Niclosamide (olamine)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VGF VGF nerve growth factor inducible 0.160088
NDRG1 N-myc downstream regulated 1 0.111759
TIMP3 TIMP metallopeptidase inhibitor 3 0.0660433
GDF15 growth differentiation factor 15 0.0609199
FTH1 ferritin, heavy polypeptide 1 0.0534197
AKAP12 A kinase (PRKA) anchor protein 12 0.0526736
HILPDA hypoxia inducible lipid droplet-associated 0.0505758
BHLHE40 basic helix-loop-helix family, member e40 0.0500434
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0498028
CD109 CD109 molecule 0.0467727
HLA-B major histocompatibility complex, class I, B 0.0421772
ESYT2 extended synaptotagmin-like protein 2 0.0421178
DDIT4 DNA-damage-inducible transcript 4 0.0420942
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0367225
EGR1 early growth response 1 0.0361414
ADM adrenomedullin 0.035812
RNF145 ring finger protein 145 0.0357466
IGFBP3 insulin-like growth factor binding protein 3 0.034219
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0337676
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0337505
KMT2E lysine (K)-specific methyltransferase 2E 0.0333731
PTMA prothymosin, alpha 0.0318639
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0289919
CABIN1 calcineurin binding protein 1 0.0284561
RPLP1 ribosomal protein, large, P1 0.0280484
TAC4 tachykinin 4 (hemokinin) 0.0280101
GOLGA4 golgin A4 0.0266861
RPL37A ribosomal protein L37a 0.025864
RPS19 ribosomal protein S19 0.0257763
RPLP2 ribosomal protein, large, P2 0.0256629
RPL35A ribosomal protein L35a 0.0254287
KMT2C lysine (K)-specific methyltransferase 2C 0.0251228
RPS6 ribosomal protein S6 0.0250013
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0248623
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0248575
ANKRD11 ankyrin repeat domain 11 0.0245529
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0243341
IGFBP5 insulin-like growth factor binding protein 5 0.0242633
RPS12 ribosomal protein S12 0.024009
TPT1 tumor protein, translationally-controlled 1 0.0239984
RPL12 ribosomal protein L12 0.0239872
PLIN2 perilipin 2 0.0238333
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0230564
S100A9 S100 calcium binding protein A9 0.0229416
INSIG1 insulin induced gene 1 0.0228219
RPS8 ribosomal protein S8 0.0226593
RPS2 ribosomal protein S2 0.0225324
S100A6 S100 calcium binding protein A6 0.0224438
KDM5B lysine (K)-specific demethylase 5B 0.0221971
IFITM3 interferon induced transmembrane protein 3 0.0220818
RNF24 ring finger protein 24 0.0220004
PHF21A PHD finger protein 21A 0.0218213
RAB6A RAB6A, member RAS oncogene family 0.0218057
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0214806
YBX1 Y box binding protein 1 0.021353
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0208665
TPI1 triosephosphate isomerase 1 0.0207924
RAB7A RAB7A, member RAS oncogene family 0.0205521
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0204564
RPLP0 ribosomal protein, large, P0 0.0202723
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0202689
FTL ferritin, light polypeptide 0.0201049
HSPB1 heat shock 27kDa protein 1 0.0201035
RLF rearranged L-myc fusion 0.0199195
CDC73 cell division cycle 73 0.0198325
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.0198135
SFTPA2 surfactant protein A2 0.0196784
CTTNBP2 cortactin binding protein 2 0.0196024
PTK2 protein tyrosine kinase 2 0.0195204
WSB1 WD repeat and SOCS box containing 1 0.0192651
RPL11 ribosomal protein L11 0.0192501
CSNK1E casein kinase 1, epsilon 0.0192117
HELZ helicase with zinc finger 0.0191494
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0190007
TPD52 tumor protein D52 0.0188956
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0187425
RPL21 ribosomal protein L21 0.0187334
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0186813
USP37 ubiquitin specific peptidase 37 0.0185669
SEC24A SEC24 family member A 0.0185107
HLA-E major histocompatibility complex, class I, E 0.0184157
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0184086
CALD1 caldesmon 1 0.0183532
RPL36 ribosomal protein L36 0.0183256
PTCHD4 patched domain containing 4 0.0183184
VEGFA vascular endothelial growth factor A 0.0178522
MTDH metadherin 0.0176815
GNAS GNAS complex locus 0.0175998
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0175629
RPL19 ribosomal protein L19 0.0174966
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0172695
HSPG2 heparan sulfate proteoglycan 2 0.0172651
RPS20 ribosomal protein S20 0.0172636
ARF1 ADP-ribosylation factor 1 0.0172486
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0172465
HLA-C major histocompatibility complex, class I, C 0.0172062
RPL8 ribosomal protein L8 0.0170487
CALR calreticulin 0.0170055
BAIAP2L1 BAI1-associated protein 2-like 1 0.0168854
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0167753

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.137116
