Niclosamide (olamine)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in Hs 766T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Niclosamide (olamine)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.196764
FLNB filamin B, beta 0.186815
TRIO trio Rho guanine nucleotide exchange factor 0.127859
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0985968
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0928603
MEF2A myocyte enhancer factor 2A 0.0713797
ANXA1 annexin A1 0.0703721
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0657064
AHNAK AHNAK nucleoprotein 0.0648818
OGA O-GlcNAcase 0.0642636
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0605967
CEMIP cell migration inducing protein, hyaluronan binding 0.0602036
MYOF myoferlin 0.0599241
KRT17 keratin 17, type I 0.0591041
FTH1 ferritin, heavy polypeptide 1 0.0584281
CANX calnexin 0.0567181
LOC112694756 uncharaterized LOC112694756 0.0558803
ESYT2 extended synaptotagmin-like protein 2 0.054871
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0540606
ENO1 enolase 1, (alpha) 0.0534386
EZR ezrin 0.0522587
SEC31A SEC31 homolog A (S. cerevisiae) 0.0502092
H1-0 H1.0 linker histone 0.0499712
EMP1 epithelial membrane protein 1 0.0487346
PGK1 phosphoglycerate kinase 1 0.0473497
KDM3A lysine (K)-specific demethylase 3A 0.0468637
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0465422
MBNL2 muscleblind-like splicing regulator 2 0.0462183
COPB1 coatomer protein complex, subunit beta 1 0.0462102
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0461561
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0460691
KIAA1217 KIAA1217 0.0455878
PLEC plectin 0.0455134
PDGFB platelet-derived growth factor beta polypeptide 0.0442943
TMSB10 thymosin beta 10 0.0442295
CALR calreticulin 0.0437577
LOXL2 lysyl oxidase-like 2 0.0435437
SRP54 signal recognition particle 54kDa 0.0430603
NAMPT nicotinamide phosphoribosyltransferase 0.0430586
MYH9 myosin, heavy chain 9, non-muscle 0.0430123
TTC3 tetratricopeptide repeat domain 3 0.0427901
SUCO SUN domain containing ossification factor 0.0427697
GOLGA2 golgin A2 0.0420312
PRELID2 PRELI domain containing 2 0.0419046
ITCH itchy E3 ubiquitin protein ligase 0.041718
GOLGA4 golgin A4 0.0412089
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0411094
AKAP9 A kinase (PRKA) anchor protein 9 0.0406562
TMF1 TATA element modulatory factor 1 0.0393875
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0388003
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0386069
ANLN anillin, actin binding protein 0.0384298
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0378167
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0375341
ACBD3 acyl-CoA binding domain containing 3 0.0374828
NAV2 neuron navigator 2 0.0374723
LMAN1 lectin, mannose-binding, 1 0.0373689
HLA-E major histocompatibility complex, class I, E 0.0372
FLNA filamin A, alpha 0.0365921
HM13 histocompatibility (minor) 13 0.0364805
COG6 component of oligomeric golgi complex 6 0.0363562
RAI14 retinoic acid induced 14 0.0358222
KIF16B kinesin family member 16B 0.0348974
HDLBP high density lipoprotein binding protein 0.0347992
DLG1 discs, large homolog 1 (Drosophila) 0.034521
CUL4B cullin 4B 0.0341353
ZNF292 zinc finger protein 292 0.0339403
MXI1 MAX interactor 1, dimerization protein 0.0338678
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0338565
FSCN1 fascin actin-bundling protein 1 0.0337877
SBF2 SET binding factor 2 0.0336795
EEF2 eukaryotic translation elongation factor 2 0.0336544
HOOK2 hook microtubule-tethering protein 2 0.033602
ASPH aspartate beta-hydroxylase 0.0334462
SQLE squalene epoxidase 0.0334012
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0330269
HELZ helicase with zinc finger 0.0328824
TNIP1 TNFAIP3 interacting protein 1 0.0323242
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0322795
DUSP6 dual specificity phosphatase 6 0.0314632
CLU clusterin 0.0313526
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.031312
STC1 stanniocalcin 1 0.0310096
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0309949
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0308843
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0307423
EFHD2 EF-hand domain family, member D2 0.0303621
CALU calumenin 0.0300902
TGM2 transglutaminase 2 0.0298948
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0298132
FN1 fibronectin 1 0.0297631
ARRDC3 arrestin domain containing 3 0.0297072
FNIP1 folliculin interacting protein 1 0.0296667
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0293
NRIP1 nuclear receptor interacting protein 1 0.0292575
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0290152
CD99 CD99 molecule 0.0286661
ZCCHC7 zinc finger, CCHC domain containing 7 0.0286553
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0285775
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0285745

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.20227
TIMP3 TIMP metallopeptidase inhibitor 3 -0.201101
