Niclosamide (olamine)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH13 cadherin 13 0.146487
VIM vimentin 0.143311
COL5A1 collagen, type V, alpha 1 0.11411
COL6A1 collagen, type VI, alpha 1 0.106274
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0968692
CXCL8 chemokine (C-X-C motif) ligand 8 0.0829397
RPS6 ribosomal protein S6 0.0746999
GOLGA4 golgin A4 0.0696309
TXNRD1 thioredoxin reductase 1 0.0684385
FTH1 ferritin, heavy polypeptide 1 0.0678014
MYO10 myosin X 0.0674742
TMSB10 thymosin beta 10 0.0649427
ASPH aspartate beta-hydroxylase 0.0647496
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0613396
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.060975
THBS1 thrombospondin 1 0.0607375
PLEC plectin 0.0602108
EXT1 exostosin glycosyltransferase 1 0.059761
DST dystonin 0.0583173
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0577727
ANKRD11 ankyrin repeat domain 11 0.0563388
PTK2 protein tyrosine kinase 2 0.0558153
RPL37A ribosomal protein L37a 0.0555383
TPT1 tumor protein, translationally-controlled 1 0.0551028
COL6A2 collagen, type VI, alpha 2 0.0548453
NAV1 neuron navigator 1 0.0531282
MYH9 myosin, heavy chain 9, non-muscle 0.051585
TAS2R14 taste receptor, type 2, member 14 0.0513738
RPL12 ribosomal protein L12 0.0502824
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0485941
LAMB3 laminin, beta 3 0.0482033
EEF2 eukaryotic translation elongation factor 2 0.0479118
RRBP1 ribosome binding protein 1 0.0469633
IGF2 insulin-like growth factor 2 0.0466247
FLNA filamin A, alpha 0.0458933
TRIO trio Rho guanine nucleotide exchange factor 0.0455406
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0442526
RPS8 ribosomal protein S8 0.0436439
FNIP1 folliculin interacting protein 1 0.0432855
RPLP1 ribosomal protein, large, P1 0.0423599
COL6A3 collagen, type VI, alpha 3 0.0421987
HMGA2 high mobility group AT-hook 2 0.0418471
AHNAK AHNAK nucleoprotein 0.0408473
RAI14 retinoic acid induced 14 0.0406539
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0401638
PRRC2C proline-rich coiled-coil 2C 0.038943
RPS12 ribosomal protein S12 0.0384352
MAML3 mastermind-like 3 (Drosophila) 0.0380124
USP34 ubiquitin specific peptidase 34 0.0379148
RPLP2 ribosomal protein, large, P2 0.0378622
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0378566
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0375407
FMNL2 formin-like 2 0.0370733
RPL11 ribosomal protein L11 0.0366626
ANKRD28 ankyrin repeat domain 28 0.0361356
ATXN1 ataxin 1 0.0355509
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0354107
ZFAND3 zinc finger, AN1-type domain 3 0.0353741
RND3 Rho family GTPase 3 0.034703
NAP1L1 nucleosome assembly protein 1-like 1 0.0338883
CALR calreticulin 0.0332935
SQSTM1 sequestosome 1 0.0328501
GRB10 growth factor receptor-bound protein 10 0.0327768
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0324248
MACF1 microtubule-actin crosslinking factor 1 0.0324239
WNK1 WNK lysine deficient protein kinase 1 0.0318616
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0315453
MTDH metadherin 0.0315163
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0314086
SAMD4A sterile alpha motif domain containing 4A 0.031321
RPL19 ribosomal protein L19 0.0312937
RPL26 ribosomal protein L26 0.031178
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0311475
RPL9 ribosomal protein L9 0.0310615
RPL37 ribosomal protein L37 0.0309932
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.03083
PTPRM protein tyrosine phosphatase, receptor type, M 0.0306568
CLMP CXADR-like membrane protein 0.0304211
ACTG1 actin gamma 1 0.0303213
ENO1 enolase 1, (alpha) 0.0302791
RPS3 ribosomal protein S3 0.0302269
APP amyloid beta (A4) precursor protein 0.0300473
RPS17 ribosomal protein S17 0.0297361
CAMTA1 calmodulin binding transcription activator 1 0.0291573
NF1 neurofibromin 1 0.0290378
GNAS GNAS complex locus 0.0289998
TTC3 tetratricopeptide repeat domain 3 0.0289221
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0287975
FMN1 formin 1 0.0286664
RPL13A ribosomal protein L13a 0.0285885
SFTPA2 surfactant protein A2 0.0285424
RPS27A ribosomal protein S27a 0.0285009
IARS1 isoleucyl-tRNA synthetase 1 0.0284915
LPP LIM domain containing preferred translocation partner in lipoma 0.0284588
PTMA prothymosin, alpha 0.0282954
MCTP1 multiple C2 domains, transmembrane 1 0.0278881
NAV2 neuron navigator 2 0.0278635
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0277344
RPS13 ribosomal protein S13 0.0276245
GOLGB1 golgin B1 0.0275771

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.315501
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.193232
ELL2 elongation factor, RNA polymerase II, 2 -0.0966164
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0549022
NDRG1 N-myc downstream regulated 1 -0.0542167
STC1 stanniocalcin 1 -0.0460364
