Niclosamide (olamine)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 0.116777
FNDC3B fibronectin type III domain containing 3B 0.0980967
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0950283
SOD2 superoxide dismutase 2, mitochondrial 0.0940451
SDK1 sidekick cell adhesion molecule 1 0.072834
TRIO trio Rho guanine nucleotide exchange factor 0.0708187
FTH1 ferritin, heavy polypeptide 1 0.0685624
USP34 ubiquitin specific peptidase 34 0.0642567
RICTOR RPTOR independent companion of MTOR, complex 2 0.0637115
CDH13 cadherin 13 0.0606612
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0605366
IGFBP3 insulin-like growth factor binding protein 3 0.0599287
PSD3 pleckstrin and Sec7 domain containing 3 0.0544148
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0541662
FN1 fibronectin 1 0.0541072
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0532378
KDM2A lysine (K)-specific demethylase 2A 0.0520354
GOLGA4 golgin A4 0.0510106
PDE4D phosphodiesterase 4D, cAMP-specific 0.0505865
NAV2 neuron navigator 2 0.0502598
GPC6 glypican 6 0.0502512
UBA6 ubiquitin-like modifier activating enzyme 6 0.0497451
FAM13A family with sequence similarity 13, member A 0.0493001
AKAP12 A kinase (PRKA) anchor protein 12 0.048196
HMGA2 high mobility group AT-hook 2 0.0471935
MEF2A myocyte enhancer factor 2A 0.0466525
RAI14 retinoic acid induced 14 0.0447225
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0444246
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0420069
DSCAM Down syndrome cell adhesion molecule 0.0418541
AKAP13 A kinase (PRKA) anchor protein 13 0.0407866
EEF2 eukaryotic translation elongation factor 2 0.0395244
HELZ helicase with zinc finger 0.039068
KMT2C lysine (K)-specific methyltransferase 2C 0.0383927
ITCH itchy E3 ubiquitin protein ligase 0.0375865
RBM39 RNA binding motif protein 39 0.0364004
JMJD1C jumonji domain containing 1C 0.03505
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0348183
DST dystonin 0.0336634
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.033506
ESYT2 extended synaptotagmin-like protein 2 0.0329228
JARID2 jumonji, AT rich interactive domain 2 0.0327152
FLNB filamin B, beta 0.0326072
MYH9 myosin, heavy chain 9, non-muscle 0.0322489
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0319356
NPAS2 neuronal PAS domain protein 2 0.0316015
PRELID2 PRELI domain containing 2 0.0314133
CD109 CD109 molecule 0.0313456
OGA O-GlcNAcase 0.0313058
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0312546
ATP13A3 ATPase type 13A3 0.0308268
MACF1 microtubule-actin crosslinking factor 1 0.0306611
SMAD3 SMAD family member 3 0.0304415
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0301189
ANKRD11 ankyrin repeat domain 11 0.0297974
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0297845
SPAG9 sperm associated antigen 9 0.0296958
TAS2R14 taste receptor, type 2, member 14 0.0292707
PIAS2 protein inhibitor of activated STAT, 2 0.0285949
SETD5 SET domain containing 5 0.0280005
LOX lysyl oxidase 0.0276815
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0276218
DLG1 discs, large homolog 1 (Drosophila) 0.0274884
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0271778
ATXN1 ataxin 1 0.0269365
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0267466
MTSS1 metastasis suppressor 1 0.026615
COPA coatomer protein complex, subunit alpha 0.0263411
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0262484
RAB1A RAB1A, member RAS oncogene family 0.0261217
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0260504
TTC3 tetratricopeptide repeat domain 3 0.025925
WAC WW domain containing adaptor with coiled-coil 0.0256203
FNIP1 folliculin interacting protein 1 0.0254881
NGLY1 N-glycanase 1 0.0254525
RUNX2 runt-related transcription factor 2 0.0253139
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0252804
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0249539
VEGFA vascular endothelial growth factor A 0.0248775
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0247318
ZEB2 zinc finger E-box binding homeobox 2 0.0246546
DOCK5 dedicator of cytokinesis 5 0.0244441
SEC31A SEC31 homolog A (S. cerevisiae) 0.024401
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0243003
ARHGAP5 Rho GTPase activating protein 5 0.0241589
PCBP2 poly(rC) binding protein 2 0.0236265
MYO1B myosin IB 0.0233534
HDAC9 histone deacetylase 9 0.0231317
PDLIM5 PDZ and LIM domain 5 0.0229429
SUCO SUN domain containing ossification factor 0.0226341
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0225493
STRN3 striatin, calmodulin binding protein 3 0.0223405
NBAS neuroblastoma amplified sequence 0.0220963
ZFAND3 zinc finger, AN1-type domain 3 0.0219131
NF1 neurofibromin 1 0.021889
LPP LIM domain containing preferred translocation partner in lipoma 0.0218234
