Niclosamide (olamine)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0291263
EFNA5 ephrin-A5 0.0290285
NUP58 nucleoporin 58 0.0285204
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0284651
KMT2C lysine (K)-specific methyltransferase 2C 0.027896
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0262993
KDM3A lysine (K)-specific demethylase 3A 0.0256586
KDM6A lysine (K)-specific demethylase 6A 0.0234898
JMJD1C jumonji domain containing 1C 0.0219671
DST dystonin 0.0207798
HELZ helicase with zinc finger 0.020613
SREBF2 sterol regulatory element binding transcription factor 2 0.020499
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0202081
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0195556
NFIA nuclear factor I/A 0.0194204
NGLY1 N-glycanase 1 0.019404
QKI QKI, KH domain containing, RNA binding 0.0186651
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0184663
ZNF638 zinc finger protein 638 0.0183641
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0182301
AUTS2 autism susceptibility candidate 2 0.0179778
FOXO3 forkhead box O3 0.0179672
FMNL2 formin-like 2 0.0173239
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0173106
TENT4A terminal nucleotidyltransferase 4A 0.0172999
OGA O-GlcNAcase 0.0171556
SSBP2 single-stranded DNA binding protein 2 0.0170866
ATRN attractin 0.0169404
CHD7 chromodomain helicase DNA binding protein 7 0.0166753
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0155246
PIAS2 protein inhibitor of activated STAT, 2 0.0153465
ESYT2 extended synaptotagmin-like protein 2 0.0148185
CAMTA1 calmodulin binding transcription activator 1 0.0148121
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0147832
PTK2 protein tyrosine kinase 2 0.0146524
ZNF292 zinc finger protein 292 0.0144215
MED13L mediator complex subunit 13-like 0.0138293
PDE8A phosphodiesterase 8A 0.013533
ASCC3 activating signal cointegrator 1 complex subunit 3 0.013526
ADGRG6 adhesion G protein-coupled receptor G6 0.0134671
ARB2A ARB2 cotranscriptional regulator A 0.0134286
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0134202
UBA6 ubiquitin-like modifier activating enzyme 6 0.013392
CDC73 cell division cycle 73 0.0132706
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.0132493
MXI1 MAX interactor 1, dimerization protein 0.0132016
FAM168A family with sequence similarity 168, member A 0.0130307
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.0129065
GARS1 glycyl-tRNA synthetase 1 0.0128913
LCORL ligand dependent nuclear receptor corepressor-like 0.012869
PDS5B PDS5 cohesin associated factor B 0.0127128
CASC3 cancer susceptibility candidate 3 0.0127112
RNF145 ring finger protein 145 0.0127035
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0126964
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0126906
FNBP1L formin binding protein 1-like 0.0126461
H1-0 H1.0 linker histone 0.012391
CABIN1 calcineurin binding protein 1 0.0123268
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0121894
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0119414
KDM2A lysine (K)-specific demethylase 2A 0.0118626
MEMO1 mediator of cell motility 1 0.0117145
KMT2E lysine (K)-specific methyltransferase 2E 0.0116918
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0116197
TET2 tet methylcytosine dioxygenase 2 0.0114174
JARID2 jumonji, AT rich interactive domain 2 0.0113511
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0111969
SMAP1 small ArfGAP 1 0.0111821
GSK3B glycogen synthase kinase 3 beta 0.011176
KIF13A kinesin family member 13A 0.0110721
SUCO SUN domain containing ossification factor 0.0110365
BMPR1A bone morphogenetic protein receptor, type IA 0.0108809
MEF2A myocyte enhancer factor 2A 0.0108527
ARHGAP32 Rho GTPase activating protein 32 0.0107164
MSMO1 methylsterol monooxygenase 1 0.0105362
GRID2 glutamate receptor, ionotropic, delta 2 0.0104796
MYO6 myosin VI 0.0104531
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0104257
ARFGEF3 ARFGEF family member 3 0.010414
ZEB1 zinc finger E-box binding homeobox 1 0.010304
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0102422
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0101096
CCNY cyclin Y 0.0100915
NKTR natural killer cell triggering receptor 0.00998298
SMAD6 SMAD family member 6 0.00994703
RLF rearranged L-myc fusion 0.00969324
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00962424
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.00961187
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.00954961
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00948957
SERTAD2 SERTA domain containing 2 0.00944943
STRN3 striatin, calmodulin binding protein 3 0.00940756
ZMYM2 zinc finger, MYM-type 2 0.00934358
USP9X ubiquitin specific peptidase 9, X-linked 0.00927023
