Niclosamide (olamine)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Niclosamide (olamine) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Niclosamide (olamine)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.106809
SOD2 superoxide dismutase 2, mitochondrial 0.0636726
CDH13 cadherin 13 0.0581584
FTH1 ferritin, heavy polypeptide 1 0.057091
MYH9 myosin, heavy chain 9, non-muscle 0.0568184
TRIO trio Rho guanine nucleotide exchange factor 0.0424156
CXCL8 chemokine (C-X-C motif) ligand 8 0.0352931
JARID2 jumonji, AT rich interactive domain 2 0.0343399
EGFR epidermal growth factor receptor 0.03278
IGFBP3 insulin-like growth factor binding protein 3 0.0308712
SEC24D SEC24 family member D 0.0288667
PLEC plectin 0.0280179
COL5A1 collagen, type V, alpha 1 0.0278965
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0278369
FNDC3B fibronectin type III domain containing 3B 0.027816
AFF4 AF4/FMR2 family, member 4 0.0271831
CD109 CD109 molecule 0.0264612
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0260149
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0258826
VEGFA vascular endothelial growth factor A 0.0249283
ATP13A3 ATPase type 13A3 0.0244753
GLS2 glutaminase 2 (liver, mitochondrial) 0.0236091
DSCAM Down syndrome cell adhesion molecule 0.02358
CYLD cylindromatosis (turban tumor syndrome) 0.0233796
IL6ST interleukin 6 signal transducer 0.0233533
ANKHD1 ankyrin repeat and KH domain containing 1 0.0232654
IARS1 isoleucyl-tRNA synthetase 1 0.0227715
ZMIZ1 zinc finger, MIZ-type containing 1 0.0226431
CADM1 cell adhesion molecule 1 0.0225236
KAZN kazrin, periplakin interacting protein 0.0220829
GRB10 growth factor receptor-bound protein 10 0.021947
LIMS1 LIM and senescent cell antigen-like domains 1 0.0219263
ANXA5 annexin A5 0.0218472
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0217552
STC2 stanniocalcin 2 0.0214273
SAMD4A sterile alpha motif domain containing 4A 0.021422
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0207714
MMP12 matrix metallopeptidase 12 0.020621
TIMP3 TIMP metallopeptidase inhibitor 3 0.0200369
KMT2C lysine (K)-specific methyltransferase 2C 0.0198938
IL6 interleukin 6 0.0198351
FXR1 fragile X mental retardation, autosomal homolog 1 0.0197474
NAV1 neuron navigator 1 0.0194217
PARD3 par-3 family cell polarity regulator 0.0193872
ADAM17 ADAM metallopeptidase domain 17 0.0193532
ZSWIM6 zinc finger, SWIM-type containing 6 0.0193368
SEC24A SEC24 family member A 0.0190975
FNIP1 folliculin interacting protein 1 0.0188758
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0188229
FLNA filamin A, alpha 0.0187859
MSN moesin 0.0187398
USP34 ubiquitin specific peptidase 34 0.0186386
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0185744
KMT2A lysine (K)-specific methyltransferase 2A 0.0183069
ERBIN erbb2 interacting protein 0.0180343
ATXN1 ataxin 1 0.0180336
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0178688
ESYT2 extended synaptotagmin-like protein 2 0.0176661
PHF21A PHD finger protein 21A 0.0176458
SSBP2 single-stranded DNA binding protein 2 0.0175966
COL4A2 collagen, type IV, alpha 2 0.0175576
CTBP2 C-terminal binding protein 2 0.0175121
COL6A1 collagen, type VI, alpha 1 0.0174064
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.017357
UBA6 ubiquitin-like modifier activating enzyme 6 0.0173392
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0172985
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0170721
MYLK myosin light chain kinase 0.016974
AHNAK AHNAK nucleoprotein 0.0169733
CCNY cyclin Y 0.0169148
C1D C1D nuclear receptor corepressor 0.016852
PTPRM protein tyrosine phosphatase, receptor type, M 0.0165224
JAK1 Janus kinase 1 0.0165032
SPAG9 sperm associated antigen 9 0.0164844
COL4A1 collagen, type IV, alpha 1 0.0164834
VEGFC vascular endothelial growth factor C 0.0161149
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0159609
HOOK2 hook microtubule-tethering protein 2 0.015927
NRXN3 neurexin 3 0.0154048
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0153215
RNF145 ring finger protein 145 0.0152912
COPA coatomer protein complex, subunit alpha 0.0152664
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0152204
HDAC9 histone deacetylase 9 0.0152179
YAP1 Yes-associated protein 1 0.0152142
TRIP12 thyroid hormone receptor interactor 12 0.0152015
COPB1 coatomer protein complex, subunit beta 1 0.0151792
CCNL1 cyclin L1 0.0150599
NBAS neuroblastoma amplified sequence 0.0150329
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0149694
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.01495
KIF1B kinesin family member 1B 0.0149165
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0149061
OGA O-GlcNAcase 0.0148895
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0148342
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0147471
