Niclosamide (olamine)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.159476
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0877135
FMNL2 formin-like 2 0.0635061
DOCK4 dedicator of cytokinesis 4 0.0613084
THSD4 thrombospondin, type I, domain containing 4 0.0594898
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0565043
SAMD4A sterile alpha motif domain containing 4A 0.0546131
FNDC3B fibronectin type III domain containing 3B 0.0545339
TRIO trio Rho guanine nucleotide exchange factor 0.0435209
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0426025
LPP LIM domain containing preferred translocation partner in lipoma 0.0423318
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0392408
CMIP c-Maf inducing protein 0.0390088
EEF2 eukaryotic translation elongation factor 2 0.0384808
SVIL supervillin 0.0384073
IGFBP3 insulin-like growth factor binding protein 3 0.0375888
TPM3 tropomyosin 3 0.0364833
UBASH3B ubiquitin associated and SH3 domain containing B 0.0363903
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0358451
ANKRD11 ankyrin repeat domain 11 0.0348783
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0342882
DOCK5 dedicator of cytokinesis 5 0.0335885
PDE4D phosphodiesterase 4D, cAMP-specific 0.0333996
SMOC1 SPARC related modular calcium binding 1 0.0323852
ERBIN erbb2 interacting protein 0.0315824
COPA coatomer protein complex, subunit alpha 0.0308515
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0302488
MACF1 microtubule-actin crosslinking factor 1 0.0296506
WAC WW domain containing adaptor with coiled-coil 0.0296437
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0292334
APP amyloid beta (A4) precursor protein 0.0292003
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0291902
MCL1 myeloid cell leukemia 1 0.0284487
EGFR epidermal growth factor receptor 0.0280872
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0280178
ARHGAP26 Rho GTPase activating protein 26 0.0278296
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0275601
FLNB filamin B, beta 0.0273384
AKAP13 A kinase (PRKA) anchor protein 13 0.0269298
PARD3 par-3 family cell polarity regulator 0.0268538
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0264882
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0264269
MYH9 myosin, heavy chain 9, non-muscle 0.0262971
PTK2 protein tyrosine kinase 2 0.0257925
DST dystonin 0.0257412
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0255579
RICTOR RPTOR independent companion of MTOR, complex 2 0.0255312
KTN1 kinectin 1 (kinesin receptor) 0.0253794
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.025154
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0248809
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0243692
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0237661
PUM2 pumilio RNA-binding family member 2 0.0237124
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0236507
MYOF myoferlin 0.0227694
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0227389
FAM107B family with sequence similarity 107, member B 0.0227387
BIRC6 baculoviral IAP repeat containing 6 0.0226074
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0224238
FLNA filamin A, alpha 0.0223182
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0222277
PDLIM5 PDZ and LIM domain 5 0.0220961
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0217672
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0214543
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0212537
KYNU kynureninase 0.0211784
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0211541
AKAP12 A kinase (PRKA) anchor protein 12 0.0210545
USP36 ubiquitin specific peptidase 36 0.0209488
SBF2 SET binding factor 2 0.0207529
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0205208
TTC28 tetratricopeptide repeat domain 28 0.0204241
ZFAND3 zinc finger, AN1-type domain 3 0.0203821
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0202575
ERRFI1 ERBB receptor feedback inhibitor 1 0.0200171
PYGL phosphorylase, glycogen, liver 0.0198399
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0197159
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0196474
CYTH1 cytohesin 1 0.0196078
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0193425
MAML3 mastermind-like 3 (Drosophila) 0.0190996
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0189999
GOLGA4 golgin A4 0.0189339
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0189195
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.018849
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0188205
BRD2 bromodomain containing 2 0.0188078
EXT1 exostosin glycosyltransferase 1 0.0188034
SMAD3 SMAD family member 3 0.0186784
SOD2 superoxide dismutase 2, mitochondrial 0.0184912
SETD5 SET domain containing 5 0.018404
ACTN1 actinin, alpha 1 0.0183768
ASPH aspartate beta-hydroxylase 0.0183645
USP34 ubiquitin specific peptidase 34 0.0182512
