Niclosamide (olamine)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.132496
MYH9 myosin, heavy chain 9, non-muscle 0.104937
PRELID2 PRELI domain containing 2 0.091901
FLNA filamin A, alpha 0.0887759
ACTG1 actin gamma 1 0.0853442
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0770649
FLNB filamin B, beta 0.0752611
LAMB3 laminin, beta 3 0.0731159
NDRG1 N-myc downstream regulated 1 0.0674805
KDM3A lysine (K)-specific demethylase 3A 0.0648623
MT2A metallothionein 2A 0.0642691
TPT1 tumor protein, translationally-controlled 1 0.0633718
H1-0 H1.0 linker histone 0.0613122
AHNAK AHNAK nucleoprotein 0.061074
FTH1 ferritin, heavy polypeptide 1 0.0583146
ERRFI1 ERBB receptor feedback inhibitor 1 0.0573748
OGA O-GlcNAcase 0.0523325
PGK1 phosphoglycerate kinase 1 0.052282
PLEC plectin 0.0444861
HELZ helicase with zinc finger 0.0427168
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0422258
CCND1 cyclin D1 0.0420831
EEF2 eukaryotic translation elongation factor 2 0.0407155
ENO1 enolase 1, (alpha) 0.0404021
LDHA lactate dehydrogenase A 0.0388534
DSG2 desmoglein 2 0.0373389
WDR45B WD repeat domain 45B 0.0371065
TPM4 tropomyosin 4 0.0369075
RPL12 ribosomal protein L12 0.0349845
RPLP0 ribosomal protein, large, P0 0.0349384
ANXA2 annexin A2 0.0347849
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0332511
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.031861
AHNAK2 AHNAK nucleoprotein 2 0.0318587
KRT18 keratin 18, type I 0.0317204
ZNF292 zinc finger protein 292 0.0316789
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0314889
YEATS2 YEATS domain containing 2 0.031182
UPP1 uridine phosphorylase 1 0.0311155
SBF2 SET binding factor 2 0.0306936
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0305447
PTPRF protein tyrosine phosphatase, receptor type, F 0.0305307
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0301157
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0299606
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0290186
CDCP1 CUB domain containing protein 1 0.0285204
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0271526
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0267842
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0260032
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0256276
BZW1 basic leucine zipper and W2 domains 1 0.0255421
KRT7 keratin 7, type II 0.0255013
SFXN1 sideroflexin 1 0.0254161
LOC112694756 uncharaterized LOC112694756 0.0253782
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0251967
CREB5 cAMP responsive element binding protein 5 0.0251628
EPN2 epsin 2 0.0249645
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0248926
SFTPA2 surfactant protein A2 0.0240796
BRWD3 bromodomain and WD repeat domain containing 3 0.0240414
HOOK2 hook microtubule-tethering protein 2 0.0239696
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0239647
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0238744
RSL1D1 ribosomal L1 domain containing 1 0.0238327
RPL11 ribosomal protein L11 0.0236275
RPL13A ribosomal protein L13a 0.0235748
ANKRD36 ankyrin repeat domain 36 0.0234697
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0231746
FTL ferritin, light polypeptide 0.022965
ARFGEF3 ARFGEF family member 3 0.0228936
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0225479
HDLBP high density lipoprotein binding protein 0.0223537
EIF4A2 eukaryotic translation initiation factor 4A2 0.0220545
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0219972
ARHGAP5 Rho GTPase activating protein 5 0.02196
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0219019
CAPN2 calpain 2, (m/II) large subunit 0.0218495
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0216509
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0215526
MT1X metallothionein 1X 0.0215026
KLF6 Kruppel-like factor 6 0.0211117
ANKRD12 ankyrin repeat domain 12 0.0208729
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0207885
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0204755
RNMT RNA (guanine-7-) methyltransferase 0.0204403
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0203064
PCLO piccolo presynaptic cytomatrix protein 0.0201059
ANLN anillin, actin binding protein 0.0199898
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0198305
PHF3 PHD finger protein 3 0.0197557
CANX calnexin 0.0197465
RPL26 ribosomal protein L26 0.0197362
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 0.0196199
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0195709
RPS24 ribosomal protein S24 0.0195583
ANKHD1 ankyrin repeat and KH domain containing 1 0.0195536
GCC2 GRIP and coiled-coil domain containing 2 0.0193215
HDAC3 histone deacetylase 3 0.0192952
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0192619
FBXL2 F-box and leucine-rich repeat protein 2 0.019137

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.199495
ALCAM activated leukocyte cell adhesion molecule -0.121046
HSPH1 heat shock 105kDa/110kDa protein 1 -0.119597
TMSB10 thymosin beta 10 -0.110701