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.121252
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0954435
PDE4D phosphodiesterase 4D, cAMP-specific -0.0827312
B2M beta-2-microglobulin -0.0786539
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0778878
DPYD dihydropyrimidine dehydrogenase -0.0711818
BCAR3 breast cancer anti-estrogen resistance 3 -0.0633928
POTEF POTE ankyrin domain family, member F -0.060813
TXNRD1 thioredoxin reductase 1 -0.0509679
RASAL2 RAS protein activator like 2 -0.0505656
ALCAM activated leukocyte cell adhesion molecule -0.048636
SULF2 sulfatase 2 -0.0486349
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0482345
HLA-B major histocompatibility complex, class I, B -0.0475604
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0464843
RALY RALY heterogeneous nuclear ribonucleoprotein -0.045821
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0454602
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.042759
ACTN4 actinin, alpha 4 -0.0425042
PLS3 plastin 3 -0.0418132
SLC35F3 solute carrier family 35, member F3 -0.0416814
TPT1 tumor protein, translationally-controlled 1 -0.0413869
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0412439
PDLIM5 PDZ and LIM domain 5 -0.04062
PICALM phosphatidylinositol binding clathrin assembly protein -0.038882
RAB7A RAB7A, member RAS oncogene family -0.0382278
SIK3 SIK family kinase 3 -0.0379847
PITPNB phosphatidylinositol transfer protein, beta -0.0378457
IFI44L interferon-induced protein 44-like -0.0377318
IFI27 interferon, alpha-inducible protein 27 -0.037487
LMO7 LIM domain 7 -0.0368502
RIGI RNA sensor RIG-I -0.0353191
IFI6 interferon, alpha-inducible protein 6 -0.0351904
RPS21 ribosomal protein S21 -0.0348173
PTK2 protein tyrosine kinase 2 -0.034178
ANO1 anoctamin 1, calcium activated chloride channel -0.0335875
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0330921
DIAPH1 diaphanous-related formin 1 -0.0325616
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0324199
SAMD9 sterile alpha motif domain containing 9 -0.0321803
RABGAP1L RAB GTPase activating protein 1-like -0.0320324
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0319016
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0314138
LRP1B low density lipoprotein receptor-related protein 1B -0.0312756
IPO7 importin 7 -0.0312206
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0299341
CDK6 cyclin-dependent kinase 6 -0.0298405
PALLD palladin, cytoskeletal associated protein -0.0291398
CRY1 cryptochrome circadian clock 1 -0.0283256
ZFAND3 zinc finger, AN1-type domain 3 -0.0279376
KCTD12 potassium channel tetramerization domain containing 12 -0.0277173
NEK7 NIMA-related kinase 7 -0.0276997
RCOR1 REST corepressor 1 -0.0273928
FTL ferritin, light polypeptide -0.0269057
LY6E lymphocyte antigen 6 complex, locus E -0.0266368
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0264935
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0258492
FOSL1 FOS-like antigen 1 -0.0257255
IGF2 insulin-like growth factor 2 -0.0256947
LRRC8A leucine rich repeat containing 8 family, member A -0.0252098
EGR1 early growth response 1 -0.0249505
HMGA2 high mobility group AT-hook 2 -0.0247915
CALB1 calbindin 1, 28kDa -0.0246253
CDK17 cyclin-dependent kinase 17 -0.0244952
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0244694
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0241147
RPS24 ribosomal protein S24 -0.0240044
WARS1 tryptophanyl-tRNA synthetase 1 -0.023793
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0237302
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0236992
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0236198
HSPG2 heparan sulfate proteoglycan 2 -0.0235969
HMGA1 high mobility group AT-hook 1 -0.0234029
FOXP1 forkhead box P1 -0.0233964
SP100 SP100 nuclear antigen -0.0233664
ACTG1 actin gamma 1 -0.0232042
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0231985
LAMC2 laminin, gamma 2 -0.0230992
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0230689
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0230473
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0228527
ISG15 ISG15 ubiquitin-like modifier -0.0228513
IFI44 interferon-induced protein 44 -0.0228115
GRB10 growth factor receptor-bound protein 10 -0.0225183
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0224886
LUZP1 leucine zipper protein 1 -0.0224235
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0224207
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.022415
SFPQ splicing factor proline/glutamine-rich -0.0223112
AKAP13 A kinase (PRKA) anchor protein 13 -0.0222943
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0222613
MTAP methylthioadenosine phosphorylase -0.0220473
CPNE8 copine VIII -0.0216682
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0215927
ARHGAP26 Rho GTPase activating protein 26 -0.0214369
ABLIM1 actin binding LIM protein 1 -0.0214129
ECE1 endothelin converting enzyme 1 -0.0213685
SOX5 SRY (sex determining region Y)-box 5 -0.0213124