Niclosamide (olamine)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.189238
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.168605
SPTBN1 spectrin, beta, non-erythrocytic 1 0.153527
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.110814
EEF2 eukaryotic translation elongation factor 2 0.101765
FBF1 Fas (TNFRSF6) binding factor 1 0.0958805
FNDC3B fibronectin type III domain containing 3B 0.0957925
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0764324
AFDN afadin, adherens junction formation factor 0.0737547
ELL2 elongation factor, RNA polymerase II, 2 0.0707219
APOB apolipoprotein B 0.0693831
DDIT4 DNA-damage-inducible transcript 4 0.0618053
SDC4 syndecan 4 0.0589567
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0571282
DSCAM Down syndrome cell adhesion molecule 0.0570725
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0565283
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0565055
KDM3A lysine (K)-specific demethylase 3A 0.0556574
JMJD1C jumonji domain containing 1C 0.0529061
RBM39 RNA binding motif protein 39 0.0495275
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0491302
C3 complement component 3 0.0486153
ENO1 enolase 1, (alpha) 0.0481509
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0470895
BHLHE40 basic helix-loop-helix family, member e40 0.0465326
AKAP12 A kinase (PRKA) anchor protein 12 0.0460236
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0446879
LOC112694756 uncharaterized LOC112694756 0.044646
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0443903
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.04397
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0439613
TF transferrin 0.0436782
WDR45B WD repeat domain 45B 0.0435495
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0426978
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0425371
CAMTA1 calmodulin binding transcription activator 1 0.0415493
KDM7A lysine (K)-specific demethylase 7A 0.0391642
INSIG2 insulin induced gene 2 0.0390002
PLEC plectin 0.0387927
GOLGA4 golgin A4 0.0386609
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0385787
RBM25 RNA binding motif protein 25 0.037958
TMEM123 transmembrane protein 123 0.0371509
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0343864
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0340894
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0340407
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0337718
SOD2 superoxide dismutase 2, mitochondrial 0.0337243
EPAS1 endothelial PAS domain protein 1 0.0335752
KIF1B kinesin family member 1B 0.0332906
HOOK2 hook microtubule-tethering protein 2 0.0328848
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.032375
SVIL supervillin 0.0318158
TRIM26 tripartite motif containing 26 0.0313482
KIF5B kinesin family member 5B 0.031319
DLC1 DLC1 Rho GTPase activating protein 0.0310096
ZNF292 zinc finger protein 292 0.0307166
NAP1L1 nucleosome assembly protein 1-like 1 0.0304211
BIRC6 baculoviral IAP repeat containing 6 0.0304034
PTPRM protein tyrosine phosphatase, receptor type, M 0.030358
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0302819
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0302253
LDHA lactate dehydrogenase A 0.029764
KTN1 kinectin 1 (kinesin receptor) 0.0295795
FLNB filamin B, beta 0.0295721
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0294963
TNS1 tensin 1 0.0294825
MACF1 microtubule-actin crosslinking factor 1 0.0294083
GPC3 glypican 3 0.0293914
CPE carboxypeptidase E 0.0293707
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0292812
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0289218
HELZ helicase with zinc finger 0.0288206
AHSG alpha-2-HS-glycoprotein 0.0279803
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0279022
UBA6 ubiquitin-like modifier activating enzyme 6 0.0277931
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0277272
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.027646
ZFAND3 zinc finger, AN1-type domain 3 0.0276417
TOP1 topoisomerase (DNA) I 0.0274171
NIPBL Nipped-B homolog (Drosophila) 0.0273904
RB1CC1 RB1-inducible coiled-coil 1 0.0270623
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0263411
SPAG9 sperm associated antigen 9 0.0263379
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0261754
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0260153
PLIN2 perilipin 2 0.0258607
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0254705
USP3 ubiquitin specific peptidase 3 0.0253704
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0252392
JAK1 Janus kinase 1 0.0252277
ARFGEF3 ARFGEF family member 3 0.025117
MTSS1 metastasis suppressor 1 0.0249423
KMT2C lysine (K)-specific methyltransferase 2C 0.0248722
SMAP1 small ArfGAP 1 0.0248647
