Niclosamide (olamine)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.156069
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.140273
CES1 carboxylesterase 1 0.137394
FAM13A family with sequence similarity 13, member A 0.096008
NAMPT nicotinamide phosphoribosyltransferase 0.0879532
TXNRD1 thioredoxin reductase 1 0.0835313
SOD2 superoxide dismutase 2, mitochondrial 0.0760172
H1-0 H1.0 linker histone 0.0735001
MKI67 marker of proliferation Ki-67 0.0681095
TBC1D22A TBC1 domain family, member 22A 0.0679231
NGLY1 N-glycanase 1 0.0647358
GCLC glutamate-cysteine ligase, catalytic subunit 0.0578126
LAMC2 laminin, gamma 2 0.0547007
PLEC plectin 0.0506369
MYH9 myosin, heavy chain 9, non-muscle 0.0491452
ARRDC3 arrestin domain containing 3 0.0484684
BRWD3 bromodomain and WD repeat domain containing 3 0.0484655
UBA6 ubiquitin-like modifier activating enzyme 6 0.0469877
RUNX1 runt-related transcription factor 1 0.0452716
LOC112694756 uncharaterized LOC112694756 0.044976
OGA O-GlcNAcase 0.0437742
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0427788
HOOK2 hook microtubule-tethering protein 2 0.0427461
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0423295
RICTOR RPTOR independent companion of MTOR, complex 2 0.0420312
SMAD3 SMAD family member 3 0.0402855
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0391736
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0389735
LAMB3 laminin, beta 3 0.0388714
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.038363
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0382372
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0381785
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0377742
AGO2 argonaute RISC catalytic component 2 0.0372271
HELZ helicase with zinc finger 0.0366264
TPD52 tumor protein D52 0.0361277
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0350116
ZC3H11A zinc finger CCCH-type containing 11A 0.0349115
SLTM SAFB-like, transcription modulator 0.0333286
ZNF292 zinc finger protein 292 0.0332805
ATP13A3 ATPase type 13A3 0.0329529
EEF2 eukaryotic translation elongation factor 2 0.0326323
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0325512
ELL2 elongation factor, RNA polymerase II, 2 0.0318716
TMEM165 transmembrane protein 165 0.0318121
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0316872
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0304322
CDCP1 CUB domain containing protein 1 0.0300909
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0298313
ADAM17 ADAM metallopeptidase domain 17 0.0292318
PRRC2C proline-rich coiled-coil 2C 0.0278655
RNMT RNA (guanine-7-) methyltransferase 0.0277011
ANO6 anoctamin 6 0.0275016
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0271636
SPAG9 sperm associated antigen 9 0.0267102
SUCO SUN domain containing ossification factor 0.0261079
JMJD1C jumonji domain containing 1C 0.0256942
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0254312
KMT2E lysine (K)-specific methyltransferase 2E 0.0254045
MARF1 meiosis regulator and mRNA stability factor 1 0.0253364
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0250241
EP300 E1A binding protein p300 0.0249654
WDR45B WD repeat domain 45B 0.0247994
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0246512
ZFC3H1 zinc finger, C3H1-type containing 0.0244054
TSC22D2 TSC22 domain family, member 2 0.0239859
SON SON DNA binding protein 0.0238461
PUM2 pumilio RNA-binding family member 2 0.0237045
ZFR zinc finger RNA binding protein 0.0235905
UBE2O ubiquitin-conjugating enzyme E2O 0.0235904
KDM2A lysine (K)-specific demethylase 2A 0.0232679
MXI1 MAX interactor 1, dimerization protein 0.0231576
GSK3B glycogen synthase kinase 3 beta 0.0230054
BRWD1 bromodomain and WD repeat domain containing 1 0.0226761
WDR26 WD repeat domain 26 0.0225746
CSNK1E casein kinase 1, epsilon 0.0225439
BZW1 basic leucine zipper and W2 domains 1 0.0224154
YEATS2 YEATS domain containing 2 0.0223896
TNIP1 TNFAIP3 interacting protein 1 0.0223333
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0222367
OSMR oncostatin M receptor 0.0221433
RLIM ring finger protein, LIM domain interacting 0.022118
TNRC6A trinucleotide repeat containing 6A 0.0220856
HYOU1 hypoxia up-regulated 1 0.0220605
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0220406
KDM3A lysine (K)-specific demethylase 3A 0.0218933
ZFAND6 zinc finger, AN1-type domain 6 0.0218819
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0216127
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0216112
KDM5B lysine (K)-specific demethylase 5B 0.0215842
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.021497
MYO1B myosin IB 0.0214564
CSDE1 cold shock domain containing E1, RNA-binding 0.0213106
USP9X ubiquitin specific peptidase 9, X-linked 0.0212055
ERRFI1 ERBB receptor feedback inhibitor 1 0.0210716
PGK1 phosphoglycerate kinase 1 0.0210349
