474
PDE10A phosphodiesterase 10A -0.0705245
EFNA5 ephrin-A5 -0.0704156
TXNRD1 thioredoxin reductase 1 -0.0624361
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0605708
AKR1C2 aldo-keto reductase family 1, member C2 -0.0601293
RPS19 ribosomal protein S19 -0.0582392
ZBTB20 zinc finger and BTB domain containing 20 -0.0570104
EHBP1 EH domain binding protein 1 -0.051764
RNF213 ring finger protein 213 -0.0508617
EGFR epidermal growth factor receptor -0.049393
RPS16 ribosomal protein S16 -0.0474549
KRT81 keratin 81, type II -0.0459407
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0420563
IGFBP4 insulin-like growth factor binding protein 4 -0.0417409
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0416664
FTH1 ferritin, heavy polypeptide 1 -0.0416293
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0409859
RPS3 ribosomal protein S3 -0.0405948
RPL37A ribosomal protein L37a -0.0384535
OSMR oncostatin M receptor -0.0378959
RPLP2 ribosomal protein, large, P2 -0.0365185
RPLP1 ribosomal protein, large, P1 -0.0358087
TNS3 tensin 3 -0.035737
GLIS3 GLIS family zinc finger 3 -0.0355803
ASPH aspartate beta-hydroxylase -0.0348458
RPL12 ribosomal protein L12 -0.033929
RPS6 ribosomal protein S6 -0.0333923
TPT1 tumor protein, translationally-controlled 1 -0.0333402
RPL26 ribosomal protein L26 -0.0330872
RPS17 ribosomal protein S17 -0.0330423
RPL23 ribosomal protein L23 -0.0329391
MAML3 mastermind-like 3 (Drosophila) -0.0320348
RPS29 ribosomal protein S29 -0.0318658
KRT18 keratin 18, type I -0.0315721
TPM1 tropomyosin 1 (alpha) -0.03135
KRT7 keratin 7, type II -0.0312396
RPL13A ribosomal protein L13a -0.0302453
RPS27A ribosomal protein S27a -0.0301821
BICC1 BicC family RNA binding protein 1 -0.0291633
DOCK5 dedicator of cytokinesis 5 -0.0290862
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0285368
RIN2 Ras and Rab interactor 2 -0.0283257
RPL19 ribosomal protein L19 -0.0281299
NRG1 neuregulin 1 -0.0280955
RPS12 ribosomal protein S12 -0.0277612
IGFBP3 insulin-like growth factor binding protein 3 -0.0275111
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0271971
VMP1 vacuole membrane protein 1 -0.0271121
EXT1 exostosin glycosyltransferase 1 -0.0268642
RPS24 ribosomal protein S24 -0.026784
FOXP1 forkhead box P1 -0.0263282
CEMIP cell migration inducing protein, hyaluronan binding -0.0262386
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0261845
RPS13 ribosomal protein S13 -0.0250435
CMIP c-Maf inducing protein -0.0246823
RPS8 ribosomal protein S8 -0.0246296
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0244622
SLC35F3 solute carrier family 35, member F3 -0.0244079
FTL ferritin, light polypeptide -0.0244041
S100A6 S100 calcium binding protein A6 -0.0243593
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.0236796
IFI6 interferon, alpha-inducible protein 6 -0.0235511
EREG epiregulin -0.0234766
RPL18 ribosomal protein L18 -0.0233399
NRP1 neuropilin 1 -0.0232631
RPS23 ribosomal protein S23 -0.0228218
RPS11 ribosomal protein S11 -0.0227056
ETV6 ets variant 6 -0.022638
THSD4 thrombospondin, type I, domain containing 4 -0.0225799
MT1X metallothionein 1X -0.0224073
RPL32 ribosomal protein L32 -0.0219098
BMERB1 bMERB domain containing 1 -0.0218309
IGF1R insulin-like growth factor 1 receptor -0.0216597
NCOA7 nuclear receptor coactivator 7 -0.0216283
RPL36A ribosomal protein L36a -0.0215994
RPL11 ribosomal protein L11 -0.0212156
RAI14 retinoic acid induced 14 -0.0210478
LPP LIM domain containing preferred translocation partner in lipoma -0.0207888
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0205356
ZFP36L1 ZFP36 ring finger protein-like 1 -0.020458
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0197902
PBX1 pre-B-cell leukemia homeobox 1 -0.0197272
RPL34 ribosomal protein L34 -0.0196976
KRT8 keratin 8, type II -0.0196376
CXCL5 chemokine (C-X-C motif) ligand 5 -0.0194725
TCF12 transcription factor 12 -0.0190447
ALCAM activated leukocyte cell adhesion molecule -0.0185045
LIMCH1 LIM and calponin homology domains 1 -0.0181672
RPL37 ribosomal protein L37 -0.0181223
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0179585
AKR1C3 aldo-keto reductase family 1, member C3 -0.0179413
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0178601
PTPRM protein tyrosine phosphatase, receptor type, M -0.0176085
RPL31 ribosomal protein L31 -0.0175261