Niclosamide (olamine)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.291297
TRIO trio Rho guanine nucleotide exchange factor 0.0474386
HLA-C major histocompatibility complex, class I, C 0.0340777
FLNA filamin A, alpha 0.0319907
KRT18 keratin 18, type I 0.0260826
LOC112694756 uncharaterized LOC112694756 0.0249321
FLNB filamin B, beta 0.0248078
SOD2 superoxide dismutase 2, mitochondrial 0.0245582
COL5A1 collagen, type V, alpha 1 0.0227079
RPLP2 ribosomal protein, large, P2 0.022303
INTS6 integrator complex subunit 6 0.0220128
HLA-A major histocompatibility complex, class I, A 0.0219495
MYH9 myosin, heavy chain 9, non-muscle 0.0218467
CALR calreticulin 0.0217289
HLA-E major histocompatibility complex, class I, E 0.0212429
EEF2 eukaryotic translation elongation factor 2 0.0207566
MT2A metallothionein 2A 0.0198315
PLEC plectin 0.0192227
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0187021
RPL21 ribosomal protein L21 0.0186237
TMSB10 thymosin beta 10 0.018207
RPL12 ribosomal protein L12 0.0177003
L1CAM L1 cell adhesion molecule 0.0176557
PHACTR1 phosphatase and actin regulator 1 0.0172425
VEGFA vascular endothelial growth factor A 0.0169566
TLE4 transducin-like enhancer of split 4 0.0166269
RPL13A ribosomal protein L13a 0.0165549
RPL35 ribosomal protein L35 0.0164775
DTNA dystrobrevin, alpha 0.0164417
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.015834
P4HB prolyl 4-hydroxylase, beta polypeptide 0.015824
ZSWIM6 zinc finger, SWIM-type containing 6 0.0157006
NAV2 neuron navigator 2 0.0155077
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0154631
SLIT2 slit homolog 2 (Drosophila) 0.0151581
STC2 stanniocalcin 2 0.0150014
SDK1 sidekick cell adhesion molecule 1 0.0148577
NCOR2 nuclear receptor corepressor 2 0.014739
PDIA4 protein disulfide isomerase family A, member 4 0.0146172
RPS12 ribosomal protein S12 0.014458
YBX1 Y box binding protein 1 0.0142244
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0129481
SHB Src homology 2 domain containing adaptor protein B 0.0127877
SAMD4A sterile alpha motif domain containing 4A 0.0120746
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0119902
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0118217
IFI6 interferon, alpha-inducible protein 6 0.0118147
RPL11 ribosomal protein L11 0.0117824
RPS3 ribosomal protein S3 0.0117602
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0115851
RPS17 ribosomal protein S17 0.0112831
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0111478
COL7A1 collagen, type VII, alpha 1 0.0111345
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.010904
FTL ferritin, light polypeptide 0.010869
ATXN1 ataxin 1 0.01084
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0106992
RPS6 ribosomal protein S6 0.0106971
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0106815
RPL37A ribosomal protein L37a 0.0106472
SEPTIN9 septin 9 0.0105873
TNS3 tensin 3 0.0105315
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0104419
IRS2 insulin receptor substrate 2 0.0104115
KRT8 keratin 8, type II 0.0103818
EGFR epidermal growth factor receptor 0.0103729
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0100597
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00998705
IFITM3 interferon induced transmembrane protein 3 0.00994052
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.00982195
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0095293
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.00940846
FOSL1 FOS-like antigen 1 0.00936788
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.00921615
DENND1A DENN/MADD domain containing 1A 0.00917349
CEP250 centrosomal protein 250kDa 0.00913897
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00912604
ADAM32 ADAM metallopeptidase domain 32 0.00906352
RPS19 ribosomal protein S19 0.00892547
RPL36 ribosomal protein L36 0.00891424
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.00889778
ZMIZ1 zinc finger, MIZ-type containing 1 0.00873936
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00865851
WSB1 WD repeat and SOCS box containing 1 0.00863547
DIPK2A divergent protein kinase domain 2A 0.00847965
RPS20 ribosomal protein S20 0.0084152
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.00837542
ZHX2 zinc fingers and homeoboxes 2 0.00828304
CTBP2 C-terminal binding protein 2 0.00824553
OGA O-GlcNAcase 0.0082298
HLA-B major histocompatibility complex, class I, B 0.00817499
RAD23B RAD23 homolog B (S. cerevisiae) 0.00810951
AFF3 AF4/FMR2 family, member 3 0.00808356
PLIN2 perilipin 2 0.00808232
FBXO42 F-box protein 42 0.007968
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00795811
CTIF CBP80/20-dependent translation initiation factor 0.00795314
CTSD cathepsin D 0.00789877
UBE2O ubiquitin-conjugating enzyme E2O 0.00777027
RPL8 ribosomal protein L8 0.00773229

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.125456
CD44 CD44 molecule (Indian blood group) -0.0558773
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0545056