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0878688
TXNRD1 thioredoxin reductase 1 -0.0822028
SVIL supervillin -0.0640882
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0632702
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0621691
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0608639
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0540415
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0529878
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0524429
ZBTB20 zinc finger and BTB domain containing 20 -0.0506157
BICD1 bicaudal D homolog 1 (Drosophila) -0.0470665
ELOVL5 ELOVL fatty acid elongase 5 -0.0457344
MSMO1 methylsterol monooxygenase 1 -0.0456446
SLMAP sarcolemma associated protein -0.0455679
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0446646
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.044149
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.043932
RPS6 ribosomal protein S6 -0.0436909
TUSC3 tumor suppressor candidate 3 -0.0435588
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0428404
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0418443
PTMA prothymosin, alpha -0.0412954
RHEX regulator of hemoglobinization and erythroid cell expansion -0.040638
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0402807
ACACA acetyl-CoA carboxylase alpha -0.0402259
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0399632
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0397776
PCED1B PC-esterase domain containing 1B -0.039385
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0393454
PTPRK protein tyrosine phosphatase, receptor type, K -0.0392123
WAC WW domain containing adaptor with coiled-coil -0.0387817
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0386541
DLC1 DLC1 Rho GTPase activating protein -0.0384076
PKM pyruvate kinase, muscle -0.0383665
EGFR epidermal growth factor receptor -0.0382357
HSPA4 heat shock 70kDa protein 4 -0.0382111
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0379842
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0362027
MACROD2 MACRO domain containing 2 -0.036103
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0354306
PTK2 protein tyrosine kinase 2 -0.0351831
WWOX WW domain containing oxidoreductase -0.0348903
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0334971
PFN1 profilin 1 -0.0334496
RAD51B RAD51 paralog B -0.0333521
WWC1 WW and C2 domain containing 1 -0.0331492
PARD3 par-3 family cell polarity regulator -0.0331331
FAT1 FAT atypical cadherin 1 -0.032763
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0324747
IARS1 isoleucyl-tRNA synthetase 1 -0.0322221
RPL5 ribosomal protein L5 -0.0320989
DLG1 discs, large homolog 1 (Drosophila) -0.031854
SREBF2 sterol regulatory element binding transcription factor 2 -0.0316375
QKI QKI, KH domain containing, RNA binding -0.031636
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0314243
PDIA3 protein disulfide isomerase family A, member 3 -0.0312392
ZNF638 zinc finger protein 638 -0.0311462
ZFAND3 zinc finger, AN1-type domain 3 -0.0309464
SETD5 SET domain containing 5 -0.0306735
ATG7 autophagy related 7 -0.0299082
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.0298881
HSPA8 heat shock 70kDa protein 8 -0.0298511
UTRN utrophin -0.0297592
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0295064
INSIG1 insulin induced gene 1 -0.0292219
PAPOLA poly(A) polymerase alpha -0.0291392
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0289393
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0288901
IGFBP3 insulin-like growth factor binding protein 3 -0.0288005
ECT2 epithelial cell transforming 2 -0.0280101
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0280036
FOSL1 FOS-like antigen 1 -0.0278678
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0273031
MAP4 microtubule-associated protein 4 -0.0269765
PDS5B PDS5 cohesin associated factor B -0.0264777
LAMA4 laminin, alpha 4 -0.0264581
DPP4 dipeptidyl-peptidase 4 -0.0264095
ADAM9 ADAM metallopeptidase domain 9 -0.0263561
HMGA2 high mobility group AT-hook 2 -0.0262062
USP34 ubiquitin specific peptidase 34 -0.0261946
PDIA6 protein disulfide isomerase family A, member 6 -0.0261798
IER3 immediate early response 3 -0.0261355
POTEF POTE ankyrin domain family, member F -0.0260219
OSBPL10 oxysterol binding protein-like 10 -0.0257705
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -0.0257613
ZNF148 zinc finger protein 148 -0.0256837
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0256783
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0256407
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0255766
TAPBP TAP binding protein (tapasin) -0.0254457
CLDN4 claudin 4 -0.025233
TBC1D5 TBC1 domain family, member 5 -0.025152
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0250387
PICALM phosphatidylinositol binding clathrin assembly protein -0.024938
FNDC3B fibronectin type III domain containing 3B -0.0249107
RPL23 ribosomal protein L23 -0.0248989