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0147186
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0146906
SETD5 SET domain containing 5 0.0146438
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0146112

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.295043
TMSB10 thymosin beta 10 -0.143988
MT2A metallothionein 2A -0.139472
PTMA prothymosin, alpha -0.0635388
VIM vimentin -0.0587672
FTL ferritin, light polypeptide -0.0587029
HLA-B major histocompatibility complex, class I, B -0.0577668
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0577034
STC1 stanniocalcin 1 -0.0513532
MT1X metallothionein 1X -0.0468635
CCNI cyclin I -0.0394917
RPL35A ribosomal protein L35a -0.0377064
S100A9 S100 calcium binding protein A9 -0.0368609
LGALS1 lectin, galactoside-binding, soluble, 1 -0.034906
ANXA2 annexin A2 -0.0328717
RPS19 ribosomal protein S19 -0.0323691
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0322048
RPS24 ribosomal protein S24 -0.0320479
H3-3B H3.3 histone B -0.03175
RPLP1 ribosomal protein, large, P1 -0.0272521
FLOT1 flotillin 1 -0.0269566
RPL37A ribosomal protein L37a -0.0264585
RACK1 receptor for activated C kinase 1 -0.0260567
S100A6 S100 calcium binding protein A6 -0.0253307
GLIS3 GLIS family zinc finger 3 -0.0251452
TGFBI transforming growth factor, beta-induced, 68kDa -0.0243374
CFDP1 craniofacial development protein 1 -0.0242859
RPS8 ribosomal protein S8 -0.0236033
EIF1 eukaryotic translation initiation factor 1 -0.0234556
WSB1 WD repeat and SOCS box containing 1 -0.0231842
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0224136
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0221829
RPS5 ribosomal protein S5 -0.0218619
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0214692
PTN pleiotrophin -0.0214184
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0211641
ASPH aspartate beta-hydroxylase -0.0210778
RPL15 ribosomal protein L15 -0.0210237
GNAS GNAS complex locus -0.0205283
RPL28 ribosomal protein L28 -0.0204973
RPL34 ribosomal protein L34 -0.0197033
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.019565
TM4SF1 transmembrane 4 L six family member 1 -0.0194726
RPL5 ribosomal protein L5 -0.0194294
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0193897
PCM1 pericentriolar material 1 -0.019246
RPS6 ribosomal protein S6 -0.019181
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.01906
RPLP2 ribosomal protein, large, P2 -0.0188018
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0186562
PDE10A phosphodiesterase 10A -0.0181924
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0179328
RPL32 ribosomal protein L32 -0.0175521
RPL38 ribosomal protein L38 -0.0175339
VDAC1 voltage-dependent anion channel 1 -0.0174256
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0173791
FAF2 Fas associated factor family member 2 -0.0173334
FNDC3A fibronectin type III domain containing 3A -0.017242
TPT1 tumor protein, translationally-controlled 1 -0.0170742
EGR1 early growth response 1 -0.0170086
ACTN4 actinin, alpha 4 -0.0168797
RRBP1 ribosome binding protein 1 -0.0168089
TUBB tubulin, beta class I -0.0167773
RPL26 ribosomal protein L26 -0.0166517
RPL30 ribosomal protein L30 -0.0165418
RPL23 ribosomal protein L23 -0.0165374
PFN1 profilin 1 -0.0165364
ANLN anillin, actin binding protein -0.0164536
HMGA2 high mobility group AT-hook 2 -0.0162053
RPL31 ribosomal protein L31 -0.0161879
LDHA lactate dehydrogenase A -0.016116
HMGB1 high mobility group box 1 -0.0159418
POTEF POTE ankyrin domain family, member F -0.0158176
PCOLCE procollagen C-endopeptidase enhancer -0.0157689
PLAUR plasminogen activator, urokinase receptor -0.0157625
IGFBP5 insulin-like growth factor binding protein 5 -0.0154645
RPL12 ribosomal protein L12 -0.0152911
ZNF395 zinc finger protein 395 -0.0151714
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0151169
PGK1 phosphoglycerate kinase 1 -0.0149657
RPS3 ribosomal protein S3 -0.0148887
RPS13 ribosomal protein S13 -0.0148449
RPL37 ribosomal protein L37 -0.0146612
FMN1 formin 1 -0.01424
IGFBP7 insulin-like growth factor binding protein 7 -0.0141428
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0140095
SNW1 SNW domain containing 1 -0.0139776
TRIM9 tripartite motif containing 9 -0.0137867
MPHOSPH8 M-phase phosphoprotein 8 -0.0137402
WDPCP WD repeat containing planar cell polarity effector -0.0137149
PRSS23 protease, serine, 23 -0.0136514
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0136096
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0135986
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0134828
NDUFA4 NDUFA4, mitochondrial complex associated -0.013482
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0134817
RPL8 ribosomal protein L8 -0.0134554
TNPO3 transportin 3 -0.013413
TRPS1 trichorhinophalangeal syndrome I -0.0133513
PURA purine-rich element binding protein A -0.0133251