Niclosamide (olamine)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
P4HB prolyl 4-hydroxylase, beta polypeptide 0.122281
EEF2 eukaryotic translation elongation factor 2 0.117192
PTMA prothymosin, alpha 0.111654
DTNA dystrobrevin, alpha 0.101324
GRB10 growth factor receptor-bound protein 10 0.0968591
PTK2 protein tyrosine kinase 2 0.0909808
TRA2A transformer 2 alpha homolog (Drosophila) 0.0891818
TMSB10 thymosin beta 10 0.0850513
PSD3 pleckstrin and Sec7 domain containing 3 0.0844508
TPT1 tumor protein, translationally-controlled 1 0.0824594
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0820054
RPL19 ribosomal protein L19 0.0814709
VIM vimentin 0.0813644
FAM13A family with sequence similarity 13, member A 0.0805385
RPL11 ribosomal protein L11 0.0789621
RORA RAR-related orphan receptor A 0.078789
CTNND1 catenin (cadherin-associated protein), delta 1 0.0768534
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0759207
RBM39 RNA binding motif protein 39 0.0736568
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0736283
MATR3 matrin 3 0.0733572
ASPH aspartate beta-hydroxylase 0.0719662
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0657175
MT2A metallothionein 2A 0.0635955
RPS12 ribosomal protein S12 0.0620856
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0592483
GOLGB1 golgin B1 0.0588146
YTHDC1 YTH domain containing 1 0.0579874
RAB1A RAB1A, member RAS oncogene family 0.0570256
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0560902
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0553675
B2M beta-2-microglobulin 0.0551884
APP amyloid beta (A4) precursor protein 0.0549704
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0547063
OGA O-GlcNAcase 0.054631
KTN1 kinectin 1 (kinesin receptor) 0.0543844
RPLP1 ribosomal protein, large, P1 0.052273
CCNY cyclin Y 0.0519446
SEC31A SEC31 homolog A (S. cerevisiae) 0.0512439
UBC ubiquitin C 0.0512027
MACF1 microtubule-actin crosslinking factor 1 0.0506157
MBNL2 muscleblind-like splicing regulator 2 0.0504358
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0503393
MSI2 musashi RNA-binding protein 2 0.0502346
RPS11 ribosomal protein S11 0.0500431
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0490476
RPL7 ribosomal protein L7 0.0481415
BIRC6 baculoviral IAP repeat containing 6 0.0476522
PKM pyruvate kinase, muscle 0.0475133
RIOK3 RIO kinase 3 0.0465025
BBX bobby sox homolog (Drosophila) 0.0461022
TNRC6A trinucleotide repeat containing 6A 0.0459514
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0456403
GOLGA4 golgin A4 0.0454345
SQSTM1 sequestosome 1 0.0452227
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0451536
NAV2 neuron navigator 2 0.0450725
CLTC clathrin, heavy chain (Hc) 0.0444167
BCLAF1 BCL2-associated transcription factor 1 0.0441979
KMT2C lysine (K)-specific methyltransferase 2C 0.0440942
PDE10A phosphodiesterase 10A 0.0440898
EIF4A2 eukaryotic translation initiation factor 4A2 0.043984
PLEC plectin 0.04391
MAP2K1 mitogen-activated protein kinase kinase 1 0.0435893
LIMCH1 LIM and calponin homology domains 1 0.0435397
FAT1 FAT atypical cadherin 1 0.043527
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0431513
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0430838
RPL36 ribosomal protein L36 0.0430695
TRIP12 thyroid hormone receptor interactor 12 0.0426058
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.042475
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0423602
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0419136
RPS8 ribosomal protein S8 0.041675
NUMB numb homolog (Drosophila) 0.0415734
YEATS2 YEATS domain containing 2 0.0410721
ANKRD11 ankyrin repeat domain 11 0.0410386
MYH9 myosin, heavy chain 9, non-muscle 0.0410144
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0410002
JMJD1C jumonji domain containing 1C 0.0404202
SFTPA2 surfactant protein A2 0.0403464
IQGAP1 IQ motif containing GTPase activating protein 1 0.0402957
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0401859
OSBPL8 oxysterol binding protein-like 8 0.0401805
TFG TRK-fused gene 0.0392249
HLA-A major histocompatibility complex, class I, A 0.0387185
YBX3 Y box binding protein 3 0.0385797
LOC112694756 uncharaterized LOC112694756 0.0384994
RPS3 ribosomal protein S3 0.0383725
AK1 adenylate kinase 1 0.037895
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0375646
PRRC2C proline-rich coiled-coil 2C 0.0375249
DSCAM Down syndrome cell adhesion molecule 0.0373073
EPS8 epidermal growth factor receptor pathway substrate 8 0.03715
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0370208
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0367502
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0363881
RPS19 ribosomal protein S19 0.0363214
PDIA3 protein disulfide isomerase family A, member 3 0.0361715
SPAG9 sperm associated antigen 9 0.0361259

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.166075
MYO1E myosin IE -0.138804