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0209696
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0206148
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0206041
KDM7A lysine (K)-specific demethylase 7A 0.0204943

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.272003
TMSB10 thymosin beta 10 -0.188836
EGFR epidermal growth factor receptor -0.164628
INTS6 integrator complex subunit 6 -0.10066
PTMA prothymosin, alpha -0.0787248
S100A10 S100 calcium binding protein A10 -0.0766671
ACTG1 actin gamma 1 -0.0759346
EGR1 early growth response 1 -0.0739723
RPL35A ribosomal protein L35a -0.0737535
CST3 cystatin C -0.0666742
FTL ferritin, light polypeptide -0.0661633
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0648817
TPT1 tumor protein, translationally-controlled 1 -0.0641358
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0608946
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.055472
RPS25 ribosomal protein S25 -0.0547408
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0519243
PKM pyruvate kinase, muscle -0.051098
RPL31 ribosomal protein L31 -0.0509929
PDLIM5 PDZ and LIM domain 5 -0.0503677
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0482348
PTPRM protein tyrosine phosphatase, receptor type, M -0.0459047
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0427131
KRT7 keratin 7, type II -0.0420069
RPL37A ribosomal protein L37a -0.0419253
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.04166
RPS8 ribosomal protein S8 -0.0408474
IFI6 interferon, alpha-inducible protein 6 -0.0398394
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0382592
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0369281
B2M beta-2-microglobulin -0.0361641
AREG amphiregulin -0.0359155
RPLP1 ribosomal protein, large, P1 -0.0358283
HOMER1 homer scaffolding protein 1 -0.0357114
S100P S100 calcium binding protein P -0.0347626
ANXA2 annexin A2 -0.0345856
NSUN6 NOP2/Sun domain family, member 6 -0.0340496
RPS23 ribosomal protein S23 -0.0335087
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0334485
RPS3 ribosomal protein S3 -0.0332572
RPS24 ribosomal protein S24 -0.0330985
PDE4D phosphodiesterase 4D, cAMP-specific -0.0330002
CAV1 caveolin 1, caveolae protein, 22kDa -0.0328372
RPS29 ribosomal protein S29 -0.0326026
CUX1 cut-like homeobox 1 -0.03211
RPS6 ribosomal protein S6 -0.0320754
ASPH aspartate beta-hydroxylase -0.0320589
VCL vinculin -0.0317477
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0305918
RPS27A ribosomal protein S27a -0.0304413
RPL34 ribosomal protein L34 -0.0302066
WASF2 WAS protein family, member 2 -0.029551
SLC38A1 solute carrier family 38, member 1 -0.0282264
LOC102724023 ES1 protein homolog, mitochondrial -0.0279164
AGR2 anterior gradient 2 -0.0271746
RPS13 ribosomal protein S13 -0.0271714
ENO2 enolase 2 (gamma, neuronal) -0.0269508
RPL37 ribosomal protein L37 -0.0269223
SCEL sciellin -0.0268907
THSD4 thrombospondin, type I, domain containing 4 -0.0267407
EIF1 eukaryotic translation initiation factor 1 -0.0265658
CCND1 cyclin D1 -0.0262889
SEC61G Sec61 gamma subunit -0.0259489
SLC38A2 solute carrier family 38, member 2 -0.0256113
EFNA5 ephrin-A5 -0.0255552
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0254518
GNAS GNAS complex locus -0.0251402
HMGA1 high mobility group AT-hook 1 -0.0249828
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0246928
KRT19 keratin 19, type I -0.0246679
LDHA lactate dehydrogenase A -0.0245497
CAV2 caveolin 2 -0.0244203
RPS27 ribosomal protein S27 -0.0242046
KDM3B lysine (K)-specific demethylase 3B -0.0241567
CATSPERB catsper channel auxiliary subunit beta -0.0241157
FNDC3B fibronectin type III domain containing 3B -0.0240698
PATJ PATJ crumbs cell polarity complex component -0.0239292
RPS12 ribosomal protein S12 -0.0237793
FUS FUS RNA binding protein -0.0234784
RPS17 ribosomal protein S17 -0.0232596
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0231685
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.023151
TNS3 tensin 3 -0.0230542
RPL11 ribosomal protein L11 -0.0228879
LPP LIM domain containing preferred translocation partner in lipoma -0.0227499
TTC3 tetratricopeptide repeat domain 3 -0.0227182
ENO1 enolase 1, (alpha) -0.0226855
CCSER1 coiled-coil serine-rich protein 1 -0.0226205
RIMS2 regulating synaptic membrane exocytosis 2 -0.0225155
IGFBP3 insulin-like growth factor binding protein 3 -0.0223266
POTEF POTE ankyrin domain family, member F -0.0222991
MYO1E myosin IE -0.0221459
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0220767
CMIP c-Maf inducing protein -0.0220429
HDAC9 histone deacetylase 9 -0.0216408
MYO1D myosin ID -0.0215836
HLA-B major histocompatibility complex, class I, B -0.0215353
RPS14 ribosomal protein S14 -0.0214713
RPLP2 ribosomal protein, large, P2 -0.0213335
S100A11 S100 calcium binding protein A11 -0.0207954