Niclosamide (olamine)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in HCT15 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Niclosamide (olamine)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.0660881
EEF2 eukaryotic translation elongation factor 2 0.0413928
TPT1 tumor protein, translationally-controlled 1 0.0408683
KRT18 keratin 18, type I 0.0384641
MYH9 myosin, heavy chain 9, non-muscle 0.0373752
LOC112694756 uncharaterized LOC112694756 0.0345436
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0271722
TMSB10 thymosin beta 10 0.0241567
ENO1 enolase 1, (alpha) 0.0228944
FTH1 ferritin, heavy polypeptide 1 0.0226688
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0225695
ERRFI1 ERBB receptor feedback inhibitor 1 0.0212605
DSCAM Down syndrome cell adhesion molecule 0.0211982
PTMA prothymosin, alpha 0.0209291
TBC1D22A TBC1 domain family, member 22A 0.020519
PLEC plectin 0.020062
NDRG1 N-myc downstream regulated 1 0.0200375
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0187473
RPL37A ribosomal protein L37a 0.0175798
ANKRD11 ankyrin repeat domain 11 0.0175168
PRELID2 PRELI domain containing 2 0.0169902
RPL11 ribosomal protein L11 0.0167838
PGK1 phosphoglycerate kinase 1 0.0164546
RPL13A ribosomal protein L13a 0.0162785
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.015605
RPL26 ribosomal protein L26 0.0150865
OGA O-GlcNAcase 0.0150431
ASPH aspartate beta-hydroxylase 0.015033
KRT8 keratin 8, type II 0.0146462
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0144446
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0144301
HDLBP high density lipoprotein binding protein 0.0143334
N4BP2L2 NEDD4 binding protein 2-like 2 0.0143055
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0142916
PLAUR plasminogen activator, urokinase receptor 0.0142714
BTBD9 BTB (POZ) domain containing 9 0.0141372
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0140067
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0135954
EZR ezrin 0.0135388
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0134453
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0134199
RPS3 ribosomal protein S3 0.0129767
RPS27A ribosomal protein S27a 0.0128376
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0128123
MCL1 myeloid cell leukemia 1 0.0126864
PDIA4 protein disulfide isomerase family A, member 4 0.0125832
RPS19 ribosomal protein S19 0.0125373
SERINC5 serine incorporator 5 0.0124667
RPS6 ribosomal protein S6 0.0122988
RAB1A RAB1A, member RAS oncogene family 0.0119462
RPS8 ribosomal protein S8 0.0118384
BZW1 basic leucine zipper and W2 domains 1 0.0117677
FLNA filamin A, alpha 0.0116821
RPLP2 ribosomal protein, large, P2 0.011679
TAS2R14 taste receptor, type 2, member 14 0.0114972
MYO9A myosin IXA 0.0114625
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0113433
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0109144
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.01088
RPL12 ribosomal protein L12 0.0108211
SEC31A SEC31 homolog A (S. cerevisiae) 0.010797
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0107537
SQSTM1 sequestosome 1 0.010745
BACE2 beta-site APP-cleaving enzyme 2 0.0106161
RPLP1 ribosomal protein, large, P1 0.0105223
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0105167
HMGB2 high mobility group box 2 0.010476
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0104632
GOLGB1 golgin B1 0.0104241
PRRC2C proline-rich coiled-coil 2C 0.0102009
MT2A metallothionein 2A 0.0101779
ARFGEF3 ARFGEF family member 3 0.0101329
RPS12 ribosomal protein S12 0.0101315
RBM39 RNA binding motif protein 39 0.0101224
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0100726
MKI67 marker of proliferation Ki-67 0.0100248
EIF1 eukaryotic translation initiation factor 1 0.00992718
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.00986751
TTC17 tetratricopeptide repeat domain 17 0.00975353
DDIT4 DNA-damage-inducible transcript 4 0.00961493
NAP1L1 nucleosome assembly protein 1-like 1 0.00956112
ESYT2 extended synaptotagmin-like protein 2 0.00952047
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00947608
KDM3A lysine (K)-specific demethylase 3A 0.00943241
H1-0 H1.0 linker histone 0.00936069
HLA-C major histocompatibility complex, class I, C 0.0091341
GOLGA2 golgin A2 0.00904342
PATJ PATJ crumbs cell polarity complex component 0.00898119
RPL27A ribosomal protein L27a 0.0089535
MAP2K1 mitogen-activated protein kinase kinase 1 0.00889768
ATXN1 ataxin 1 0.00884223
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.00883466
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00877333
RPL19 ribosomal protein L19 0.00868363
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.00861533
RPL18 ribosomal protein L18 0.00858777
RPS13 ribosomal protein S13 0.00858073
ARHGAP5 Rho GTPase activating protein 5 0.00854133
ANKRD12 ankyrin repeat domain 12 0.00847705
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.00844435

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0616141
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0381959
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0259294
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0232882