NDRG1 N-myc downstream regulated 1 -0.121377
KYNU kynureninase -0.11306
MAST4 microtubule associated serine/threonine kinase family member 4 -0.10495
IGF2 insulin-like growth factor 2 -0.103345
KRT17 keratin 17, type I -0.0934637
LAMB3 laminin, beta 3 -0.0902367
ANXA2 annexin A2 -0.0860585
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0779125
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0774331
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0766942
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0760329
NKD1 naked cuticle homolog 1 (Drosophila) -0.0750413
OSMR oncostatin M receptor -0.0748236
AKAP13 A kinase (PRKA) anchor protein 13 -0.0727523
ELL2 elongation factor, RNA polymerase II, 2 -0.0727098
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0722447
MCTP1 multiple C2 domains, transmembrane 1 -0.0713455
BTG1 B-cell translocation gene 1, anti-proliferative -0.0706903
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0694584
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0692988
MCTP2 multiple C2 domains, transmembrane 2 -0.067978
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0677256
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0677007
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0655277
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.064274
STC1 stanniocalcin 1 -0.0629261
ATOSA atos homolog A -0.0609787
ANXA1 annexin A1 -0.0598055
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0596751
MBD5 methyl-CpG binding domain protein 5 -0.0590729
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0586682
ABI1 abl-interactor 1 -0.0560397
FMN1 formin 1 -0.0557447
MAML2 mastermind-like 2 (Drosophila) -0.0546923
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.053981
EZR ezrin -0.0536119
ATXN1 ataxin 1 -0.0532485
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0521751
MREG melanoregulin -0.0519446
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0508044
ABHD17C abhydrolase domain containing 17C -0.0506666
TRIO trio Rho guanine nucleotide exchange factor -0.0497167
FBXO11 F-box protein 11 -0.0494198
PARD3 par-3 family cell polarity regulator -0.0489622
VCL vinculin -0.0482205
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0481689
LAMA4 laminin, alpha 4 -0.048164
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0480026
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0474415
RUNX1 runt-related transcription factor 1 -0.0472943
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0468569
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0452346
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0450907
TPM4 tropomyosin 4 -0.0449374
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0447178
EXT1 exostosin glycosyltransferase 1 -0.0443268
MACC1 metastasis associated in colon cancer 1 -0.0429898
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0426198
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0420825
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0418511
KLF5 Kruppel-like factor 5 (intestinal) -0.0417475
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0415045
MAP4 microtubule-associated protein 4 -0.0411587
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.041007
IGF1R insulin-like growth factor 1 receptor -0.0408488
AKAP12 A kinase (PRKA) anchor protein 12 -0.0408429
MXD1 MAX dimerization protein 1 -0.0406069
RPTOR regulatory associated protein of MTOR, complex 1 -0.0405946
HMGA2 high mobility group AT-hook 2 -0.0400486
MCL1 myeloid cell leukemia 1 -0.0385607
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0375211
RPS24 ribosomal protein S24 -0.0373969
SHB Src homology 2 domain containing adaptor protein B -0.036708
TTC17 tetratricopeptide repeat domain 17 -0.0363883
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0362026
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0361761
CEMIP cell migration inducing protein, hyaluronan binding -0.0361673
CLINT1 clathrin interactor 1 -0.0351365
BACE2 beta-site APP-cleaving enzyme 2 -0.0350073
DIAPH2 diaphanous-related formin 2 -0.0348914
MDM4 MDM4, p53 regulator -0.0347924
ACTN4 actinin, alpha 4 -0.0345992
SVIL supervillin -0.0343597
ZC3H11A zinc finger CCCH-type containing 11A -0.0341841
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0341486
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.0337965
FBF1 Fas (TNFRSF6) binding factor 1 -0.0337162
SCAF11 SR-related CTD-associated factor 11 -0.0335742
EXOC4 exocyst complex component 4 -0.0318147
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0315761
DOCK5 dedicator of cytokinesis 5 -0.0313174
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0312972
SH3KBP1 SH3-domain kinase binding protein 1 -0.0309277
RIGI RNA sensor RIG-I -0.0307922
RPL34 ribosomal protein L34 -0.030633
DOCK4 dedicator of cytokinesis 4 -0.0306008
PNISR PNN-interacting serine/arginine-rich protein -0.0305225
BPTF bromodomain PHD finger transcription factor -0.0303647