IQGAP1 IQ motif containing GTPase activating protein 1 0.0217052
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0216947
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0212651
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0211603

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.239484
TMSB10 thymosin beta 10 -0.140579
MT2A metallothionein 2A -0.138342
VIM vimentin -0.1172
FTL ferritin, light polypeptide -0.104058
RPLP1 ribosomal protein, large, P1 -0.0828649
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0717316
RPL35A ribosomal protein L35a -0.064198
RPS19 ribosomal protein S19 -0.062049
NAMPT nicotinamide phosphoribosyltransferase -0.0594056
PTMA prothymosin, alpha -0.0546709
C15ORF48 chromosome 15 open reading frame 48 -0.0508554
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0484895
RPL32 ribosomal protein L32 -0.0477465
RPL23 ribosomal protein L23 -0.0453539
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0450202
RPLP2 ribosomal protein, large, P2 -0.0450052
B2M beta-2-microglobulin -0.0445191
IER3 immediate early response 3 -0.0433171
RPL34 ribosomal protein L34 -0.0429037
RPS29 ribosomal protein S29 -0.0428712
RPS21 ribosomal protein S21 -0.0423899
EIF1 eukaryotic translation initiation factor 1 -0.0417419
RPL36 ribosomal protein L36 -0.0409822
RPS24 ribosomal protein S24 -0.0398136
RPL31 ribosomal protein L31 -0.0395285
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0359988
RPS8 ribosomal protein S8 -0.0359573
RPL12 ribosomal protein L12 -0.0357735
RPS6 ribosomal protein S6 -0.0352181
TPT1 tumor protein, translationally-controlled 1 -0.0315476
RPS13 ribosomal protein S13 -0.0299265
RPL28 ribosomal protein L28 -0.0299176
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0298391
SLC38A1 solute carrier family 38, member 1 -0.0293756
RPL37A ribosomal protein L37a -0.0292318
S100A10 S100 calcium binding protein A10 -0.0287316
RPLP0 ribosomal protein, large, P0 -0.0285103
RPL19 ribosomal protein L19 -0.0269297
RPS3 ribosomal protein S3 -0.0267602
RPL37 ribosomal protein L37 -0.0264636
RPS16 ribosomal protein S16 -0.0261745
RPS25 ribosomal protein S25 -0.0260524
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0258868
RPL11 ribosomal protein L11 -0.024551
RPS12 ribosomal protein S12 -0.0243763
RPS23 ribosomal protein S23 -0.0243205
RPL5 ribosomal protein L5 -0.024297
S100A9 S100 calcium binding protein A9 -0.0240402
RPL9 ribosomal protein L9 -0.0237646
YBX3 Y box binding protein 3 -0.0235223
HLA-B major histocompatibility complex, class I, B -0.0234922
IFITM3 interferon induced transmembrane protein 3 -0.0229095
RPS5 ribosomal protein S5 -0.0224996
RACK1 receptor for activated C kinase 1 -0.0223545
RPL38 ribosomal protein L38 -0.0223366
RPS11 ribosomal protein S11 -0.0223231
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0214053
VDAC1 voltage-dependent anion channel 1 -0.0212896
IFI6 interferon, alpha-inducible protein 6 -0.0212554
GSTP1 glutathione S-transferase pi 1 -0.0212425
TM4SF1 transmembrane 4 L six family member 1 -0.0209663
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0208743
RPL18 ribosomal protein L18 -0.0208156
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0203693
SEC61G Sec61 gamma subunit -0.0202314
HAS2 hyaluronan synthase 2 -0.0200344
RPS27 ribosomal protein S27 -0.019901
EGR1 early growth response 1 -0.0198489
BASP1 brain abundant, membrane attached signal protein 1 -0.0197782
EIF5B eukaryotic translation initiation factor 5B -0.0192803
RPL7A ribosomal protein L7a -0.0191833
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0191161
ENO1 enolase 1, (alpha) -0.0190456
ACTG1 actin gamma 1 -0.0188436
RPS15 ribosomal protein S15 -0.0186023
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0185889
RPL30 ribosomal protein L30 -0.0184988
ATP5F1E ATP synthase F1 subunit epsilon -0.0183351
RPL8 ribosomal protein L8 -0.018265
RPS10 ribosomal protein S10 -0.0181787
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0180676
RPL15 ribosomal protein L15 -0.0175741
SRGN serglycin -0.0173323
S100A6 S100 calcium binding protein A6 -0.0172535
RPL35 ribosomal protein L35 -0.0170956
HMGA1 high mobility group AT-hook 1 -0.0168355
RPS14 ribosomal protein S14 -0.0162909
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0161443
TXNRD1 thioredoxin reductase 1 -0.0159717
PKM pyruvate kinase, muscle -0.0159575
RPL26 ribosomal protein L26 -0.0157664
RPL27A ribosomal protein L27a -0.0157221
RPS20 ribosomal protein S20 -0.01568
PFN1 profilin 1 -0.0155944
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0155509
CD44 CD44 molecule (Indian blood group) -0.0153398
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0150243
MT1X metallothionein 1X -0.0148282
RPL13A ribosomal protein L13a -0.014578