UBC ubiquitin C -0.132861
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.113076
FN1 fibronectin 1 -0.112746
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.112182
VIM vimentin -0.108257
ASPH aspartate beta-hydroxylase -0.090965
FMN1 formin 1 -0.0816283
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0724655
IFI16 interferon, gamma-inducible protein 16 -0.0681072
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0667957
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0625351
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0607388
GPC6 glypican 6 -0.0596842
AHNAK AHNAK nucleoprotein -0.0594398
ZYX zyxin -0.0575537
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.057253
LRMDA leucine rich melanocyte differentiation associated -0.0511357
ENO1 enolase 1, (alpha) -0.0508192
PCDH7 protocadherin 7 -0.0454984
WWTR1 WW domain containing transcription regulator 1 -0.0419416
TMEM178B transmembrane protein 178B -0.0418984
PCBP2 poly(rC) binding protein 2 -0.0407678
VMP1 vacuole membrane protein 1 -0.03982
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0372104
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0369693
LDHA lactate dehydrogenase A -0.0368681
COL19A1 collagen, type XIX, alpha 1 -0.036105
TSC22D1 TSC22 domain family, member 1 -0.0344796
FRMD4A FERM domain containing 4A -0.0344783
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0343304
IL6ST interleukin 6 signal transducer -0.0340968
SRPK2 SRSF protein kinase 2 -0.03351
ANKRD28 ankyrin repeat domain 28 -0.0326905
APP amyloid beta (A4) precursor protein -0.0319335
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.031693
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0312768
SMYD3 SET and MYND domain containing 3 -0.0312713
ZMYND8 zinc finger, MYND-type containing 8 -0.0308701
GSK3B glycogen synthase kinase 3 beta -0.0308261
NHSL1 NHS-like 1 -0.0308216
GAS7 growth arrest-specific 7 -0.0306818
NAMPT nicotinamide phosphoribosyltransferase -0.0300127
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0299872
LEF1 lymphoid enhancer-binding factor 1 -0.0297917
ACTN1 actinin, alpha 1 -0.0296981
ACTN4 actinin, alpha 4 -0.0295361
SETBP1 SET binding protein 1 -0.029191
LAMB1 laminin, beta 1 -0.0290923
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0288125
MACROD2 MACRO domain containing 2 -0.0285672
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0279388
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0278603
RO60 Ro60, Y RNA binding protein -0.0273756
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.02693
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0268816
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0268407
PI15 peptidase inhibitor 15 -0.0267793
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0263286
PHC2 polyhomeotic homolog 2 (Drosophila) -0.026093
AHR aryl hydrocarbon receptor -0.0259914
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0259432
HMCN1 hemicentin 1 -0.0257588
DPYD dihydropyrimidine dehydrogenase -0.0249776
PKM pyruvate kinase, muscle -0.0249444
DUSP6 dual specificity phosphatase 6 -0.0248805
CLIC4 chloride intracellular channel 4 -0.0248689
SDC2 syndecan 2 -0.0239963
PRELID2 PRELI domain containing 2 -0.0229871
SFPQ splicing factor proline/glutamine-rich -0.022981
EXOC4 exocyst complex component 4 -0.0228683
ZBTB20 zinc finger and BTB domain containing 20 -0.022823
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0227545
FAF1 Fas (TNFRSF6) associated factor 1 -0.0223885
TAGLN2 transgelin 2 -0.0223186
FBXO32 F-box protein 32 -0.0221017
LPP LIM domain containing preferred translocation partner in lipoma -0.0220754
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0217705
EXOC6B exocyst complex component 6B -0.0212434
RCAN1 regulator of calcineurin 1 -0.0210497
TNNC1 troponin C type 1 (slow) -0.021044
UHMK1 U2AF homology motif (UHM) kinase 1 -0.0209395
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0208262
DOCK4 dedicator of cytokinesis 4 -0.0207915
SOX13 SRY (sex determining region Y)-box 13 -0.0205787
RTN4 reticulon 4 -0.0203925
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0201949
SAMD4A sterile alpha motif domain containing 4A -0.0201569
TRIM9 tripartite motif containing 9 -0.0200681
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0199282
PARD3B par-3 family cell polarity regulator beta -0.0197624
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0196841
AKAP13 A kinase (PRKA) anchor protein 13 -0.0196627
ENAH enabled homolog (Drosophila) -0.0193856
ETV1 ets variant 1 -0.0193452
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.019179
FBXL17 F-box and leucine-rich repeat protein 17 -0.0191766
INPP5F inositol polyphosphate-5-phosphatase F -0.019108
BICD1 bicaudal D homolog 1 (Drosophila) -0.0190137
TM4SF1 transmembrane 4 L six family member 1 -0.018832