Niclosamide (olamine)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.246977
HSPH1 heat shock 105kDa/110kDa protein 1 0.133299
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.110045
HSPA1A heat shock 70kDa protein 1A 0.0529293
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0507753
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0471414
HSPA8 heat shock 70kDa protein 8 0.0459516
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0436161
MOB4 MOB family member 4, phocein 0.0424374
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0353624
SSBP2 single-stranded DNA binding protein 2 0.0352552
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0336852
ELOVL5 ELOVL fatty acid elongase 5 0.0324535
MSMO1 methylsterol monooxygenase 1 0.0323413
NPAS4 neuronal PAS domain protein 4 0.032142
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.0296604
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0284189
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0273282
ZMAT4 zinc finger, matrin-type 4 0.0266746
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0257272
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0254221
GPBP1 GC-rich promoter binding protein 1 0.0252415
APP amyloid beta (A4) precursor protein 0.0245983
TRIO trio Rho guanine nucleotide exchange factor 0.0233517
STIP1 stress-induced phosphoprotein 1 0.0227123
HSPB1 heat shock 27kDa protein 1 0.0224598
PDS5B PDS5 cohesin associated factor B 0.0223653
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.0222158
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0214829
PDIA6 protein disulfide isomerase family A, member 6 0.0214585
USPL1 ubiquitin specific peptidase like 1 0.021311
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0211479
CHD1 chromodomain helicase DNA binding protein 1 0.0204507
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0204195
BCLAF1 BCL2-associated transcription factor 1 0.02026
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0200069
JAM3 junctional adhesion molecule 3 0.0198899
HSPE1-MOB4 HSPE1-MOB4 readthrough 0.019613
WAC WW domain containing adaptor with coiled-coil 0.0195991
HSPA1B heat shock 70kDa protein 1B 0.0189478
TSPYL2 TSPY-like 2 0.0185986
HSPE1 heat shock 10kDa protein 1 0.0180683
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0175687
FMNL2 formin-like 2 0.0175247
AKAP13 A kinase (PRKA) anchor protein 13 0.0173127
FXR1 fragile X mental retardation, autosomal homolog 1 0.0173004
OSBPL9 oxysterol binding protein-like 9 0.0172721
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0172711
SREBF2 sterol regulatory element binding transcription factor 2 0.0169738
XPO1 exportin 1 0.0169672
FNDC3B fibronectin type III domain containing 3B 0.0169434
WDR43 WD repeat domain 43 0.0164005
TRA2A transformer 2 alpha homolog (Drosophila) 0.0158633
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0157595
PUM2 pumilio RNA-binding family member 2 0.015409
PRPF8 pre-mRNA processing factor 8 0.0152438
SQSTM1 sequestosome 1 0.0142673
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0142397
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0142173
PUM1 pumilio RNA-binding family member 1 0.0141162
TSC22D2 TSC22 domain family, member 2 0.014068
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.0140292
QKI QKI, KH domain containing, RNA binding 0.0140136
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0139772
MED13L mediator complex subunit 13-like 0.0138502
NCKAP1 NCK-associated protein 1 0.013665
PTK2 protein tyrosine kinase 2 0.0136005
BAIAP2 BAI1-associated protein 2 0.0134766
NUP58 nucleoporin 58 0.0131667
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0130322
CCNL1 cyclin L1 0.0129782
TRA2B transformer 2 beta homolog (Drosophila) 0.0129618
ADAM9 ADAM metallopeptidase domain 9 0.0127702
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0127507
IARS1 isoleucyl-tRNA synthetase 1 0.0127245
MARCHF6 membrane associated ring-CH-type finger 6 0.0126167
MSN moesin 0.0125949
SNAP25 synaptosomal-associated protein, 25kDa 0.0125579
RSRC2 arginine/serine-rich coiled-coil 2 0.0124848
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0123328
BRD2 bromodomain containing 2 0.0122827
COPA coatomer protein complex, subunit alpha 0.0122678
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0122286
AZIN1 antizyme inhibitor 1 0.0121158
TPM3 tropomyosin 3 0.012039
RAD23B RAD23 homolog B (S. cerevisiae) 0.0120051
SFPQ splicing factor proline/glutamine-rich 0.0119299
CHKA choline kinase alpha 0.0119218
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0118012
EEF2 eukaryotic translation elongation factor 2 0.0117271
CAMTA1 calmodulin binding transcription activator 1 0.0116993
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0116613
HSPA4 heat shock 70kDa protein 4 0.011636
FOS FBJ murine osteosarcoma viral oncogene homolog 0.011604
UBC ubiquitin C 0.0114574
SNX9 sorting nexin 9 0.0114016