TXNRD1 thioredoxin reductase 1 -0.0530271
EXT1 exostosin glycosyltransferase 1 -0.0452552
LDHA lactate dehydrogenase A -0.0430765
ABI3BP ABI family, member 3 (NESH) binding protein -0.0407498
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0404077
ENO1 enolase 1, (alpha) -0.0393219
FN1 fibronectin 1 -0.0386123
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0385141
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.038312
NAMPT nicotinamide phosphoribosyltransferase -0.0345536
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0345205
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0344997
KPNB1 karyopherin (importin) beta 1 -0.0336504
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.033445
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0329254
ERBIN erbb2 interacting protein -0.0325998
IL6ST interleukin 6 signal transducer -0.032084
DEK DEK proto-oncogene -0.0287528
PGK1 phosphoglycerate kinase 1 -0.0276067
HEG1 heart development protein with EGF-like domains 1 -0.0273478
NIPBL Nipped-B homolog (Drosophila) -0.0270786
CAVIN1 caveolae associated protein 1 -0.0264448
OSMR oncostatin M receptor -0.026345
CUL4B cullin 4B -0.0259227
ANXA2 annexin A2 -0.0253645
RAD21 RAD21 homolog (S. pombe) -0.0244307
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0240631
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0239979
UGCG UDP-glucose ceramide glucosyltransferase -0.0238822
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0230113
B2M beta-2-microglobulin -0.0228975
CANX calnexin -0.022889
CENPF centromere protein F, 350/400kDa -0.0228636
CCND1 cyclin D1 -0.0225973
TMSB4X thymosin beta 4, X-linked -0.0223941
ZNF432 zinc finger protein 432 -0.02231
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0214144
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0212902
GOLGB1 golgin B1 -0.0211128
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0209941
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0209827
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0206805
PALM2AKAP2 PALM2 and AKAP2 fusion -0.020383
ASPH aspartate beta-hydroxylase -0.0202806
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0200101
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0199422
STAU1 staufen double-stranded RNA binding protein 1 -0.0199044
MKI67 marker of proliferation Ki-67 -0.0197146
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0196643
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0193227
PDIA3 protein disulfide isomerase family A, member 3 -0.0191383
SENP5 SUMO1/sentrin specific peptidase 5 -0.0189221
POTEF POTE ankyrin domain family, member F -0.0186486
ELL2 elongation factor, RNA polymerase II, 2 -0.0184581
DIAPH3 diaphanous-related formin 3 -0.0176434
POSTN periostin, osteoblast specific factor -0.0176068
CAPRIN1 cell cycle associated protein 1 -0.0175146
ACTG1 actin gamma 1 -0.0174754
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.017366
VIM vimentin -0.0171532
RAI14 retinoic acid induced 14 -0.0170786
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0170744
STAT1 signal transducer and activator of transcription 1, 91kDa -0.016524
PPME1 protein phosphatase methylesterase 1 -0.016162
PSIP1 PC4 and SFRS1 interacting protein 1 -0.0159042
IPO7 importin 7 -0.0158986
PODXL podocalyxin-like -0.0157606
ZBTB20 zinc finger and BTB domain containing 20 -0.0156256
TPT1 tumor protein, translationally-controlled 1 -0.0155792
ITCH itchy E3 ubiquitin protein ligase -0.0155474
ATAD2 ATPase family, AAA domain containing 2 -0.0154489
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0153809
CLTC clathrin, heavy chain (Hc) -0.0151613
GOLT1B golgi transport 1B -0.015133
NEK7 NIMA-related kinase 7 -0.0150745
TPX2 TPX2, microtubule-associated -0.0150338
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0149576
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0147387
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0147173
PTBP3 polypyrimidine tract binding protein 3 -0.0145962
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0145895
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0144324
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.014341
SMC5 structural maintenance of chromosomes 5 -0.0143137
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0141976
SSR1 signal sequence receptor, alpha -0.0141393
TARS1 threonyl-tRNA synthetase 1 -0.0140347
PRRC2C proline-rich coiled-coil 2C -0.0140066
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0139508
CD59 CD59 molecule, complement regulatory protein -0.0138638
MYL12B myosin, light chain 12B, regulatory -0.0138206
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0137906
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0136662
TPM1 tropomyosin 1 (alpha) -0.0136381
RPL35A ribosomal protein L35a -0.0136231
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0135711
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0135566