BRWD3 bromodomain and WD repeat domain containing 3 0.00915509
TAOK1 TAO kinase 1 0.00915135
UBE2H ubiquitin-conjugating enzyme E2H 0.00912148
ATP11B ATPase, class VI, type 11B 0.00902998
FOXO1 forkhead box O1 0.00899457
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0089897

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.16618
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.128718
PTMA prothymosin, alpha -0.100855
RPS6 ribosomal protein S6 -0.0961626
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0756604
RPS8 ribosomal protein S8 -0.0753814
RPLP1 ribosomal protein, large, P1 -0.075267
TMSB10 thymosin beta 10 -0.0741185
RPL11 ribosomal protein L11 -0.0732472
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0682199
ACTG1 actin gamma 1 -0.0680963
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0671222
IFI6 interferon, alpha-inducible protein 6 -0.0614418
RPLP2 ribosomal protein, large, P2 -0.0585353
RPS12 ribosomal protein S12 -0.0570605
RPS3 ribosomal protein S3 -0.0555771
RPL37A ribosomal protein L37a -0.0547481
RPS21 ribosomal protein S21 -0.0538676
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0532589
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0511764
SLIT2 slit homolog 2 (Drosophila) -0.0501161
RPL12 ribosomal protein L12 -0.049477
RPL34 ribosomal protein L34 -0.0487521
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0486356
RPS29 ribosomal protein S29 -0.0485955
RPS19 ribosomal protein S19 -0.0480569
RPL26 ribosomal protein L26 -0.0458462
ENO1 enolase 1, (alpha) -0.0423278
RPS17 ribosomal protein S17 -0.0404506
RPL31 ribosomal protein L31 -0.0397477
RPL19 ribosomal protein L19 -0.0392392
RPS27A ribosomal protein S27a -0.0384812
RPS25 ribosomal protein S25 -0.038457
RPL28 ribosomal protein L28 -0.0379169
RPL23 ribosomal protein L23 -0.0378558
RPL35A ribosomal protein L35a -0.0377734
TENM3 teneurin transmembrane protein 3 -0.0372904
RPS13 ribosomal protein S13 -0.0370426
CENPF centromere protein F, 350/400kDa -0.0369768
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0369348
RPL9 ribosomal protein L9 -0.036303
RPL7A ribosomal protein L7a -0.03628
RPL36 ribosomal protein L36 -0.0357415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0355666
RPLP0 ribosomal protein, large, P0 -0.0354629
RPS24 ribosomal protein S24 -0.035218
RPL13A ribosomal protein L13a -0.0350503
RAD51B RAD51 paralog B -0.0348638
TPT1 tumor protein, translationally-controlled 1 -0.0346471
B2M beta-2-microglobulin -0.0338714
RPS11 ribosomal protein S11 -0.0328848
RPS16 ribosomal protein S16 -0.0327873
PFN1 profilin 1 -0.0326789
RPL32 ribosomal protein L32 -0.0322144
RPS5 ribosomal protein S5 -0.0310664
RPL35 ribosomal protein L35 -0.0302953
RPL37 ribosomal protein L37 -0.0296048
RPL38 ribosomal protein L38 -0.0292298
HMGB1 high mobility group box 1 -0.0289877
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0289122
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.028899
RPL18 ribosomal protein L18 -0.0287845
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0283956
RPS14 ribosomal protein S14 -0.0283796
MYL12B myosin, light chain 12B, regulatory -0.0283124
TPI1 triosephosphate isomerase 1 -0.0282801
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0282627
S100A9 S100 calcium binding protein A9 -0.0276039
GNAS GNAS complex locus -0.0275378
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0273825
DEK DEK proto-oncogene -0.0272939
RPL27A ribosomal protein L27a -0.0271046
RPS2 ribosomal protein S2 -0.0270149
EIF5B eukaryotic translation initiation factor 5B -0.0267952
RPS10 ribosomal protein S10 -0.0266923
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0266526
RPL36A ribosomal protein L36a -0.0265621
KPNB1 karyopherin (importin) beta 1 -0.0265391
SOX4 SRY (sex determining region Y)-box 4 -0.0265012
RACK1 receptor for activated C kinase 1 -0.0262082
RPS23 ribosomal protein S23 -0.0260135
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0257904
RPS15 ribosomal protein S15 -0.0256002
MKI67 marker of proliferation Ki-67 -0.0253331
LDHA lactate dehydrogenase A -0.025195
SERBP1 SERPINE1 mRNA binding protein 1 -0.0250841
ISG15 ISG15 ubiquitin-like modifier -0.0250154
HMGA1 high mobility group AT-hook 1 -0.0247791
RPL8 ribosomal protein L8 -0.0246604
VIM vimentin -0.0246487
RPL30 ribosomal protein L30 -0.0244906
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0243919
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0243631
MAGEA4 melanoma antigen family A4 -0.0241042
RPL5 ribosomal protein L5 -0.0240804
OSBPL10 oxysterol binding protein-like 10 -0.0238601
PDE4D phosphodiesterase 4D, cAMP-specific -0.023839
YBX1 Y box binding protein 1 -0.0233325
RPS28 ribosomal protein S28 -0.0233097
BPTF bromodomain PHD finger transcription factor -0.0228505