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0113674
TTC19 tetratricopeptide repeat domain 19 0.0113538
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.01121
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.010977

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.220259
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.090062
PTMA prothymosin, alpha -0.0872948
RIMS2 regulating synaptic membrane exocytosis 2 -0.0861827
TENM1 teneurin transmembrane protein 1 -0.0755697
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0739857
NALF1 NALCN channel auxiliary factor 1 -0.0710691
CALCA calcitonin-related polypeptide alpha -0.0673419
MT2A metallothionein 2A -0.0643883
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0603083
ENO1 enolase 1, (alpha) -0.0568562
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.055718
FTL ferritin, light polypeptide -0.0533967
RPS3 ribosomal protein S3 -0.0532442
SASH1 SAM and SH3 domain containing 1 -0.0516708
SNTG1 syntrophin, gamma 1 -0.0513527
IFI6 interferon, alpha-inducible protein 6 -0.0497616
RPS21 ribosomal protein S21 -0.0492703
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0491706
SMYD3 SET and MYND domain containing 3 -0.048602
NCKAP5 NCK-associated protein 5 -0.0466703
RPS8 ribosomal protein S8 -0.0459235
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0450963
RPL26 ribosomal protein L26 -0.0428106
CNKSR3 CNKSR family member 3 -0.0393157
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0391842
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.0389877
ADGRL2 adhesion G protein-coupled receptor L2 -0.0385958
S100A9 S100 calcium binding protein A9 -0.0383426
FGF14 fibroblast growth factor 14 -0.0383145
RNF213 ring finger protein 213 -0.0373927
PDE4B phosphodiesterase 4B, cAMP-specific -0.0372196
RPS6 ribosomal protein S6 -0.0371048
RPL37A ribosomal protein L37a -0.0370482
NRG1 neuregulin 1 -0.0369345
RIT2 Ras-like without CAAX 2 -0.0364682
PDE4D phosphodiesterase 4D, cAMP-specific -0.0360805
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -0.0358709
RPL8 ribosomal protein L8 -0.0355735
RPLP1 ribosomal protein, large, P1 -0.0351963
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.034594
CENPF centromere protein F, 350/400kDa -0.0332968
ZBTB20 zinc finger and BTB domain containing 20 -0.0318825
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.031854
TMSB10 thymosin beta 10 -0.0313429
ARB2A ARB2 cotranscriptional regulator A -0.0308842
RPS19 ribosomal protein S19 -0.030862
RPL11 ribosomal protein L11 -0.0307153
SYT1 synaptotagmin I -0.0305161
RPL23 ribosomal protein L23 -0.0303097
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0298981
ISG15 ISG15 ubiquitin-like modifier -0.0295758
RPS16 ribosomal protein S16 -0.0295489
RPS27A ribosomal protein S27a -0.0295064
ATP5F1E ATP synthase F1 subunit epsilon -0.029387
RAD51B RAD51 paralog B -0.029026
ZNF292 zinc finger protein 292 -0.0288985
RPL38 ribosomal protein L38 -0.0285738
RPL12 ribosomal protein L12 -0.0285502
RPS29 ribosomal protein S29 -0.0282494
PEX5L peroxisomal biogenesis factor 5-like -0.0280895
PTCHD4 patched domain containing 4 -0.0280135
RPL37 ribosomal protein L37 -0.0276391
RPL19 ribosomal protein L19 -0.0276045
IGF1R insulin-like growth factor 1 receptor -0.0274153
RPS27 ribosomal protein S27 -0.027304
TSHZ2 teashirt zinc finger homeobox 2 -0.0265194
VGF VGF nerve growth factor inducible -0.0261624
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0260994
NIPSNAP2 nipsnap homolog 2 -0.0260788
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0259554
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0259375
RPL31 ribosomal protein L31 -0.025623
RPS25 ribosomal protein S25 -0.0255607
RPL36 ribosomal protein L36 -0.0255397
WWOX WW domain containing oxidoreductase -0.0254834
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0249584
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0248322
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0247852
NOVA1 neuro-oncological ventral antigen 1 -0.0245476
RPL32 ribosomal protein L32 -0.0241177
KIF26B kinesin family member 26B -0.0239357
EFNA5 ephrin-A5 -0.0236947
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0235076
RPS17 ribosomal protein S17 -0.0234887
RPL35 ribosomal protein L35 -0.0233383
KIAA0825 KIAA0825 -0.0232032
FOXP1 forkhead box P1 -0.0231651
RPL36AL ribosomal protein L36a-like -0.0231041
RPLP2 ribosomal protein, large, P2 -0.0230748
RPH3AL rabphilin 3A-like (without C2 domains) -0.023014
TXNRD1 thioredoxin reductase 1 -0.0229286
FAAH2 fatty acid amide hydrolase 2 -0.0228782
CNTNAP2 contactin associated protein-like 2 -0.0227181
RPL30 ribosomal protein L30 -0.0223384
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0223153
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0221504
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0218705
RACK1 receptor for activated C kinase 1 -0.0218697
ACTG1 actin gamma 1 -0.0218473