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0435207
FAM13A family with sequence similarity 13, member A -0.0431444
EGR1 early growth response 1 -0.0430784
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0423894
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0375709
CDCP1 CUB domain containing protein 1 -0.0366998
HILPDA hypoxia inducible lipid droplet-associated -0.0365184
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0361376
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0355039
ZNF292 zinc finger protein 292 -0.0336856
LDHA lactate dehydrogenase A -0.0334922
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0325114
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0296024
FNDC3B fibronectin type III domain containing 3B -0.0283603
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0282102
NAMPT nicotinamide phosphoribosyltransferase -0.027421
IGFBP3 insulin-like growth factor binding protein 3 -0.0255665
USP3 ubiquitin specific peptidase 3 -0.0253385
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0241882
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0241776
PGK1 phosphoglycerate kinase 1 -0.0238722
TXNIP thioredoxin interacting protein -0.0232484
NUP58 nucleoporin 58 -0.0230884
HELZ helicase with zinc finger -0.0220598
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0217967
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.021584
CLEC1B C-type lectin domain family 1, member B -0.0212235
LOX lysyl oxidase -0.0210789
PDIA3 protein disulfide isomerase family A, member 3 -0.0202766
FAM162A family with sequence similarity 162, member A -0.0194809
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0193953
PLAUR plasminogen activator, urokinase receptor -0.0192151
BHLHE41 basic helix-loop-helix family, member e41 -0.0188757
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.0183444
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0176129
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0175808
UBC ubiquitin C -0.0163186
DEPP1 DEPP autophagy regulator 1 -0.0162759
SSBP2 single-stranded DNA binding protein 2 -0.0155686
RNF24 ring finger protein 24 -0.01517
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0149533
MT1X metallothionein 1X -0.0145634
JUN jun proto-oncogene -0.0135668
ARRDC3 arrestin domain containing 3 -0.0134209
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0134101
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0133293
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0133266
SYAP1 synapse associated protein 1 -0.0132225
WDR45B WD repeat domain 45B -0.0130298
RLF rearranged L-myc fusion -0.0130251
RYBP RING1 and YY1 binding protein -0.012552
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0124195
CNOT8 CCR4-NOT transcription complex, subunit 8 -0.0118829
MEF2A myocyte enhancer factor 2A -0.0118623
CLIC4 chloride intracellular channel 4 -0.0117432
DUSP6 dual specificity phosphatase 6 -0.0116284
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0113559
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0110665
HOOK2 hook microtubule-tethering protein 2 -0.0109582
KMT2E lysine (K)-specific methyltransferase 2E -0.0108864
VCL vinculin -0.0108271
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0107064
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0106903
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0105185
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0104393
TFG TRK-fused gene -0.0101746
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0100647
LPIN2 lipin 2 -0.0099095
SGO2 shugoshin 2 -0.00974233
DOT1L DOT1-like histone H3K79 methyltransferase -0.0096435
CKAP2 cytoskeleton associated protein 2 -0.0094977
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.00938022
TENM2 teneurin transmembrane protein 2 -0.00937304
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.00928165
MIMS1 mitochondrial inner membrane scaffold 1 -0.00914331
KCTD9 potassium channel tetramerization domain containing 9 -0.00889646
ANKRD37 ankyrin repeat domain 37 -0.00888542
SKIC3 SKI3 subunit of superkiller complex -0.00876893
INSIG2 insulin induced gene 2 -0.00870196
BSG basigin (Ok blood group) -0.00868293
NGLY1 N-glycanase 1 -0.00836976
WDPCP WD repeat containing planar cell polarity effector -0.0083276
MXI1 MAX interactor 1, dimerization protein -0.00829312
ADM adrenomedullin -0.0081775
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.00807263
TMEM123 transmembrane protein 123 -0.0080215
PRELID2 PRELI domain containing 2 -0.00797077
CHSY1 chondroitin sulfate synthase 1 -0.0079519
CCND1 cyclin D1 -0.00773431
PER2 period circadian clock 2 -0.00771105
SPRED2 sprouty-related, EVH1 domain containing 2 -0.00771029
RNF220 ring finger protein 220 -0.00755074
CYB5R3 cytochrome b5 reductase 3 -0.00752324
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.00744657