QKI QKI, KH domain containing, RNA binding 0.0242785
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0242718
DENND4A DENN/MADD domain containing 4A 0.0242528
MATR3 matrin 3 0.0239194
IQSEC1 IQ motif and Sec7 domain 1 0.0236377

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.175159
IGFBP1 insulin-like growth factor binding protein 1 -0.0768665
GPC6 glypican 6 -0.0752849
MT2A metallothionein 2A -0.0698188
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0653906
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0576808
EHBP1 EH domain binding protein 1 -0.0505561
APOA2 apolipoprotein A-II -0.0460539
TMSB10 thymosin beta 10 -0.0442452
NPAS2 neuronal PAS domain protein 2 -0.0404726
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0379137
RPL37A ribosomal protein L37a -0.0357746
RPLP2 ribosomal protein, large, P2 -0.0312438
RPS19 ribosomal protein S19 -0.0305061
DST dystonin -0.0305056
VCL vinculin -0.0296043
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0292596
PTCHD4 patched domain containing 4 -0.0291821
ZBTB20 zinc finger and BTB domain containing 20 -0.0279363
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0274493
MAML2 mastermind-like 2 (Drosophila) -0.0261917
RPS12 ribosomal protein S12 -0.0254247
ASPH aspartate beta-hydroxylase -0.024953
FAT1 FAT atypical cadherin 1 -0.0246598
RPS29 ribosomal protein S29 -0.0231344
INTS6 integrator complex subunit 6 -0.0225663
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0217207
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0213454
RPLP1 ribosomal protein, large, P1 -0.0203851
LPP LIM domain containing preferred translocation partner in lipoma -0.0201153
KRT18 keratin 18, type I -0.0196589
RIGI RNA sensor RIG-I -0.0191522
EGR1 early growth response 1 -0.018174
RPL31 ribosomal protein L31 -0.018067
NKD1 naked cuticle homolog 1 (Drosophila) -0.0174498
ACTN4 actinin, alpha 4 -0.0171774
EXT1 exostosin glycosyltransferase 1 -0.0167986
RNF213 ring finger protein 213 -0.0167255
DNAH17 dynein, axonemal, heavy chain 17 -0.0167056
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0162624
SOX5 SRY (sex determining region Y)-box 5 -0.0161928
RPL35A ribosomal protein L35a -0.0158709
S100A9 S100 calcium binding protein A9 -0.0155069
IFI6 interferon, alpha-inducible protein 6 -0.0154987
RPS21 ribosomal protein S21 -0.0150692
FOXP1 forkhead box P1 -0.014905
ITGAV integrin, alpha V -0.0148335
RPL36 ribosomal protein L36 -0.0148259
APOA1 apolipoprotein A-I -0.01467
DSPP dentin sialophosphoprotein -0.0146491
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0145252
CDK6 cyclin-dependent kinase 6 -0.0143544
IFITM1 interferon induced transmembrane protein 1 -0.014345
APOC1 apolipoprotein C-I -0.0142373
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0142024
KRT23 keratin 23, type I -0.0139675
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.013854
TPM1 tropomyosin 1 (alpha) -0.0136999
PTMA prothymosin, alpha -0.0135276
CST3 cystatin C -0.0132354
HDAC4 histone deacetylase 4 -0.0130916
RPS13 ribosomal protein S13 -0.0130492
SP100 SP100 nuclear antigen -0.0130433
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0128218
GMDS GDP-mannose 4,6-dehydratase -0.0124801
LMCD1 LIM and cysteine-rich domains 1 -0.0123952
RPS10 ribosomal protein S10 -0.0122489
MX2 MX dynamin-like GTPase 2 -0.0122316
RPL26 ribosomal protein L26 -0.0121652
PDLIM5 PDZ and LIM domain 5 -0.0120722
PDE4D phosphodiesterase 4D, cAMP-specific -0.0120035
RPS27 ribosomal protein S27 -0.0117456
PTPRK protein tyrosine phosphatase, receptor type, K -0.0116277
IER3 immediate early response 3 -0.0114859
ZFHX3 zinc finger homeobox 3 -0.0114785
DNAH5 dynein, axonemal, heavy chain 5 -0.0114454
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0113802
RPL37 ribosomal protein L37 -0.0112142
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0111334
GK glycerol kinase -0.0111087
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0108158
UTRN utrophin -0.0107497
PLSCR1 phospholipid scramblase 1 -0.0107188
RPS16 ribosomal protein S16 -0.0106757
SYN3 synapsin III -0.01066
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0104396
RPS15 ribosomal protein S15 -0.0104237
RPL28 ribosomal protein L28 -0.0103908
RPS23 ribosomal protein S23 -0.0102299
ENKUR enkurin, TRPC channel interacting protein -0.0101435
RPL38 ribosomal protein L38 -0.010139
RAD51B RAD51 paralog B -0.0101044
RASAL2 RAS protein activator like 2 -0.0100289
COL27A1 collagen, type XXVII, alpha 1 -0.0100273
RPS14 ribosomal protein S14 -0.00998588
ISG15 ISG15 ubiquitin-like modifier -0.00995635
VCAN versican -0.00994754
RPL9 ribosomal protein L9 -0.00992798
HMGA2 high mobility group AT-hook 2 -0.00986853
ETFB electron-transfer-flavoprotein, beta polypeptide -0.00975386