Niclosamide (olamine)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MCL1 myeloid cell leukemia 1 0.0980385
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0957361
THSD4 thrombospondin, type I, domain containing 4 0.0869772
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0800231
EEF2 eukaryotic translation elongation factor 2 0.0662898
RAD51B RAD51 paralog B 0.0653821
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0652671
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0617226
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0556079
IGF1R insulin-like growth factor 1 receptor 0.0553724
TAS2R14 taste receptor, type 2, member 14 0.0550843
VCL vinculin 0.053955
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0502369
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0498967
AEBP2 AE binding protein 2 0.048984
USP34 ubiquitin specific peptidase 34 0.0488726
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0484923
ZFAND3 zinc finger, AN1-type domain 3 0.0479629
PDLIM5 PDZ and LIM domain 5 0.0478874
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0468281
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.046239
EXOC4 exocyst complex component 4 0.046123
TRIO trio Rho guanine nucleotide exchange factor 0.045448
INTS6 integrator complex subunit 6 0.0452241
NABP1 nucleic acid binding protein 1 0.0446352
OSMR oncostatin M receptor 0.0425753
MACF1 microtubule-actin crosslinking factor 1 0.0424615
ZSWIM6 zinc finger, SWIM-type containing 6 0.0422612
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.042121
AFF3 AF4/FMR2 family, member 3 0.042022
FMNL2 formin-like 2 0.0394854
NF1 neurofibromin 1 0.0392091
PRH1 proline-rich protein HaeIII subfamily 1 0.0386691
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0384848
RIMS2 regulating synaptic membrane exocytosis 2 0.0383572
HMGA2 high mobility group AT-hook 2 0.0372666
YAP1 Yes-associated protein 1 0.0369373
TRIP12 thyroid hormone receptor interactor 12 0.0367923
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0365662
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0359972
ATXN1 ataxin 1 0.0352625
EXT1 exostosin glycosyltransferase 1 0.0352469
FBXO11 F-box protein 11 0.0351051
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0348712
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0348409
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0347532
GRAMD1B GRAM domain containing 1B 0.0344862
AHNAK AHNAK nucleoprotein 0.034112
WNT2B wingless-type MMTV integration site family, member 2B 0.0340678
WWOX WW domain containing oxidoreductase 0.0340526
DOCK5 dedicator of cytokinesis 5 0.0339138
PDE4D phosphodiesterase 4D, cAMP-specific 0.0335013
DSCAM Down syndrome cell adhesion molecule 0.0334663
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0327228
MYH9 myosin, heavy chain 9, non-muscle 0.0321427
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0318303
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0318236
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.031182
FNDC3B fibronectin type III domain containing 3B 0.0308639
PRKCE protein kinase C, epsilon 0.0298842
PTK2 protein tyrosine kinase 2 0.0295839
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0291205
RABGAP1L RAB GTPase activating protein 1-like 0.0291136
DENND1A DENN/MADD domain containing 1A 0.0284689
MCTP1 multiple C2 domains, transmembrane 1 0.0284489
PHF3 PHD finger protein 3 0.0281136
CDK17 cyclin-dependent kinase 17 0.0280512
SFPQ splicing factor proline/glutamine-rich 0.0279133
NIPBL Nipped-B homolog (Drosophila) 0.0279077
LARP4B La ribonucleoprotein domain family, member 4B 0.0277319
WNK1 WNK lysine deficient protein kinase 1 0.0275302
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0273589
EGR1 early growth response 1 0.0270353
ZBTB20 zinc finger and BTB domain containing 20 0.0269623
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0269489
NEK10 NIMA-related kinase 10 0.0267504
TIAM1 T-cell lymphoma invasion and metastasis 1 0.0260316
SMYD3 SET and MYND domain containing 3 0.026005
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0257681
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0257373
RYR3 ryanodine receptor 3 0.0256859
PLEC plectin 0.0255745
WWTR1 WW domain containing transcription regulator 1 0.0255456
PDE10A phosphodiesterase 10A 0.0254334
LPP LIM domain containing preferred translocation partner in lipoma 0.0254101
SLC38A2 solute carrier family 38, member 2 0.0254056
CSDE1 cold shock domain containing E1, RNA-binding 0.0247963
H1-0 H1.0 linker histone 0.0246071
RYK receptor-like tyrosine kinase 0.0245767
HOMER1 homer scaffolding protein 1 0.0243485
BICD1 bicaudal D homolog 1 (Drosophila) 0.0242143
PRELID2 PRELI domain containing 2 0.0241012
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0239716
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0239692
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0237147