POTEF POTE ankyrin domain family, member F -0.0219726
PDIA3 protein disulfide isomerase family A, member 3 -0.020194
PCBP2 poly(rC) binding protein 2 -0.0195414
FAT1 FAT atypical cadherin 1 -0.0188781
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0188765
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0173657
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0131539
PCM1 pericentriolar material 1 -0.0121592
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0121379
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0117634
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0108693
VDAC1 voltage-dependent anion channel 1 -0.0106501
TENM3 teneurin transmembrane protein 3 -0.0102628
HILPDA hypoxia inducible lipid droplet-associated -0.009819
PTBP3 polypyrimidine tract binding protein 3 -0.00968318
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.00965721
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.00857672
PRDX2 peroxiredoxin 2 -0.00826484
ACACA acetyl-CoA carboxylase alpha -0.00814632
TXNIP thioredoxin interacting protein -0.00783847
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.00767025
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.00763747
SRSF3 serine/arginine-rich splicing factor 3 -0.00761485
KDM2A lysine (K)-specific demethylase 2A -0.00748086
PFN1 profilin 1 -0.0072835
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0072725
PUM1 pumilio RNA-binding family member 1 -0.00700571
TAPBP TAP binding protein (tapasin) -0.00698678
BAG6 BCL2-associated athanogene 6 -0.006921
INSIG1 insulin induced gene 1 -0.00687067
TRA2B transformer 2 beta homolog (Drosophila) -0.00683789
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.00676789
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.00667237
RBBP4 retinoblastoma binding protein 4 -0.00666928
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0066395
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.00655247
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.00654945
CD46 CD46 molecule, complement regulatory protein -0.00644683
SETD5 SET domain containing 5 -0.00622507
CYB5R3 cytochrome b5 reductase 3 -0.00616848
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.00615721
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.00611243
HELLS helicase, lymphoid-specific -0.00584702
SAMD8 sterile alpha motif domain containing 8 -0.00581621
TFG TRK-fused gene -0.00574338
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.00573811
NFIB nuclear factor I/B -0.00572509
ITCH itchy E3 ubiquitin protein ligase -0.00572309
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.00568234
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.00567187
FTL ferritin, light polypeptide -0.00566764
CHMP2B charged multivesicular body protein 2B -0.00565867
PAWR PRKC, apoptosis, WT1, regulator -0.00563382
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0056079
RHOA ras homolog family member A -0.00554545
TSC22D2 TSC22 domain family, member 2 -0.00552774
RBMX RNA binding motif protein, X-linked -0.00552493
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.00546086
CCAR1 cell division cycle and apoptosis regulator 1 -0.00541931
BRWD1 bromodomain and WD repeat domain containing 1 -0.00540007
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.00536371
GGNBP2 gametogenetin binding protein 2 -0.0052827
SERINC3 serine incorporator 3 -0.0052701
AGRN agrin -0.00524459
RNF43 ring finger protein 43 -0.0050748
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0050694
KMT2E lysine (K)-specific methyltransferase 2E -0.00502747
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.00501431
DIAPH2 diaphanous-related formin 2 -0.00500348
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.00499238
PER1 period circadian clock 1 -0.00491659
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.00491057
SIN3A SIN3 transcription regulator family member A -0.00486865
TRAM1 translocation associated membrane protein 1 -0.00486742
RYBP RING1 and YY1 binding protein -0.00485495
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -0.00484691
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.00481462
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.00471897
MACROD2 MACRO domain containing 2 -0.00468449
UFM1 ubiquitin-fold modifier 1 -0.00464343
KIF2A kinesin heavy chain member 2A -0.00463811
MICU1 mitochondrial calcium uptake 1 -0.00463704
PARP1 poly (ADP-ribose) polymerase 1 -0.00462998
SNX3 sorting nexin 3 -0.00461957
KCTD3 potassium channel tetramerization domain containing 3 -0.00458847
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -0.0045649
LIN7C lin-7 homolog C (C. elegans) -0.00455871
ATP5F1B ATP synthase F1 subunit beta -0.00454743
ATP11B ATPase, class VI, type 11B -0.00453427
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa -0.00453199
SERP1 stress-associated endoplasmic reticulum protein 1 -0.00452967
WBP2 WW domain binding protein 2 -0.00452367
LCOR ligand dependent nuclear receptor corepressor -0.00447508
TPI1 triosephosphate isomerase 1 -0.00443076
ZC3H15 zinc finger CCCH-type containing 15 -0.00441932
MORF4L2 mortality factor 4 like 2 -0.00441221