DENND4A DENN/MADD domain containing 4A 0.0182314
MBNL1 muscleblind-like splicing regulator 1 0.0181297
MSN moesin 0.0180383
AHNAK AHNAK nucleoprotein 0.0178331
CCNL1 cyclin L1 0.0177706
CFLAR CASP8 and FADD-like apoptosis regulator 0.0177263

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.194941
FTL ferritin, light polypeptide -0.145738
TMSB10 thymosin beta 10 -0.0992428
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0881765
RPLP1 ribosomal protein, large, P1 -0.0586787
RPL23 ribosomal protein L23 -0.0578798
VIM vimentin -0.0555718
TFPI2 tissue factor pathway inhibitor 2 -0.0392694
RPS21 ribosomal protein S21 -0.0368831
RPL35A ribosomal protein L35a -0.0364095
RPS19 ribosomal protein S19 -0.0331843
TPT1 tumor protein, translationally-controlled 1 -0.031827
TM4SF1 transmembrane 4 L six family member 1 -0.0315895
EIF1 eukaryotic translation initiation factor 1 -0.0307842
PTMA prothymosin, alpha -0.0307043
RPS29 ribosomal protein S29 -0.0305009
RPL31 ribosomal protein L31 -0.0299888
RPL19 ribosomal protein L19 -0.0272407
C15ORF48 chromosome 15 open reading frame 48 -0.0271636
ATP5F1E ATP synthase F1 subunit epsilon -0.0257527
RPL36 ribosomal protein L36 -0.0249761
RPS23 ribosomal protein S23 -0.0226858
RPL7 ribosomal protein L7 -0.0217625
RPS8 ribosomal protein S8 -0.0205573
RPL34 ribosomal protein L34 -0.0191173
MYL12B myosin, light chain 12B, regulatory -0.0186791
RACK1 receptor for activated C kinase 1 -0.0179557
PM20D1 peptidase M20 domain containing 1 -0.0176858
RPS16 ribosomal protein S16 -0.0175892
RPS27A ribosomal protein S27a -0.017545
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0174628
S100A11 S100 calcium binding protein A11 -0.01729
HMGB1 high mobility group box 1 -0.0170071
RPL28 ribosomal protein L28 -0.0168138
AREG amphiregulin -0.0158382
RPS24 ribosomal protein S24 -0.015739
RPL8 ribosomal protein L8 -0.0155601
RPL32 ribosomal protein L32 -0.0153975
SLC38A1 solute carrier family 38, member 1 -0.0150471
CAVIN1 caveolae associated protein 1 -0.0149106
NNMT nicotinamide N-methyltransferase -0.0144887
RPS27 ribosomal protein S27 -0.0142976
GABARAPL2 GABA(A) receptor-associated protein-like 2 -0.0140143
RPS20 ribosomal protein S20 -0.013983
RPS5 ribosomal protein S5 -0.0139583
S100A10 S100 calcium binding protein A10 -0.0138112
NPR2 natriuretic peptide receptor 2 -0.0137205
RPLP0 ribosomal protein, large, P0 -0.0128612
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0127329
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0125291
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0124783
RPL30 ribosomal protein L30 -0.0124118
RPL5 ribosomal protein L5 -0.0123717
RPS15 ribosomal protein S15 -0.0123459
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0122102
RPL38 ribosomal protein L38 -0.0122061
RPL36AL ribosomal protein L36a-like -0.0122029
RPS13 ribosomal protein S13 -0.012192
S100A9 S100 calcium binding protein A9 -0.0119664
FGG fibrinogen gamma chain -0.0117671
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.011753
VDAC1 voltage-dependent anion channel 1 -0.0115207
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.011506
RPL37 ribosomal protein L37 -0.011255
RPL12 ribosomal protein L12 -0.0109983
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0109781
RPLP2 ribosomal protein, large, P2 -0.0108126
RPS25 ribosomal protein S25 -0.0106873
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -0.0106026
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0104282
GSTP1 glutathione S-transferase pi 1 -0.0104032
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0103795
UBB ubiquitin B -0.0103232
ACTG1 actin gamma 1 -0.0103125
RPL9 ribosomal protein L9 -0.0102847
RAD21 RAD21 homolog (S. pombe) -0.0102714
ROMO1 reactive oxygen species modulator 1 -0.00993956
TUBB4B tubulin, beta 4B class IVb -0.00979101
SERF2 small EDRK-rich factor 2 -0.00974076
IFITM3 interferon induced transmembrane protein 3 -0.00963779
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.00955725
TPI1 triosephosphate isomerase 1 -0.00947879
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.00936362
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.00923377
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.00918142
KLF6 Kruppel-like factor 6 -0.00912088
SRSF7 serine/arginine-rich splicing factor 7 -0.00911007
RAN RAN, member RAS oncogene family -0.00888094
IER3 immediate early response 3 -0.0088665
RPL18 ribosomal protein L18 -0.00878471
RPS3 ribosomal protein S3 -0.00877676
UBL5 ubiquitin-like 5 -0.00870556
RPL11 ribosomal protein L11 -0.00864455
RPS14 ribosomal protein S14 -0.00852223
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.00851624
ZNF292 zinc finger protein 292 -0.00845219
LMNA lamin A/C -0.00814262
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -0.00805527
PRDX1 peroxiredoxin 1 -0.00788441
B2M beta-2-microglobulin -0.00783272