ELL2 elongation factor, RNA polymerase II, 2 0.0235077
STAU1 staufen double-stranded RNA binding protein 1 0.0229202
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0228908
DNAH14 dynein, axonemal, heavy chain 14 0.0228316
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0224607

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.177582
TMSB10 thymosin beta 10 -0.0745426
VIM vimentin -0.0669123
PTMA prothymosin, alpha -0.0654794
MT2A metallothionein 2A -0.0509293
RPL35A ribosomal protein L35a -0.0495094
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0425447
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0422257
FTL ferritin, light polypeptide -0.0412982
RPLP1 ribosomal protein, large, P1 -0.0397218
RPS8 ribosomal protein S8 -0.0394372
KTN1 kinectin 1 (kinesin receptor) -0.0373372
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0341821
RPS19 ribosomal protein S19 -0.0340412
RPS3 ribosomal protein S3 -0.0316901
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0316358
TPI1 triosephosphate isomerase 1 -0.0314393
AKAP9 A kinase (PRKA) anchor protein 9 -0.0313443
RPS27 ribosomal protein S27 -0.0310626
PFN1 profilin 1 -0.0303078
RPL8 ribosomal protein L8 -0.028125
RPL37 ribosomal protein L37 -0.027852
RPLP2 ribosomal protein, large, P2 -0.0253868
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.025187
RPL36 ribosomal protein L36 -0.0249806
RPL37A ribosomal protein L37a -0.0247714
RPS6 ribosomal protein S6 -0.024164
ENO1 enolase 1, (alpha) -0.0238559
EIF5B eukaryotic translation initiation factor 5B -0.0226196
ATP5F1B ATP synthase F1 subunit beta -0.0226138
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0222951
YBX1 Y box binding protein 1 -0.0221855
TXNRD1 thioredoxin reductase 1 -0.0220364
LDHB lactate dehydrogenase B -0.0219665
PDIA3 protein disulfide isomerase family A, member 3 -0.0219036
MYL12B myosin, light chain 12B, regulatory -0.0217866
WSB1 WD repeat and SOCS box containing 1 -0.0210699
RPL26 ribosomal protein L26 -0.0209955
RPS21 ribosomal protein S21 -0.0204603
RPL34 ribosomal protein L34 -0.0204598
RPL31 ribosomal protein L31 -0.0200447
LMAN1 lectin, mannose-binding, 1 -0.0199179
RPL23 ribosomal protein L23 -0.0198628
PKM pyruvate kinase, muscle -0.0196096
P4HB prolyl 4-hydroxylase, beta polypeptide -0.019295
AKAP12 A kinase (PRKA) anchor protein 12 -0.0191325
HLA-B major histocompatibility complex, class I, B -0.0191151
GOLGA4 golgin A4 -0.0188328
YBX3 Y box binding protein 3 -0.0187516
RPS29 ribosomal protein S29 -0.0186871
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0186741
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0184601
KDM2A lysine (K)-specific demethylase 2A -0.0179174
TPT1 tumor protein, translationally-controlled 1 -0.0175967
RPL5 ribosomal protein L5 -0.0174901
GSTP1 glutathione S-transferase pi 1 -0.0171085
IKBIP IKBKB interacting protein -0.0170792
PTMS parathymosin -0.0169312
ACBD3 acyl-CoA binding domain containing 3 -0.0166574
RPS12 ribosomal protein S12 -0.016594
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.016446
KPNB1 karyopherin (importin) beta 1 -0.0164186
POTEF POTE ankyrin domain family, member F -0.0163659
RPS15 ribosomal protein S15 -0.0161421
RPL12 ribosomal protein L12 -0.0160752
LOC102724023 ES1 protein homolog, mitochondrial -0.0160558
SRP54 signal recognition particle 54kDa -0.0160395
FAM13A family with sequence similarity 13, member A -0.0160313
RPL32 ribosomal protein L32 -0.0159693
S100A11 S100 calcium binding protein A11 -0.0159201
S100A6 S100 calcium binding protein A6 -0.0157981
RPS14 ribosomal protein S14 -0.0157963
TMEM165 transmembrane protein 165 -0.0156327
ZFP36L1 ZFP36 ring finger protein-like 1 -0.015518
ATP5F1E ATP synthase F1 subunit epsilon -0.015298
DEK DEK proto-oncogene -0.0152459
B2M beta-2-microglobulin -0.0152392
NPEPPS aminopeptidase puromycin sensitive -0.0151362
RPL38 ribosomal protein L38 -0.015059
MT1X metallothionein 1X -0.0149965
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0149949
HMGA1 high mobility group AT-hook 1 -0.0149097
NOP58 NOP58 ribonucleoprotein -0.0148878
RPL9 ribosomal protein L9 -0.014849
RPS27A ribosomal protein S27a -0.0145746
WDR45B WD repeat domain 45B -0.0145717
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0142263
CHD1L chromodomain helicase DNA binding protein 1-like -0.014177
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0139495
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0137795
RAB6A RAB6A, member RAS oncogene family -0.0136831
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0134481
SRSF11 serine/arginine-rich splicing factor 11 -0.0134007
RPS10 ribosomal protein S10 -0.0133592
RPL36A ribosomal protein L36a -0.0132463
RPL30 ribosomal protein L30 -0.0132198
SEC61G Sec61 gamma subunit -0.0131764
PREPL prolyl endopeptidase-like -0.0131167
VDAC1 voltage-dependent anion channel 1 -0.0130457
ZNF292 zinc finger protein 292 -0.0130373